This paper follows the circuitous path of theories concerning the origins of viruses from the early years of the twentieth century until the present, considering RNA viruses in particular. I focus on three periods during which new understandings of the nature of viruses guided the construction and reconstruction of origin hypotheses. During the first part of the twentieth century, viruses were mostly viewed from within the framework of bacteriology and the discussion of origin centered on the “degenerative” or the “retrograde (...) evolution theory.” However, concomitantly, in the context of origin-of-life theorizing, the notion that viruses are vestiges of a prebiotic world was also being contemplated. In the 1960s the idea that viruses were genetic elements that “escaped” from cells became prevalent. These traditional hypotheses are being revisited nowadays by evolutionary virologists, who have placed them within a new conceptual framework that is supported by cutting-edge genomic and proteomic data. Two current, opposing scenarios of virus origin are presented. The philosophical dimensions of “revisiting” the original hypotheses are briefly discussed. (shrink)

During the 1960s, Howard M. Temin (1934-1994), dared to advocate a "heretical" hypothesis that appeared to be at variance with the central dogma of molecular biology, understood by many to imply that information transfer in nature occurred only from DNA to RNA. Temin's provirus hypothesis offered a simple explanation of both virus replication and viral-induced cancer and stated that Rous sarcoma virus, an RNA virus, is replicated via a DNA intermediate. Popular accounts of this scientific episode, written after the discovery (...) of an RNA-directed DNA polymerase in 1970, tend to describe the reaction to his proposition as ardent opposition. Typically these accounts use a 'molecular biology' standpoint emphasizing the central dogma's part in its rejection. In this article, however, this episode will be examined from a joint perspective of virology and experimental cancer research. From this perspective it is clear that Temin's work was well within the epistemological and methodological boundaries of virology and cancer research. Still, scientists did have reasons to doubt the provirus hypothesis, but these do not seem to be good enough to either justify an account that portrays Temin as a renegade or his ideas as heretical. (shrink)

This article outlines and compares current and proposed global institutional mechanisms to increase equitable access to COVID-19 vaccines, focusing on their institutional and operational complementarities and overlaps. It specifically considers the World Health Organization's (WHO’s) COVAX (COVID-19 Vaccines Global Access) model as part of the Access to COVID-19 Tools Accelerator (ACT-A) initiative, the WHO’s COVID-19 Technology Access Pool (C-TAP) initiative, the proposed TRIPS (Trade-Related Aspects of Intellectual Property Agreement) intellectual property waiver and other proposed WHO and World Trade Organization technology (...) transfer proposals. We argue that while various individual mechanisms each have their specific individual merits—and in some cases weaknesses—overall, many of these current and proposed mechanisms could be highly complementary if used together to deliver equitable global access to vaccines. Nonetheless, we also argue that there are risks posed by the proliferation of proposals in this context, including the potential to disperse stakeholder attention or to delay decisive action. Therefore, we argue that there is now a clear need for concerted global multilateral action to recognise the complementarities of specific models and to provide a pathway for collaboration in attaining global equitable access to vaccines. The institutional infrastructure or proposals to achieve this amply exist at this point in time—but much greater cooperation from industry and clear, decisive and coordinated action from states and international organisations are urgently needed. (shrink)

As the premier early modern advocate of an Epicurean alternative to the prevailing neo-Scholastic framework of Aristotelianism, Pierre Gassendi promoted not only ancient but also innovative reasoning on behalf of atomism, probabilism, empiricism, psychological hedonism, social contractarianism, and a range of other stances associated with the philosophy of the Garden. Much commentary has focused on the extent to which Gassendi ‘baptizes’ Epicurean thought. Beyond this aspect of his Epicureanism are questions as to whether, and how, Gassendi is true to core (...) Epicurean thinking, and what he preserves and promotes as valuable to philosophical and natural investigations of his time. Indeed, much subsequent modern philosophy builds on or reacts to an Epicurean legacy bequeathed by Gassendi, comprising his adjustments to, constraints on, or corrections of, the canonical views. Yet, for all his amendments, he retains as a primary philosophical motivation the Epicurean goal of striving for ataraxia. In this, he signals his firm commitment to philosophy in the tradition of the canonical Epicurean views. And, as with Epicurus’ own notion, his account of the centrality of attaining tranquility directs us to a better understanding of our nature and that of the world around us; amenable, in Gassendi’s framework, to Christian thought and contemporary natural philosophical investigations. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Sunyata and Otherness:Applying Mutually Transformative Categories from Buddhist-Christian Dialogue in ChristologySusie Paulik Babka“The universe is expanding,” the physicists tell us. “But doesn’t an expansion of something mean the presupposition of boundaries?” my naïve mind inquires, thinking too much in terms of discrete substances. Can “something” expand “into” nothing, “into” emptiness? Shot through with “dark energy” (the name an intellectual signifier allowing physicists to speak of the ineffable), the immensity (...) of the universe teaches a lesson in humility before mystery and the radically new. Dark energy makes up 74 percent of the universe and is responsible for increasing the rate of the universe’s expansion; it may be explained as the energy of empty space, or space devoid of matter and gravity. Although an unobservable phenomenon, dark energy penetrates the known universe as that which counteracts gravity’s relationship to matter, causing a negative pressure in regions of the universe devoid of matter to expand. Hence, the energy of emptiness is the reason for the universe’s expansion; emptiness is the reason reality is better described by rapid change and impermanence than stasis and immutability.While it would seem that these developments do not impact religious thinking, the Dalai Lama and others have argued that because science helps us understand the nature of reality, it affects the paradigm in which we consider the veracity of religious ideas. In his words, “if scientific analysis were conclusively to demonstrate certain claims in Buddhism to be false, then we must accept the findings of science and abandon those claims.”1 This is a bold statement, challenging both East and West to consider that when derived from only one source, even our most treasured religious ideas are narrowly conceived.The Western worldview has kept pace neither with the challenges of cosmic and subatomic physics nor with a more sophisticated global community. Since Parmenides in the pre-Socratic era, Western thought has been dominated by Greek philosophical categories, in which the perfection of beings is regarded in immutability and stasis, and things ideally tend toward independence or self-sufficiency. These categories [End Page 73] not only are inadequate to describe reality discovered through scientific means but also fail to articulate the meaning of the religious and cultural encounters taking place between East and West. Writes Joseph O’Leary, “The encounter with Buddhist thought enhances the hermeneutical task of theology, by opening up the possibility that Christian truth today can be more luminously presented in a discourse influenced by Buddhist analytical methods and ontological insights than in the old frameworks formed in dialogue with Greek ontology.”2Deconstructing substance ontology in the West suggests not only that science is a valuable conversation partner to religion but also that religions be conversation partners with each other. Christians should consider how divine or ultimate reality is manifest in other religions and abandon claims to exclusive truth. As Joseph O’Leary argues,The religions need each other, whatever their utter self-sufficiency on the plane of abstruse theological claims. The religions, as human historical trajectories, are inevitably marked by incompleteness and tragic failures. The tensions between them are not to be suppressed by dogmatic self-affirmation, but to be interpreted as the tension of “truth” itself, making itself felt within the finitude and brokenness of the human language striving to express it.3Truth for the Dalai Lama is “pursued by means of critical investigation,” requiring conversation with modern thought forms as well as both religious and secular Western traditions. If Christian theology is to be relevant today, it must continue to deconstruct the classical metaphysical categories that impede the appreciation of what is possible or true, especially in the encounter with non-Christian and non-Western thought, culture, and religious practice. Interreligious encounter necessitates the questioning of ontotheology, the classical metaphysical logic that refers to the rational basis for naming God, the supreme being, with supreme attributes, such as eternity, immutability, omniscience, and omnipotence. Ontotheology is related to the substance ontologies that describe the relation between God and the world and East and West in terms of dualism that according to Paul Knitter “so stresses the difference between two realities, so separates them... (shrink)

Theology, vulnerability, and art as the consciousness of grief -- Christology positive and im-positive -- Dedication to vulnerability in the form of art -- Visual art as a resource for theology of the incarnation -- Beyond language, beyond reason: vulnerability, art, and the problem of catastrophic suffering -- The presence of the absent God: incarnation and abstract expressionism.

In The Cruel Radiance, Susie Linfield challenges the idea that photographs of political violence exploit their subjects and pander to the voyeuristic tendencies of their viewers. Instead she argues passionately that looking at such images—and learning to see the people in them—is an ethically and politically necessary act that connects us to our modern history of violence and probes the human capacity for cruelty. Grappling with critics from Walter Benjamin and Bertolt Brecht to Susan Sontag and the postmoderns—and analyzing (...) photographs from such events as the Holocaust, China’s Cultural Revolution, and recent terrorist acts—Linfield explores the complex connection between photojournalism and the rise of human rights ideals. In the book’s concluding section, she examines the indispensable work of Robert Capa, James Nachtwey, and Gilles Peress and asks how photography should respond to the increasingly nihilistic trajectory of modern warfare. A bracing and unsettling book, The Cruel Radiance convincingly demonstrates that if we hope to alleviate political violence, we must first truly understand it—and to do that, we must begin to look. (shrink)

This new and expanded edition of The Logic of Real Arguments explains a distinctive method for analysing and evaluating arguments. It discusses many examples, ranging from newspaper articles to extracts from classic texts, and from easy passages to much more difficult ones. It shows students how to use the question 'What argument or evidence would justify me in believing P?', and also how to deal with suppositional arguments beginning with the phrase 'Suppose that X were the case.' It aims to (...) help students to think critically about the kind of sustained, theoretical arguments which they commonly encounter in the course of their studies, including arguments about the natural world, about society, about policy, and about philosophy. It will be valuable for students and their teachers in a wide range of disciplines including philosophy, law and the social sciences. (shrink)

Can the Hippocratic and Judeo-Christian traditions be synthesized with contemporary thought about practical reason, virtue and community to provide real-life answers to the dilemmas of healthcare today? Bishop Anthony Fisher discusses conscience, relationships and law in relation to the modern-day controversies surrounding stem cell research, abortion, transplants, artificial feeding and euthanasia, using case studies to offer insight and illumination. What emerges is a reason-based bioethics for the twenty-first century; a bioethics that treats faith and reason with equal seriousness, that (...) shows the relevance of ancient wisdom to the complexities of modern healthcare scenarios and that offers new suggestions for social policy and regulation. Philosophical argument is complemented by Catholic theology and analysis of social and biomedical trends, to make this an auspicious example of a new generation of Catholic bioethical writing which has relevance for people of all faiths and none. (shrink)

As ever more countries enter the global economy, reshaping the body has become the means by which women are encouraged to enter modernity. Once bodies were local, marked by their own local traditions. Today, variety is replaced by uniformity. The formerly plump Miss Nigeria is superseded by a thin westernized version and sets the trend for how contemporary Nigerian women are to look. Encouraged to see the body as a consuming center, a personal logo that signifies our membership of the (...) global community, bodies across the world are being commercialized and restructured. This development means that we are losing bodies as we lose mother tongue languages. Standardization is supplanting diversity as facsimile bodies become the new calling card of belonging and identity. (shrink)

This paper draws on the ethics of care to investigate how citizens grappled with ethical tensions in the mundane practice of grocery shopping at the height of the Covid-19 pandemic. We use this case to address the broader question of what it means ‘to care’ in the context of a crisis. Based on a qualitative longitudinal cross-country interview study, we find that the pandemic transformed ordinary shopping spaces into places fraught with a sense of fear and vulnerability. Being forced to (...) face one’s own vulnerability created an opportunity for individuals to relate to one another as significant others through a sense of “response-ability”, or the capacity of people to respond to ethical demands through situated ethical reasoning. We argue for a practical ethos of care in which seemingly small decisions such as how often to go shopping and how much to buy of a particular product serve as a means to relate to both specified and generalized others—and through this, ‘care with’ society. Our study contributes to displacing the continuing prevalence of an abstract and prescriptive morality in consumption ethics with a situated and affective politics of care. This vocabulary seems better suited to reflect on the myriad of small and unheroic care acts in times of crisis and beyond. (shrink)

_A lively intellectual history that explores how prominent midcentury public intellectuals approached Zionism and then the State of Israel itself and its conflicts with the Arab world_ In this lively intellectual history of the political Left, cultural critic Susie Linfield investigates how eight prominent twentieth-century intellectuals struggled with the philosophy of Zionism, and then with Israel and its conflicts with the Arab world. Constructed as a series of interrelated portraits that combine the personal and the political, the book includes (...) philosophers, historians, journalists, and activists such as Hannah Arendt, Arthur Koestler, I. F. Stone, and Noam Chomsky. In their engagement with Zionism, these influential thinkers also wrestled with the twentieth century’s most crucial political dilemmas: socialism, nationalism, democracy, colonialism, terrorism, and anti‑Semitism. In other words, in probing Zionism, they confronted the very nature of modernity and the often catastrophic histories of our time. By examining these leftist intellectuals, Linfield also seeks to understand how the contemporary Left has become focused on anti‑Zionism and how Israel itself has moved rightward. (shrink)

This book fills a critical niche that has long been overlooked. It specifically focuses on somatic practices to decrease stress and improve heart health. It will combine science, time-tested somatic mindfulness techniques, and patient stories to provide hope and help.

In this paper we will be discussing the ethical risks of the transcendental quality of virtual spaces as they apply to digital health, especially in relation to new attempts to construct a “social mediome.” As we will discuss in the following section, phenomenology has raised criticisms against the context-lessness and ethical opacity of technology. The creation of a social mediome seems to come as an answer to this criticism as it creates a context that gives voice and flesh to human (...) beings within their virtual lives. Yet, as we will discuss in this paper, the transcendental quality of this social mediome might involve the risk of normalizing health in a way that would prevent individuals from achieving well-being according to the meaning that they personally attribute to it. (shrink)

In this paper, we review recent neuroimaging investigations of disorders of consciousness and different disciplines' understanding of consciousness itself. We consider potential tests of consciousness, their legal significance, and how they map onto broader themes in U.S. statutory law pertaining to advance directives and surrogate decision-making. In the process, we outline a taxonomy of themes to illustrate and clarify the variance in state-law definitions of consciousness. Finally, we discuss broader scientific, ethical, and legal issues associated with the advent of neuroimaging (...) for disorders of consciousness and conclude with policy recommendations that could help to mitigate confusion in this realm. (shrink)

Ahighly successful guide to encourage classroomdiscussion fordeveloping children's thinking, learning and literacy skills containsmaterial on the latest trends in teaching thinking, including dialogic teaching, creativity and personalized learning. This sourcebook of ideas is essential reading for anyone seeking to develop children's minds, to build their self-esteem or to improve the quality of teaching and learning in schools.

How contensted notions of modernity, civilisation and being governed were envisioned through the aid of photography.

How contensted notions of modernity, civilisation and being governed were envisioned through the aid of photography.

This article explores the discursive construction, regulation and performance of the body in the context of the swimming pool. The near-naked state of the swimmer’s body presents a potential threat to the interaction order, insofar as social encounters may be misconstrued as sexual, and so rituals are enacted to create a ‘civilized’ definition of the situation. The term ‘performative regulation’ is introduced to theorize this process, as a synergy of the symbolic interactionist models of dramaturgy (Goffman) and negotiated order (Strauss) (...) and the post-structuralist concept of disciplinary power (Foucault). The regulation and representation of the swimmer’s body can be understood as mutually constitutive mechanisms, enforced by the pool-as-institution but enacted through the embodied practices of individual actors in the pool-as-interaction. Crossley’s notion of reflexive body techniques is applied to interpret this dualistic process in relation to communicative gestures and facework rituals, which implicates both individual and social bodies in the somatization of the interaction order. (shrink)

This article rewrites the history of the tomb of Philip the Bold made for the Chartreuse de Champmol in Dijon, through a close reading and re-transcription of the entire archival record, including some previously unknown documents, paying careful attention to what their terminology and chronology reveal about time, cost, materials and process; it analyses the scale of the project, and in particular the acquisition and working of materials: limestone from Tonnerre, ‘alabaster’ as spolia from Autun, black marble from Dinant, white (...) marble, presumably from Italy, via Paris, alabaster from Grenoble and a pinkish limestone from Resne, near Dijon. By reconsidering this record, along with the physical and visual evidence of the existing monument, it argues that there was not one but two tombs made for Philip the Bold: the first was completed by Jean de Marville and then rejected by Philip, and perhaps also by the Carthusians; the second, that we have today, was started again from scratch in the early 1390s by Claus Sluter, in collaboration, possibly, with Jacques de Baerze. The story of how these two tombs were planned, worked on, adapted or restarted, along with what Marville’s abandoned project may have looked like, and what may have become of its constituent parts, is woven into the narrative of Philip’s political and religious ambitions, the role of his wife Margaret of Flanders, and of the construction and decoration of the Chartreuse de Champmol itself. (shrink)

The work of psychiatrist R. D. Laing deserves recognition as a key contribution to sociological theory, in dialogue with the interactionist and interpretivist sociological traditions. Laing encourages us to identify meaningful social action in what would otherwise appear to be nonsocial phenomena. His interpretation of schizophrenia as a rational strategy of withdrawal reminds us of the threat that others can pose to the self and how social relations are implicated in even the most "private" and "internal" of experiences. He developed (...) a far-reaching critical theory of the self in modern society, which challenges the medicalization and biochemical reduction of human problems. Using the case of shyness as an example, the article seeks to demonstrate the importance of Laing's theories for examining the fragility of the self in relation to contemporary social order. (shrink)

We bring together recent discussions on data capitalism and biocapitalization by studying value flows in consumer genomics firms—an industry at the intersection between health care and technology realms. Consumer genomics companies market genomic testing services to consumers as a source of fun, altruism, belonging and knowledge. But by maintaining a multisided or platform business model, these firms also engage in digital capitalism, creating financial profit from data brokerage. This is a precarious balance to strike: If these companies’ business models consist (...) of assetizing the pool of genomic data that they assemble, then part of their work has to revolve around obscuring to consumers any uncertainties that would potentially impinge on these processes of assemblage. We reflect on the nature of these practices and the market relationships that enable them, and we relate this reflection to debates around alternative market arrangements that would potentially mitigate the extractive tendencies of these and other digital health firms. (shrink)

Centralised, compliance-focused approaches to research ethics have been normalised in practice. In this paper, we argue that the dominance of such systems has been driven by neoliberal approaches to governance, where the focus on controlling and individualising risk has led to an overemphasis of decontextualised ethical principles and the conflation of ethical requirements with the documentation of ‘informed consent’. Using a UK-based case study, involving a point-of-care-genetic test as an illustration, we argue that rather than ensuring ethical practice such compliance-focused (...) approaches may obstruct valuable research. We call for an approach that encourages researchers and research communities—including regulators, ethics committees, funders and publishers of academic research—to acquire skills to make morally appropriate decisions, and not base decision-making solely on compliance with prescriptive regulations. We call this ‘ethical preparedness’ and outline how a research ethics system might make space for this approach. (shrink)

Explora-se no presente artigo a função que o reconhecimento do outro desempenha para a moralidade no âmbito da obra Good and Evil: An Absolute Conception, de Raimond Gaita, a partir da centralidade da noção de remorso, entendido como a recordação do significado moral para o agente daquilo que ele fez. Serão resgatados os exemplos partir dos quais Gaita pretende enfatizar o peso da moralidade e o significado de se fazer o mal moralmente para alguém. Não se pode compreender, segundo o (...) filósofo, uma situação como moralmente problemática se não for inteligível que quem a realizou deveria sentir um remorso genuíno diante constatação do mal gerado a partir de suas ações. (shrink)

This article identifies and explores the realm of ‘social nothingness’: objects, people, events and places that do not empirically exist, yet are experienced as subjectively meaningful. Taking a phenomenological approach, I investigate how people perceive, imagine and reflect upon the meanings of unlived experience: whatever is significantly not present, never appeared or cannot happen to them. These ‘negative symbolic social objects’ include no-things, no-bodies, non-events and no-where places: for example, rejected roles, unpursued careers or absent people. Reversing some key concepts (...) from phenomenology, I examine the process of ‘negative noesis’ in three aspects. ‘Negative intentionality’ describes people’s motivational stance towards absent things, such as feelings of missing, wishing, haunting, avoidance or surrender. ‘Negative embodiment’ is the corporeal grounding of negational acts, through experiences of impairment, incapacity, severance, disturbance and decline. ‘Negative temporality’ describes the recognition of past or future impossible selves and their place within biographical identity stories. (shrink)

Nothing really matters. All the things that we do not do, have or become in our lives can be important in shaping self-identity. From jobs turned down to great loves lost, secrets kept and truths untold, people missed and souls unborn, we understand ourselves through other, unlived lives that are imaginatively possible. This book explores the realm of negative social phenomena - no-things, no-bodies, non-events and no-where places - that lies behind the mirror of experience. Taking a symbolic interactionist perspective, (...) the author argues that these objects are socially produced, emerging from and negotiated through our relationships with others. Nothing is interactively accomplished in two ways, through social acts of commission and omission. Existentialism and phenomenology encourage us to understand more deeply the subjective experience of nothing; this can be pursued through conscious meaning-making and reflexive self-awareness. The Social Life of Nothing is a thought-provoking book that will appeal to scholars across the social sciences, arts and humanities, but its message also resonates with the interested general reader. (shrink)

Background: Recent research demonstrates that people sometimes make different medical decisions for others than they would make for themselves. This finding is particularly relevant to end-of-life decisions, which are often made by surrogates and require a trade-off between prolonging life and maintaining quality of life. We examine the impact of decision role, patient age, decision maker age and multiple individual differences on these treatment decisions. Methods: Participants read a scenario about a terminally ill cancer patient faced with a choice between (...) an aggressive chemotherapy regimen that will extend life by two years and palliative treatments to control discomfort for one remaining month. Participants were randomly assigned to one of three decision roles (patient, physician, or an abstract other) and the scenario randomly varied whether the patient was described as 25 or 65-years old. Results: When deciding for a 65-year old patient, approximately 60% of participants selected aggressive chemotherapy regardless of decision role. When deciding for a 25-year old patient, however, participants were more likely to select chemotherapy for a patient (physician role) or another person (abstract other) than for themselves (70%, 67%, and 59%, respectively). In addition, confidence that powerful others (eg, physicians) control one’s health, as well as respondents’ age and race, consistently predicted treatment choices. Conclusions: Patient age appears to influence medical decisions made for others but not those that we make for ourselves. These findings may help to explain the discord that often occurs when younger cancer patients refuse life-extending treatments. (shrink)

Explora-se no presente artigo a função que o reconhecimento do outro desempenha para a moralidade no âmbito da obra Good and Evil: An Absolute Conception, de Raimond Gaita, a partir da centralidade da noção de remorso, entendido como a recordação do significado moral para o agente daquilo que ele fez. Serão resgatados os exemplos partir dos quais Gaita pretende enfatizar o peso da moralidade e o significado de se fazer o mal moralmente para alguém. Não se pode compreender, segundo o (...) filósofo, uma situação como moralmente problemática se não for inteligível que quem a realizou deveria sentir um remorso genuíno diante constatação do mal gerado a partir de suas ações. (shrink)

During the 1930s and 1940s, American physical organic chemists employed electronic theories of reaction mechanisms to construct models offering explanations of organic reactions. But two molecular rearrangements presented enormous challenges to model construction. The Claisen and Cope rearrangements were predominantly inaccessible to experimental investigation and they confounded explanation in theoretical terms. Drawing on the idea that models can be autonomous agents in the production of scientific knowledge, I argue that one group of models in particular were functionally autonomous from the (...) Hughes–Ingold theory. Cope and Hardy’s models of the Claisen and Cope rearrangements were resources for the exploration of the Hughes–Ingold theory that otherwise lacked explanatory power. By generating ‘how-possibly’ explanations, these models explained how these rearrangements could happen rather than why they did happen. Furthermore, although these models were apparently closely connected to theory in terms of their construction, I argue that partial autonomy issued in extra-logical factors concerning the attitudes of American chemists to the Hughes–Ingold theory. And in the absence of a complete theoretical hegemony, a degree of consensus was reached concerning modelling the Claisen rearrangement mechanism.Keywords: Models; Explanation; Physical organic chemistry; Rearrangements. (shrink)