Objective: Pulmonary complications could badly affect the recovery of neurological function and neurological prognosis of neurological critically ill patients. This study evaluated the effect of high-flow nasal cannula therapy on decreasing pulmonary complications in neurologically critically ill patients.Patients and Methods: The patients admitted to the intensive care unit with serious neurological disease and receiving oxygen therapy were retrospectively reviewed. Patients were divided into the HFNC group and the conventional oxygen therapy group. We analyzed the data within these two groups, including (...) patients’ baseline data, short-term outcomes of respiratory complications, general outcomes including hospital stay, ICU stay and mortality, and neurological functions. To analyze the relevant factors, we performed multivariable logistic regression analysis.Results: A total of 283 patients met the criteria, including 164 cases in the HFNC group and 119 cases in the COT group. The HFNC group had remarkably less mechanical ventilation requirement with lower phlegm viscosity. Even more, ICU stay and total hospital stay were significantly shortened in the HNFC group.Conclusion: HFNC decreased pulmonary complications in neurologically critically ill patients and improved recovery of neurological function and neurological prognosis. (shrink)

T cells, which are derived from hematopoietic stem cells (HSCs), are the most important components of adaptive immune system. Based on the expression of αβ and γδ receptors, T cells are mainly divided into αβ and γδ T cells. In the thymus, they share common progenitor cells, while undergoing a series of well‐characterized and different developmental processes. N6‐Methyladenosine (m6A), one of the most abundant modifications in mRNAs, plays critical roles in cell development and maintenance of function. Recently, we have demonstrated (...) that the depletion of m6A demethylase ALKBH5 in lymphocytes specifically induces an expansion of γδ T cells through the regulation of Jag1/Notch2 signaling, but not αβ T cells, indicating a checkpoint role of ALKBH5 and m6A modification in the early development of γδ T cells. Based on previous studies, many key pathway molecules, which exert dominant roles in γδ T cell fate determination, have been identified as the targets regulated by m6A modification. In this review, we mainly summarize the potential regulation between m6A modification and these key signaling molecules in the γδ T cell lineage commitment, to provide new perspectives in the checkpoint of γδ T cell development. (shrink)

Ben shu gong you ba jiang zu cheng, fen bie shi sheng ren bi ke xue er zhi, Wang Yangming de xin xue ti xi, shi gong yu bing xue, wen xue si xiang yu shi wen chuang zuo, jiao yu si xiang yu shi jian, Yangming hou xue, Yangming xue zai jin xian dai de ying xiang, Yangming wen hua yu Guizhou lü you. Mei ge lun ti lun shu ji zhong, shen du shi zhong, xu shu xing (...) yu yan tong su liu chang, gu shi xing qiang, hen shi he da zhong du zhe yue du. wei qi fa du zhe si kao, zeng qiang yue du xiao guo, zai mei yi jiang zhi hou shi liang she zhi le yi xie ming ci jie shi, jian da tao lun ti. ling pei he xiang guan wen zi, she zhi le yi xie tu pian, bei ke he Yangming shu fa zuo pin deng, ju you ji jia de guan shang xing. (shrink)

Call "radical moral theorizing" the project of developing a moral theory that not only tries to conform to our existing moral intuitions, but also manifests various theoretical virtues: consistency, simplicity, explanatory depth, and so on. Many moral philosophers assume that radical moral theorizing does not require any particular metaethical commitments. In this paper, I argue against this assumption. The most natural justification for radical moral theorizing presupposes moral realism, broadly construed; in contrast, there may be no justification for radical moral (...) theorizing if moral anti-realism is true. (shrink)

本书是一本哲学自选文集,它收录了赵汀阳的《伦理学思路的改变》、《道德的维度或生活的维度》、《法律的道德余地》、《人之常情》等19篇文章。.

According to the received account of guilt in the philosophical literature, one cannot feel guilt unless one takes oneself to have done something morally wrong. But ordinary people feel guilt in many cases in which they do not take themselves to have done anything morally wrong. In this paper, I focus on one kind of guilt without perceived wrongdoing, guilt about being merely causally responsible for a bad state-of-affairs. I go on to present a novel account of guilt that explains (...) guilt about mere causal responsibility, according to which guilt represents part of the self as bound up with what is bad. (shrink)

本书收录“关于命运的知识”、“从知识眼光到创作眼光”、“一个或所有问题”、“千年观念故事”、“理解20世纪的精神财富”等19篇文章。.

该书考察了传统理性主义的理性观从发端、变异到确立、扩展的历史演变,从中对理性与其相关的范畴进行了辨析;分析了由传统理性主义到非理性主义及反理性主义的转向等内容。.

Aristotle and Xunzi on Shame, Moral Education and the Good Life is the first major work that takes two philosophers from the ancient Greek and early Chinese traditions to stimulate discussion of an interdisciplinary nature on the rich and complex topic of the emotions, in particular shame. It features sophisticated comparative analysis of the Greek and Chinese texts while bringing the ancient materials to bear on modern controversies such as the role of shame in moral education and social cohesion. Despite (...) fundamental differences in their social-historical and intellectual backgrounds, Aristotle and Xunzi bear striking similarities in several respects: their concept of humans as essentially members of communities, as having a unique set of characteristics that set them apart from other living things, and as beings in need of moral training to fulfil their potential and become integrated into a well-ordered society. The two philosophers' discourses on shame reveal important insights into their ideals of human nature, moral education and the good life. This book tackles directly the methodological problems that are relevant to anyone interested in cross-cultural comparisons and organises discussion of the ancient sources in such a way as to facilitate a thorough integration of perspectives from the cultural traditions concerned. This approach provides sufficient focus to allow for detailed textual analysis while giving scope for making constant connections to the broader comparative questions at issue. (shrink)

本书的思想创新和理论力度颇有古代哲学家气度,作者认为伦理学只有幸福和公正两个基本问题,并且声称发现了关于幸福和公正的最好理论,并提出了著名的“无立场”哲学方法论。.

本书将马克思主义与科学社会主义置于“当代诠释学的视野”加以解读、追问和探寻,试图在新时代地平线上构建一个当代诠释学与马克思主义相融通的视域。.

本书立足于中国刑法的理论与实践,并比较考察德、日等大陆法系,以及英、美等英美法系诸国与地区的立法及其实务。从刑法效力范围的基础理论入手,通过刑法之于时、地、人、事等四个方面进行研究和探讨。.

本书沿着康有为所开启的研究儒学的政治哲学途径,放弃晚清儒家在接受近代西方政制文化观念和价值取向的前提下所采取的“托古改制”的政治性立场,建构先秦儒家政治哲学的意义逻辑,论述了先秦儒学的基本性格与思想主 题。.

The purpose of this study is to analyze the relationship between psychology and modern art design education in colleges, and to provide the basis for improving the quality of art education in colleges. Based on the relevant theory, the characteristics of educational psychology and art psychology and the correlation between them were analyzed from the angle of art education. According to the characteristics of college students' psychological development, the significance of art psychology-related courses was analyzed. Through the form of questionnaire, (...) a total of 200 students were randomly selected from Xi'an Academy of Fine Arts and Xi'an University of Science and Technology, respectively. A total of 400 questionnaires were issued, and 382 valid questionnaires were recovered. The results show that almost all students in two colleges think pedagogy and educational psychology are the theoretical basis for art teachers, while less than one-third of students in Xi'an University of Science and Technology think that art psychology is the theoretical basis for art teachers. The difference between the students' aesthetic and life values in the two colleges is significant. In the 15 directions of life values, there are significant differences in five directions: spirit—material, enrichment—emptiness, enthusiasm—apathy, hope—despair, and dedication—acceptance. It shows that the psychological and values of college students are changeable, and the educators should pay attention to the education in the related fields of psychology. This exploration was conducted based on educational psychology, which is of great significance for improving the educational level of art psychology in colleges and enable students to form correct aesthetic standards and life values. (shrink)

Ben shu bao han zheng zhi dao de de qi yuan he fa zhan, zheng zhi dao de de ben zhi, jie gou he she hui zuo yong deng shi si zhang de nei rong.

本书包括社会建构论与科学社会研究的转向、科学知识社会学的学术实践、双重黑箱:传统社会学的科学观等。.

本书分为五个部分,包括:西方哲学总论;西方哲学史研究;现代西方哲学研究;中西哲学和文化的比较;“大哲学”的观念。.

本书共三章,内容包括:儒者关怀的宏观定位——对佛老之学的批判反思、个体生命的意义安置——修养学说的形成和发展、社会理想的执着追求——改造现实的理论与实践。.

This paper examines the role existence plays in measurement validity. I argue that existing popular theories of measurement and of validity follow a correspondence framework, which starts by assuming that an entity exists in the real world with certain properties that allow it to be measurable. Drawing on literature from the sociology of measurement, I show that the correspondence framework faces several theoretical and practical challenges. I suggested the validity-first framework of measurement, which starts with a practice-based validation process as (...) the basis for a measurement theory, and only posits objective existence when it is scientifically useful to do so. (shrink)

本书介绍了当代西方哲学思潮的兴起和演变过程,着重评介了对当今中国大学生震动强烈的实用主义思想、观点、实质及造成影响的时代背景和大学生的心理基础.

本书精选二十世纪外国美学文艺学名著175种,分别介绍其体系构架和主要观点,并兼及史实性、资料性的说明。.

本书作者从哲学的角度把复杂性问题概括为五个方面,一一论述其内容,从中引出哲学结论,并以这些哲学结论来纠正、补充、丰富和发展辩证唯物主义的若干原理。.

本书分两部分,一部分是就先秦每一时代及其重要思想家的重要思想进行了阐述;另一部分是对先秦思想史的部分重要学术问题进行了探讨。.

本书概括了发展社会主义市场经济条件下军人道德品质的主要特点;提出了发展社会主义市场经济条件下军人道德品质培养的主要矛盾是军人道德品质现有水平和培养目标之间的矛盾;揭示了发展社会主义市场经济条件下军人道 德品质培养的基本规律。在以上研究成果的基础上,本文提出了发展社会主义市场经济条件下军人道德品质培养的基本思路和对策。.

It is a commonplace in economics that we should disregard sunk costs. The sunk cost effect might be widespread, goes the conventional wisdom, but we would be better off if we could rid ourselves of it. In this paper, I argue against the orthodoxy by showing that the sunk cost effect is often beneficial. Drawing on discussions of related topics in dynamic choice theory, I show that, in a range of cases, being disposed to honor sunk costs allows an agent (...) to mimic a resolute chooser, someone who adopts the best plan at the outset of a decision problem and sticks with it, even when resoluteness is unfeasible. I discuss several kinds of cases in which honoring sunk costs coincides with resolute choice. (shrink)

This article is based on the author's extensive research on the missionaries to Tibet from the Disciples of Christ USA, and discusses various missionary efforts to transmit scientific and practical knowledge such as medicine, building, and agriculture in Eastern Tibet from 1904–1919. It shows that American missionaries played a prominent and distinctive role in the dissemination of scientific and practical knowledge as a result of their hard work and wisdom. In this sense, they made an important contribution to the development (...) of Tibetan society and the modernization movement in early twentieth-century Eastern Tibet. (shrink)

This open access book sheds light on the term gongsheng/kyōsei, which is used in Chinese and Japanese to not only translate “symbiosis” in biology but also broadly deployed in philosophical, social and political contexts. It is a cross-contextual attempt to study the foundation of gongsheng/kyōsei as a philosophy of co-becoming, with exploration of its significance for thinking about the planetary challenges of our times.

This book centers on rethinking foundational values in the era of frontier technologies by tapping into the wisdom of Chinese philosophical traditions. It tries to answer the following questions: How is the essence underpinning humans, nature, and machines changing in this age of frontier technologies? What is the appropriate ethical framework for regulating human–machine relationships? What human values should be embedded in or learnt by AI? Some interesting points emerged from the discussions. For example, the three dominant schools of Chinese (...) thinking–Confucianism, Daoism and Buddhism– invariably reflect non-anthropocentric perspectives and none of them places humanity in a supreme position in the universe. While many Chinese philosophers are not convinced by the prospect of machine intelligence exceeding that of humans, the strong influence of non-anthropocentrism in the Chinese thinking contributed to much less panic in China than in the West about the existential risks of AI. The thinking is that as human beings have always lived with other forms of existence, living with programs or other forms of “beings,” which may become more capable than humans, will not inevitably lead to a dystopia. Second, all three schools emphasize self-restraint, constant introspection, and the pursuit of sage-hood or enlightenment. These views therefore see the potential risks posed by frontier technologies as an opportunity for the humanity to engage in introspection on the lessons learned from our social and political history. It is long overdue that humanity shall rethink its foundational values to take into account a multi-being planetary outlook. This book consists of nine leading Chinese philosophers’ reflections on AI’s impact on human nature and the human society. This is a groundbreaking work, which has pioneered the in-depth intellectual exploration involving traditional Chinese philosophy and frontier technologies and has inspired multidisciplinary and across area studies on AI, philosophy, and ethical implications. (shrink)

In this paper, I explore an intriguing view of definable numbers proposed by a Cambridge mathematician Ernest Hobson, and his solution to the paradoxes of definability. Reflecting on König’s paradox and Richard’s paradox, Hobson argues that an unacceptable consequence of the paradoxes of definability is that there are numbers that are inherently incapable of finite definition. Contrast to other interpreters, Hobson analyses the problem of the paradoxes of definability lies in a dichotomy between finitely definable numbers and not finitely definable (...) numbers. To bypass this predicament, Hobson proposes a language dependent analysis of definable numbers, where the diagonal argument is employed as a means to generate more and more definable numbers. This paper examines Hobson’s work in its historical context, and articulates his argument in detail. It concludes with a remark on Hobson’s analysis of definability and Alan Turing’s analysis of computability. (shrink)