The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

The development of the Functional Genomics Investigation Ontology (FuGO) is a collaborative, international effort that will provide a resource for annotating functional genomics investigations, including the study design, protocols and instrumentation used, the data generated and the types of analysis performed on the data. FuGO will contain both terms that are universal to all functional genomics investigations and those that are domain specific. In this way, the ontology will serve as the “semantic glue” to provide a common understanding of data (...) from across these disparate data sources. In addition, FuGO will reference out to existing mature ontologies to avoid the need to duplicate these resources, and will do so in such a way as to enable their ease of use in annotation. This project is in the early stages of development; the paper will describe efforts to initiate the project, the scope and organization of the project, the work accomplished to date, and the challenges encountered, as well as future plans. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Vaccine research, as well as the development, testing, clinical trials, and commercial uses of vaccines involve complex processes with various biological data that include gene and protein expression, analysis of molecular and cellular interactions, study of tissue and whole body responses, and extensive epidemiological modeling. Although many data resources are available to meet different aspects of vaccine needs, it remains a challenge how we are to standardize vaccine annotation, integrate data about varied vaccine types and resources, and support advanced vaccine (...) data analysis and inference. To address these problems, the community-based Vaccine Ontology (VO) has been developed through collaboration with vaccine researchers and many national and international centers and programs, including the National Center for Biomedical Ontology (NCBO), the Infectious Disease Ontology (IDO) Initiative, and the Ontology for Biomedical Investigations (OBI). VO utilizes the Basic Formal Ontology (BFO) as the top ontology and the Relation Ontology (RO) for definition of term relationships. VO is represented in the Web Ontology Language (OWL) and edited using the Protégé-OWL. Currently VO contains more than 2000 terms and relationships. VO emphasizes on classification of vaccines and vaccine components, vaccine quality and phenotypes, and host immune response to vaccines. These reflect different aspects of vaccine composition and biology and can thus be used to model individual vaccines. More than 200 licensed vaccines and many vaccine candidates in research or clinical trials have been modeled in VO. VO is being used for vaccine literature mining through collaboration with the National Center for Integrative Biomedical Informatics (NCIBI). Multiple VO applications will be presented. (shrink)

When are morally good actions beautiful, when indeed they are? In this paper, it is argued that morally good actions are beautiful when they appear to express the deep or true self, and in turn tend to give rise to an emotion which is characterised by feelings of being moved, unity, inspiration, and meaningfulness, inter alia. In advancing the case for this claim, it is revealed that there are additional sources of well-formedness in play in the context of moral beauty (...) in addition to those that have tended to be focused on to date: one which is connected to imagining a deep location for the goodness concerned, and another which is connected to imagining that the goodness stems from capacities which are essential to the person. (shrink)

In this article, robust evidence is provided showing that an individual’s moral character can contribute to the aesthetic quality of their appearance, as well as being beautiful or ugly itself. It is argued that this evidence supports two main conclusions. First, moral beauty and ugliness reside on the inside, and beauty and ugliness are not perception-dependent as a result; and, second, aesthetic perception is affected by moral information, and thus moral beauty and ugliness are on the outside as well.

According to the most important objection to the existence of moral beauty, true judgements of moral beauty are not possible as moral judgements require being motivated to act in line with the moral judgement made, and judgements of beauty require not being motivated to act in any way. Here, I clarify the argument underlying the objection, and show that it does not show that moral beauty does not exist. I present two responses: namely, that the beauty of moral beauty does (...) not lie in the moral goodness per se (the “adjacent properties” response); and that only a dispositional motivation to act is required for the moral judgements that are typically made as part of judgements of moral beauty, whereas aesthetic judgements only rule out state motivations to act (the “equivocation of motivation required” response). In addressing the objection, I show how moral beauty is consistent with disinterestedness, and so should be accepted more widely; and also clarify where the beauty in moral beauty resides, and how the moral-aesthetic distinction should be drawn. (shrink)

What is the nature of the concept BEAUTY? Does it differ fundamentally from nearby concepts such as PRETTINESS? It is argued that BEAUTY, but not PRETTINESS, is a dual-character concept. Across a number of contexts, it is proposed that BEAUTY has a descriptive sense that is characterised by, inter alia, having intrinsically pleasing appearances; and a normative sense associated with deeply-held values. This account is supported across two, pre-registered, studies (N=500), and by drawing on analysis of corpus data. It is (...) suggested that this can help to explain why beauty, unlike prettiness, is thought to be deep in both the sense of being important, and in the sense of being less closely tied to sensory surfaces. (shrink)

Very diverse societies pose real problems for Rawlsian models of public reason. This is for two reasons: first, public reason is unable accommodate diverse perspectives in determining a regulative ideal. Second, regulative ideals are unable to respond to social change. While models based on public reason focus on the justification of principles, this book suggests that we need to orient our normative theories more toward discovery and experimentation. The book develops a unique approach to social contract theory that focuses on (...) diverse perspectives. It offers a new moral stance that author Ryan Muldoon calls, "The View From Everywhere," which allows for substantive, fundamental moral disagreement. This stance is used to develop a bargaining model in which agents can cooperate despite seeing different perspectives. Rather than arguing for an ideal contract or particular principles of justice, Muldoon outlines a procedure for iterated revisions to the rules of a social contract. It expands Mill's conception of experiments in living to help form a foundational principle for social contract theory. By embracing this kind of experimentation, we move away from a conception of justice as an end state, and toward a conception of justice as a trajectory. (shrink)

Why are moral actions beautiful, when indeed they are? This paper assesses the view, found most notably in Schiller, that moral actions are beautiful just when they present the appearance of freedom by appearing to be the result of internal harmony (the Schillerian Internal Harmony Thesis). I argue that while this thesis can accommodate some of the beauty involved in contrasts of the ‘continent’ and the ‘fully’ virtuous, it cannot account for all of the beauty in such contrasts, and so (...) needs to be weakened considerably (to the Internal Harmony Thesis). To account for the remaining beauty that cannot be fully accommodated even by this revised thesis, as well as the beauty contained in contrasts that involve agents who experience internal conflict as a result of being sensitive to different sources of moral value to an appropriate extent, a number of further theses need to be posited: namely, that the beauty of some moral actions is to be accommodated in terms of internal disharmony (the Internal Disharmony Thesis), and in terms of a felt harmony between the appreciator of the action and the executor of the action (the Affective Harmony Thesis). As such, in contrast to Schiller, I suggest that we need to take a pluralist and context-sensitive approach to accommodating the beauty of moral actions. (shrink)

Which traits are beautiful? And is their beauty perceptual? It is argued that moral virtues are partly beautiful to the extent that they tend to give rise to a certain emotion— ecstasy—and that compassion tends to be more beautiful than fair-mindedness because it tends to give rise to this emotion to a greater extent. It is then argued, on the basis that emotions are best thought of as a special, evaluative, kind of perception, that this argument suggests that moral virtues (...) are partly beautiful to the extent that they tend to give rise to a certain kind of evaluative perceptual experience. (shrink)

In The Conditions for Ethical Chemical Restraint, Crutchfield and Redinger (2024) propose ethical standards for the use of chemical restraints, which they consider normatively distinct from physica...

I offer the first sustained defence of the claim that ugliness is constituted by the disposition to disgust. I advance three main lines of argument in support of this thesis. First, ugliness and disgustingness tend to lie in the same kinds of things and properties (the argument from ostensions). Second, the thesis is better placed than all existing accounts to accommodate the following facts: ugliness is narrowly and systematically distributed in a heterogenous set of things, ugliness is sometimes enjoyed, and (...) ugliness sits opposed to beauty across a neutral midpoint (the argument from proposed intensions). And third, ugliness and disgustingness function in the same way in both giving rise to representations of contamination (the argument from the law of contagion). In making these arguments, I show why prominent objections to the thesis do not succeed, cast light on some of the artistic functions of ugliness, and, in addition, demonstrate why a dispositional account of disgustingness is correct, and present a novel problem for warrant-based accounts of disgustingness (the ‘too many reasons’ problem). (shrink)

Which traits are beautiful? And is their beauty perceptual? It is argued that moral virtues are partly beautiful to the extent that they tend to give rise to a certain emotion—ecstasy—and that compassion tends to be more beautiful than fair-mindedness because it tends to give rise to this emotion to a greater extent. It is then argued, on the basis that emotions are best thought of as a special, evaluative, kind of perception, that this argument suggests that moral virtues are (...) partly beautiful to the extent that they tend to give rise to a certain kind of evaluative perceptual experience. (shrink)

I argue that the main existing accounts of the relationship between the beauty of environmental entities and their moral standing are mistaken in important ways. Beauty does not, as has been suggested by optimists, confer intrinsic moral standing. Nor is it the case, as has been suggested by pessimists, that beauty at best provides an anthropocentric source of moral standing that is commensurate with other sources of pleasure. I present arguments and evidence that show that the appreciation of beauty tends (...) to cause a transformational state of mind that is more valuable than mere pleasure, but that leads us to falsely represent beautiful entities as being sentient and, in turn, as having intrinsic moral standing. To this extent, beauty is not, then, a source of intrinsic moral standing; it’s a source of a more important anthropocentric value than has hitherto been acknowledged. (shrink)

The problem : commerce and corruption -- Smith's defense of commercial society -- What is corruption? : political and psychological perspectives -- Smith on corruption : from the citizen to the human being -- The solution : moral philosophy -- Liberal individualism and virtue ethics -- Social science vs. moral philosophy -- Types of moral philosophy : natural jurisprudence vs. ethics -- Types of ethics : utilitarianism, deontology, and virtue ethics -- Virtue ethics : modern, ancient, and Smithean -- Interlude (...) : the what and the how of TMS VI -- The what : Sith's "practical system of morality" -- The how : rhetoric, audience, and the methods of practical ethics -- The how : the ascent of self-love in three stages -- Prudence or commercial virtue -- The challenge : from praise to prudence -- Educating the vain : fathers and sons -- Self-interest rightly understood -- The advantages and disadvantages of prudence -- Magnanimity or classical virtue -- The problems of prudence and the therapy of magnanimity -- Up from individualism : desert, praiseworthiness, conscience -- Modernity, antiquity, and magnanimity -- The dangers of magnanimity -- Beneficence or christian virtue -- Between care and caritas -- Benevolence and beneficence and the human telos -- The character and purposes of the wise and virtuous man -- Wisdom and virtue and Adam Smith's apology -- Epilogue: The "economy of greatness". (shrink)

This essay examines Friedman's recent approach to the analysis of physical theories. Friedman argues against Quine that the identification of certain principles as ‘constitutive’ is essential to a satisfactory methodological analysis of physics. I explicate Friedman's characterization of a constitutive principle, and I evaluate his account of the constitutive principles that Newtonian and Einsteinian gravitation presuppose for their formulation. I argue that something close to Friedman's thesis is defensible.

Addiction remains a challenging disorder, both to treat and to conceptualise. While the temporal dimension of addiction has been noted before, here the aim is to ground this understanding in a coherent phenomenological-neuroscience framework. Addiction is partly understood as drawing the subject into a predominantly “now” orientated existence, with the future closed or experienced as extremely distant. Another feature of this temporal structuring is that past experiences, which are crucial in advancing intentionally forward, are experienced in addiction as a void. (...) This has implications for the generation of meaning and forming of self, amongst others. While there are areas of the brain that regulate temporal processing, there is no single location. Recent addiction research has implicated the insula and in turn this area is implicated in temporal and interoceptive awareness. Similarly these areas of disruption may affect self processes. Disruption of interoception and thus of self, may help explain why addiction is complex and involves multiple aspects of subjectivity. (shrink)

I examine two claims that arise in Brown’s account of inertial motion. Brown claims there is something objectionable about the way in which the motions of free particles in Newtonian theory and special relativity are coordinated. Brown also claims that since a geodesic principle can be derived in Einsteinian gravitation, the objectionable feature is explained away. I argue that there is nothing objectionable about inertia and that while the theorems that motivate Brown’s second claim can be said to figure in (...) a deductive-nomological explanation, their main contribution lies in their explication rather than their explanation of inertial motion. (shrink)

What is a language? What do scientific grammars tell us about the structure of individual languages and human language in general? What kind of science is linguistics? These and other questions are the subject of Ryan M. Nefdt's Language, Science, and Structure. -/- Linguistics presents a unique and challenging subject matter for the philosophy of science. As a special science, its formalisation and naturalisation inspired what many consider to be a scientific revolution in the study of mind and language. (...) Yet radical internal theory change, multiple competing frameworks, and issues of modelling and realism have largely gone unaddressed in the field. Nefdt develops a structural realist perspective on the philosophy of linguistics which aims to confront the aforementioned topics in new ways while expanding the outlook toward new scientific connections and novel philosophical insights. On this view, languages are real patterns which emerge from complex biological systems. Nefdt's exploration of this novel view will be especially valuable to those working in formal and computational linguistics, cognitive science, and the philosophies of science, mathematics, and language. (shrink)

"Fénelon is arguably the most neglected of all the major philosophers of early modernity. His political masterwork was the most-read book in eighteenth-century France after the Bible, yet to now we have lacked a single interpretive monograph in English devoted specifically to his thought. This monograph aims to correct this by providing the first such book-length study. In focusing specifically on Fénelon's political thought, it has three primary aims. The first is to provide a reconstruction of Fénelon's political ideas accessible (...) to those who might be encountering Fénelon directly or at length for the first time. The second is to demonstrate the connections between Fénelon's political thought and several other fields to which he made significant and long-recognized contributions, including not only philosophy and political science but also economics, education, literature, theology, and spirituality. Third, the book aims to cut several new edges in our extant understanding and appreciation of Fénelon's political thought and its significance. On this front, it specifically argues that Fénelon is better understood as a moderate and modern thinker rather than as a radical or reactionary, and that Fénelon deserves to be seen not merely as a political thinker but as a political philosopher. Finally, The Political Philosophy of Fénelon argues for Fénelon's relevance to our political world today. Fénelon was a nuanced and insightful diagnostician of ills from egocentrism and social atomism to authoritarianism and imperialism, and our understanding of these phenomena so familiar to us today can benefit from attending to his insights"--. (shrink)

Addiction remains a challenging disorder, both to treat and to conceptualise. While the temporal dimension of addiction has been noted before, here the aim is to ground this understanding in a coherent phenomenological-neuroscience framework. Addiction is partly understood as drawing the subject into a predominantly “now” orientated existence, with the future closed or experienced as extremely distant. Another feature of this temporal structuring is that past experiences, which are crucial in advancing intentionally forward, are experienced in addiction as a void. (...) This has implications for the generation of meaning and forming of self, amongst others. While there are areas of the brain that regulate temporal processing, there is no single location. Recent addiction research has implicated the insula and in turn this area is implicated in temporal and interoceptive awareness. Similarly these areas of disruption may affect self processes. Disruption of interoception and thus of self, may help explain why addiction is complex and involves multiple aspects of subjectivity. (shrink)

In this article, an account of the architecture of the cognitive contamination system is offered, according to which the contamination system can generate contamination represen- tations in circumstances that do not satisfy the norms of contamination, including in cases of mere visual contact with disgusting objects. It is argued that this architecture is important for explaining the content, logic, distribution, and persistence of maternal impression beliefs – according to which fetal defects are caused by the pregnant mother’s experiences and actions (...) – which in turn provide important evidence of the architecture of the cognitive contamination system. (shrink)

In this paper, I argue that cases of radical selftransformation (cases in which an agent willfully changes a foundational element of their motivational structure) constitute an important philosophical puzzle. Though our inclination to hold people responsible for such changes suggests that we regard radical transformation as (in some sense) self-determined, it is difficult to conceive how a transformation that extends to the heart of an agent’s practical life can be attributed to the agent at all. While I contend that the (...) best way to solve this puzzle is to deny that radical transformations are in fact self-determined, many maintain the opposite. The defense of my thesis involves showing how the conditions that must be met in order to coherently attribute transformation to an agent are not satisfied in cases of radical transformation. Radical transformation is, thus, something that happens to an agent, not something that is done by her. (shrink)

Business and Economic textbooks warn against committing the Sunk Cost Fallacy: you, rationally, shouldn't let unrecoverable costs influence your current decisions. In this paper, I argue that this isn't, in general, correct. Sometimes it's perfectly reasonable to wish to carry on with a project because of the resources you've already sunk into it. The reason? Given that we're social creatures, it's not unreasonable to care about wanting to act in such a way so that a plausible story can be told (...) about you according to which your diachronic behavior doesn't reveal that you've suffered, what I will call, diachronic misfortune. Acting so as to hide that you've suffered diachronic misfortune involves striving to make yourself easily understood while disguising any shortcomings that might damage your reputation as a desirable teammate. And making yourself easily understood to others while hiding your flaws will, sometimes, put pressure on you to honor sunk costs. (shrink)

Let’s say that you regard two things as on a par when you don’t prefer one to other and aren’t indifferent between them. What does rationality require of you when choosing between risky options whose outcomes you regard as on a par? According to Prospectism, you are required to choose the option with the best prospects, where an option’s prospects is a probability-distribution over its potential outcomes. In this paper, I argue that Prospectism violates a dominance principle—which I call The (...) Principle of Predominance—because it sometimes requires you to do something that’s no better than the alternatives and might be worse. I argue that this undermines the strongest argument that’s been given in favor of Prospectism. (shrink)

I argue that any plausible decision theory for agents with incomplete preferences which obeys the Never Worse Principle will violate Transitivity. The Never Worse Principle says that if one option never does worse than another, you shouldn’t disprefer it. Transitivity says that if you prefer X to Y and you prefer Y to Z, then you should prefer X to Z. Violating Transitivity allows one to be money pumped. Although agents with incomplete preferences are already, in virtue of having incomplete (...) preferences, vulnerable to being money pumped, I argue that the money pump argument for Transitivity is more serious than the one for Completeness. (shrink)

Robert Sparrow argues that several initially plausible arguments in favor of the deployment of autonomous weapons systems (AWS) in warfare fail, and that their deployment faces a serious moral objection: deploying AWS fails to express the respect for the casualties of war that morality requires. We critically discuss Sparrow’s argument from respect and respond on behalf of some objections he considers. Sparrow’s argument against AWS relies on the claim that they are distinct from accepted weapons of war in that they (...) either fail to transmit an attitude of respect or they transmit an attitude of disrespect. We argue that this distinction between AWS and widely accepted weapons is illusory, and so cannot ground a moral difference between AWS and existing methods of waging war. We also suggest that, if deploying conventional soldiers in some situation would be permissible, and if we could expect deploying AWS to cause fewer civilian casualties, then it would be consistent with an intuitive understanding of respect to deploy AWS in this situation. (shrink)

Modern commercial society has been criticized for attenuating virtue and inhibiting the ethical self-realization of its participants. But Adam Smith, a founding father of liberal commercial modernity, anticipated precisely this critique and took specific measures to circumvent it. This article presents these measures via an analysis of his response to the critique of liberal commercial modernity set forth by Rousseau. It principally argues that Smith's distinctions of the love of praise from the love of praiseworthiness, and the love of glory (...) from the love of virtue, were elements of a normative moral education that sought to elevate civilized man's corrupted self-love, and thereby recover within modern commercial society a respect for ethical nobility. (shrink)

Recent global events demonstrate that analytical frameworks to aid professionals in healthcare ethics must consider the pervasive role of social structures in the emergence of bioethical issues. To address this, the authors propose a new sociologically informed approach to healthcare ethics that they term “social bioethics.” Their approach is animated by the interpretive social sciences to highlight how social structures operate vis-à-vis the everyday practices and moral reasoning of individuals, a phenomenon known as social discourse. As an exemplar, the authors (...) use social bioethics to reframe common ethical issues in psychiatric services and discuss potential implications. Lastly, the authors discuss how social bioethics illuminates the ways healthcare ethics consultants in both policy and clinical decision-making participate in and shape broader social, political, and economic systems, which then cyclically informs the design and delivery of healthcare. (shrink)

European Journal of Philosophy, EarlyView.

: In this essay, I argue that Kierkegaard endorses a “grace model” of ethical transformation – that radical normative change is not a function of agent-choice, rational or otherwise. After showing how grace functions in Kierkegaard’s account of religious transformation, I go on to argue that he offers a parallel account in the case of ethical conversion, the latter drawing from a description of transformation detailed in Kierkegaard’s Repetition. There we find an example of ethical transformation that challenges received interpretations (...) of the mechanics of Kierkegaard’s aesthetic-to-ethical transition. In the same way that God’s love is said to transform the heart of the Christian, Kierkegaard thinks that certain ethical encounters transform the desires and commitments of the aesthete. (shrink)

Smith scholars have become interested of late in his thoughts on religion, and particularly the question of the degree to which Smith's understanding of religion was indebted to the influence of his close friend Hume. Until now this debate has largely focused on three elements of Smith's religious thought: his personal beliefs, his conception of natural religion, and his treatment of revealed religion. Yet largely unexplored has been one of the most important elements of Smith's thinking about religion: namely his (...) treatment of ‘the natural principles of religion’ in TMS 3.5. What follows aims to reconstruct this treatment and thereby shed light on what Smith might have meant by ‘the natural principles of religion’, and how he understood the relationship of religion and morality more generally – an understanding, it is argued, that significantly differs from Hume's, and reveals Smith to have been a critic of Hume's vision of the relationship of religion to morality, for all their agreements on other fronts. (shrink)

In this paper, we outline a new method for evaluating the human impact of machine-learning applications. In partnership with Underwriters Laboratories Inc., we have developed a framework to evaluate the impacts of a particular use of machine learning that is based on the goals and values of the domain in which that application is deployed. By examining the use of artificial intelligence in particular domains, such as journalism, criminal justice, or law, we can develop more nuanced and practically relevant understandings (...) of key ethical guidelines for artificial intelligence. By decoupling the extraction of the facts of the matter from the evaluation of the impact of the resulting systems, we create a framework for the process of assessing impact that has two distinctly different phases. (shrink)

While many of the most important figures in the history of philosophy have employed the concept of the simulacrum in one way or another, a detailed study of this usage has yet to be written. In this essay, I will attempt to tell the story of a sequence in that history of that usage, by focusing on one of Deleuze's case studies of the concept of the simulacrum. To do so, I will focus primarily on one the appendices to The (...) Logic of Sense: ‘Lucretius and the Simulacrum’. In order to understand what I will call the Deleuze–Lucretius encounter, I will proceed as follows. After a few initial guiding remarks regarding the general project of the ‘inversion of Platonism’, we will outline some of the most fundamental features of atomistic physics. This will allow us to discuss Lucretius’ thoughts on the clinamen, the swerve. This, in turn, leads directly to the concept of the simulacrum. With such a picture of Lucretian physics in hand, I will pivot to a discussion of Lucretius’ ethics. The ethics consists of a critique of superstition in terms of a general project of demystification. Although this sequence will concentrate mostly on what became one of the appendices to The Logic of Sense, I will end by looking at the more general usage of Lucretian atomism, especially as it functions in Difference and Repetition and The Logic of Sense. (shrink)

Knowledge concerning the relation of the addicted subject to time is deepened through a phenomenological analysis. The theoretical understanding of lived-time, or temporality, is explored with particular reference to the theories of Heidegger, Fuchs and van den Berg. Grounded in a description of the lived experiences of addicted persons, it is argued that the temporal relation of the addict is drawn, by the adoption of an addictive existence, primarily towards “the now” which predisposes the addict to various consequences. These include (...) impulsiveness, sleep disturbance, pain and social alienation. The relation of addiction to death is also briefly discussed in its temporal dimension. Implications for treatment and therapy are explored. (shrink)

European Journal of Philosophy, EarlyView.

In the A-preface of the Critique of Pure Reason, Kant kindly warns his readers to pay special attention to the chapter on the “Deduction of the Pure Concepts of the Understanding.” Looking to mitigate the reader's effort, Kant goes on to explain the chapter's methodology, suggesting that the inquiry will have “two sides.” One side deals with the “objective validity” of the pure categories of the understanding; he calls this the “objective deduction.” The other deals with the powers of cognition (...) on which the understanding rests; he calls this the “subjective deduction.” Having gone to such great lengths to outline his method ahead of time, it comes as no small surprise that the actual chapter offers no clear indication of where the two deductions are located. In this essay, I attempt to solve this puzzle. On the way, I engage with both traditional and recent interpretations of the subjective deduction, arguing that they fail—in one way or another—to satisfy the criteria that Kant develops in the preface. (shrink)

In response to cancer, patients may be thrown into precarious processes of remaking their purpose, identity, and connections to the world around them. Thoughtful and thorough responses to these issues can be supported by person-centered phenomenological approaches to caring for patients. The importance of perspectives on illness offered by theoretical phenomenology will become apparent through the example of the experience of nausea, or perhaps more accurately put—chemo sickness. The focus here is on how chemo sickness alters one's way of relating (...) to the world. I will examine the phenomenon of nausea through the lens of the phenomenological concept of mood—an existential feeling that engenders a diffused tone permeating through one's world and shapes the envisioned possibilities on one's horizon. (shrink)

When you are indifferent between two options, it’s rationally permissible to take either. One way to decide between two such options is to flip a fair coin, taking one option if it lands heads and the other if it lands tails. Is it rationally permissible to employ such a tie-breaking procedure? Intuitively, yes. However, if you are genuinely risk-averse—in particular, if you adhere to risk-weighted expected utility theory (Buchak in Risk and rationality, Oxford University Press, 2013) and have a strictly (...) convex risk-function—the answer will often be no: the REU of deciding by coin-flip will be lower than the REU of choosing one of the options outright (so long as at least one of the options is a nondegenerate gamble). This turns out to be a significant worry for risk-weighted expected utility theory. I argue that it adds real bite to established worries about diachronic consistency afflicting views, like risk-weighted expected utility theory, that violate Independence. And that, while these worries might be surmountable, surmounting them comes at a price. (shrink)

Recently a call has gone up for a revival of the "politics of humanity." But what exactly is the "politics of humanity"? For illumination this paper turns to Hume's analysis of humanity's foundational role in morality and modern politics. Its aims in so doing are twofold. First, it aims to set forth a new understanding of the unity of Hume's practical and epistemological projects in developing his justifications for and the implications of his remarkable and underappreciated claim that humanity is (...) the only sentiment on which a moral system can be founded. Second, by attending to Hume's substantive definition of humanity and its relationship to benevolence and sympathy in particular, it aims to clarify the relationship between the principal elements of the politics of humanity: "humanism" or secularism, "humane" or other-directed values, and mutual recognition of our shared "humanness.". (shrink)

Are mandatory lockdown measures, which place restrictions on one’s freedom to move and assemble, justifiable? Offhand, such measures appear to compromise important rights to secure goals of public health. Proponents of such measures think the trade-off is worth it; opponents think it isn’t. However, one might think that casting the debate in these terms concedes too much to the opponents. Mandatory lockdown measures don’t infringe important rights because no one has a right to impose a risk of grievous harm on (...) others—and, in the context of a pandemic, participating in the prohibited activities (e.g., going out to the bar) does just that. -/- This chapter explores whether this defense of mandatory lockdown measures holds up. It, first, considers whether we have a right against risk imposition—and, if so, how such a right is best understood. It then considers the objection that, even if there is such a right, people who voluntarily choose to engage in the prohibited activities—at least if fully appraised of the risks involved—effectively waive it. The chapter argues that this objection fails. (shrink)

Knowledge concerning the relation of the addicted subject to time is deepened through a phenomenological analysis. The theoretical understanding of lived-time, or temporality, is explored with particular reference to the theories of Heidegger, Fuchs and van den Berg. Grounded in a description of the lived experiences of addicted persons, it is argued that the temporal relation of the addict is drawn, by the adoption of an addictive existence, primarily towards “the now” which predisposes the addict to various consequences. These include (...) impulsiveness, sleep disturbance, pain and social alienation. The relation of addiction to death is also briefly discussed in its temporal dimension. Implications for treatment and therapy are explored. (shrink)

I argue, contra Mohan Matthen, that at least some aesthetic pleasures arising from the appreciation of aesthetic features of artworks are what he calls ‘r-pleasures’ as opposed to ‘f-pleasures’—and moreover, that the paradigm aesthetic pleasure appears to be an r-pleasure on Matthen's terms. I then argue that talk of r- and f-pleasures does not distinguish different kinds, but two different features of pleasure; so this supposed distinction cannot be used to characterize a sui generis aesthetic pleasure.

Neurological diseases, particularly in the context of aging, have serious impacts on quality of life and can negatively affect bone health. The brain-bone axis is critically important for skeletal metabolism, sensory innervation, and endocrine cross-talk between these organs. This review discusses current evidence for the cellular and molecular mechanisms by which various neurological disease categories, including autoimmune, developmental, dementia-related, movement, neuromuscular, stroke, trauma, and psychological, impart changes in bone homeostasis and mass, as well as fracture risk. Likewise, how bone may (...) affect neurological function is discussed. Gaining a better understanding of brain-bone interactions, particularly in patients with underlying neurological disorders, may lead to development of novel therapies and discovery of shared risk factors, as well as highlight the need for broad, whole-health clinical approaches toward treatment. (shrink)