Discovery science in health over the past two decades has embraced, with considerable enthusiasm, the potential of two movements: precision medicine and the ascent of big data. Each of these developments has been suggested to hold substantial promise both to advance our health science and to lead to the development of approaches that can improve health.Precision medicine—emerging naturally from the Human Genome Project almost two decades ago—promises to use genomic and molecular approaches to identify the causes of disease particular to (...) individuals with the end of helping develop tailored treatments and interventions. This approach builds on what is perhaps a deeply held... (shrink)

Åsa Burman has recently introduced the important notion of telic power and differentiated it from deontic power in an attempt to build a bridge between ideal and non-ideal social ontology. We find Burman’s project promising but we argue that more is to be done to make it entirely successful. First, there is a palpable tension between Burman’s claim that telic power can be ontologically independent of deontic power and her examples, which suggests that these forms of power share the same (...) basis. Second, it is not completely clear how telic power helps non-ideal social ontologists explain oppression, since Burman thinks that both forms of power are transparent to social agents. We offer solutions to both problems. First, we question the thesis that telic power can exist without deontic power. Burman contends that this is possible because some social roles involving telic power can exist independently of institutions, which are––in her opinion––the source of deontic power. Against Burman, we suggest that all social roles involve deontic power, whether or not they are institutional. Second, we argue that while the exercise of deontic power requires a mutual recognition of the social roles of the interacting agents and, therefore, an acceptance of the associated norms, the exercise of telic power does not require acceptance of the relevant norms. This is why invoking telic power is useful in explaining how oppression and injustice can arise. Lastly, we suggest that the relation between teleological normativity and telic power has not been fully clarified by Burman and requires a deeper analysis. (shrink)

Introduction and ObjectiveThe early identification of depressive patients having a poor evolution, with frequent relapses and/or recurrences, is one of the priority challenges in this study of high prevalence mental disorders, and specifically in depression. So, this study aims to analyze the factors that may be associated with an increased risk of recurrence of major depression episodes in patients treated in primary care.MethodsA retrospective, descriptive study of cases-controls was proposed. The cases consisted of patients who had been diagnosed with major (...) depression and who had presented recurrences, in comparison with patients who had experienced a single major depression episode with no recurrence. The variables of the study are age at first episode; number of episodes; perception of severity of the depression episode suffered prior to recurrence; number of residual symptoms; physical and psychiatric comorbidity; history of anxiety disorders; family psychiatric history; high incidence of stressful life events ; and experiences of physical, psychological, or sexual abuse in childhood. The differences of the variables were compared between the case subjects and the control subjects, using the Mann–Whitney, chi-square, and Fisher’s U statistics. A multivariate analysis was performed.ResultsThe average age of those suffering more than one depressive episode is significantly older, and a higher percentage of subjects who have experienced more than one depressive episode have a history of anxiety disorders. In the multivariate analysis, the variables that obtained a significant value in the logistic regression analysis were age and having suffered sexual abuse during childhood.ConclusionThese indicators should be considered by primary care physicians when attending patients suffering from major depression. (shrink)

This book reexamines the birth of quantum mechanics, in particular examining the development of crucial and original insights of Bohr. In particular, it gives a detailed study of the development and the interpretation given to Bohr's Principle of Correspondence. It also describes the role that this principle played in guiding Bohr's research over the critical period from 1920 to 1927.

This paper investigates the link between the consumer perception that a company is socially oriented and the consumer intention to buy products marketed by that company. We suggest that this link exists when at least two conditions prevail: (1) the products sold by that company comply with ethical and social requirements; (2) the company has an acknowledged commitment to protect consumer rights and interests. To test these hypotheses, we conducted a survey among the clients of retail chains offering Fair Trade (...) products. The results show that socially oriented companies can successfully leverage their reputation to market products with high symbolic values. (shrink)

The aim of the paper is resurrecting the “Demarcation Problem”, which was considered dead in a paper written by Larry Laudan in 1983. I will go through the analysis of Imre Lakatos’ thought, which represents the most mature synthesis between the fallibilism of science and the rationality of the demarcation attitude. Lakatos’ philosophical trick is directed to acknowledge the inclinations of the contemporary philosophers, to grasp the best they can offer, and to propose a more suitable philosophy of science. He (...) follows the middle path between dogmatism and skepticism: the favorite position in order to safeguard the phenomena suggesting a rational unity of the science in an “anarchic” historical period. (shrink)

This article analyses how the philosopher Piero Martinetti conceptualizes the survival of a person’s soul after death. Martinetti’s stance is strongly influenced by the philosophy of Plotinus. Martinetti shows that the relation between singularity and multiplicity is expressed in human beings as two different and complimentary perspectives: a fundamental identity in the atemporal dimension of the intelligible life of the spirit and a dynamic tension in the empiric order of the spatio-temporal becoming. Both dimensions express themselves in a finalistic way, (...) attracted from the One who operates in them as a force of harmonization and concentration. The One as Omnitudo realitatis is the cornerstone of Martinetti’s position in regards to the survival of the individual soul after death: a concentration that happens mysteriously, because it transcends the ability of the human mind to understand it – yet, it certainly happens. ≪One thing only we know: what is worth living will live.≫. (shrink)

I discuss two competing theories of the progressive: the theory proposed in Parsons (1980, 1985, 1989, 1990) and the theory proposed in Landman (1992). These theories differ in more than one way. Landman regards the progressive as an intentional operator, while Parsons doesn't. Moreover, Landman and Parsons disagree on what uninflected predicates denote. For Landman, cross the street has in its denotation complete events of crossing the street; the aspectual contribution of English simple past (perfective aspect) is the identity function. (...) For Parsons, both complete and incomplete events of crossing the street can be in the denotation of the base VP; perfective aspect restricts its denotation to the events that culminate. I present a version of ParsonÕs theory that avoids the problems raised by Landman, in particular the problem posed for Parsons by creation verbs. The repaired version and Landman's theory still differ in the way they analyze uninflected verbs. The repaired version and Landman's theory still differ in the way they analyze uninflected predicates. I present evidence from Slavic languages that both theories are needed. Finally, I discuss some evidence that may favor one or the other approach to the semantics of the English progressive. (shrink)

We largely agree with Grimwade et al ’s1 conclusion that challenge trial participants may ethically be paid, including for risk. Here, we add further arguments, clarify some points from the perspective of economics and indicate areas where economists can support the development of a framework for ethically justifiable payment. Our arguments apply to carefully constructed and monitored controlled human infection model trials that have been appropriately reviewed and approved. Participants in medical studies perform a service. Outside the domain of research (...) participation, there is nearly universal agreement that workers providing a service should be compensated fairly, and that work involving more discomfort and risk should be compensated more generously. Accordingly, labour regulations impose floors, not caps on compensation. Caps, even if intended to protect against undue inducement, also raise concerns about illegal price-fixing that disadvantages workers. Such limits on payment for egg donors have successfully been challenged in court.i Moreover, caps on compensation may harm everyone at risk of infection, not just potential participants. Insufficient compensation may impede the recruitment of enough suitable subjects, for example, when representativeness of the subject sample is required. Delays in vaccine development not only prolong disruption of social, educational and economic activity but also lead to excess infections and deaths. Unlike paid CHIM participants, individuals exposed to such infection do not accept it voluntarily, are not compensated for it, and are unlikely to receive the level of medical supervision afforded to closely monitored CHIM participants. Payment caps can lead to attempts to circumvent the regulation. For example, many countries …. (shrink)

According to the theoretical framework relating hypnosis to attention, baseline attentional functioning in highly hypnotizable individuals should be more efficient than in low hypnotizable individuals. However, previous studies did not find differences in Stroop-like tasks in which the measure indicative of the Stroop interference effect was based on response latencies. This study was designed to determine whether subjects with different levels of hypnotic susceptibility show differences in baseline attentional functioning. To assess this hypothesis, high, medium, and low hypnotizable subjects performed (...) a Stroop task designed to evaluate accuracy performance, before being subjected to hypnotic induction. Results showed that the Stroop interference effect was smaller in high hypnotizable subjects than in low hypnotizable subjects, whereas it was not different between high, and medium hypnotizable subjects. This outcome supports the notion that baseline attentional functioning is related to hypnotic susceptibility. (shrink)

Resumen En este texto se intenta mostrar que la radicalización de la tesis expresada por Platón en el libro X de la República no permite "apreciar" el valor que el filósofo ateniense sabe que posee la poesía, pues ella podría ser un medio para el ejercicio reflexivo si se sirve de la sobriedad que la filosofía propone. Para realizar esta tarea es menester trazar tres puntos sobre los cuales gira este texto: primero, se ubica al lector en la discusión entre (...) poesía y filosofía para comprender el contexto de la crisis entre estos dos factores de la educación en la antigüedad griega; segundo, se aborda la crítica establecida en el libro X sobre la falta de rigor que muestran los poetas en la búsqueda del conocimiento; finalmente se vislumbra o abre una posibilidad interpretativa acerca del interés que puede tener la proposición de una "poesía filosófica" en la obra de Platón.The following text will try to show that radicalization of the thesis expressed by Plato in the book X does not allow "to "estímate" the value that the Athenian philo-sopher knows that poetry possesses, since poetry might be a means for the reflexive exercise if it takes advantage of the sobriety that philosophy proposes. To carry out this task it is necessary to define three points on which this paper will be about: first, the author will inform the reader about the old discussion among poetry and philosophy to understand the context of the crisis between these two forms of teaching; Second, criticism established in the book X on the lack of rigor in the search of knowledge that poets have will be addressed. Finally, the paper glimpses or opens an interpretive possibility about the interest that the proposition of a "philosophical poetry" can have in Plato's work. (shrink)

In this paper we propose a semantic analysis of sentences of the form "In fiction x, p" based on this picture of context. We argue that the derived contexts for sentences in the scope of "In fiction X" are determined by three factors: what the beliefs of the author are taken to be, the conventions established for the fiction, and a defeasible presumption of reliability of the narrator. We develop a formal implementation based on the notion of a system of (...) spheres centered on a set of worlds. (edited). (shrink)

Smartphones abrangem várias funcionalidades – telefonia, e-mails, dispositivo de áudio e vídeo, interação por meio de aplicativos – que têm operado transformações nas formas como os sujeitos se movimentam, aprendem e habitam os centros urbanos. Inscrita no referencial dos Estudos Culturais, este artigo é resultado de uma pesquisa exploratória que problematiza os usos de smartphones e certos deslocamentos no entendimento sobre aprendizagem. Assim, dois movimentos de investigação se interligam, sendo o primeiro uma exposição sobre a emergência de smartphones, e o (...) segundo um exame das relações entre os sujeitos e um tipo de mobilidade operada por smartphones. Os resultados indicam um tipo de aprendizagem diante das telas ao estilo móvel, ensinando formas de ser sujeito na sociedade contemporânea. (shrink)

English summary: The relationship between Jean-Paul Sartre and the left in France and Europe has always been a tense one. This work examines the integration of the figure of Trotsky and his ideas into the broad range of Sartre's discourse and traces its importance for the development of an independent intellectual course with respect to philosophy and politics. German description: Die Beziehung zwischen Jean-Paul Sartre und der Linken in Frankreich und Europa gestaltete sich stets spannungsreich. In der vorliegenden Arbeit wird (...) die Integration der Figur und der Ideen Trotzkis in die diskursive Klaviatur Sartres in Augenschein genommen und deren Bedeutung fur die Entwicklung eines unabhangigen intellektuellen Kurses in philosophischer wie politischer Hinsicht nachgezeichnet. (shrink)

Scholarly research largely converges on the argument that trust is of paramount importance to drive economic agents toward mutually satisfactory, fair, and ethically compliant behaviors. There is, however, little agreement on the meaning of trust, whose conceptualizations differ with respect to actors, relationships, behaviors, and contexts. At present, we know much better what trust does than what trust is. In this article, we present an extensive review and analysis of the most prominent articles on trust in market relationships. Using computer-aided (...) content analysis and network analysis methods, we identify key, recurring dimensions that guided the conceptualization of trust in past research, and show how trust can be developed as a multifaceted and layered construct. Our results are an important contribution to a convergence of research toward a shared and common view of the meaning of trust. This process is important to ensure the body of trust research’s internal theoretical consistency, and to provide reliable and common principles for the management of business relationships – a context in which opportunism and imperfect information may induce economic actors to cheat and stray from fair and ethically compliant behaviors. (shrink)

Scholarly research largely converges on the argument that trust is of paramount importance to drive economic agents toward mutually satisfactory, fair, and ethically compliant behaviors. There is, however, little agreement on the meaning of trust, whose conceptualizations differ with respect to actors, relationships, behaviors, and contexts. At present, we know much better what trust does than what trust is. In this article, we present an extensive review and analysis of the most prominent articles on trust in market relationships. Using computer-aided (...) content analysis and network analysis methods, we identify key, recurring dimensions that guided the conceptualization of trust in past research, and show how trust can be developed as a multifaceted and layered construct. Our results are an important contribution to a convergence of research toward a shared and common view of the meaning of trust. This process is important to ensure the body of trust research's internal theoretical consistency, and to provide reliable and common principles for the management of business relationships — a context in which opportunism and imperfect information may induce economic actors to cheat and stray from fair and ethically compliant behaviors. (shrink)

The aim of this paper is to describe the lack of equipment in a neighborhood of Palma de Mallorca, Foners in regard to their population. New residents with migration phenomenon presents a situation of inequality that can lead to negative social processes but were offset requirements. The description is carried out in the area intended to be a claim on integration from a multicultural perspective. A collection of data detailing the shortcomings and proposes targets for intervention through a plan of (...) rehabilitation in the territory. (shrink)

The article deals with the ambiguous relation between fear and expertise, and examines how it affects institutions’ legitimation. In contemporary societies the so-called expert systems can be considered as powerful trust creators. However their power can also cause fear, as their control over the majority of everyday life tasks can have a “disabling” effect on lay people. This double-edged role deeply influences the relation between citizens and institutions, the latter considerably relying on expertise in order to be perceived as rational (...) actors. Fear, therefore, can be considered as a central element in determining the legitimacy of institutions in modern societies. (shrink)

In Italian Sign Language (LIS), when past or future time adverbs are present, the signs for verbs exhibit the same manual configurations whether the sentence reports a past event or a future event. Facts of this kind, also observed for American Sign Language (ASL) and other sign languages, have led some authors (Friedman, among others) to conclude that these languages, on a par with spoken languages like Chinese, lack grammatical tense. Neidle et al. and Jacobowitz and Stokoe have challenged this (...) view for ASL and have argued that ASL sentences contain tense markers. I present some data showing that LIS verbs inflect for tense. I argue, moreover, that the apparent lack of tense inflection when LIS past and future time adverbs are present is due to the fact that these adverbs shift the s-point and that LIS past and future tenses are absolute tenses. I provide a formal account of the LIS tense system based on these assumptions. The account is implemented in Heim’s analysis of tense. (shrink)

This article addresses the modern concept of sovereignty as a multivocal and conflictual semantic field, arguing for the necessity to trace its genealogy based on the structural tensions that haunt its logical framework – as well as its representations – rather than on a linear historiographic reconstruction. In particular, the scrutiny I propose aims to examine a series of exchanges that have been characterizing this concept since the beginning: the global and the European, the maritime and the territorial, the colony (...) and the state, the imperial and the proprietary. The problematic balance between ‘imperium’ and ‘dominium’ is indeed assumed here as the turning point of the rise of a sovereign power that appears to be originally rooted in the very production and governance of the global space, thus giving up all possible Eurocentric narratives of modernity. To illustrate my argument, I focus on the frontispieces to three of Thomas Hobbes’s most important books, that is, his translation of Thucydides’ Peloponnesian Wars, De Cive and Leviathan. A thorough analysis of these images enables us to understand how these lines of force traverse the very heart of modern European political concepts, along with the mirroring effects that constantly bounce their normative construction of subjectivity back and forth from the periphery to the centre and, ultimately, from the market to the state. (shrink)