The recent emergence of reprogramming technologies to convert brain cell types or epigenetically alter neurons and neural progenitors in vivo and in situ hold significant promises in brain repair and neuronal aging reversal. However, given the significant epigenetic and transcriptomic changes to components of the existing neuronal cells and network, we question if these reprogramming technology might inadvertently alter or erase memory engrams, conceivably resulting in changes in narrative identity or personality. We suggest that the nature of (...) these alterations might be less predictable compared to memory and personality changes known to be associated with diseases, drugs or brain stimulation therapies. While research in applying reprogramming technologies to neurological ailments and aging should continue, more targeted analyses should be put in place in animal experiments to gauge the severity and degree of memory alterations, and appropriate risk and benefit analyses should be conducted before these technologies move into human trials. (shrink)

This study uses panel data to investigate the different roles of the Chinese government in influencing companies’ decision making about corporate environmental reporting (CER) via a two-stage process. The results show that the Chinese government appears to mainly influence the decision whether to disclose or not, but has limited influence on how much firms disclose. The results also show that the traditional model of authoritarian capitalism (under which state-owned enterprises [SOEs] are the major governance arrangement) is transforming into a new (...) model. In the new model of authoritarian capitalism, the Chinese government uses newer, more sophisticated tools to manage both state-owned and non–state-owned companies. In addition, these new governance arrangements appear to be more efficient than the traditional model. The findings of this study have implications for both the Chinese government and for Chinese companies, as well as making important contributions to the literature and knowledge of CER in China. (shrink)

An in-situ transmission electron microscopy straining technique has been used to investigate the dynamics of dislocation-defect interactions in ion-irradiated copper and the subsequent formation of defect-free channels. Defect removal frequently required interaction with multiple dislocations, although screw dislocations were more efficient at annihilating defects than edge dislocations were. The defect pinning strength was determined from the dislocation curvature prior to breakaway and exhibited values ranging from 15 to 175 MPa. Pre-existing dislocations percolated through the defect field but did not (...) show long-range motion, indicating that they are not responsible for creating the defect-free channels and have a limited contribution to the total plasticity. Defect-free channels were associated with the movement of many dislocations, which originated from grain boundaries or regions of high stress concentration such as at a crack tip. These experimental results are compared with atomistic simulations of the interaction of partial dislocations with defects in copper and a dispersed-barrier-hardening crystal plasticity model to correlate the observations to bulk mechanical properties. (shrink)

In the framework of the minimalist program, the assumption that wh-in-situ move covertly to be assigned wide scope is infeasible. Rather, it is assumed that they must be interpretable in situ, and that syntactic conditions like ‘superiority’ are effects of economy, which restricts overt rather than covert movement of a wh-element. The remaining syntactic problem for this line of reasoning is the putative ECP effects of adverbial wh-adjuncts, which were the strongest evidence for covert movement. A serious semantic (...) problem is that the interpretative procedures which have been proposed for wh-in-situ – unselective binding or absorption – fail to capture correctly their interpretation. I will argue first that both problems are solved if the interpretation in situ employs choice functions, and it is the function variable, rather than an individual variable, which is long-distance bound by the question existential operator. Adverbial adjuncts, which cannot be interpreted via choice functions, cannot, therefore, be interpreted in situ. However, the concept of economy underlying the account of overt superiority effects requires both theoretical and empirical clarification (as it leaves some empirical problems unaddressed). I argue, following a proposal by Golan (1993), that in this case the economy considerations apply at the interface (‘interface economy’) and that they consider not only different derivations out of the same numeration, but also their semantic representation. (shrink)

This chapter describes the development of a workshop series focused on helping students develop research lab ethics guidelines. The workshop was developed through a National Science Foundation-funded project that situates ethics education within the research environment. Students in four departments at a private research university were recruited to join a Student Ethics Committee that collaboratively developed context-specific codes-of-ethics-based guidelines for their departments. These bottom-up developed guidelines were revised in an iterative process, including feedback from faculty, other graduate students, and the (...) original Student Ethics Committee. The goal of the workshops was to promote the cultivation of an ethical culture in experimental laboratories by integrating research stakeholders in a bottom-up approach to developing context-specific guidelines and to identify factors that students consider relevant to the ethical conduct of research. After describing the workshop series, this chapter presents a qualitative content analysis of the guidelines. The guidelines developed by the Student Ethics Committees reflect the current culture of experimental labs in these departments and the ethical issues that students think are important. The content of these guidelines and the ethical issues the students focused on contrast in some key ways with what ethical issues faculty who head research groups saw as paramount. The chapter describes the first two iterations of the ethics education workshop module, a qualitative analysis of the first draft of these guidelines, and finally reflects on future work in this area of in situ ethics education. (shrink)

L’exposition d’art dans des paysages est devenu populaire au Japon, avec la multiplication récente de festivals d’art locaux. Dans ces festivals, qui attirent chacun des centaines de milliers de visiteurs, coexistent des œuvres hétérogènes. Certaines sont des sculptures autonomes, d’autres des installations qui se fondent dans le paysage, et d’autres encore sont des œuvres de type « art relationnel ». Bien que ces œuvres in situ affirment leur lien essentiel avec le site naturel rural et avec le corps du (...) spectateur — constituant un événement, une expérience, une rencontre éphémère —, les relations avec le site comme avec le visiteur sont complexes et ambigües. Il y a des œuvres in situ, mais parfois aussi in aliquo situ : des œuvres qui peuvent être installées n’importe où. Qu’est-ce qui attire les visiteurs dans ces expositions? Quels sont donc la nature et le mérite de leur localisation? Si les visiteurs apprécient de voir des œuvres dans ces paysages cela peut être en partie lié au principe japonais traditionnel d’expérience des lieux dit meisho-meguri, ou « pèlerinage vers des sites célèbres ». Cette pratique issue du Moyen Âge est associée historiquement au sacré. Aujourd’hui ce pèlerinage prend la forme du tourisme moderne mais conserve un sens traditionnel invisible car les visiteurs se déplacent à travers une série de lieux géographiques selon un jeu culturellement codé. Selon nous, dans le cas des visites d’œuvres d’art en zones rurales, l’appréciation des œuvres d’art participe à ce même jeu traditionnel de se déplacer physiquement dans une série de lieux. Cette dimension spirituelle implicite modifie à son tour la perception des œuvres. Ainsi on dira que la pratique japonaise de visiter ces expositions d’art in situ témoigne de la survivance d’une tradition, et constitue ainsi un système alternatif d’expérience esthétique. The installations of artwork in natural landscapes have become popular in Japan with the recent increase in local art festivals. In these art festivals where hundreds of thousands of visitors gather, heterogeneous installations coexist; some are autonomous sculptures, some are fused into the natural landscape, and some belong to “relational art”. Although most works assert the essential quality of their location, and the experience as “an event”, their relationships to the rural areas and to the body of the visitor are complex and ambiguous. Some works are really in situ, but some are in aliquo situ—that is, works that could be installed anywhere. What attracts visitors to these exhibitions? Hence what is the nature and merit of the location? What is the relation to the visitor’s bodily presence? If visitors enjoy the site-specificity of the artwork this may be linked to the traditional Japanese system of experiencing places as meisho-meguri—i.e. “a pilgrimage to a series of famous sites”. This practice comes from the Middle Ages and was by then spiritual. While today these pilgrimages appear as a form of modern tourism, they retain a culturally coded character because visitors’s journey is like “a game of visiting a series of geographical places”. According to me, in the case of the visit of artistic sites, the appreciation of the artwork participates in this same game of bodily displacement to a series of places. This implicit spiritual underpinning conversely modifies the visitor’s perception of the works. Thus I propose that visiting artistic sites in natural settings in Japan appears as informed by this Japanese particular tradition, and thus constitutes an alternative system of contemporary aesthetic experience. (shrink)

A legal obligation to conduct weapons reviews is a means by which the international community can ensure that States assess whether the use of new types of weapons in armed conflict would raise humanitarian concerns. The use of artificial intelligence in weapon systems greatly complicates the process of conducting reviews, particularly where a weapon system is capable of continuing to ‘learn’ on its own after being deployed on the battlefield. This paper surveys current understandings of the weapons review challenges presented (...) by in situ learning and outlines some concepts which may inform appropriate changes to existing weapons review processes. The main arguments made are that: a distinction should be drawn between learning capabilities that are limited to optimising existing behaviour and capabilities that extend to acquiring new behaviours; and the extent of a weapon system’s learning capabilities should be used as the basis for defining a schedule of weapons reviews. (shrink)

This paper emerges from and aims to contribute to conversations on agricultural biodiversity loss, value, and renewal. Standard international responses to the crisis of agrobiodiversity erosion focus mostly on ex situ preservation of germplasm, with little financial and strategic support for in situ cultivation. Yet, one agrarian collective in the Peruvian Andes—the Parque de la Papa (Parque)—has repatriated a thousand native potatoes from the gene bank in Lima so as to catalyze in situ regeneration of lost agricultural (...) biodiversity in the region. Drawing on participant action research and observation, this paper engages with the projects underway at the Parque—as well as “indigenous biocultural heritage” (IBCH), the original action-framework guiding the Parque’s work. IBCH grounds the ecology of successful crop diversity within the Andean cosmovisión, or worldview—which is included, but marginalized, in mainstream agrobiodiversity conservation policies. The IBCH concept counters apolitical renderings of agrobiodiversity erosion, arguing that this disregard of biocultural heritage perpetuates colonialist devaluations of efficacious “traditional ecological knowledge” and epistemologies. Accordingly, this paper discerns here an on-site, or in situ, political ecology of agricultural biodiversity conservation. (shrink)

El crecimiento de las naciones y la creación de ideologías territoriales (como los nacional-ismos, regionalismos) ha supuesto numerosos cambios contemporáneos. Estas ideologías no sólo han conllevado nuevas connotaciones sobre la creciente importancia de la identidad territorial (tanto a nivel nacional como regional) sino que también han desarrollado un nuevo sistema complejo de ideologías desde una perspectiva local. En este artículo se trata de examinar la relación entre las ideologías políticas y la arquitectura dentro del contexto gallego y español. El foco (...) principal es el nacionalismo manifestado en el urbanismo durante el periodo 1918–1960 en Galicia. En el periodo republicano y después de la Guerra Civil española, esta región y más concretamente la ciudad de Santiago de Compostela se convirtió en centro de atención. Este discurso del nacionalismo territorial es un fenómeno capital en el proceso de rehabilitación de Santiago de Compostela y conlleva un fuerte impacto en la creación de una imagen significativa de la ciudad histórica. De este modo, la ciudad se convierte en una fábrica de ideas como el centro y la periferia, Europa occidental, un lugar de ideología marginal frente a las grandes narraciones centralistas del Estado. (shrink)

The conservation of rice plant genetic diversity is particularly important for resource-poor farmers in economically marginal areas of the Philippines. This paper discusses the state of rice plant genetic diversity in the Philippines and the reasons behind the decrease in diversity witnessed over the last 30 years. A case study describes the in situ management of rice plant genetic diversity by resource-poor farmers from the Philippine island of Bohol, throughout the traditional, green revolution, and post-green revolution periods. This analysis (...) demonstrates that farmers tend to favor genetically heterogeneous varieties that adapt to varied environments. The case study also reviews an NGO-sponsored agricultural biodiversity project that demonstrates that rice plant genetic diversity can be increased by empowering farmers – providing them with access to varieties, knowledge of varietal trials, varietal selection, and varietal breeding, as well as increasing the linkages they have with other farmers and institutions. (shrink)

Unlike adjunct wh’s-in-situ, argument wh’s-in-situ do not seem to be subject to island constraints in Chinese and other East Asian languages. This difference in island sensitivity between argument and adjunct wh’s-in-situ is known as argument–adjunct asymmetry in the theoretical literature. Recently, this long-established asymmetry is challenged by a formal judgment study. It was claimed in the study that this asymmetry is an illusion and both argument and adjunct wh’s-in-situ are subject to island constraints. The present study (...) demonstrates that such a claim is not convincing because it is based on problematic experimental design. We designed two experiments to test the island effects on Chinese wh’s-in-situ. The results reaffirm that the argument–adjunct asymmetry in Chinese wh’s-in-situ is indeed present, contrary to the findings of previous formal judgment study, and they also corroborate our assumption that when object wh’s-in-situ like shénme ‘what’ are located inside a relative clause, they are subject to a pragmatic constraint, suggesting that the VP in the relative clause tends to describe the prominent/salient feature of the relativized nominal head. (shrink)

In recent years, the concept of social capital – broadly defined as co-operative networks based on regular, personal contact and trust – has been widely applied within cross-disciplinary human science research, primarily by economists, political scientists and sociologists. In this article, I argue why and how fieldwork anthropologists should fill a gap in the social capital literature by highlighting how social capital is being built in situ. I suggest that the recent inventions of “bridging” and “bonding” social capital, e.g., (...) inclusive and exclusive types of social capital, are fruitful concepts to apply in an anthropological fieldwork setting. Thus, my case study on the relationship between local people and newcomers in the rural Danish marginal municipality of Ravnsborg seeks to reveal processes of bridging/bonding social capital building. Such a case study at the micro level has general policy implications for a cultural clash between two different groups by demonstrating the complexity of a social capital mix where bonding social capital strongly prevails. This ultimately leads to a “social trap” (Rothstein 2005), implying widespread distrust and serious social and economic costs for a whole population. (shrink)

The “Human Genome Project” was completed in 2003, shifting the focus to proteome and transcriptome research. One approach to proteomics involves the comprehensive visualization of the localization of proteins in all tissues and organs. We discuss in situ phospho‐protein atlases, which are systematized representations of the localization of proteins. Protein atlases provide important information about the identity and presence of proteins in specific organs, tissues and cells under physiological and pathological conditions. Antibody‐based immunohistochemical analysis is a powerful method for (...) generating a protein atlas. However, it is difficult to localize phosphorylated proteins under in vivo physiological conditions, even with immunohistochemistry, because these proteins tend to be dephosphorylated or phosphorylated due to the experimental manipulations. We also discuss an improved immunohistochemical method for precisely detecting phosphorylated protein, using the detection of phosphorylated ERK1/2 as an example. We consider that it is possible and useful to generate a phospho‐protein atlas. (shrink)

One of the major adjustments brought on by the North American Free Trade Agreement (NAFTA) was a change in the relationship between Mexican agricultural support institutions and the small-scale agricultural sector. Post-NAFTA restructuring programs sought to correct previous inefficiencies in this sector, but they have also had the effect of marginalizing the producers who steward and manage the country’s reserve of maize (Zea mays) genetic diversity. Framed by research suggesting that certain maize varieties in a rain-fed farming region in southern (...) Sonora are in danger of loss due chiefly to long-term drought, this article explores the ramifications of post-NAFTA agricultural policies for in situ maize diversity conservation. Qualitative methods, including semi-structured interviews with agricultural support institutions and participant observation with farmers, were used to gather data on dryland farmers’ access to research and extension, as well as possibilities for collective action. In southern Sonora, agricultural support is oriented primarily toward high-tech production, and there are structural barriers to small-scale farmers’ access to research and extension institutions. Further, collective action around agriculture is limited. These circumstances represent significant limitations to farmers’ options for accessing new techniques which might help maintain maize diversity in the context of economic and environmental change. (shrink)

Zero pronominals challenge Type Logical Grammar in two ways. One, TLG displays a linear resource management regime for semantic composition, meaning that pronominals call for special treatment if they want to do resource multiplication. Two, as a grammar of lexicalism, TLG applies to phonologically realized lexical entries only, illegitimating the phonetically null items during syntactic derivation. Jägor extends the inventory of category-forming connectives of TLG by a third kind of implication that creates categories of anaphoric items and solves the first (...) problem above. This article goes a step further to tackle the second one. In order to formalize the constructions with zero pronominals, we design a ternary category A B C and include the latter into Jägor’s system. The proposed system is proof-theoretically well-behaved. It is complete, sound, and decidable. More importantly, zero pronominals of various forms can be derived in the system. (shrink)

Recent studies suggest that a non‐isotopic in situ hybridisation (NISH) approach can be successfully employed to investigate the carrier status of female relatives in families of selected patients with Duchenne muscular dystrophy (DMD) or Hunter syndrome, whose diseases are due to a specific X chromosome deletion.Whilst the majority of metaphase spreads from normal females show specific hybridisation signals on both X chromosomes when tested with either dystrophin or Hunter gene‐derived probes, only one X chromosome in each metaphase spread will (...) show the relevant hybridisation complex in female carriers of deletions involving the dystrophin or Hunter gene.Thus, the NISH method can be a valuable diagnostic tool for the detection of the carrier status of female relatives of patients with X chromosome deletions. (shrink)

Transplant surgeons in the USA have begun performing a novel organ procurement protocol in the setting of circulatory death. Unlike traditional donation after circulatory death (DCD) protocols,in situnormothermic perfusion DCD involves reperfusing organs, including the heart, while still contained in the donor body. Some commentators, including the American College of Physicians, have claimed thatin situreperfusion after circulatory death violates the widely accepted Dead Donor Rule (DDR) and conclude thatin situreperfusion is ethically impermissible. In this paper I argue that, in terms (...) of respecting the DDR,in situreperfusion cardiac transplantation does not differ from traditional DCD cardiac transplantation. I do this by introducing and defending a refined conception of circulatory death, namelyvegetative state function permanentism. I also argue against the controversial brain occlusion feature of thein situreperfusion DCD protocol, on the basis that it is ethically unnecessary and generates the problematic appearance of ethical dubiousness. (shrink)

Produites entre 1967 et 1974, les Organisations d’espaces de Jean-Michel Sanejouand constituent un exemple d’installations avant la lettre. Les définissant en opposition par rapport aux pratiques artistiques traditionnelles, notamment la sculpture, leur auteur a l’ambition d’induire de nouvelles relations entre l’intervention artistique, l’espace qui l’accueille et les personnes qui en font l’expérience. Notre analyse se propose d’exposer de quelle façon ces relations sont mises en œuvre par l’artiste et de pointer leurs singularités. Il s’agit d’abord de revenir sur les circonstances (...) qui amènent Sanejouand à faire du rapport à l’espace la donnée centrale de ses interventions et à tourner le dos à la production d’œuvres autonomes déplaçables au profit d’une pratique in situ. Ensuite, l’investigation porte sur les qualités des matériaux présents dans les Organisations d’espaces et sur la manière dont l’artiste les utilise. Si certains matériaux sont présents antérieurement dans son œuvre, nous montrons comment l’artiste cherche désormais à déplacer l’attention de l’objet vers ce que celui-ci révèle ou perturbe dans le lieu où il prend place. L’observation menée permet ainsi de mettre en lumière une différence qualitative dans la prise en compte du lieu au sein des Organisations d’espaces, par rapport aux œuvres précédentes de l’artiste. Enfin, l’action menée sur le lieu et son but sont interrogés. La volonté de Sanejouand de désaliéner l’individu permet de comprendre pourquoi celui-ci conçoit les Organisations d’espaces comme des expériences perceptives qui font des lieux et de leur stabilité des espaces, pour reprendre les distinctions posées par Michel de Certeau. Produced between 1967 and 1974, Jean-Michel Sanejouand’s Organisations d’espaces are an example of installation art before the term existed. Defining them in opposition to traditional artistic practices, especially sculpture, their author has the ambition to induce new relationships between the artistic intervention, the space that welcomes it and the people who experience it. Our analysis proposes to expose how these relationships are implemented by the artist and to point out their singularities. First of all, it is a question to return to the circumstances that lead Sanejouand to make the relationship with space the heart of his interventions and to turn his back on the production of autonomous works that can be displaced in favor of a site-specific practice. Then, the investigation focuses on the qualities of the materials present in the Organisations d’espaces and on the way in which the artist uses them. If some materials are previously present in his work, we show how the artist now seeks to shift the attention of the object towards what it reveals or disturbs in the place where it takes place. The observation carried out thus provides the possibility to highlight a qualitative difference in the way Organizations d’espaces take into account the places, compared to the previous works of the artist. Finally, the action carried out on the place and its purpose are questioned. Sanejouand’s desire to de-alienate the individual makes it possible to understand why he conceives Organisations d’espaces as perceptive experiences that turn places and their stability into spaces, to use the distinctions put forward by Michel de Certeau. (shrink)

In this commentary, we set out the specifics of how Glowacki's game theoretical framework for the evolution of peace could be incorporated within broader cultural evolutionary approaches. We outline a formal proposal for prisoner's dilemma games investigating raid-based conflict. We also centre an ethnographic lens to understand the norms surrounding war and peace in intergroup interactions in small-scale communities.

The usual problems of measurement and its meaning are complicated and magnified when the object of study is in principle and in fact inaccessible. When a phenomenon occurs in a place where our instruments cannot reach, what can the relation between the instrument, its reading, and the phenomenon be? This essay asks how researchers have addressed questions about inaccessible processes of Earth's magnetic field on the surface, at the edge of space and under its surface. This case takes us beyond (...) simple contrasts of inductive and deductive methods, or field sciences versus basic sciences, to a messier, more nuanced view of inherently complex sciences. The article focuses on investigations of Earth's magnetism and electricity, but its perspectives are applicable to many areas of recent science. (shrink)

This article examines the particular aesthetic experience brought about by soundwalks. In each case, the point of departure is the phenomenological analysis of two case study: Janet Cardiff’s Walks and the audio-tours Remote x by Rimini Protokoll. Drawing upon Husserl and Merleau-Ponty, I will examine the conflicts of perception and the peculiar shift from one order of perception to another that punctuate the spectator’s walking, as well as the intertwining of the real and the imaginary coming into being in such (...) performances and experienced at the very level of his bodily inscription in space. More specifically, my aim is to address the challenge that the aesthetic experience here in question sets to Husserl’s phenomenology of perception and to show how the extension of the notion of perception achieved by Merleau-Ponty makes it possible to overcome the paradox. (shrink)

Cet article explore l’expérience esthétique particulière que nous procurent les promenades sonores. En partant d’une étude d’un cas paradigmatique – les tournées audio Remote X du collectif Rimini Protokoll – et par le biais d’une réflexion sur la perception opérant à partir de Husserl et Merleau-Ponty, je m’intéresse en particulier aux renversements perceptifs qui émaillent le parcours déambulatoire du spectateur ainsi qu’au brouillage entre le réel et l’imaginaire, qu’il éprouve au niveau même de son inscription corporelle dans l’espace. Une telle (...) approche mène à la conclusion que la notion de perception synesthésique offerte par Merleau-Ponty permet non seulement de dépasser le défi posé à la théorie husserlienne de l’imagination ( phantasia ) par l’expérience esthétique ici en question, mais aussi et, de surcroît, de penser le paradoxe d’une affinité du divers sensoriel qui affleure dans les performances contemporaines lorsque de multiples dispositifs médiatiques sont en jeu. (shrink)

Current methods of reprogramming differentiated cells into induced pluripotent stem cells remain slow and inefficient. In a recent report published online in Nature, Bhutani et al.1 developed a cell fusion strategy, achieving quick and efficient reprogramming toward pluripotency. Using this assay, they identified an immune system protein called activation‐induced cytidine deaminase, or AID, which unexpectedly is actually able to “aid” in reprogramming due to its involvement in DNA demethylation that is required for induction of the two key (...) pluripotency genes, Oct4 and Nanog. More recently, Popp et al. 2 also reported online in Nature that AID is important for complete cell reprogramming in mammals. Together, these findings provide new insights into how cells are reprogrammed, identify the specific role of AID in cell fate reversal, and advance the field of regenerative medicine. (shrink)

The recent successful conversion of adult cells into induced pluripotent stem (iPS) cells through direct reprogramming opens a new chapter in the study of disease and the development of regenerative medicine. It also provides a historic opportunity to turn away from the ethically problematic use of embryonic stem cells isolated through the destruction of human embryos. Moreover, because iPS cells are patient specific, they render therapeutic cloning unnecessary. To maximize therapeutic benefit, adult stem cell research will need to be (...) pursued in parallel with studies using iPS cells. Among the four alternative methods presented by the President’s Council on Bioethics, direct reprogram- ming is the most ethically acceptable. Nonetheless, iPS cells are tainted by their association with the human embryonic stem cell lines, derived in the past, which will be required for their validation. This concern is one that can be resolved. Human iPS cells will serve to stem the tide of human embryonic stem cell research, changing it and diverting stem cell research in a more ethical direction. (shrink)