Cramer et al's proposal to view mental disorders as the outcome of network dynamics among symptoms obviates the need to invoke latent traits to explain co-occurrence of symptoms and syndromes. This commentary considers the consequences of such a network view for genetic association studies.

"Humanae Vitae" rightfully insists on a total vision of human life, conjugal love, and responsible parenthood in a specifically human dimension for transcending the merely physiological.

It is common to assume that the problem of induction arises only because of small sample sizes or unreliable data. In this paper, I argue that the piecemeal collection of data can also lead to underdetermination of theories by evidence, even if arbitrarily large amounts of completely reliable experimental and observational data are collected. Specifically, I focus on the construction of causal theories from the results of many studies (perhaps hundreds), including randomized controlled trials and observational studies, where the studies (...) focus on overlapping, but not identical, sets of variables. Two theorems reveal that, for any collection of variables V, there exist fundamentally different causal theories over V that cannot be distinguished unless all variables are simultaneously measured. Underdetermination can result from piecemeal measurement, regardless of the quantity and quality of the data. Moreover, I generalize these results to show that, a priori, it is impossible to choose a series of small (in terms of number of variables) observational studies that will be most informative with respect to the causal theory describing the variables under investigation. This final result suggests that scientific institutions may need to play a larger role in coordinating differing research programs during inquiry. (shrink)

Hannah Arendt disavowed the title of “philosopher,” and is known above all as a political theorist. But the relationship between philosophy and politics animates her entire oeuvre. We find her addressing the topic in The Human Condition (1958), in Between Past and Future (a collection of essays written in the early 1960s), and in Men in Dark Times (another collection of essays, this one from the late sixties). It is treated in her Lectures on Kant’s Political Philosophy, composed during the (...) seventies, and also in the posthumous Life of the Mind, two of three projected volumes of which were complete when she died in 1975. Certainly, Arendt’s thought cannot be understood without taking into account her deep suspicion of and equally deep commitment to philosophy in the context of political reflection. For all that, her writings on this abiding preoccupation do not gel into a systematically articulated theory or programmatic statement. Instead, they reflect Arendt’s appreciation of what remained for her a “vital tension” – an enigma. (shrink)

Human desires for survival and things conducive to survival seem to be exactly what one would expect given natural selection. Thus, one might intuitively assume that such desires provide evidence for evolutionary naturalism. The purpose of this paper is to show that they do not: desires for survival, things conducive to survival, and other natural desires found in human beings are not an evidential asset to evolutionary naturalism. Indeed, they are severely problematic due to their intentionality and the fact that (...) they fit just as well, if not better, with theism. (shrink)

Nihilism is the logic of nothing as something, which claims that Nothing Is. Its unmaking of things, and its forming of formless things, strain the fundamental terms of existence: what it is to be, to know, to be known. But nihilism, the antithesis of God, is also like theology. Where nihilism creates nothingness, condenses it to substance, God also makes nothingness creative. Negotiating the borders of spirit and substance, theology can ask the questions of nihilism that other disciplines do not (...) ask: Where is it? What is it made of? Why is it so destructive? How can it be made holy, or overcome? Genealogy of Nihilism rereads Western history in the light of nihilistic logic, which pervades two millennia of Western thought and is coming to fruition in our present age in a virulently dangerous manner. From Parmenides to Alain Badiou, via Plotinus, Avicenna, Duns Scotus, Ockham, Descartes, Spinoza, Kant, Hegel, Heidegger, Sartre, Lacan, Deleuze and Derrida, a genealogy of nothingness can be witnessed in development, with devastating consequences for the way we live. Conor Cunningham's elaborate and sophisticated theology, spanning the disciplines of philosophy, science and popular culture, permits us to see not simply how modernity has formulated its philosophies of nothing, but how these philosophies might be transfigures by the crucial difference theology makes, and so be reconcilable with life and the living - with the very gift which being is. (shrink)

This book explores the uses of the term “paradigm” with respect to both logos and myth in Plato, with a focus on Sophist and Statesman. In so doing, Conor Barry argues for a unitary as opposed to a developmental conception of Plato's dialogues.

Theology after Heidegger must take into account history and language as constitutive elements in the pursuit of meaning. Quite often, this prompts a hurried flight from metaphysics to an embrace of an absence at the center of Christian narrativity. In this book, Conor Sweeney explores the "postmodern" critique of presence in the context of sacramental theology, engaging the thought of Louis-Marie Chauvet and Lieven Boeve. Chauvet is an influential postmodern theologian whose critique of the perceived onto-theological constitution of presence (...) in traditional sacramental theology has made big waves, while Boeve is part of a more recent generation of theologians who even more wholeheartedly embrace postmodern consequences for theology. Sweeney considers the extent to which postmodernism a la Heidegger upsets the hermeneutics of sacramentality, asking whether this requires us to renounce the search for a presence that by definition transcends us. Against both the fetishization of presence and absence, Sweeney argues that metaphysics has a properly sacramental basis, and that it is only through this reality that the dialectic of presence and absence can be transcended. The case is made for the full but restless signification of the mother's smile as the paradigm for genuine sacramental presence. (shrink)

While scholarly research on the relationship between female board representation and strategic decision-making has gained momentum, employee policy outcomes have remained relatively understudied. Integrating theory from the ethics of care perspective with research on the glass ceiling and workplace voice, we seek to understand the circumstances under which female directors influence policy changes for firm employees. We argue that firms with increasing female board representation are more likely to enact human capital development policies benefiting firm employees. However, this positive relationship (...) will ultimately diminish as boards accrue an increasing number of female directors. We further predict that the presence of a female leader at the firm (serving in the role of either the CEO or the board chair) will moderate this diminishing effect. Using a sample of S&P 1500 firms, we find support for our hypotheses. The findings from this study provide evidence that while female board representation is positively related to human capital development policies, this effect is nuanced and impacted by the presence of female leadership at the top of organizations. Our paper extends existing research on the nature of female directors’ influence on ethical decisions, emphasizing the impact of these directors on employees. (shrink)

My argument in this paper is that Charles Taylor’s view of liberty and ethics unites Isaiah Berlin’s liberal pluralism with Elizabeth Anscombe’s virtue ethics. Berlin identifies, in “Two Concepts of Liberty,” a tradition of negative liberty advocated by figures like Locke and Mill. He maintains that this concept of liberty is unique to modernity, and it is the form of liberty best suited to the political sphere. The much older concept of positive liberty, which is found in ancient philosophers like (...) Plato and Aristotle, as well as modern thinkers like Hegel, Berlin regards as ill-suited to the political sphere. Anscombe, in “Modern Moral Philosophy,” specifically identifies and criticizes the Anglo-Saxon tradition of moral philosophy. Utilitarian thinkers like Mill are, for Anscombe, consequentialists. The virtue ethics of Aristotle gives a basis for the intrinsic goodness and badness of actions not in sentiment but reason. Charles Taylor draws upon the views of both thinkers. He advocates a liberal pluralism in a manner comparable to Berlin. However, Taylor strongly emphasizes, with Anscombe, that the most complete conception of ethical and political life must be rooted in virtue ethics and positive liberty. Thus, Taylor’s views constitute a synthesis of the approaches of his two mentors. (shrink)

Using the work of Lacan but with reference to a number of other philosophers, this article argues eight main theses: first of all, that non-Platonic philosophical construction follows after a foundational destruction; second, that philosophy generally has a nothing outside its text, one that allows for the formation of that text—for example, Kant forms the text of phenomena only by way of the noumena; third, that this transcendental nothing renders all identities ideal, however that is conceived—an example being Badiou’s notion (...) of “belonging,” one derived from the work of Georg Cantor and Paul Cohen; fourth, that a consequence of this ideality is mereological nihilism; fifth, due to this mereological nihilism any existent is only ever an aggregate, that is, an aggregate of some base element, or “stuff ”—a position that returns such philosophy to that of the ancients; sixth, this collapses idealism and materialism into each other, a collapse marked by what is referred to throughout as an impossible monism. Moreover, this impossible monism is a result of philosophy’s constant production of a bastard trinity—a dual monism, as it were. Seventh, that there are two models of difference evident in non-Platonic philosophy: the first is that of a block, with difference cut into it—like Swiss cheese, as it were—while the second is a flux which we seek to arrest with local regimes of stability. Eighth, and finally, that theology, in line with Plato, suggests the possibility of another difference, namely, a peaceable one. (shrink)

Ethics, Animals and Science provides an introduction to ethics, aimed especially at those who work with animals in a scientific setting. Following an introduction to ethics in general, the book goes on to concentrate on the ethical issues which are closely associated with the most commonly occurring topics in debates on the use of animals in research. An attempt is made to find common premises for discussions which in the past have often proved to be mere dialogues of the deaf.

Does our future lie in global citizenship?

According to contemporary nonpositivist theories, legal obligations are a subset of our genuine moral obligations. Debates within nonpositivism then turn on how we delimit the legal “domain” of morality. Recently, nonpositivist theories have come under criticism on two grounds. First, that they are underinclusive, because they cannot explain why paradigmatically “legal” obligations are such. Second, that they are overinclusive, because they count as “legal” certain moral obligations that are plainly nonlegal. This paper undertakes both a ground-clearing exercise for and a (...) defense of nonpositivism. It argues, in particular, that Dworkin's claims about the legal domain of morality in his later work are often mischaracterized by critics, because these critics fail to read these claims in light of his earlier theory of “Law as Integrity.” A nonpositivist theory that unifies Dworkin's earlier and later work, I argue, deals with the criticisms leveled at nonpositivist theories better than other nonpositivist competitors. (shrink)

This study examines the semantics of a root form underlying a wide range of Dene lexical expressions. The root evolved from a simple nominal denoting “club” to expressions lexicalizing the movement of stick-like objects and the rotation of helicopter blades. These semantic extensions arise through source-in-target and target-in-source metonymies. Drawing on Cognitive Linguistics, especially the theory of metonymy, offers a method of describing the range of meanings expressed by this root in a concise manner. Focusing on the results of metonymic (...) meaning extensions also opens the way to addressing questions in the history of Dene languages. This study contributes to increasing the typological scope of Cognitive Linguistic approaches and argues for the usefulness of the theory in addressing problems in Dene linguistics. (shrink)

According to the fitting-attitudes account of value, for X to be good is for it to be fitting to value X. But what is it for an attitude to be fitting? A popular recent view is that it is for there to be sufficient reason for the attitude. In this paper we argue that proponents of the fitting-attitudes account should reject this view and instead take fittingness as basic. In this way they avoid the notorious ‘wrong kind of reason’ problem, (...) and can offer attractive accounts of reasons and good reasoning in terms of fittingness. (shrink)

Biobanking, the large-scale, systematic collection of data and tissue for open-ended research purposes, is on the rise, particularly in clinical research. The infrastructures for the systematic procurement, management and eventual use of human tissue and data are positioned between healthcare and research. However, the positioning of biobanking infrastructures and transfer of tissue and data between research and care is not an innocuous go-between. Instead, it involves changes in both domains and raises issues about how distinctions between research and care are (...) drawn and policed. Based on an analysis of the emergence and development of clinical biobanking in the Netherlands, this article explores how processes of bio-objectification associated with biobanking arise, redefining the ways in which distinctions between research and clinical care are governed. (shrink)

As Catholics, like all people of goodwill, work to confront the ongoing legacy of racism in the United States, they need additional resources to understand and challenge the suprapersonal aspects of racism at the social level. Building on existing Catholic analyses of racism as a form of cultural sin and incorporating recent refinements in the concept of structural sin, this paper argues that Catholic social thought can yield a more comprehensive account of systemic racism as a structural and cultural problem. (...) This combined analysis provides the theological resources to help Catholics recognize a duty to confront racism and promote racial justice as a natural extension of their faith commitments. (shrink)

Feminine beauty was implicated in colonial ways of seeing Indigenous peoples. The Australian ‘Native Belle’, as the feminine type of the noble savage, caught the European imagination at the time that European women such as Mary Wollstonecraft inaugurated a critique of feminine beauty as enslaving. Representations of the native belle were disseminated through new forms of communication and were implicated in prevailing discourses of Indigenous peoples such as ethnology. The native belle demonstrates a European longing for feminine beauty that was (...) natural and unaffected. This type also demonstrates that ideas of visual identity as manifest in feminine beauty were important descriptors of racial difference. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:William of Tyre, Livy, and the Vocabulary of ClassConor KostickThe most valuable source for the history of the early crusades and the Kingdom of Jerusalem is undoubtedly William of Tyre's A History of Deeds Done Beyond The Sea. A work of great scholarship and careful detail, it is particularly important in that William was Chancellor of the Kingdom of Jerusalem from 1174 and Archbishop of Tyre from 1175 to (...) his death c. 1185 and so was closely placed to the political decision making of the period. William was also a careful and highly educated scholar; although born in Jerusalem, he spent twenty years among the leading intellectuals of France and Italy and, after pursuing an avid interest in the liberal arts, devoted himself to civil law and the teachings of the masters at Bologna.1 In this respect William is far more than a narrator of crusading history, for which he would be highly regarded; he is also an important figure in the intellectual advances of the twelfth century. A close examination of William's vocabulary of social order shows that in his work he advanced the evolution of twelfth-century social concepts and also shed some light on the social structure of the Kingdom of Jerusalem.The History was commissioned by King Amalric of Jerusalem in 1167 and took its final form after redrafting by William in 1184, and it is clear that in his work William reveals a very rich vocabulary to describe social classes (see appendix). William actually uses the term classis to mean a social category of person. Current scholarship in history, sociology, and political theory would consider it anachronistic to talk about class in the twelfth century. Indeed, the use of classis as a term for social category must have been extremely rare as even such eminent scholars of lexicographers as Charles Dufresne Du Cange and Jan Frederik Niermeyer do not note it.Insofar as medieval writers before William discussed society, they referred to ordines, the orders of society. In the early part of the eleventh century even [End Page 353] the most advanced discussion of the subject of class had not progressed beyond the work of Adalbero, Bishop of Laon, and Gerard, Bishop of Cambrai, writing c. 1025, who had articulated the famous tripartite division of society according to function—those who pray, those who fight, and those who labor.2William uses the term ordo to mean order in the theological sense and ordines to indicate social order, but equally often he uses the term classis for the same purpose. For example, in describing the character of Baldwin III, he writes that "[Baldwin] acquired so great favor to himself from the commoners and the greater people that he was more popular with both classes [classis] than his predecessors."3 After the defeat of King Louis VII at Mount Cadmus, 7 January 1148, during the Second Crusade, William describes how the women fearfully cast about during for the return of fathers, lords, husbands, and sons: "and while they did not find what they sought they spent the night kept awake by the burden of their cares... nevertheless there returned in the night some of each of these classes [classis]."4Classis also appears in the phrase secundae classis homines, a phrase used three times to indicate a category of middle-class person. In describing the distant origins of the Hospitallers he says that it was a time when "there also flocked [to Jerusalem] some of the other nations, both nobles and the second class of men."5 At the fall of Balbis (3 November 1168) King Amalric's troops, "scarcely spared the old people and children, and were not any more merciful to the second class of persons."6 For his campaign beginning December 1170 the king's formidable opponent Saladin "increased his army with commoners and the second class of people."7 It is interesting to note that in these last two examples the term is referring to Muslim society, which William must have considered as socially diverse as his own. The existence and activity of a middle class of person as subjects of his history required William to use... (shrink)

A cross-disciplinary dialogue among writers who are sympathetic to the humanist tradition, and interested in developing a new humanist project through debate. The book emerges from the Institute of Ideas' festival, the Battle of Ideas.

Ideas can define and transform society, but how healthy is intellectual life today? In a period when Big Brother refers not to George Orwell but to a reality TV show, and when bright young things are developing gameshow formats rather than scribbling essays; when thinkers join think tanks to design short-term government policy rather than reflecting on and challenging the status quo, and when the ever growing number of graduates seem more interested in job prospects than academic endeavour, is intellectual (...) life in terminal decline? This book looks at the idea of the public intellectual, considering whether such thinkers are becoming an endangered species. It also looks at the legacy of relativism and ethical doubts about the pursuit of knowledge, and the effect of such developments on intellectual life. The final section considers the expansion of higher education and the changing role of the academic. Taken together, the essays in this collection form a comprehensive overview of the intellectual climate today, and the possibilities for the future. This volume was previously published as a special issue of the journal _Critical Review of International Social and Political Philosophy _. (shrink)

The dorsal anterior cingulate cortex is a key node in the human salience network. It has been ascribed motor, pain-processing and affective functions. However, the dynamics of information flow in this complex region and how it responds to inputs remain unclear and are difficult to study using non-invasive electrophysiology. The area is targeted by neurosurgery to treat neuropathic pain. During deep brain stimulation surgery, we recorded local field potentials from this region in humans during a decision-making task requiring motor output. (...) We investigated the spatial and temporal distribution of information flow within the dACC. We demonstrate the existence of a distributed network within the anterior cingulate cortex where discrete nodes demonstrate directed communication following inputs. We show that this network anticipates and responds to the valence of feedback to actions. We further show that these network dynamics adapt following learning. Our results provide evidence for the integration of learning and the response to feedback in a key cognitive region. (shrink)

A deontological approach to surgical ethics advocates that patients have the right to receive the best care that can be provided. The ‘learning curve’ in surgical skill is an observable and measurable phenomenon. Surgical training may therefore carry risk to patients. This can occur directly, through inadvertent harm, or indirectly through theatre inefficiency and associated costs. Trainee surgeon operating, however, is necessary from a utilitarian perspective, with potential risk balanced by the greater societal need to train future independent surgeons.New technology (...) means that the surgical learning curve could take place, at least in part, outside of the operating theatre. Simulation-based deliberate practice could be used to obtain a predetermined level of proficiency in a safe environment, followed by simulation-based assessment of operative competence. Such an approach would require an overhaul of the current training paradigm and significant investment in simulator technology. This may increasingly be viewed as necessary in light of well-discussed pressures on surgical trainees and trainers.This article discusses the obligations to trainees, trainers and training bodies raised by simulation technology, and outlines the current arguments both against and in favour of a simulation-based training-to-proficiency model in surgery. The significant changes to the current training paradigm that would be required to implement such a model are also discussed. (shrink)

In a book on Justinian’s wars of conquest, Peter Heather has argued that Rome’s ability to wage war in the sixth century CE was helped, to a large degree, by the military revolution that took place in Late Antiquity, which consisted of two principal parts: an increased deployment of Roman soldiers to the eastern frontier, and a shift towards Hunnic tactics. In this essay, however, I argue that these claims are misguided, and using five criteria set out by Lee Brice (...) in an article on military revolution during the reigns of Philip II and Alexander the Great of Macedon, I show that the changes which Heather argues in favour of had begun long before Late Antiquity. Instead, what we see is the continued gradual evolution of Rome’s military, with the Roman state shifting troops to the east from the beginning of the imperial era, and the first documented implementation of steppe-inspired changes dating to the second century. (shrink)