First published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

Here we discuss the hypothesis that the RNA components of the Ro ribonucleoproteins (RNPs), the Y RNAs, can be processed into microRNAs (miRNAs). Although Ro RNPs, whose main protein components Ro60 and La are targeted by the immune system in several autoimmune diseases, were discovered many years ago, their function is still poorly understood. Indeed, recent data show that miRNA-sized small RNAs can be generated from Y RNAs. This hypothesis leads also to a model in which Ro60 acts as a (...) modulator in the Y RNA-derived miRNA biogenesis pathway. The implications of these Y RNA-derived miRNAs, which may be specifically produced under pathological circumstances such as in autoimmunity or during viral infections, for the enigmatic function of Ro RNPs are discussed. (shrink)

In contrast to vertical gene transfer from parent to offspring, horizontal (or lateral) gene transfer moves genetic information between different species. Bacteria and archaea often adapt through horizontal gene transfer. Recent analyses indicate that eukaryotic genomes, too, have acquired numerous genes via horizontal transfer from prokaryotes and other lineages. Based on this we raise the hypothesis that horizontally acquired genes may have contributed more to adaptive evolution of eukaryotes than previously assumed. Current candidate sets of horizontally acquired eukaryotic genes may (...) just be the tip of an iceberg. We have recently shown that adaptation of the thermoacidophilic red algaGaldieria sulphurariato its hot, acid, toxic‐metal laden, volcanic environment was facilitated by the acquisition of numerous genes from extremophile bacteria and archaea. Other recently published examples of horizontal acquisitions involved in adaptation include ice‐binding proteins in marine algae, enzymes for carotenoid biosynthesis in aphids, and genes involved in fungal metabolism.Editor's suggested further reading in BioEssaysJumping the fine LINE between species: Horizontal transfer of transposable elements in animals catalyses genome evolution Abstract. (shrink)

Dentre os problemas tradicionais da Epistemologia, uma das controvérsiasmais persistentes é a questão da inserção versus isenção de valores naciência. Filiando-se a uma longa tradição crítica, o filósofo Hugh Laceydesenvolve um exame contundente acerca dos fundamentos da ciência emsua interação com a sociedade, questionando a noção tradicional deneutralidade científica. Pretendemos nesse trabalho estender a crítica deLacey às ciências sociais, e especificamente à Economia. Argumentamosque a ortodoxia da ciência econômica moderna , atravésda incorporação do paradigma mecanicista da física clássica, bem comode (...) todo instrumental analítico das estratégias materialistas, não representaum tipo de compreensão neutra dos fenômenos econômicos, mas sim umaparticularmente notável manifestação dos valores predominantes nessasociedade , da qual faz parte.Assim, procuramos mostrar que, também no âmbito social, a preeminênciados aspectos nomológicos e quantitativos da realidade na formulação dasteorias econômicas de tradição neoclássica espelha valores sociais altamenteestimados nas sociedades modernas.Among the traditional problems in Epistemology, one of the most persistentcontroversies is the question of value insertion versus value exemption inscience. The philosopher Hugh Lacey, in consonance with a long criticaltradition, advances a sharp examination of the foundations of science andits interaction with society, questioning the traditional notion of scientificneutrality. In this essay we intend to extend Lacey’s criticism to the socialsciences – specifically to Economics. We argue that modern economicsorthodoxy , by the adoption of the mechanicalparadigm of classical physics and all the analytical instruments of thematerialist strategies, does not represent a type of neutral understandingof the economic phenomena, but instead, a particularly considerablemanifestation of the predominant values of the society of which it is a part. So, we intend to showthat also in the social scope, the favoring of the nomological and quantitativeaspects of reality mirrors social values highly regarded in modern societies. (shrink)

There is no reason to expect that the twenty-first century will not see the rise of new modes of religiosity, which will demand new styles of analysis and new categories of thought.

What factors drove the transformation of the cyanobacterial progenitor of plastids (e.g. chloroplasts) from endosymbiont to bona fide organelle? This question lies at the heart of organelle genesis because, whereas intracellular endosymbionts are widespread in both unicellular and multicellular eukaryotes (e.g. rhizobial bacteria, Chlorella cells in ciliates, Buchnera in aphids), only two canonical eukaryotic organelles of endosymbiotic origin are recognized, the plastids of algae and plants and the mitochondrion. Emerging data on (1) the discovery of non‐canonical plastid protein targeting, (2) (...) the recent origin of a cyanobacterial‐derived organelle in the filose amoeba Paulinella chromatophora, and (3) the extraordinarily reduced genomes of psyllid bacterial endosymbionts begin to blur the distinction between endosymbiont and organelle. Here we discuss the use of these terms in light of new data in order to highlight the unique aspects of plastids and mitochondria and underscore their central role in eukaryotic evolution. BioEssays 29:1239–1246, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

The opportunity cost model (OCM) aims to explain various phenomena, among which the finding that performance degrades if executive functions are used repeatedly (). We argue that an OCM account of resource depletion requires two unlikely assumptions, and we discuss an alternative that does not require these assumptions. This alternative model describes the interplay between executive function and motivation.

Along with offering an historically-oriented interpretive reconstruction of the syntax of PM ( rst ed.), I argue for a certain understanding of its use of propositional function abstracts formed by placing a circum ex on a variable. I argue that this notation is used in PM only when de nitions are stated schematically in the metalanguage, and in argument-position when higher-type variables are involved. My aim throughout is to explain how the usage of function abstracts as “terms” (loosely speaking) is (...) not inconsistent with a philosophy of types that does not think of propositional functions as mind- and language-independent objects, and adopts a nominalist/substitutional semantics instead. I contrast PM’s approach here both to function abstraction found in the typed λ-calculus, and also to Frege’s notation for functions of various levels that forgoes abstracts altogether, between which it is a kind of intermediary. (shrink)

In this paper, we introduce the notion of intuitionistic fuzzy PMS-subalgebras under homomorphism and Cartesian product and investigate several properties. We study the homomorphic image and inverse image of the intuitionistic fuzzy PMS-subalgebras of a PMS-algebra, which are also intuitionistic fuzzy PMS-subalgebras of a PMS-algebra, and find some other interesting results. Furthermore, we also prove that the Cartesian product of intuitionistic fuzzy PMS-subalgebras is again an intuitionistic fuzzy PMS-subalgebra and characterize it in terms of its level sets. Finally, we consider (...) the strongest intuitionistic fuzzy PMS-relations on an intuitionistic fuzzy set in a PMS-algebra and demonstrate that an intuitionistic fuzzy PMS-relation on an intuitionistic fuzzy set in a PMS-algebra is an intuitionistic fuzzy PMS-subalgebra if and only if the corresponding intuitionistic fuzzy set in a PMS-algebra is an intuitionistic fuzzy PMS-subalgebra of a PMS-algebra. (shrink)

Boddy and his colleagues have published several articles on “corporate psychopathy” using what they refer to as a Psychopathy Measure—Management Research Version. They based this measure on the items that comprise the Interpersonal and Affective dimensions of the Hare Psychopathy Checklist-Revised, a widely used copyrighted and controlled instrument. The PM-MRV not only misspecifies the construct of psychopathy, but also serves as an example of the problems associated with an attempt to form a “new” scale by adapting items from a proprietary (...) scale. The PCL-R measures a superordinate construct underpinned by four correlated dimensions or first-order factors, not just the two in the PM-MRV. The other two dimensions are Lifestyle and Antisocial, which together form Factor 2 of the PCL-R. As defined by the PCL-R, psychopathy requires high scores on both Factor 1 and Factor 2. Lack of validity aside, even if the PM-MRV were to be a useful measure of Factor 1, it would not discriminate between psychopathy and other “dark personalities,” such as Machiavellianism and narcissism, which, along with psychopathy, form the Dark Triad. This lack of discrimination stems from the fact that each of these personalities shares features measured by Factor 1 and, by implication, by the PM-MRV. Research findings based on the PM-MRV may have some meaning with respect to dark personalities in general, but their relevance to psychopathy, as measured with the PCL-R, is tenuous at best. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:78 Discussion c:\users\kenneth\documents\type3401\rj 3401 193 red.docx 2014-05-14 8:54 PM MORE WIT IN PM Michael E. Berumen 37155 Dickerson Run Windsor, co 80550, usa [email protected] eldom does one find a piece by Bertrand Russell without a morsel of humour or wryness. Sometimes the Russellian wit is obvious. Other times it is more subtle, maybe even requiring a second look just to be sure. Headlong into some of his most technical (...) and difficult works, a delightful bon mot might suddenly punctuate the philosophical solemnity. One doesn’t ordinarily think of Principia Mathematica as a sourcebook for Russellian waggishness, but it is there, to be sure—albeit one will negotiate many pages of symbols and scant prose before finding a specimen. Perhaps the best-known witticism amongst cognoscenti is, after having proved 1 + 1 = 2 (PM ∗110.643, 2: 83), the authors observe, “The above proposition is occasionally useful.” The most complete directory for these jewels that I know is by Kenneth Blackwell.1 I thought it unlikely another would be found, so imagine my surprise when, after having dusted off my seldom-used Volume 3 to look something up, I came across a droll nugget that (to the best of my knowledge) has not been highlighted before. Something tells me Russell was biting down on his pipe stem and had a twinkle in his eye when he (I assume Russell, but they, anyway) wrote in the summary of Section A of Part vi, “Quantity”: Great difficulties are caused, in this section, by the existence-theorems and the question of types. These difficulties disappear if the axiom of infinity is assumed, but it seems improper to make the theory of (say) 2/3 depend upon the assumption that the number of objects in the universe is not finite. (PM 3: 234; italics mine) “Improper” indeed, the erstwhile Victorian says! By way of explanation, he goes on to say, We have, accordingly, taken pains not to make this assumption, except where, as in the theory of real numbers, it is really essential, and not merely convenient. Even that has a bit of Russellian sarcasm. So, accept the challenge and find another. In the meantime, take comfort in the knowledge that the sometimes controversial Axiom of Infinity is an unnecessary assumption in mixing one part soda and two parts Red Hackle. 1 “The Wit and Humour of Principia Mathematica”, Russell 31 (2011): 151–60. S... (shrink)

This paper analyses the ethical considerations using the stakeholder theory on two specific domains of the newly implemented ‘Ayushman Bharat-Pradhan Mantri Jan Arogya Yojna ’ scheme by the Government of India. The paper recommends a solidarity-based approach over an entitlement based one that focuses on out-of-pocket expenses for the most vulnerable and a stewardship role from the private sector to ensure equity, accountability, and sustainability of PM-JAY scheme.

Fundamental changes in sciences offer new perspectives for the management of complexity. Increased complexity in society, economics, and technology requires a new and suitable organization and management. What are the consequences and results for project management? That is the theme of this article. First of all it will given a short introduction to project management, which will be later called "traditional project management" or "project management 1st order (PM-1)." Then, the challenges by the fundamental changes in sciences and the increased (...) complexity in society, economics, and technology will be discussed. It will state that traditional project management cannot solve these challenges. The widespread working-themes and results of the research program "Beyond Frontiers of Traditional Project Management" as an answer to these challenges will be presented at a glance. Subsequently, it will discuss some selected results of the research program: The principle-definition and foundation of "Evolution of 1st and 2nd Order." The Evolution of 1st Order and the impact on Project Management methods and processes. Evolution of 2nd Order and the Grand Evolutionary Systems Theory (GEST) of E. Laszlo as also the impact on Project Management methods and processes. Management of crisis: turn a change to advantage or risk-assurance? Thereafter, the concept of "Project Management Second Order (PM-2)" is presented as a highlighted result of the research program, as a new paradigm in project management, and as an answer to the challenges, described earlier will be explained in detail. Finally, a real example of transfer evolutionary and self-organizational management principles in a real project life will be demonstrated. (shrink)

(2000). Full transcript of inaugural AARST Science Policy Forum, New York Hilton, Friday 20 November 1998, 7?9 pm. Social Epistemology: Vol. 14, No. 2-3, pp. 131-180.

This article examines a select sample of popular magazines and self-help books to address the question: How is premenstrual syndrome constructed discursively as a legitimate disease worthy of medical attention and public discussion? The author finds that some women have been active participants in the construction of PMS as a medical disease. In particular, she finds that accounts of women's experiences of premenstrual symptoms figure prominently in the rhetorical legitimation of PMS as a medical phenomenon in the popular press and (...) self-help books. At the same time, the author examines the gendered assumptions about gender, health, and normality that underlie how women's “experiences” are incorporated into the construction of PMS. In particular, she asks whose experience is part of the medical legitimation of premenstrual symptoms and argues that the case of PMS illustrates the need for feminists to problematize biological as well as social experiences. (shrink)

This paper aims at re-evaluating the significance of Peripatetic features in Severus’ exegesis of the Timaeus through a comparison between Severus’ doxography in the PM and the fragment of his treatise on the soul quoted by Eusebius. Indeed, until now, the scholarly literature has been inclined to consider Severus as a plain anti-Aristotelian and pro-Stoic Platonist. However the recent edition of the Porphyrian lost treatise On Principles and Matter allows us to grasp more clearly to what extant Severus’ view on (...) the nature of the soul and on the bodily motion is grounded on an in-depth knowledge of the Peripatetic debates of his time. (shrink)