Philosophy; philosophical theology; philosophical anthropology; history.

Experimentation is at the heart of scientific inquiry. In the behavioral and neural sciences, where only a limited number of observations can often be made, it is ideal to design an experiment that leads to the rapid accumulation of information about the phenomenon under study. Adaptive experimentation has the potential to accelerate scientific progress by maximizing inferential gain in such research settings. To date, most adaptive experiments have relied on myopic, one-step-ahead strategies in which the stimulus on each trial is (...) selected to maximize inference on the next trial only. A lingering question in the field has been how much additional benefit would be gained by optimizing beyond the next trial. A range of technical challenges has prevented this important question from being addressed adequately. This study applies dynamic programming, a technique applicable for such full-horizon, “global” optimization, to model-based perceptual threshold estimation, a domain that has been a major beneficiary of adaptive methods. The results provide insight into conditions that will benefit from optimizing beyond the next trial. Implications for the use of adaptive methods in cognitive science are discussed. (shrink)

We present the theory, the experimental evidence and fundamental physical consequences concerning the existence of families of undistorted progressive waves (UPWs) of arbitrary speeds 0≤ϑ<∞, which are solutions of the homogeneuous wave equation, the Maxwell equations, and Dirac, Weyl, and Klein-Gordon equations.

Doubly robust (DR) estimators are an important class of statistics derived from a theory of semiparametric efficiency. They have become a popular tool in causal inference, including applications to dynamic treatment regimes. The doubly robust estimators for the mean response to a dynamic treatment regime may be conceived through the augmented inverse probability weighted (AIPW) estimating function, defined as the sum of the inverse probability weighted (IPW) estimating function and an augmentation term. The IPW estimating function of the causal estimand (...) via marginal structural model is defined as the complete-case score function for those subjects whose treatment sequence is consistent with the dynamic regime in question divided by the probability of observing the treatment sequence given the subject's treatment and covariate histories. The augmentation term is derived by projecting the IPW estimating function onto the nuisance tangent space and has mean-zero under the truth. The IPW estimator of the causal estimand is consistent if (i) the treatment assignment mechanism is correctly modeled and the AIPW estimator is consistent if either (i) is true or (ii) nested functions of intermediate and final outcomes are correctly modeled.Hence, the AIPW estimator is doubly robust and, moreover, the AIPW is semiparametric efficient if both (i) and (ii) are true simultaneously. Unfortunately, DR estimators can be inferior when either (i) or (ii) is true and the other false. In this case, the misspecified parts of the model can have a detrimental effect on the variance of the DR estimator. We propose an improved DR estimator of causal estimand in dynamic treatment regimes through a technique originally developed by [4] which aims to mitigate the ill-effects of model misspecification through a constrained optimization.In addition to solving a doubly robust system of equations, the improved DR estimator simultaneously minimizes the asymptotic variance of the estimator under a correctly specified treatment assignment mechanism but misspecification of intermediate and final outcome models. We illustrate the desirable operating characteristics of the estimator through Monte Carlo studies and apply the methods to data from a randomized study of integrilin therapy for patients undergoing coronary stent implantation. The methods proposed here are new and may be used to further improve personalized medicine, in general. (shrink)

BackgroundParent-mediated intervention has been studied in promoting skill acquisition or behavior change in the children with autism spectrum disorder. Most studies emphasize on the improvement of child’s core symptoms or maladaptive behaviors, making parental perceived competence and self-efficacy secondary. Yet, the evaluations of intervention implementation are under-reported, especially when translating such interventions into a new population or context. This research investigated the intervention implementation of a 12-week parent coaching intervention which was delivered through telehealth and tailored to Chinese population. The (...) intervention was based on the Parent-mediated Early Start Denver Model with culturally adapted lectures, manuals, and demonstration and commentary videos. This study aimed to evaluate the intervention implementation by assessing parents’ satisfaction, acceptability, appropriateness, and feasibility.MethodA randomized controlled trial was conducted with two telehealth conditions: self-directed and web+group therapy. Parents in the self-directed condition received intervention individually through the online learning platform. The web+group therapy condition navigated the same program with weekly 1.5-h group coaching sessions via videoconferencing. This mixed-methods study used a concurrent convergent design to evaluate the intervention implementation at post-intervention. The quantitative data was collected from the Program Evaluation Survey and the qualitative data was collected from five focus groups.ResultsParents in self-directed group reported significantly lower scores in total perceived competence than parents in web+group therapy condition, while there was no group difference on the total self-efficacy. Tailored feedback, demonstration and commentary videos, peer commenting, live coaching, and guided reflection were the top-five acceptable telehealth strategies that were strongly endorsed by parents. Family centered care, home-based intervention, strategies relative to daily activities, the remote learning platform, and the program-based community were elements that parents considered when evaluating the program’s appropriateness. Parent modeling, step-by-step instructions, and tailored feedback were key components in making intervention strategies feasible for parents to implement at home.ConclusionFindings indicate the application of telehealth was acceptable, appropriate, and feasible for Chinese parents. Group-based parent coaching intervention via videoconferencing could be a promising home-based service model to increase parental perceived competence. A large-scale RCT is needed to investigate the effectiveness of group-based PMI via telehealth. (shrink)

Özlem, Doğan; philosophy; biography; Turkey.

According to phenomenal conservatism or dogmatism, perceptual experiences can give us immediate justification for beliefs about the external world in virtue of having a distinctive kind of phenomenal character—namely phenomenal force. I present three cases to show that phenomenal force is neither pervasive among nor exclusive to perceptual experiences. The plausibility of such cases calls out for explanation. I argue that contrary to a long-held assumption, phenomenal force is a separate, non-perceptual state generated by some metacognitive mechanisms that monitor one’s (...) first-order mental processes and states. This new account advances our understanding of the nature of phenomenal force. (shrink)

The persistent challenge of formulating ontic structuralism in a rigorous manner, which prioritizes structures over the entities they contain, calls for a transformation of traditional logical frameworks. I argue that Univalent Foundations (UF), which feature the axiom that all isomorphic structures are identical, offer such a foundation and are more attractive than other proposed structuralist frameworks. Furthermore, I delve into the significance in the case of the hole argument and, very briefly, the nature of symmetries.

Recent studies have identified practical wisdom as a critical area for exploration in the domains of management and leadership. This paper delves into the cultivation and manifestation of practical wisdom in leadership, emphasizing the potential of narratives as an efficacious tool, as corroborated by academic literature. Employing practical wisdom theory and a refined analytical model, we examine the role of narratives as a key instrument for practically wise leaders. Through the provision of theoretical underpinnings and empirical evidence, our study seeks (...) to elucidate the tripartite interconnectedness of practical wisdom, narratives, and leadership. Subsequently, a conceptual model is developed and illustrated, outlining the relationship between narratives and practical wisdom across diverse leadership contexts. This analysis positions practical wisdom as a fundamental guidance for leaders’ narrative practices. Acknowledging the paper’s conceptual focus, we discuss the practical and theoretical implications of the proposed model and advocate for empirical inquiry to further enhance understanding of narrative practices in practically wise leadership. (shrink)

Ms. B. was a 70-year-old woman who presented with a chief complaint of “my belly got puffy.” She noted that her waistband got progressively tighter as her abdomen swelled up on the month prior to her admission. Although not painful, the swelling caused considerable discomfort and anorexia.Ms. B. was a 70-year-old woman who presented with a chief complaint of “my belly got puffy.” She noted that her waistband got progressively tighter as her abdomen swelled up on the month prior to (...) her admission. Although not painful, the swelling caused considerable discomfort and anorexia.Ms. B. had come to the university hospital by referral from her primary care doctor. She was my first patient on my junior clerkship in internal medicine, a specialty I was particularly interested in going into. It is a rare opportunity for a medical student to pick up a mystery case. Ms. B. had come to us without a diagnosis. (shrink)

Lu Jia's New Discourses: A Political Manifesto from the Early Han Dynasty is a readable yet accurate translation by Paul R. Goldin and Elisa Levi Sabattini. Celebrated as "a man-of-service with a mouth [skilled] at persuasion", Lu Jia (c. 228-140 BCE) became one of the leading figures of the early Han dynasty, serving as a statesman and diplomat from the very beginning of the Han empire. This book is a translation of Lu Jia's New Discourses, which laid out the reasons (...) for rise and fall of empires. Challenged by the new Emperor to produce a book explaining why a realm that was conquered on horseback cannot also be ruled on horseback, Lu Jia produced New Discourses, to great acclaim. (shrink)

The development of CSR reflects the level and characteristics of professional sports organizations, and the CSR of professional sports clubs varies among different countries and regions. In order to explore the content of the CSR of Chinese professional sports clubs in a more comprehensive and systematic way, this study organizes previous studies on the CSR of clubs in different countries and regions, and analyzes the differences between Chinese professional sports clubs and clubs in Europe, North America, Japan, and other countries (...) and regions. We collected the opinions of 20 experts through semi-structured interviews and combined them with the “Five in One” overall layout to construct and explain the CSR system of professional sports clubs in China in the new era, filling the gaps in research on this topic. Research suggests that social economic responsibility, social political responsibility, social cultural responsibility, social construction responsibility, and social ecological responsibility constitute the CSR system of professional sports clubs in China. Within a certain range, the larger the scale and stronger the comprehensive strength of a club, the stronger its ability to fulfill its responsibilities, the more targets it fulfills, and the richer its content. The institutional environment and social awareness may account for this difference, and in a government-led social environment or in the case of nationalized club ownership, the Chinese plan may be more applicable. Our research not only provides theoretical reference for subsequent research on the CSR content of professional sports clubs but also helps guide the CSR practice of clubs of different sizes, thereby promoting the exploration of diversified CSR development patterns of professional sports clubs in the academic community. (shrink)

The deduction of categories in the 1781 edition of the Critique of the Pure Reason (A Deduction) has “two sides”—the “objective deduction” and the “subjective deduction”. Kant seems ambivalent about the latter deduction. I treat it as a significant episode of Kant’s thinking about categories that extended from the early 1770s to around 1790. It contains his most detailed answer to the question about the origin of categories that he formulated in the 1772 letter to Marcus Herz. The answer is (...) that categories are generated a priori through a kind of intellectual “epigenesis”. This account leaves unexplained why precisely such and such categories should be generated. While this observation caused Kant to worry about the hypothetical status of the subjective deduction in 1781, he would come to acquiesce in the recognition that the ground of the possibility of categories is itself inscrutable. I call this his “methodological skepticism”. (shrink)