The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Part 1. FOUNDERS AND FIRSTCOMERS1: David Zimmerman: 'Protests Butter no Parsnips': Lord Beveridge and the Rescue of Refugee Academics from Europe, 1933-19382: William Lanouette: A Narrow Margin of Hope: Leo Szilard in the Founding Days of CARA3: Paul Weindling: From Refugee Assistance to Freedom of Learning: the Strategic Vision of A. V. Hill, 1933-19644: Gustav Born: Refugee Scientists in a New Environment5: Georgina Ferry: Max Perutz and the SPSLPART 2. TESS - THE LINCHPIN6: Paul Broda: Esther Simpson: A Correspondence7: (...) Lewis Elton: Eva and EstherPART 3. ASSOCIATES AND ALLIES8: Gerald Kreft: 'Dedicated to Represent the True Spirit of the German Nation in the World': Philipp Schwartz , Founder of the Notgemeinschaft9: Tibor Frank: Organized Rescue Operations in Europe and the United States, 1933-194510: Susan Cohen: In Defence of Academic Women Refugees: The British Federation of University Women11: Stina Lyon: Karl Mannheim and Viola Klein: Refugee Sociologists in Search of Social Democratic PracticePART 4. REVERSING THE GAZE12: Christian Fleck: Austrian Refugee Social Scientists13: Antoon de Baets: Plutarch's Thesis: The Contribution of Refugee Historians to Historical Writing, 1945-201014: Marina Yu Sorokina: Within Two Tyrannies: The Soviet Academic Refugees of the Second World War15: Antonín Kostlán and Soña Strbáñová: Czech Scholars in Exile, 1948-198916: Shula Marks: 'Bending the rules': South African Refugees in the UK, 1960-198017: Alan Phillips: Refugee Academics from Chile: WUS-SPSL CollaborationLucia Muñoz: Postscript. (shrink)

Current Legal Problems was established after the Second World War as a series of public lectures on law. It is now regarded as the most significant such series in the United Kingdom. Each year edited texts are reproduced in the form of a volume. This year's is the 56th such volume. The range of subject-matter as ever is wide. Subjects explored this year include the jurisprudence of Genesis; the law of delict; fair trials and safe convictions; and war, terrorism, and (...) international law. Amongst the contributors to this volume are Joseph Thomson, Lord Phillips of Worth Matravers, and Philippe Sands QCLReadership: Legal scholars and practitioners. (shrink)

Journal of Philosophy of Education, Volume 56, Issue 1, Page 180-189, February 2022.

Errol Lord offers a new account of the nature of rationality: what it is for one to be rational is to correctly respond to the normative reasons one possesses. Lord defends novel views about what it is to possess reasons and what it is to correctly respond to reasons, and dispels doubts about whether we ought to be rational.

Although people generally agree that innocent targets of culpable aggression are justified in harming the aggressors in self-defence, there is considerable disagreement regarding whether innocents are justified in defending themselves when their doing so would harm other innocent people. I argue in this essay that harming innocent aggressors and active innocent threats in self-defence is indeed justified under certain conditions, but that defensive actions in such cases are justified as permissions rather than as claim rights. This justification therefore differs from (...) that of self-defence against culpable aggressors, since defensive acts of the latter type are justified as claim rights rather than mere permissions. I argue, however, that the two justifications are alike in that both rest on considerations of distributive justice. (shrink)

An argument against treating our bodies as commodities No one wants to be treated like an object, regarded as an item of property, or put up for sale. Yet many people frame personal autonomy in terms of self-ownership, representing themselves as property owners with the right to do as they wish with their bodies. Others do not use the language of property, but are similarly insistent on the rights of free individuals to decide for themselves whether to engage in commercial (...) transactions for sex, reproduction, or organ sales. Drawing on analyses of rape, surrogacy, and markets in human organs, Our Bodies, Whose Property? challenges notions of freedom based on ownership of our bodies and argues against the normalization of markets in bodily services and parts. Anne Phillips explores the risks associated with metaphors of property and the reasons why the commodification of the body remains problematic. What, she asks, is wrong with thinking of oneself as the owner of one's body? What is wrong with making our bodies available for rent or sale? What, if anything, is the difference between markets in sex, reproduction, or human body parts, and the other markets we commonly applaud? Phillips contends that body markets occupy the outer edges of a continuum that is, in some way, a feature of all labor markets. But she also emphasizes that we all have bodies, and considers the implications of this otherwise banal fact for equality. Bodies remind us of shared vulnerability, alerting us to the common experience of living as embodied beings in the same world. Examining the complex issue of body exceptionalism, Our Bodies, Whose Property? demonstrates that treating the body as property makes human equality harder to comprehend. (shrink)

The mass movement of people across the globe constitutes a major feature of world politics today. -/- Whatever the cause of the movement - often war, famine, economic hardship, political repression or climate change - the governments of western capitalist states see this 'torrent of people in flight' as a serious threat to their stability and the scale of this migration indicates a need for a radical re-thinking of both political theory and practice, for the sake of political, social and (...) economic justice. -/- This book argues that there is at present a serious gap between the legal and social practices of immigration and naturalisation in liberal democratic states and any theoretical justification for such practices that can be made within the tradition of liberal political philosophy. How can liberal states develop institutions of democratic citizenship and at the same time justifiably exclude 'outsiders' from participating in those institutions? The book examines various responses to this contradiction within the liberal tradition, and finds none of them satisfactory - there are no consistently liberal justifications for immigration control and this has serious implications both for liberal practice and theory. (shrink)

Leading philosopher of religion D. Z. Phillips argues that intellectuals need not see their task as being for or against religion, but as one of understanding it. What stands in the way of this task are certain methodological assumptions about what enquiry into religion must be. Beginning with Bernard Williams on Greek gods, Phillips goes on to examine these assumptions in the work of Hume, Feuerbach, Marx, Frazer, Tylor, Marett, Freud, Durkheim, Le;vy-Bruhl, Berger and Winch. The result exposes confusion, but (...) also gives logical space to religious belief without advocating personal acceptance of that belief, and shows how the academic study of religion may return to the contemplative task of doing conceptual justice to the world. Religion and the Hermeneutics of Contemplation extends in important ways D. Z. Phillips' seminal 1976 book Religion Without Explanation. It will be of interest to scholars and students of philosophy, anthropology, sociology and theology. (shrink)

In his recent article 1 Stewart Sutherland rightly and trenchantly criticizes some accounts of hope which ignore, or radically misrepresent, how it is conceived in religious contexts. The most surprising, to me, is Chesterton's, that hope is ‘the power of being cheerful in circumstances which we know to be desperate’. Surprising, not so much for its content as for its source. However, this particular example could be of one who would risk giving scandal for the sake of wit; what he (...) could have had in mind is that ‘the sufferings of this present time are not worthy to be compared with the glory which shall be revealed in us’ . Sutherland also makes clear the unhelpfulness of the ‘Anglo-Saxon’ analysts' account of the concept; not least because it is given without reference to the religious concept, and often is irrelevant to the notion of hope ‘in its proper conceptual surroundings’. (shrink)

Professor Sutherland has argued that ‘God wills the good’ should be regarded as an analytic truth, with the consequence that any account of what is God's will in which it does not appear to be good is either a mistake about God's will or a mistake about what is good.

I am concerned with a very problematic concept of identity which one encounters in studies of practical problems concerning the adoption of children. The notion is problematic in the extreme, as I shall try to show. It seems to crop up not only in the work of researchers on this topic, but in the spontaneous and untutored accounts of themselves given by adoptees. The question is whether there is a concept here at all: by which I mean not, instead, a (...) family of concepts linked by family resemblances, but rather some disparate ideas linked only by verbal similarities, and run together for mistaken theoretical purposes. The notion arises crucially in attempts to deal with practical questions arising in determining policies with regard to adoption: with regard to the placement of children for adoption, and the advice to be given to adoptive parents and to adopted children, whether young or adult, who encounter, or perhaps do not even encounter, difficulties. (shrink)

Phillip Cary argues that Augustine invented or created the concept of self as an inner space--as space into which one can enter and in which one can find God. This concept of inwardness, says Cary, has worked its way deeply into the intellectual heritage of the West and many Western individuals have experienced themselves as inner selves. After surveying the idea of inwardness in Augustine's predecessors, Cary offers a re-examination of Augustine's own writings, making the controversial point that in (...) his early writings Augustine appears to hold that the human soul is quite literally divine. Cary goes on to contend that the crucial Book 7 of the Confessions is not a historical report of Augustine's "conversion" experience, but rather an explanation of his intellectual development over time. (shrink)

Business ethics is a topic receiving much attention in the literature. However, the term 'business ethics' is not adequately defined. Typical definitions refer to the rightness or wrongness of behavior, but not everyone agrees on what is morally right or wrong, good or bad, ethical or unethical. To complicate the problem, nearly all available definitions exist at highly abstract levels. This article focuses on contemporary definitions of business ethics by business writers and professionals and on possible areas of agreement among (...) the available definitions. Then a definition is synthesized that is broad enough to cover the field of management in a sense as full as most managers might conceive of it. (shrink)

Wittgenstein always thought that he had not been understood, and indeed that it was very unlikely that many people ever would understand him. Russell not only failed to understand Wittgenstein's later work; according to Wittgenstein himself, Russell profoundly failed to understand even the Tractatus. Professor Anscombe says even she did not understand him, and that to attempt to give an account of what he says is only to express one's own ordinariness or mediocrity or lack of complexity. Certainly, most people (...) acquainted with the Tractatus, when that work was Wittgenstein's only published book, gave it what now seems a quite crass positivistic interpretation. Wittgenstein's own preface to the Tractatus, despite its last sentence, does not help. He does tell us that the whole sense of the work is that what can be said can be said clearly, and what we cannot talk about we must consign to silence: but this does not make it clear that what we cannot talk about is all that is really important. Even when one has realised all this, however, one is aware mostly of one's failure to understand; and that if one did get any distance in understanding the last sixth of the Tractatus, the process would be extremely difficult, and the results quite astonishing. (shrink)

Business ethics is a topic receiving much attention in the literature. However, the term 'business ethics' is not adequately defined. Typical definitions refer to the rightness or wrongness of behavior, but not everyone agrees on what is morally right or wrong, good or bad, ethical or unethical. To complicate the problem, nearly all available definitions exist at highly abstract levels. This article focuses on contemporary definitions of business ethics by business writers and professionals and on possible areas of agreement among (...) the available definitions. Then a definition is synthesized that is broad enough to cover the field of management in a sense as full as most managers might conceive of it. (shrink)

People may have open minds on whether a life-extending drug or technology is going to be developed before their sixties and may strongly desire that development. Do they therefore hope that it occurs? Do they hope for it in the substantive sense of “pinning their hopes” on the development? No, they do not. Hoping for a prospect in that sense certainly presupposes having an open mind on whether it will occur and having a desire for its occurrence. But, more crucially, (...) it means investing the prospect with a characteristic, galvanizing, and orientating role: it involves setting aside doubts about the possible nonoccurrence of the prospect and acting accordingly. This article offers a characterization of hope in that substantive sense and argues both that it can be rational and that it is ubiquitous. (shrink)

Composition as identity, as I understand it, is a theory of the composite structure of reality. The theory’s underlying logic is irreducibly plural; its fundamental primitive is a generalized identity relation that takes either plural or singular arguments. Strong versions of the theory that incorporate a generalized version of the indiscernibility of identicals are incompatible with the framework of plural logic, and should be rejected. Weak versions of the theory that are based on the idea that composition is merely analogous (...) to identity are too weak to be interesting, lacking in metaphysical consequence. I defend a moderate version according to which composition is a kind of identity, and argue that the difference is metaphysically substantial, not merely terminological. I then consider whether the notion of generalized identity, though fundamental, can be elucidated in modal terms by reverse engineering Hume’s Dictum. Unfortunately, for realists about possible worlds, such as myself,... (shrink)

In this paper we offer a new argument for the existence of God. We contend that the laws of logic are metaphysically dependent on the existence of God, understood as a necessarily existent, personal, spiritual being; thus anyone who grants that there are laws of logic should also accept that there is a God. We argue that if our most natural intuitions about them are correct, and if they are to play the role in our intellectual activities that we take (...) them to play, then the laws of logic are best construed as necessarily existent thoughts -- more specifically, as divine thoughts about divine thoughts. We conclude by highlighting some implications for both theistic arguments and antitheistic arguments. (shrink)

Introduction : rethinking historical distance : from doctrine to heuristic -- Machiavelli between history and chronicle -- A study in contrasts : Machiavelli, Guicciardini, and the idea of example -- "The most illustrious philosopher and historian of the age" : Hume and the balances of enlightenment history -- "What sympathy then touches every human heart!" : emotional identification in enlightenment and romantic histories -- Hundred Scottish ministers write the history of everyday life : contrasting distances in Sinclair's "Statistical account of (...) Scotland" -- Past and present : contrastive narratives in the romantic age -- "The very web and texture of society as it really exists" : literary history in historiographical perspective -- "A topic that history will proudly record", or, What is the "history" in history painting? -- On the advantage and disadvantage of sentimental history for life -- Alternative histories in the public realm : familiarizing and defamiliarizing the past -- Epilogue : My Lai and moral luck, or, 'Tis forty years since. (shrink)

Errol Lord explores the boundaries of epistemic normativity. He argues that we can understand these better by thinking about which mental states are competitors in rationality’s competition. He argues that belief, disbelief, and two kinds of suspension of judgment are competitors. Lord shows that there are non-evidential reasons for suspension of judgment. One upshot is an independent motivation for a certain sort of pragmatist view of epistemic rationality.

Niche construction refers to the activities of organisms that bring about changes in their environments, many of which are evolutionarily and ecologically consequential. Advocates of niche construction theory (NCT) believe that standard evolutionary theory fails to recognize the full importance of niche construction, and consequently propose a novel view of evolution, in which niche construction and its legacy over time (ecological inheritance) are described as evolutionary processes, equivalent in importance to natural selection. Here, we subject NCT to critical evaluation, in (...) the form of a collaboration between one prominent advocate of NCT, and a team of skeptics. We discuss whether niche construction is an evolutionary process, whether NCT obscures or clarifies how natural selection leads to organismal adaptation, and whether niche construction and natural selection are of equivalent explanatory importance. We also consider whether the literature that promotes NCT overstates the significance of niche construction, whether it is internally coherent, and whether it accurately portrays standard evolutionary theory. Our disagreements reflect a wider dispute within evolutionary theory over whether the neo-Darwinian synthesis is in need of reformulation, as well as different usages of some key terms (e.g., evolutionary process). (shrink)

It follows from Humean principles of plenitude, I argue, that island universes are possible: physical reality might have 'absolutely isolated' parts. This makes trouble for Lewis's modal realism; but the realist has a way out. First, accept absolute actuality, which is defensible, I argue, on independent grounds. Second, revise the standard analysis of modality: modal operators are 'plural', not 'individual', quantifiers over possible worlds. This solves the problem of island universes and confers three additional benefits: an 'unqualified' principle of compossibility (...) can be accepted; the possibility of nothing can be accommodated; and the identity of indiscernible worlds can be decisively refuted. (shrink)

To properly understand behavior, we must obtain both ultimate and proximate explanations. Put briefly, ultimate explanations are concerned with why a behavior exists, and proximate explanations are concerned with how it works. These two types of explanation are complementary and the distinction is critical to evolutionary explanation. We are concerned that they have become conflated in some areas of the evolutionary literature on human behavior. This article brings attention to these issues. We focus on three specific areas: the evolution of (...) cooperation, transmitted culture, and epigenetics. We do this to avoid confusion and wasted effort—dangers that are particularly acute in interdisciplinary research. Throughout this article, we suggest ways in which misunderstanding may be avoided in the future. (shrink)

In this chapter, I survey what I call Lewisian approaches to modality: approaches that analyze modality in terms of concrete possible worlds and their parts. I take the following four theses to be characteristic of Lewisian approaches to modality. (1) There is no primitive modality. (2) There exists a plurality of concrete possible worlds. (3) Actuality is an indexical concept. (4) Modality de re is to be analyzed in terms of counterparts, not transworld identity. After an introductory section in which (...) I motivate analyzing modality in terms of possible worlds, I devote one section to each of these four theses. For each thesis, I take Lewis’s interpretation and defense as my starting point. I then consider and endorse alternative ways of accepting the thesis, some of which disagree substantially with Lewis’s interpretation or defense. There is more than one way to be a Lewisian about modality. (shrink)

Experience is inescapably temporal. But how do we experience time? Temporal experience is a fundamental subject in philosophy – according to Husserl, the most important and difficult of all. Its puzzles and paradoxes were of critical interest from the Early Moderns through to the Post-Kantians. After a period of relative neglect, temporal experience is again at the forefront of debates across a wealth of areas, from philosophy of mind and psychology, to metaphysics and aesthetics. The Routledge Handbook of Philosophy of (...) Temporal Experience is an outstanding reference source to the key debates in this exciting subject area and represents the first collection of its kind. Comprising nearly thirty chapters by a team of international contributors, the _Handbook_ is organised into seven clear parts: Ancient and early modern perspectives Nineteenth and early twentieth-century perspectives The structure of temporal experience Temporal experience and the philosophy of mind Temporal experience and metaphysics Empirical perspectives Aesthetics Within each part key topics concerning temporal experience are examined, including canonical figures such as Locke, Kant and Husserl; extensionalism, retentionalism and the specious present; interrelations between temporal experience and time, agency, dreaming, and the self; empirical theories of perceiving and attending to time; and temporal awareness in the arts including dance, music and film. The Routledge Handbook of Philosophy of Temporal Experience is essential reading for students and researchers of philosophy of mind and psychology. It is also extremely useful for those in related fields such as metaphysics, phenomenology and aesthetics, as well as to psychologists and cognitive neuroscientists. (shrink)

: The transplantation of adult human neural stem cells into prenatal non-humans offers an avenue for studying human neural cell development without direct use of human embryos. However, such experiments raise significant ethical concerns about mixing human and nonhuman materials in ways that could result in the development of human-nonhuman chimeras. This paper examines four arguments against such research, the moral taboo, species integrity, "unnaturalness," and human dignity arguments, and finds the last plausible. It argues that the transfer of human (...) brain or retinal stem cells to nonhuman embryos would not result in the development of human-nonhuman chimeras that denigrate human dignity, provided such stem cells are dissociated. The article provides guidelines that set ethical boundaries for conducting such research that are consonant with the requirements of human dignity. (shrink)

Culls dozens of life lessons from the pages of J.R.R. Tolkien's epic tale, examining the author's treatment of such issues as happiness, morality, and the search for ultimate truth.

According to David Lewis, a realist about possible worlds must hold that actuality is relative: the worlds are ontologically all on a par; the actual and the merely possible differ, not absolutely, but in how they relate to us. Call this 'Lewisian realism'. The alternative, 'Leibnizian realism', holds that actuality is an absolute property that marks a distinction in ontological status. Lewis presents two arguments against Leibnizian realism. First, he argues that the Leibnizian realist cannot account for the contingency of (...) actuality. Second, he argues that the Leibnizian realist cannot explain why skepticism about one's own actuality is absurd. In this paper, I mount a defense of Leibnizian realism. (shrink)

Originally published in 1934, this book presents the content of the Rede Lecture for that year, which was delivered by Lord Macmillan at Cambridge University. This book will be of value to anyone with an interest in law, philosophy and psychology.

This is the review of a book by Paula Byrne on Lord Mansfield's great-niece, Dido, whom he raised as his own daughter. Lord Mansfield was the Lord Chief Justice of England in the Eighteenth Century. The child was brought to him as an infant and grew up to become what we would today term his paralegal clerk in his Library at Kenwood House. His great-niece was the child of a black slave and his sister's son, Sir John (...) Lindsay. This is also a narrative of the British Slave trade including some of Lord Mansfield's judgements at the King's Bench Division, Royal Courts of Justice. (shrink)