Proteolysis-targeting chimeric molecules represent an emerging technique that is receiving much attention for therapeutic intervention. The mechanism is based on the inhibition of protein function by hijacking a ubiquitin E3 ligase for protein degradation. The hetero-bifunctional PROTACs contain a ligand for recruiting an E3 ligase, a linker, and another ligand to bind with the protein targeted for degradation. Thus, PROTACs have profound potential to eliminate “undruggable” protein targets, such as transcription factors and non-enzymatic proteins, which are not limited to physiological (...) substrates of the ubiquitin-proteasome system. These findings indicate great prospects for PROTACs in the development of therapeutics. However, there are several limitations related to poor stability, biodistribution, and penetrability in vivo. This review provides an overview of the main PROTAC-based approaches that have been developed and discusses the promising opportunities and considerations for the application of this technology in therapies and drug discovery. The hetero-bifunctional PROTAC molecules contain a ligand for recruiting an E3 ligase linked with a ligand to bind with the protein targeted for degradation. Thus, PROTACs have profound potential to eliminate “undruggable” disease-causing proteins, which are not limited to physiological substrates of the ubiquitin-protease system, suggesting great prospects for therapeutic development. (shrink)

From the end of 2018 in China, the Big-data Driven Price Discrimination (BDPD) of online consumption raised public debate on social media. To study the consumers’ attitude about the BDPD, this study constructed a semantic recognition frame to deconstruct the Affection-Behavior-Cognition (ABC) consumer attitude theory using machine learning models inclusive of the Labeled Latent Dirichlet Allocation (LDA), Long Short-Term Memory (LSTM), and Snow Natural Language Processing (NLP), based on social media comments text dataset. Similar to the questionnaires published results, this (...) article verified that 61% of consumers expressed negative sentiment toward BDPD in general. Differently, on a finer scale, this study further measured the negative sentiments that differ significantly among different topics. The measurement results show that the topics “Regular Customers Priced High” (69%) and “Usage Intention” (67%) occupy the top two places of negative sentiment among consumers, and the topic “Precision Marketing” (42%) is at the bottom. Moreover, semantic recognition results that 49% of consumers’ comments involve multiple topics, indicating that consumers have a pretty clear cognition of the complex status of the BDPD. Importantly, this study found some topics that had not been focused on in previous studies, such as more than 8% of consumers calling for government and legal departments to regulate BDPD behavior, which indicates that quite enough consumers are losing confidence in the self-discipline of the platform enterprises. Another interesting result is that consumers who pursue solutions to the BDPD belong to two mutually exclusive groups: government protection and self-protection. The significance of this study is that it reminds the e-commerce platforms to pay attention to the potential harm for consumers’ psychology while bringing additional profits through the BDPD. Otherwise, the negative consumer attitudes may cause damage to brand image, business reputation, and the sustainable development of the platforms themselves. It also provides the government supervision departments an advanced analysis method reference for more effective administration to protect social fairness. (shrink)

In order to highlight the role of music teaching in the teaching of ideological and political courses, this study puts forward research on the integration of music teaching and ideological and political teaching. This study analyzes the promotion and necessity of college music teaching to ideological and political work, constructs a fusion model of college music teaching and ideological and political work, introduces deep learning methods, and weakens the influence of errors in the data of college music teaching and ideological (...) and political work. This study also optimized the integration mode of college music teaching and ideological and political work and realized the model research of college music teaching and ideological and political work. The experimental results show that the resource output amplitude controlled by the deep learning method has the best stability, and there is no large amplitude fluctuation during the experiment. The output amplitude and control time of the fusion resource are guaranteed and the fusion path of music teaching and ideological and political education is clearer. The maximum control time of the fusion resource of this method is 23.55 ms. (shrink)

Mobile English learning has multiple advantages and brings enormous benefits to EFL learners. However, not everyone adopts it, and the determinants of learners’ adoption intention have not yet been investigated fully. This study aimed to better understand learners’ adoption by employing the theory of planned behaviour in conjunction with the influences of technostress and compatibility. Based on existing literature, a research model was proposed and verified with a sample of 409 undergraduates from a Chinese university. The results indicated that in (...) the context of mobile English learning: Individuals with higher adoption intention are more likely to engage in mobile English learning with higher frequency. Practical implications related to mobile English learning were discussed. (shrink)

In this paper, we propose to incorporate the local attention in WaveNet-CTC to improve the performance of Tibetan speech recognition in multitask learning. With an increase in task number, such as simultaneous Tibetan speech content recognition, dialect identification, and speaker recognition, the accuracy rate of a single WaveNet-CTC decreases on speech recognition. Inspired by the attention mechanism, we introduce the local attention to automatically tune the weights of feature frames in a window and pay different attention on context information for (...) multitask learning. The experimental results show that our method improves the accuracies of speech recognition for all Tibetan dialects in three-task learning, compared with the baseline model. Furthermore, our method significantly improves the accuracy for low-resource dialect by 5.11% against the specific-dialect model. (shrink)

The problem of generalizing the power option-pricing model to incorporate more empirical features becomes an urgent and necessary event. A new power option pricing method is designed for the financial market uncertainty that simultaneously involves randomness and fuzziness. The randomness in market uncertainty is modeled by a time-fractional diffusion model, which describes trend memory in underlying asset prices. The fuzziness in market uncertainty is characterized by a triangular interval type-2 fuzzy numbers, which better captures the fuzziness of underlying asset prices. (...) Considering the decision-maker’s subjective judgment, we show the price mean value with the possibility-necessity weight and pessimistic-optimistic index under the type-2 fuzzy environment. We develop the power option pricing model with the time-fractional diffusion model and the triangular interval type-2 fuzzy numbers. Furthermore, the analytic solutions of pricing call power option and put power option are obtained and verified by the variational iterative reconstruction method. Our study shows that power option pricing, which adopts the time-fractional model and the triangular interval type-2 fuzzy numbers, can better capture the trend memory and double fuzziness of the real market. In addition, a numerical example is provided to illustrate that the power option means the value is decreasing with respect to the pessimistic-optimistic index and is fluctuating with respect to the possibility-necessity weight index. (shrink)

Positioning accuracy of micropositioning stage in scanning ion conductance microscopy is the key to obtain high-precision scanning model. Most piezoelectric ceramic micromotion platforms are used for that, and hysteresis characteristics are the main reason for the nonlinear characteristics of piezoelectric ceramics and the influence on the control accuracy. In order to solve this problem, backpropagation algorithm based on whale optimization algorithm is used to model the hysteresis, which is directly used as a feedforward controller to compensate the hysteresis effect, and (...) the robust adaptive moving average control method is used for feedback control. The results show that the hysteresis model of backpropagation algorithm based on the whale optimization algorithm can fit the hysteresis curve well, and the maximum fitting error is 0.2050 μm, only 0.256%. By adopting feedforward and feedback, feedforward robust adaptive moving average control algorithm decreases the hysteresis from 17.64% to 2.51%, which enables the output of the piezoelectric ceramic controller to track the expected displacement well and makes it possible to improve the scanning accuracy. (shrink)

ObjectivesTo simulate hemodynamic changes after extraluminal compression in pulsatile tinnitus patients with a prominent transverse-sigmoid sinus junction.MethodsOne patient-specific case was reconstructed based on computed tomography venography images of a PT patient. The compression degree served as a new index in this study. Cases with 10, 20, 30, 40, 50, 60, 70, 80, and 90% of the compression degree of the control subject were constructed. Steady-state computational fluid dynamics were assessed. The wall pressure distribution, wall maximum pressure and flow pattern of (...) the PTSJ were calculated to evaluate hemodynamic differences among all cases.ResultsWith increasing compression, the wall pressure at the compression point and downstream of the PTSJ decreased but increased upstream. When the compression degree exceeded 70%, the upstream pressure increased significantly. Above 50% compression, the blood flow pattern downstream of the sigmoid sinus tended to spiral, especially after 80% compression. Beyond 60% compression, the blood flow pattern under the compression axis became more medial.ConclusionMechanical compression of PTSJ changes wall pressure and blood flow patterns. The degree of compression should be carefully observed to avoid possible complications or reoccurrence. (shrink)

The rapid development of computers and technology affects modern daily life. Individuals in the digital age need to develop computational thinking skills. Existing studies have shown that programming teaching is conducive to cultivating students’ CT, and various learning models have different effects on the cultivation of CT. This study proposed a problem-oriented learning model that is closely related to programming and computational thinking. In all, 60 eighth-grade students from a middle school in China were divided into an experimental group which (...) adopted the POL model, and a control group which adopted the lecture-and-practice learning model. The results showed that the students who were instructed using the POL model performed better than those who were instructed using the LAP model on CT concepts, CT practices, and CT perspectives. Significant differences were found for CT concepts and CT perspectives, but not for CT practices. Findings have implications for teachers who wish to apply new learning models to facilitate students’ CT skills, and the study provides a reference case for CT training and Python programming teaching. (shrink)

PurposeThe purpose of this study was to perform the translation and adaption of the Cognitive Reserve Index questionnaire into Chinese and assess the reliability of the Chinese version.Materials and MethodsThe Chinese version of the Cognitive Reserve Index questionnaire was created from a standard forward-backward translation. A total of 371 volunteers, aged between 20 and 89 years, participated in this survey. Participants were divided into three age-groups, and subgroup differences were examined by independent samples t-tests, ANOVA analysis as well as post-hoc (...) analysis. Pearson correlation analysis was applied to test the association between the total scores and each subscore. The internal consistency and test-retest reliability of the Cognitive Reserve Index questionnaire were assessed. The test-retest reliability was measured among 40 participants with a 2-week interval using intraclass correlation coefficient.ResultsStrong correlations were observed between the total scores and each subscore. In contrast, it was found low to moderate correlations among three subscores. The internal consistency was acceptable. The intraclass correlation coefficient for total scores of the Chinese version of the Cognitive Reserve Index questionnaire was 0.87.ConclusionThe Chinese version of the Cognitive Reserve Index questionnaire was a potentially reliable and practical tool for evaluating cognitive reserve accumulated through a person's life span. (shrink)

Although emerging evidence has implicated structural/functional abnormalities of patients with Autism Spectrum Disorder, definitive neuroimaging markers remain obscured due to inconsistent or incompatible findings, especially for structural imaging. Furthermore, brain differences defined by statistical analysis are difficult to implement individual prediction. The present study has employed the machine learning techniques under the unified framework in neuroimaging to identify the neuroimaging markers of patients with ASD and distinguish them from typically developing controls. To enhance the interpretability of the machine learning model, (...) the study has processed three levels of assessments including model-level assessment, feature-level assessment, and biology-level assessment. According to these three levels assessment, the study has identified neuroimaging markers of ASD including the opercular part of bilateral inferior frontal gyrus, the orbital part of right inferior frontal gyrus, right rolandic operculum, right olfactory cortex, right gyrus rectus, right insula, left inferior parietal gyrus, bilateral supramarginal gyrus, bilateral angular gyrus, bilateral superior temporal gyrus, bilateral middle temporal gyrus, and left inferior temporal gyrus. In addition, negative correlations between the communication skill score in the Autism Diagnostic Observation Schedule and regional gray matter volume in the gyrus rectus, left middle temporal gyrus, and inferior temporal gyrus have been detected. A significant negative correlation has been found between the communication skill score in ADOS_G and the orbital part of the left inferior frontal gyrus. A negative correlation between verbal skill score and right angular gyrus and a significant negative correlation between non-verbal communication skill and right angular gyrus have been found. These findings in the study have suggested the GM alteration of ASD and correlated with the clinical severity of ASD disease symptoms. The interpretable machine learning framework gives sight to the pathophysiological mechanism of ASD but can also be extended to other diseases. (shrink)

This research investigated how interpersonal communication with a large audience can influence communicators’ attitudes. Research on the saying-is-believing effect has shown that when an individual’s attitude is perceived in advance by a communicator, the communicator tunes the message to the person, which biases the communicator’s attitude toward the person’s attitude. In this study, we examined the conditions under which audience tuning and attitude bias can occur with audiences containing more than one individual. We manipulated communicators’ perceived group entity for a (...) large audience and the audience’s prior attitudinal valence and measured the audience’s epistemic trust. The results showed that communicators tuned their messages to the audience’s attitude when they perceived group entitativity and epistemic trust. Furthermore, tuning the message to the audience was found to bias communicators’ subsequent impressions of the topic in a direction closer to the audience’s attitude. These results suggest that perceiving a large audience as a group influences the subsequent impressions of electronic word-of-mouth product or service communicators. (shrink)

Introduction: The effect of promoting a physical reaction by the described action is called the action-sentence compatibility effect. It has been verified that physical motion changes depending on the time phase and grammatical expression. However, it is unclear how adverbs and onomatopoeia change motion simulations and subsequent movements.Methods: The subjects were 35 healthy adults. We prepared 20 sentences each, expressing actions related to hands and feet. These were converted into 80 sentences, with the words “Slow” or “Quick” added to the (...) words related to the speed of movement, and 80 sentences with the words “Fast” and onomatopoeia “Satto” added. Additionally, 20 unnatural sentences were prepared for each stimulus set as pseudo sentences. Choice reaction time was adopted; subjects pressed the button with their right hand only when the presented text was correctly understood. The reaction time and the number of errors were recorded and compared.Results: As a result of a two-way repeated ANOVA, an interaction effect was observed in RTs and NoE in set A. “Hand and Fast” had significantly faster RTs than “Hand and Slow” and “Foot and Fast.” Furthermore, “Hand and Fast” had a significantly higher NoE than others. In set B, the main effects were observed in both RTs and NoE. “Hand” and “Satto” had significantly faster RTs than “Foot” and “Quick,” respectively. Additionally, an interaction effect was observed in NoE, wherein “Foot and Satto” was significantly higher than “Hand and Satto” and “Foot and Quick.”Conclusion: In this study, the word “Fast” promoted hand response, reaffirming ACE. The onomatopoeia “Satto” was a word that conveys the speed of movement, but it was suggested that the degree of understanding may be influenced by the body part and the attributes of the subject. (shrink)

In a congested large-scale subway network, the distribution of passenger flow in space-time dimension is very complex. Accurate estimation of passenger path choice is very important to understand the passenger flow distribution and even improve the operation service level. The availability of automated fare collection data, timetable, and network topology data opens up a new opportunity to study this topic based on multisource data. A probability model is proposed in this study to calculate the individual passenger’s path choice with multisource (...) data, in which the impact of the network time-varying state on passenger path choice is fully considered. First, according to the number and characteristics of OD candidate paths, the AFC data among special kinds of OD are selected to estimate the distribution of passengers’ walking time and waiting time of each platform. Then, based on the composition of path travel time, its real-time probability distribution is formulated with the distribution of walking time, waiting time, and in-vehicle time as parameters. Finally, a membership function is introduced to evaluate the dependence between passenger’s travel time and the real-time travel time distribution of each candidate path and take the path with the largest membership degree as passenger’s choice. Finally, a case study with Beijing Subway data is applied to verify the effectiveness of the model presented in this study. We have compared and analysed the path calculation results in which the time-varying characteristics of network state are considered or not. The results indicate that a passenger’s path choice behavior is affected by the network time-varying state, and our model can quantify the time-varying state and its impact on passenger path choice. (shrink)

Growth mindset refers to our core belief that our talents can be developed through practice, which may influence our thoughts and behaviors. Growth mindset has been studied in a variety of fields, including education, sports, and management. However, few studies have explored whether differences in individuals’ growth mindsets influence college students’ self-reported mental health. Using the Growth Mindset Scale, Adolescent Self-rating Life Events Checklist, and SCL-90 Scale, data was collected from 2,505 freshmen in a University in China. Findings revealed that (...) the students within the growth mindset group scored significantly lower on “mental health issues” and “stress due to life events” than the students in the fixed mindset group. Our findings suggest that individuals with a growth mindset are less prone to mental health problems than individuals with a fixed mindset. (shrink)

Supply chain financing guaranteed by third-party logistics firms is an effective way to solve the financing difficulties of small and medium-sized enterprises. Studies have explored factors that affect the willingness of supply chain financial credit providers under guarantee of 3PL firms. However, whether the scale of 3PL firms will affect the bank’s credit decision has not been studied, as well as the neural processing of credit decisions. To clarify these issues, this study extracted behavioral and event-related potentials data when participants (...) performed a selection task of judging whether to grant credit to guaranteed financing-seeking enterprises according to the large or small scale of the 3PL guaranteeing firms. The behavioral results showed that under the condition of a large-scale 3PL guaranteeing firm, the willingness to provide credit to SMEs was higher than that under the condition of a small-scale 3PL guaranteeing firm. This finding indicates there was credit scale discrimination against 3PL guaranteeing firms in supply chain finance. The ERP results showed that compared with the condition of a large-scale 3PL guaranteeing firm, a greater N2 amplitude was induced under the condition of a small-scale 3PL guaranteeing firm, which indicated that credit decision makers experienced greater perceived risk and more decision-making conflict. In contrast, a larger LPP amplitude was detected under the condition of a large-scale 3PL guaranteeing firm, which indicated that large-scale 3PL guaranteeing firms received more positive comments and more positive emotions from credit decision makers than small-scale 3PL guaranteeing firms. Based on these results, this study reveals the cognition process of credit decision makers regarding the impact of the 3PL guaranteeing firm scale on the willingness to provide credit in supply chain finance and explains the theory of credit scale discrimination from the perspective of decision neuroscience. (shrink)

Expletive pronouns have posed significant challenges to both linguistic studies and natural language processing in Chinese. Based on the data from the Chinese corpus at the Center for Chinese Linguistics of Peking University, this paper investigates the automatic dependency parsing errors of expletive ta and relative constructions and provides a detailed quantitative analysis of the characteristics of the constructions in question. The findings not only provide evidence to show that even in radical pro-drop languages such as Mandarin, pleonastics can occur (...) in both object and subject positions but also offer important insights for Chinese natural language processing. (shrink)

Scholars are the main force behind academic entrepreneurship. The method of how to stimulate scholars’ academic entrepreneurial intention and how to further promote social and economic development are important questions for the academic community. Research on the “net effect” of the factors affecting academic entrepreneurial intention has achieved some theoretical results. However, the results that affect academic entrepreneurial intention are complex and not influenced by a single factor, but rather by the interaction between various factors. Therefore, this study used a (...) fuzzy set qualitative comparative analysis research method to explore how various factors can affect scholars’ academic entrepreneurial intention from two dimensions: the Big Five personality traits and academic entrepreneurial motivation. Our findings showed two configurations that affect high academic entrepreneurial intention of university scholars: the openness to experience—ribbon—dominant path, and the ribbon—dominant path. Additionally, two configurations were revealed for the formation of not-high academic entrepreneurial intention: extraversion—conscientiousness—inhibition and extraversion—agreeableness—gold—hindrance paths. Moreover, this study revealed that a causal asymmetry exists between the high and the not-high academic entrepreneurial intention configurations. This study broadens the application of the fuzzy set qualitative comparative analysis method in the research of academic entrepreneurial intention and provides theoretical and practical insights for researchers and practitioners on how to effectively stimulate scholars’ academic entrepreneurial intention. (shrink)

Dynamic capabilities are crucial to the survival and development of enterprises in the BOP market. The research focuses on the double-edged sword impact of relational embeddedness on dynamic capabilities via ambidextrous learning, that is moderate embeddedness facilitates dynamic capabilities while overembeddedness inhibits them. Furthermore, this study investigates whether human capital moderates the relationships between relational embeddedness and ambidextrous learning. Selecting 264 samples for empirical research, firstly, the results show that the relational embeddedness in the BOP cooperation network has an inverted (...) U-shaped influence on ambidextrous learning and dynamic capabilities. Secondly, exploratory learning and exploitative learning play a mediating role in relational embeddedness and dynamic capabilities. Thirdly, prior experience plays a positive moderating role in relational embeddedness and exploitative learning. The conclusions facilitate understanding the antecedents of dynamic capabilities and the black box of “embeddedness paradox,” and provide empirical evidence for adjusting the human capital of enterprises, enhancing the exploratory learning capability and exploitative learning capability, and coping with the overembeddedness effects. (shrink)

Di yi juan. Si wei xue, yuan li lun he zhe xue juan -- Di er juan. Mei xue juan -- Di san juan. Fu hao fen xi he yu yan fen xi juan -- Di si juan. Wen hua xue yu dao de zhe xue juan -- Di wu juan. Shi wen juan.

4E cognition is the defining feature of second-generation cognitive science, which replaces a computer-like cognitive processing model with one that highlights the interactive dynamism between the mind, the body and the environment. Research on literary reading in light of 4E cognition has piqued scholarly interest in the theoretical and empirical study of embodied reading. Karin Kukkonen’s 4E Cognition and Eighteenth Century Fiction is the first monograph in this field that proposes a historical approach to cognitive literary studies and examines how (...) the novel finds its “feet” as well as its “body” in the process of becoming a mature literary genre in the... (shrink)

This paper presents an overall view of the Philosophy of Tian-xia, a particular form of neo-universalism developed by its author and very much debated in the last years. The system of Tian-xia, or ‘all-under-heaven’, is a philosophical re-elaboration of an ancient form of Chinese universalism. The world is constituted as a global unity and a basic concept of political philosophy. It aims at a world institution as a way to rethink all problems in the world as problems of the world. (...) Zhao Tingyang has analytically developed this view in some recent publications in Chinese. This article represents the most recent attempt to provide a synthetic view of his philosophy of ‘all-under-heaven’. (shrink)

本书的重点是谈作者对波普尔的看法,主要包括对波普尔思想的理解和对波普尔思想的评论和批评两部分。.

The social sciences face a problem of sample non-representation, where the majority of samples consist of undergraduate students from Euro-American institutions. The problem has been identified for decades with little trend of improvement. In this paper, I trace the history of sampling theory. The dominant framework, called the design-based approach, takes random sampling as the gold standard. The idea is that a sampling procedure that is maximally uninformative prevents samplers from introducing arbitrary bias, thus preserving sample representation. I show how (...) this framework, while good in theory, faces many challenges in application. Instead, I advocate for an alternative framework, called the model-based approach to sampling, where representative samples are those balanced in composition, however they were drawn. I argue that the model-based framework is more appropriate in the social sciences because it allows for systematic assessment of imperfect samples and methodical improvement in resource-limited scientific contexts. I end with practical proposals of improving sample quality in the social sciences. (shrink)

According to the safety principle, if one knows that p, then one’s belief in p could not easily have been false. In this paper, I pose a dilemma for safety theorists by asking the following question: In evaluating whether or not a belief is safe, must we only examine the error-possibilities of the same belief as formed in the actual world? If ‘yes’, safety meets a familiar objection regarding necessary truths and the objection also extends to contingent propositions. If ‘no’, (...) however, there is no necessity of safety for knowledge. It is argued that this dilemma poses a threat for a number of safety principles from the recent literature. In the end, I draw implications of my arguments for the debate between robust and anti-luck virtue epistemologies. The result is that anti-luck virtue epistemology suffers from the difficulty with the safety principle whereas the robust variant remains intact. (shrink)

One interesting and potentially attractive feature of the sensitivity account of knowledge is that it not only preserves knowledge of ordinary propositions, but also concedes the skeptic's intuition that we do not know skeptical hypotheses do not obtain. This paper challenges the sensitivity‐based reply to the skeptic, advocated by Robert Nozick, among others. Sensitivity generates an implausibly bizarre result that although we do not know we are not brains in vats (because a belief to this effect is insensitive), a real (...) BIV who is in a much worse epistemic situation can sensitively believe that it is not in the good case. This result reveals a fundamental problem with the sensitivity conditional: its antecedent is not suitable for picking out possibilities that are relevant for our epistemic evaluation. I then offer a systematic explanation of why it is the safety account—the main competitor of sensitivity—that picks out a more suitable set of possibilities. A consequence of this comparison is that the safety account delivers an overall more satisfying reply to the skeptic than sensitivity does. (shrink)

Within educational philosophy and theory, there has been an international re-turn to envision study as an alternative formation to disrupt the defining learning logic. As an enrichment, this paper articulates “Daoist onto-un-learning” as an Eastern form of study, drawing upon Roger Ames’s interpretation of the ancient Chinese correlative cosmology and relational personhood thinking. This articulation is to dialogue with the conceptualizations of study shared by Giorgio Agamben, Derek Ford, and Tyson Lewis, and unfolds in three steps. First, I examine how (...) their conceptualizations of study constrain the studier-doing-study logic as a commonsensical expression of “foundational individualism” and anthropocentric disordering. Second, re-invoking the ancient Chinese wisdom, I envision “Daoist onto-un-learning” as a non-individualistic and non-anthropocentric form of study, re-configuring study and learning no longer as two disparate, if not necessarily oppositional, formations but into a Daoist bipolar yin-yang movement. Finally, I story-tell my doctoral research experience as a Daoist onto-un-learning journey, a spiralling learning-study movement, to unpack the ways it suspends and overturns the modern-Western trap/trope of anthropocentric-foundational individualism. In so doing, this paper further internationalizes and supplements the current study scholarship in relation to learning in a way so-far hardly explored yet cross-culturally provocative. (shrink)

Solidarity is a widespread but under-explored phenomenon. In this paper, I give a philosophical account of solidarity, answering three salient questions: What motivates acts of solidarity? What unifies different acts into tokens of a single type of act, one of solidarity? And what values do acts of solidarity exhibit? The answer to all three, I argue, involves a certain way of relating to others: identifying with them on the basis of shared features, and identifying with the larger group that one (...) and the others both belong to. (shrink)

Agamben’s potentiality, and Chinese dao, entail experiencing movement on being. This article presents our experiments with these movements in the context of pedagogy, putting at stake our mode of existence in thinking. We examine Agamben’s potentiality as an aporetic experience in pedagogy. We find echoes of dao movement in a controversial pedagogical event in China. Interlacing potentiality and dao with our experience of pedagogical thinking, each makes the other intelligible. We show that reasonings of pedagogy in the USA and China (...) repeat the very paradoxes and exclusions they seek to overcome. We also gesture towards a way that, suspending and holding pedagogical reasoning in being empty, welcomes what cannot be learned or taught. This way also offers an example for comparative education. (shrink)

With the gradual deepening of environmental problems and the increase in consumer awareness of environmental protection, many enterprises have already begun to pay attention to green supply chain management. However, the price of green products is higher than that of nongreen products, which is an enormous challenge for many small- or medium-sized enterprises. To study the pricing and coordination of green supply chains under capital constraints, a model consisting of a manufacturer and a capital-constrained retailer is established; the manufacturer invests (...) in green products and provides a deferred payment contract. Setting the situation without capital constraints as a benchmark, this study explores the impact of the retailer’s capital constraints on the manufacturer’s product greenness design; an interesting result shows that deferred payment can help encourage the retailer to order more products and improve the profit of the manufacturer and the efficiency of the entire supply chain as well as the product’s greenness level simultaneously. However, the profit of the retailer will be hurt by the deferred payment contract. Therefore, to guarantee the profit of the entire channel and to make the two agents obtain a win-win outcome, a new two-way revenue-sharing contract is designed to coordinate the green supply chain. (shrink)

With the mutual exchange and integration of world football, modern football is in an increasingly comprehensive direction. This research mainly discusses complexity computer simulation in the study of the overall play of campus football. Complexity computer simulation is used to design the background of the simulated football field, and the area is divided according to the size ratio of the actual football field. Then, it uses drawing software to draw the football and player controls. The construction of the knowledge base (...) of this paper is mainly combined with the functional modules of rapid formation and response tactics. In the fast formation function, the required formation can be quickly given through football experience and knowledge rules. In the applied tactics function, for the responsibilities of forwards, midfielders, defenders, and other roles, the tactics implemented are given, including partially coordinated offensive and defensive tactics, personal offensive and defensive tactics, and set-ball tactics. The “holistic play” football tactics studied in this paper use XML files as recording and playback data, which not only greatly reduce the amount of file data but also make the operation of XML files intuitive and simple. XML can not only realize the recording and playback of player and football track but also be used in the function of rapid formation. The coach uses the “holistic play” football tactics simulation to demonstrate the movement route through the image, guide the players in each position to perceive the game scene by observing the movement route, and analyze and judge the tactical coordination of their respective positions. The computer simulation tactical analysis of the precision of the passing and running and the path coefficient of the passing factor is 0.606 and 0.59, respectively. This research helps to provide guidance on the overall playing tactics of football. (shrink)

本书收录“关于命运的知识”、“从知识眼光到创作眼光”、“一个或所有问题”、“千年观念故事”、“理解20世纪的精神财富”等19篇文章。.

This article introduces the problem of inexistence to studies in genre and gender, providing a hermeneutic point of reference for literary history and trans theory. It seeks to negotiate the affinities and disaffinities between queer and trans by foregrounding the latter’s struggle for existence against the former’s mobilization of a rhetoric of negative relationality, while at the same time preserving the bonds of intimacy across and beyond the coalition of LGBTQIA+. Such queer intimacy is read in relation to a haptic (...) technology of queer close reading, enabling differentially sexed bodies to imaginatively inhabit each other. I begin by considering how Djuna Barnes’s close, haptic readings of Henry James and Marcel Proust enact a reversal of sex, but I consider how the affective evidence of these trans moments do not amount to trans existence but raise the ethical necessity of holding open the difference between the ephemeral trans experiences within cis existence and the real struggle for trans existence of trans subjects today. Such a divide, however, is simultaneously held against the moments of intimacy that are capable of being produced across cis and trans subjects through such close reading and cross-inhabitation of bodies. To read trans literary history before trans, I thus propose the notion of trans inexistence through an interpretation of Jacques Maritain’s figure of the “angel” and Hegel’s “beautiful soul.” By situating Barnes’s and Jean Genet’s own characterizations of their transfeminine characters in terms of the angel in a post-Romantic, Catholic context, I interpret the trans angel as a figure of inexistence, tied to a minimal transcendence from the terms of history and materiality, including the sexed body. Finally, I consider how Genet’s phenomenology of proprioception draws together the problems of queer intimacy, haptic reading, and trans inexistence. In analyzing how Genet and his characters cross-inhabit each other’s bodies via proprioceptive mimicry, I unfold both the vast potential and the limits of the intimacies constructed across cis male and transfeminine lives and the accompanying role played by the literary mode of romance. (shrink)

In a recent paper, Helton and Nanay, 415–423, 2019) present a new argument against two modal accounts of knowledge—safety and sensitivity. Their argument is based on the phenomenon of amodal completion. According to them, amodal completion experience can ground knowledge; but in some instances, such knowledge is neither sensitive nor safe. Thus, they conclude that neither sensitivity nor safety is a necessary condition for knowledge. This paper pushes back. In particular, I defend the following three theses. First, Helton and Nanay’s (...) argument for the claim that amodal completion itself can ground knowledge is unsound. Second, their objection against sensitivity is best construed as merely another instantiation of the old objection against sensitivity regarding inductive knowledge. Thus, sensitivity theorists have nothing to worry about over and above the old objection. Third, safety theorists can plausibly defend their account, insofar as they acknowledge that one’s ‘awareness’ of error-possibilities can affect the epistemic status of one’s belief. My conclusion is that reflections on the phenomenon of amodal completion fail to generate any new objections against modal accounts of knowledge. (shrink)

As an idealist form of realism, or realist form of idealism, the system of ‘All-under-Heaven’ seeks to find a rational and optimal solution to the problem of political conflict. Howeve...