Obtaining ‘informed consent’ from every individual participant involved in health research is a mandatory ethical practice. Informed consent is a process whereby potential participants are genuinely informed about their role, risk and rights before they are enrolled in the study. Thus, ethics committees in most countries require ‘informed consent form’ as part of an ethics application which is reviewed before granting research ethics approval. Despite a significant increase in health research activity in low-and middle-income countries in recent years, only limited (...) work has been done to address ethical concerns. Most ethics committees in LMICs lack the authority and/or the capacity to monitor research in the field. This is important since not all research, particularly in LMICs region, complies with ethical principles, sometimes this is inadvertently or due to a lack of awareness of their importance in assuring proper research governance. With several examples from Nepal, this paper reflects on the steps required to obtain informed consents and highlights some of the major challenges and barriers to seeking informed consent from research participants. At the end of this paper, we also offer some recommendations around how can we can promote and implement optimal informed consent taking process. We believe that paper is useful for researchers and members of ethical review boards in highlighting key issues around informed consent. (shrink)

Embryos and microscopes share a long, remarkable history and biologists have always been intrigued to watch how embryos develop under the microscope. Here we discuss the advances in microscopy which have greatly influenced our current understanding of embryogenesis. We highlight the evolution of microscopes and the optical technologies that have been instrumental in studying various developmental processes. These imaging modalities provide mechanistic insights into the dynamic cellular and molecular events which drive lineage commitment and morphogenetic changes in the developing embryo. (...) We begin the journey with a brief history of microscopy to study embryos. First, we review the principles and optics of light, fluorescence, confocal, and electron microscopy which have been key techniques for imaging cellular and molecular events during embryonic development. Next, we discuss recent key imaging modalities such as light‐sheet microscopy, which are suitable for whole embryo imaging. Further, we highlight imaging techniques like multiphoton and super resolution microscopy for beyond light diffraction limit, high resolution imaging. Lastly, we review some of the scattering‐based imaging methods and techniques used for imaging human embryos. (shrink)

A fascinating collection of essays by leading scholars in the field engage with the idea of religious pluralism mooted by John Hick to offer incisive insights on religious pluralism and related themes and to address practical aspects such as interreligious spirituality and worship in a multi-faith context.

This volume contains fresh scholarly contributions to mark the birth centenary of John Hick, the internationally well-known philosopher of religion, whose works continue to have significant global relevance in today’s religiously diverse and conflict-ridden world. His writings have reset the parameters of religious pluralism. Up till now, Hick’s religious pluralism has been mainly seen in relation to the Western context where Christianity is the predominant religion. This volume includes both Western and non-Western engagement with his thinking in contexts such as (...) Japan, China, Korea, Nigeria, and India, where Christianity is a minority religion with little political power. Its distinctiveness lies in widening the debate on religious pluralism by bringing Hick’s pluralistic hypothesis into a constructive cross-cultural and interreligious conversation with scholars of Hinduism, Jainism, Daoism, Judaism, Christianity, Islam and African traditional religions. In doing so, this collection examines how Hick’s philosophy of religious pluralism has been received, appropriated and appraised by these scholars. It has been appreciated and critiqued in equal measure, and continues to impact on current thinking on religious pluralism. This volume makes a significant contribution to the debate initiated by Hick. -/- . (shrink)

The notion of the “manly Englishman” and the “effeminate Bengali” was a recurring theme in nineteenth-century colonial discourse, and has now become the subject of extensive scholarly discussion in various academic disciplines. Both the colonizer and the colonized produced varied, com plex and ambivalent images of each other and their religious traditions. This paper looks at how the colonized reacted to the colonizers’ versions of Hinduism, focusing particularly on how Swami Vivekananda, a nineteenth century Bengali Hindu saṃnyāsi, responded to colonial (...) and missionary representations of Hinduism as an effeminate religion. In doing so, the paper draws attention to how Vivekananda drew on resources from within and outside the tradition, in order to forge a distinctive style of Hinduism— “a man-making religion”—a robust kind of Vedantic spirituality that combined both physical and spiritual manliness. (shrink)

GENERALIZED RECUBION THEORY II © North-Holland Publishing Company (1978) MONOTONE QUANTIFIERS AND ADMISSIBLE SETS Ion Barwise University of Wisconsin ...

J. N. Crossley [1] raised the question of whether the implication 2 + A = A ⇒ 1 + A = A is true for constructive order types (C.O.T.'s). Using an earlier definition of constructive order type, A. G. Hamilton [2] presented a counterexample. Hamilton left open the general question, however, since he pointed out that Crossley considers only orderings which can be embedded in a standard dense r.e. ordering by a partial recursive function, and that his counterexample fails to (...) meet this requirement. We resolve the question by finding a C.O.T. A which meets Crossley's requirement and such that 2 + A = A but 1 + A ≠ A. At the suggestion of A. B. Manaster and A. G. Hamilton we easily extend this construction to show that for any n ≧ 2, there is a C.O.T. A such that n + A = A but m + A ≠ A for 0 < m < n. Hence, Theorem 3 of [2] and all of its corollaries hold with the new definition of C.O.T. The construction is not difficult and requires no priority argument. The techniques are similar to those developed in [3], but no outside results are needed here. (shrink)

The novel coronavirus has not only brought along disruptions to daily socio-economic activities, but sickness and deaths due to its high contagion. With no widely acceptable pharmaceutical cure, the best form of prevention may be precautionary measures which will guide against infections and curb the spread of the disease. This study explored the relationship between COVID-19 knowledge, risk perception, and precautionary behavior among Nigerians. The study also sought to determine whether this relationship differed for men and women. A web-based cross-sectional (...) design approach was used to recruit 1,554 participants from all geopolitical zones in Nigeria, through social media platforms using a snowball sampling technique. Participants responded to web-based survey forms comprising demographic questions and adapted versions of the Ebola knowledge scale, SARS risk perception scale, and precautionary behavior scale. Moderated mediation analysis of the data showed that risk perception mediated the association between COVID-19 knowledge and precautionary behavior and this indirect effect was in turn moderated by gender. Results indicate that having adequate knowledge of COVID-19 was linked to higher involvement in precautionary behavior through risk perception for females but not for males. It was also noted that awareness campaigns and psychological intervention strategies on COVID-19 related activities may be particularly important for males more than females. Drawing from the health belief model, we recommend that COVID-19 awareness campaigns should target raising more awareness of the risks associated with the infection to make individuals engage more in precautionary behaviors. (shrink)

This article develops a more comprehensive understanding of data mining by examining the application of this technology in the marketplace. In addition to exploring the technological issues that arise from the use of these applications, we address some of the social concerns that are too often ignored.As more firms shift more of their business activities to the Web, increasingly more information about consumers and potential customers is being captured in Web server logs. Sophisticated analytic and data mining software tools enable (...) firms to use the data contained in these logs to develop and implement a complex relationship management strategy. Although this new trend in marketing strategy is based on the old idea of relating to customers as individuals, customer relationship management actually rests on segmenting consumers into groups based on profiles developed through a firm's data mining activities. Individuals whose profiles suggest that they are likely to provide a high lifetime value to the firm are served content that will vary from that which is served to consumers with less attractive profiles. (shrink)

In the future systems of ambient intelligence will include decision support systems that will automate the process of discrimination among people that seek entry into environments and to engage in search of the opportunities that are available there. This article argues that these systems must be subject to active and continuous assessment and regulation because of the ways in which they are likely to contribute to economic and social inequality. This regulatory constraint must involve limitations on the collection and use (...) of information about individuals and groups. The article explores a variety of rationales or justifications for establishing these limits. It emphasizes the unintended consequences that flow from the use of these systems as the most compelling rationale. (shrink)