A study of the reception of Aristotle's Prior Analytics in the first half of the twelfth century. It is shown that Peter Abaelard was perhaps acquainted with as much as the first seven chapters of Book I of the Prior Analytics but with no more. The appearance at the beginning of the twelfth century of a short list of dialectical loci which has puzzled earlier commentators is explained by noting that this list formalises the classification of extensional relations between (...) general terms and that this classification had already be put forward by Boethius in his de Syllogismo Categorico and Introductio ad Syllogismos Categoricas . It is pointed out the kind of text referred to as an ` Introductio ' at the beginning of the twelfth-century follows very closely the structure of Boethius own Introductio and adds to it material drawn from his accounts of loci and the conditional propositions. It is argued that the reception of the Prior Analytics has to be understood against the background of this well developed tradition of treating together syllogisms, loci , and conditional propostions. Referring to a challenge to the formal validity of Darapti in the Ars Meliduna the paper concludes by illustrating that the theory of the syllogism presented in Prior Analytics was still controversial in the middle of the twelfth-century. (shrink)

_Abstract_: We argue that theoretical debates in biology and cognitive science often are based around differences in the posited _locus of control _for biological and cognitive phenomena. Internalists about locus of control posit that specific causal control over the phenomenon is exerted by factors internal (to the relevant subsystem) of an organism. Externalists posit that causally specific influence is due to external factors. In theoretical biology, we suggest, a minimal agreement has developed that the locus of control for heritable variation (...) is _distributed _– that is, both internal and external factors exert specific, non-redundant causal influence on evolved traits. We suggest that debates in cognitive science, particularly surrounding “enactivism”, should also embrace a distributed locus of control. We show how both internal and external factors contribute non-redundantly to psychological capacities and behavior. We further suggest that embracing a distributed locus of control provides a basis for a revisionary, but substantive account of “mental representation”. _Keywords_: Locus of control; Internalism/Externalism; Evolutionary Biology; Cognitive Science; Mental Representation _ Loci di controllo distribuiti: superare le vecchie dicotomie nella biologia e nella scienza cognitiva _ _Riassunto_: Numerose discussioni in biologia e nella scienza cognitiva vertono spesso su differenze nella individuazione del _locus di controllo_ dei fenomeni biologici e cognitivi. Posizioni internaliste rispetto al _locus di controllo_ ritengono che il controllo causale specifico su un fenomeno biologico o cognitivo venga esercitato da fattori interni a (un sottosistema rilevante) di un organismo. Al contrario, posizioni esternaliste assumono che specifiche influenze causali siano dovute a fattori esterni. In questo articolo mostriamo che nell’ambito della biologia teorica si è giunti a un minimo accordo rispetto al fatto che il _locus di controllo_ per l’emergere di variazioni ereditarie è _distribuito _– ossia dovuto sia a fattori interni che esterni all’organismo che esercitano influenze specifiche e non-ridondanti sui tratti che si sono evoluti. Riteniamo che tale accordo debba essere raggiunto anche nell’ambito della scienza cognitiva, in particolare per quel che concerne l’_enattivismo_. In questo articolo mostriamo che sia i fattori interni che quelli esterni contribuiscono in maniera non-ridondante alle capacità psicologiche e al comportamento di un individuo. Inoltre sosterremo che l’adozione di un _locus di controllo _distribuito possa costituire un buon punto di partenza per una revisione sostanziale della nozione di “rappresentazione mentale”. _Parole chiave_: Locus di controllo causale; Internalismo/Esternalismo; Biologia evolutiva; Scienze cognitive; Rappresentazione mentale _ _. (shrink)

Brain arteriovenous malformations (bAVMs) are abnormal vessels that are prone to rupture, causing life-threatening intracranial bleeding. The mechanism of bAVM formation is poorly understood. Nevertheless, animal studies revealed that gene mutation in endothelial cells (ECs) and angiogenic stimulation are necessary for bAVM initiation. Evidence collected through analyzing bAVM specimens of human and mouse models indicate that cells other than ECs also are involved in bAVM pathogenesis. Both human and mouse bAVMs vessels showed lower mural cell-coverage, suggesting a role of pericytes (...) and vascular smooth muscle cells (vSMCs) in bAVM pathogenesis. Perivascular astrocytes also are important in maintaining cerebral vascular function and take part in bAVM development. Furthermore, higher inflammatory cytokines in bAVM tissue and blood demonstrate the contribution of inflammatory cells in bAVM progression, and rupture. The goal of this paper is to provide our current understanding of the roles of different cellular loci in bAVM pathogenesis. (shrink)

In relation to the task of making an expedient selection from the available loci within the topical potential that strategic manoeuvring envisages for the argumentation stage, this paper proposes a version of topics, which is both inspired to the traditional doctrine of topics and consistent with the theoretical framing and the methodological tenets that are proper of modern semantics and current theory of argumentation. The argumentative relevance of communication context in its institutionalised and interpersonal components is brought to light. (...) Three main aspects are focussed on: the strong synergy of the topical and the endoxical components in argument construction, the use of topics in analysis and evaluation of arguments and the heuristic function of topics in the production process. (shrink)

Commonplacing was one of the most widely practiced types of paper technology in the early modern period. Yet its place and function in medicine remain largely unexplored. Based on about two dozen manuscripts from the sixteenth and seventeenth centuries in which physicians used commonplacing to record excerpts from their reading as well as personal observations and ideas, this paper offers a first survey of the roles, forms and epistemic effects of medical commonplacing in the early modern period. Three principal types (...) of commonplacing are identified, namely the systematic, the alphabetical and the sequential. The advantages and disadvantages of each type with regard to economy of space and time, flexibility, and order are pointed out. Among the potential epistemic effects of collecting and ordering information under “heads” are, in particular, a heightened awareness of contradictions between authors or observations on a specific topic, an appreciation for snippets of information as fact-like elements of knowledge inviting rearrangement, and a certain shift towards the notion of diseases as distinct entities endowed with specific, empirically observable properties. (shrink)

Este trabajo se centra en cómo en la España de la segunda mitad del siglo XVIII con motivo de la reforma de los estudios teológicos tanto en los Seminarios –necesaria para la mejora de la formación de uno de los principales agentes del propugnado y urgente cambio religioso– como en las Universidades –en las que se quería sustituir la influencia jesuítica por otra más de acorde con las ideas regalistas– se impulsó la creación de las cátedras De locis theologicis, muchas (...) de las cuales debían seguir el tratado de Melchor Cano y otras seguir a otros tratadistas, pero teniendo presente en sus explicaciones la docta obra de Melchor Cano. También se estudiará en la reforma del Plan de Estudios de la Orden de Frailes Predicadores, así como el rechazo que de todo ello tuvo el importante ilustrado valenciano Gregorio Mayans y Ciscar. The work is about how in the Spain of the second half of the 18th century owing to the theological studies reform as much in Seminaries-necessary to the education improvement of one of the main agents of the proposed and urgent religious change-as in Universities-in which it was wanted to substitute the Jesuitical influence for another more appropriate to the regalist ideas– the creation of the Locis theologicis chairs, many of which had to follow Melchor Cano’s treatise, and other chairs had to follow other authors, was promoted; but bearing in mind in their explanations Melchior Cano’s erudite work. Such treatise will also be studied in the reform of the Order of Preacher’ curriculum, as well as the rejection of all that by the important learned Gregorio Mayans y Ciscar, native of Valencia. (shrink)

Paradoxically, DNA sequence polymorphisms in cancer risk loci rarely correlate with the expression of cancer genes. Therefore, the molecular mechanism underlying an individual's susceptibility to cancer has remained largely unknown. However, recent evaluations of the correlations between DNA methylation and gene expression levels across healthy and cancerous genomes have revealed enrichment of disease‐related DNA methylation variations within disease‐associated risk loci. Moreover, it appears that transcriptional enhancers embedded in cancer risk loci often contain DNA methylation sites that closely (...) define the expression of prominent cancer genes, despite the lack of significant correlations between gene expression levels and the surrounding disease‐associated polymorphic sequences. We suggest that DNA methylation variations may obscure the effect of co‐residing risk sequence alleles. Analysis of enhancer methylation data may help to reveal the regulatory circuits underlying predisposition to cancers and other common diseases.Editor's suggested further reading in BioEssays DNA methylation reprogramming in cancer: Does it act by re‐configuring the binding landscape of Polycomb repressive complexes? Abstract. (shrink)

Loci personarum, ‘topics for persons’ were used in Latin rhetoric for the description of persons, their external circumstances, physical attributes, or qualities of character. They stood in the way of fusing rhetoric and dialectic, the goal of sixteenth-century ‘humanistic’ logic: the project of a unified theory of invention depends on the exclusion of loci personarum from the domain of dialectic proper. But still they cannot easily be replaced in the class room. Bartholomaeus Keckermann resolved these difficulties: he proposed (...) to abandon the notion that loci personarum could play a role in finding new arguments concerning persons. So they pose no risks for a unified theory of invention, because they can only be used for the exposition of information that we already have. Since loci personarum are concerned with individuals, the knowledge about individuals that is available to us is inescapably circumstantial and contingent, defying the claim of generality or necessity of dialectic made by Keckermann’s sixteenth-century predecessors. However, our thinking about persons is primarily interested in those aspects that we do not share with other members of our species. For Keckermann, persons are therefore logically different from most individuals belonging to other species. (shrink)

Este trabajo se centra en cómo en la España de la segunda mitad del siglo XVIII con motivo de la reforma de los estudios teológicos tanto en los Seminarios –necesaria para la mejora de la formación de uno de los principales agentes del propugnado y urgente cambio religioso– como en las Universidades –en las que se quería sustituir la influencia jesuítica por otra más de acorde con las ideas regalistas– se impulsó la creación de las cátedras De locis theologicis, muchas (...) de las cuales debían seguir el tratado de Melchor Cano y otras seguir a otros tratadistas, pero teniendo presente en sus explicaciones la docta obra de Melchor Cano. También se estudiará en la reforma del Plan de Estudios de la Orden de Frailes Predicadores, así como el rechazo que de todo ello tuvo el importante ilustrado valenciano Gregorio Mayans y Ciscar. The work is about how in the Spain of the second half of the 18th century owing to the theological studies reform as much in Seminaries-necessary to the education improvement of one of the main agents of the proposed and urgent religious change-as in Universities-in which it was wanted to substitute the Jesuitical influence for another more appropriate to the regalist ideas– the creation of the Locis theologicis chairs, many of which had to follow Melchor Cano’s treatise, and other chairs had to follow other authors, was promoted; but bearing in mind in their explanations Melchior Cano’s erudite work. Such treatise will also be studied in the reform of the Order of Preacher’ curriculum, as well as the rejection of all that by the important learned Gregorio Mayans y Ciscar, native of Valencia. (shrink)

This essay explores Nietzsche’s visit to Orta, including his visit with Lou von Salomé to Sacro Monte. Yet there are two Sacri Monti, one at Orta and one, some distance away, at Varallo. Lou reports that Nietzsche described this visit as the «most charming dream» [entzückendsten Traum] of his life and scholars have concluded that this dream refers to Nietzsche’s erotic moment – just a kiss – with Lou. This essay argues for a hermeneutico-phenomenological consideration of the locus itself: featuring (...) nearly a dozen (doubled that number at Varallo) architecturally unique oratories and hundreds of brilliantly painted, nearly life-size statues set in landscape designed to recreate the particular atmosphere of the Mediterranean world, both Jerusalem and Athens, transposed to the north of Italy. This “weather” would have captivated the Nietzsche who worked on the intersection between what texts tell us about antiquity and the world, the “barest hem of which”, as he once put it, we cannot begin to touch. (shrink)

This essay explores Nietzsche’s visit to Orta, including his visit with Lou von Salomé to Sacro Monte. Yet there are two Sacri Monti, one at Orta and one, some distance away, at Varallo. Lou reports that Nietzsche described this visit as the «most charming dream» [entzückendsten Traum] of his life and scholars have concluded that this dream refers to Nietzsche’s erotic moment – just a kiss – with Lou. This essay argues for a hermeneutico-phenomenological consideration of the locus itself: featuring (...) nearly a dozen (doubled that number at Varallo) architecturally unique oratories and hundreds of brilliantly painted, nearly life-size statues set in landscape designed to recreate the particular atmosphere of the Mediterranean world, both Jerusalem and Athens, transposed to the north of Italy. This “weather” would have captivated the Nietzsche who worked on the intersection between what texts tell us about antiquity and the world, the “barest hem of which”, as he once put it, we cannot begin to touch. (shrink)

Contemporary process metaphysics has achieved a number of important results, most significantly in accounting for emergence, a problem on which substance metaphysics has foundered since Plato. It also faces trenchant problems of its own, among them the related problems of boundaries and individuation. Historically, the quest for ontology may thus have been largely responsible for the persistence of substance metaphysics. But as Plato was well aware, an ontology of substantial things raises serious, perhaps insurmountable problems for any account of our (...) epistemic access to such things. Physical things are subject to change, and as such, they are poor objects of knowledge—if knowledge is to be more reliable than mere opinion. There is a reading of Plato’s Theaetetus on which knowledge may be understood as a relation between an epistemic subject and a logos, where logoi are intrinsically dialectical, and where dialectic is a kind of intersubjective activity. Insofar as this epistemology may be attributed to Plato, the project of this paper is Platonic in spirit. It is also, in a sense, Kantian, in that it divorces ontology from the search for things-in-themselves, redirecting our attention from things to objects: epistemic objects. Such objects can be understood, as Maurice Merleau-Ponty proposed, as shared by multiple subjects by virtue of their participation in an intersubjective world, constituted by what Shaun Gallagher calls participatory sense-making. On an epistemology constructed in this way, the fact that both epistemic objects and their subject are mutable is no obstacle to knowledge. Far-from-equilibrium systems are forever mutable; at thermodynamic equilibrium, there would be neither subject, nor object. Epistemic objects, on this picture, are metastable loci of interactive potential. (shrink)

In questo saggio argomento che esistono due modi di pensare i luoghi: l’uno accetta l’idea che alcuni di essi abbiano una dimensione trascendente, che per semplificare potremmo chiamare il Genius loci, ovvero il loro spirito, la loro anima; l’altro tende a svuotarli di significati che vanno al di là dell’esperienza sensibile. Chiamerò “religioso” e “profano” questi due modi di pensare: come si caratterizzano? E come definiscono l’idea di luogo? Soprattutto, quali sono le conseguenze dell’adozione dell’uno o dell’altro modo di (...) pensare? Queste sono le domande che mi pongo in questo saggio. (shrink)

The present paper examines the rudimentary concept of the Protestant theology as an academic discipline which was enunciated by Melanchthon in his prolegomena to all Latin and German versions of Loci which were the instrument indispensable for educating a next generation of the Protestant divines and for disseminating the ideas of the Reformation worldwide.

Contemporary process metaphysics has achieved a number of important results, most significantly in accounting for emergence, a problem on which substance metaphysics has foundered since Plato. It also faces trenchant problems of its own, among them the related problems of boundaries and individuation. Historically, the quest for ontology may thus have been largely responsible for the persistence of substance metaphysics. But as Plato was well aware, an ontology of substantial things raises serious, perhaps insurmountable problems for any account of our (...) epistemic access to such things. Physical things are subject to change, and as such, they are poor objects of knowledge—if knowledge is to be more reliable than mere opinion. There is a reading of Plato’s Theaetetus on which knowledge may be understood as a relation between an epistemic subject and a logos, where logoi are intrinsically dialectical, and where dialectic is a kind of intersubjective activity. Insofar as this epistemology may be attributed to Plato, the project of this paper is Platonic in spirit. It is also, in a sense, Kantian, in that it divorces ontology from the search for things-in-themselves, redirecting our attention from things to objects: epistemic objects. Such objects can be understood, as Maurice Merleau-Ponty proposed, as shared by multiple subjects by virtue of their participation in an intersubjective world, constituted by what Shaun Gallagher calls ‘‘participatory sense-making.’’ On an epistemology constructed in this way, the fact that both epistemic objects and their subject are mutable is no obstacle to knowledge. Far-from-equilibrium systems are forever mutable; at thermodynamic equilibrium, there would be neither subject, nor object. Epistemic objects, on this picture, are metastable loci of interactive potential. (shrink)

This paper aims to single out and to highlight the fundamental tenets of Agricola’s De inuentione dialectica. After the structure of the volume, its theoretical perspective and its educational concern are illustrated, Agricola’s understanding of the fundamental notion of locus is expounded. In this relation his particular use of the medieval term habitudo and the exclusion of maxims, which had been the main concern of the Medieval doctrine of loci, show a certain distance from the Medieval tradition. Several innovative (...) and constructive contributions of Agricola’s work are stressed, in particular the elaboration of a new taxonomy of loci and the discovery of the relevant role played by loci not only in argumentation but also in exposition and in explanation. In this way, loci acquire the status of intentiones secundae, i.e. of meta-categorical concepts which govern the connections ensuring textual congruity. A reading of this text in the light of contemporary argumentation theory reveals a surprising topicality and richness of concrete contributions in some dialectical and rhetorical domains, like argument schemes, topical potential, and presentational techniques. (shrink)

This article examines argument structures and strategies in pro and con argumentation about the possibility of human-level artificial intelligence (AI) in the near term future. It examines renewed controversy about strong AI that originated in a prominent 1999 book and continued at major conferences and in periodicals, media commentary, and Web-based discussions through 2002. It will be argued that the book made use of implicit, anticipatory refutation to reverse prevailing value hierarchies related to AI. Drawing on Perelman and Olbrechts-Tyteca's (1969) (...) study of refutational argument, this study considers points of contact between opposing arguments that emerged in opposing loci, dissociations, and casuistic reasoning. In particular, it shows how perceptions of AI were reframed and rehabilitated through metaphorical language, reversal of the philosophical pair artificial/natural, appeals to the paradigm case, and use of the loci of quantity and essence. Furthermore, examining responses to the book in subsequent arguments indicates the topoi characteristic of the rhetoric of technology advocacy. (shrink)

Normative philosophy believes that argumentation concerning values is rational because there is a deeper value to which all are committed. Citing Ronald Dworkin’s 1977’s Taking Rights Seriously, Will Kymlicka suggests that this “ultimate value” is equality. Having a standard enables rationality because it enables competing theories to show “that one of the theories does a better job living up to the standard that they all recognize”. The measure for whether an argument weighs as much as it claims is how well (...) it accounts for treating people equally and fairly. Fair and equal treatment is measurable enough, and for the same reason values generally are: it helps form the reality of... (shrink)

This paper looks into the relation between judgment and authority from the point of view of humanistic logic. It shows that the position of a domain of objects by a thinking subject endowed with authority is the preliminary condition of judgments which are not merely cognitive and include instead historical and cultural aspects. This lesson was disseminated in the work of Rudolph Agricola and Petrus Ramus. Too bad, however, too little attention has been given as yet to the vital role (...) played by the doctrine of the loci until Immanuel Kant. (shrink)

We investigated the feasibility of a short intervention using the Method of Loci, a well-known visuospatial mnemonic, to improve episodic memory recall performance in schizophrenia. The MoL training protocol comprised encoding and recall of two lists of items, a training session and practice with MoL. Then, participants had the opportunity to put into practice the newly learned MoL and were instructed to encode and recall two new lists of items using. This approach was first validated with healthy individuals. Subsequently, (...) five individuals with schizophrenia completed the protocol. Improvement in healthy individuals was observed for the word list. No significant memory improvement was denoted in the schizophrenia group, possibly due to participants' difficulties using the method efficiently and due to fatigue. The MoL seems to require episodic memory, working memory monitoring and executive functions, making it suboptimal for a population with impairments in all those domains. Future research should examine the use of other strategies, better suited for individuals with cognitive impairments like those found in schizophrenia. (shrink)

This volume includes the critical edition of five apologias in which Erasmus defended his New Testament translation and commentary against Diego López de Zúñiga and Sancho Carranza. The edition is partly based on manuscript sources never used before.

“Languages are all the same, but not boringly so.” I think this is my own maxim, not one of the late great Kenneth Hale ’s. But it is nevertheless something that he taught me, by example, if not by explicit precept. Ken Hale believed passionately in a substantive notion of Universal Grammar that underlies all languages. But this did not blind him to the details—even the idiosyncrasies—of less-studied “local” languages. On the contrary, I believe it stimulated his famous zeal for (...) those details and idiosyncrasies. It is against the backdrop of what is universal that idiosyncrasies become interesting and meaningful. Conversely, it is often the fact that quite different, language particular constructions obey the same abstract constraints that provides the most striking evidence that those constraints are universal features of human language. (shrink)

Many ethicists writing about automated systems attribute agency to these systems. Not only that; they seemingly attribute an autonomous or independent form of agency to these machines. This leads some ethicists to worry about responsibility-gaps and retribution-gaps in cases where automated systems harm or kill human beings. In this paper, I consider what sorts of agency it makes sense to attribute to most current forms of automated systems, in particular automated cars and military robots. I argue that whereas it indeed (...) makes sense to attribute different forms of fairly sophisticated agency to these machines, we ought not to regard them as acting on their own, independently of any human beings. Rather, the right way to understand the agency exercised by these machines is in terms of human–robot collaborations, where the humans involved initiate, supervise, and manage the agency of their robotic collaborators. This means, I argue, that there is much less room for justified worries about responsibility-gaps and retribution-gaps than many ethicists think. (shrink)

A total of 1918 loci, detected by the hybridization of 938 expressed sequence tag unigenes from 26 Triticeae cDNA libraries, were mapped to wheat homoeologous group 4 chromosomes using a set of deletion, ditelosomic, and nulli-tetrasomic lines. The 1918 EST loci were not distributed uniformly among the three group 4 chromosomes; 41, 28, and 31% mapped to chromosomes 4A, 4B, and 4D, respectively. This pattern is in contrast to the cumulative results of EST mapping in all homoeologous groups, (...) as reported elsewhere, that found the highest proportion of loci mapped to the B genome. Sixty-five percent of these 1918 loci mapped to the long arms of homoeologous group 4 chromosomes, while 35% mapped to the short arms. The distal regions of chromosome arms showed higher numbers of loci than the proximal regions, with the exception of 4DL. This study confirmed the complex structure of chromosome 4A that contains two reciprocal translocations and two inversions, previously identified. An additional inversion in the centromeric region of 4A was revealed. A consensus map for homoeologous group 4 was developed from 119 ESTs unique to group 4. Forty-nine percent of these ESTs were found to be homoologous to sequences on rice chromosome 3, 12% had matches with sequences on other rice chromosomes, and 39% had no matches with rice sequences at all. Limited homology was found between wheat ESTs on homoeologous group 4 and the Arabidopsis genome. Forty-two percent of the homoeologous group 4 ESTs could be classified into functional categories on the basis of blastX searches against all protein databases. (shrink)

Lange Zeit wurde in der modernen Forschung die These vertreten, dass der Dominikanertheologe Melchior Cano , dessen Werk de locis theologicis die wohl erste moderne fundamentaltheologische Schrift darstellt, aus der subjektiven Sicht der Gegenreformation ohne Autopsie der reformatorischen Schriften gegen die sich verbreitenden Ansichten der Lutheraner argumentierte. Dass sich eine derartige These in den loci nicht verifizieren lässt, möchte die vorliegende Untersuchung herausstellen.For quite an amount of time modern researchers argued that the Dominican theologian Melchior Cano - his most (...) famous writing de locis theologicis should certainly be seen as the first fundamental work of modern theology - has kept on writing against the spreading doctrine of the Lutheran theology from the prospect of the catholic counter-reformation and without knowing or viewing the writings of the reformation. The present study will proove that this kind of thesis is definitely not to verify in the loci. (shrink)