As clinical trials end, little is understood about how participants exiting from clinical trials approach decisions related to the removal or post-trial use of investigational brain implants, such as deep brain stimulation (DBS) devices. This empirical bioethics study examines how research participants experience the process of exit from research at the end of clinical trials of implanted neural devices. Using a modified grounded theory study design, we conducted semi-structured, in-depth interviews with 16 former research participants from clinical trials of DBS (...) and responsive neurostimulation (RNS). Open-ended questions elicited motivations for joining the trial, understanding of study procedures at the time of initial informed consent, the process of exiting from research, and decisions about device removal or post-trial device use. Thematic analysis identified categories related to: limited preparedness for the end of research participation, straightforwardness of decisions to explant or keep the device, reconciling with the end of research participation, reconciling post-trial expectations, and achieving a sense of closure after exit from research. A preliminary theoretical model describes contextual factors influencing the process and experience of exit from research. Experiences of clinical trial participants should guide research practices to enhance the ethical design and conduct of clinical trials in DBS and other brain devices. (shrink)

Fried and Kollár constructed a fully faithful functor from the category of graphs to the category of fields. We give a new construction of such a functor and use it to resolve a longstanding open problem in computable model theory, by showing that for every nontrivial countable structure${\cal S}$, there exists a countable field${\cal F}$of arbitrary characteristic with the same essential computable-model-theoretic properties as${\cal S}$. Along the way, we develop a new “computable category theory”, and prove that our functor and (...) its partially defined inverse are computable functors. (shrink)

State concussion laws and sport-league policies are important tools for protecting public health, but also present implementation challenges. Both state laws and league policies often require athletes provide written acknowledgement of having received concussion-related information and/or of their responsibility to report concussion-related symptoms. This paper examines these requirements in two ways: an analysis of the variation in state laws and sport-league policies and a study of their effects in a cohort of collegiate football players.

Medical-legal partnerships connect legal advocates to healthcare providers and settings. Maintaining effectiveness of medical-legal partnerships and consistently identifying opportunities for innovation and adaptation takes intentionality and effort. In this paper, we discuss ways in which our use of data and quality improvement methods have facilitated advocacy at both patient (client) and population levels as we collectively pursue better, more equitable outcomes.

Several researchers point to disorganized attachment as a core feature of borderline personality disorder (BPD). However, recent studies suggest that specific internal working models (IWMs) of each parent combine to account for child outcomes and that a secure relationship with one parent can protect against the deleterious effects of an insecure relationship with the other parent. It was thus hypothesized that adolescents with BPD are more likely to be disorganized with both their parents, whereas non-clinical controls are more secure with (...) at least one of their caregivers. Thirty-six adolescents with BPD and 30 control participants (aged 13-19) were included. Psychiatrist diagnosis was verified with the SIDP-IV and comorbidity was assessed using the Kiddie-SADS. Reported trauma was assessed with the Childhood Trauma Questionnaire. Attachment IWMs of each parent were assessed with the Attachment Multiple Model Interview (AMMI), which enables separate coding for each attachment figure and in which disorganization is conceptualized as conflicting attachment strategies within a specific relationship. Results of a logistic regression analysis suggested that beyond insecure attachment, being disorganized not just with one but with both parents is particularly characteristic of adolescents with BPD. Conversely, belonging to the non-clinical group was predicted by higher security scores with the father and lower deactivation with the mother. Although higher levels of childhood abuse or neglect were reported by adolescents with BPD, the retained attachment dimensions predicted group membership over and above reported trauma. These findings have important implications for clinical intervention and highlight the protective role fathers may have. (shrink)

The Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans was first developed to establish a standard of practice in research ethics by the three federal agencies responsible for funding institutional research in Canada: Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council, and Social Sciences and Humanities Research Council. In 2010, a second edition of the policy, known as the TCPS 2, was released with updated information and expanded coverage of research ethics issues. According to the TCPS (...) 2, the Agencies’ mandate is “to promote research that is conducted according to the highest ethical standards,” and the TCPS 2 serves as a benchmark for this with respect for human dignity as its underlying value. Research institutions receiving Agency funding are to comply with this policy statement by forming Research Ethics Boards to review all research involving human participants. The intention behind this review requirement is to provide a proportionate assessment of the benefit-to-risk ratio of the research, and in that process, to safeguard “respect for persons”, express a “concern for welfare”, and uphold “justice”. Research may not proceed until ethics approval is granted by an institution’s REB. The current study evaluates REB members’ perspectives on their knowledge of research ethics, and juxtaposes these perceptions with those of researchers. Specifically, we are interested in the extent to which REB members with less experience read the TCPS 2, and whether those with less experience have decreased confidence in their ethics knowledge. (shrink)

PurposePrevious studies examining the relationship between health-related quality of life and speech perception ability in cochlear implant users have yielded variable results, due to a range of factors, such as a variety of different HRQoL questionnaires and CI speech testing materials in addition to CI configuration. In order to decrease inherent variability and better understand the relationship between these measures in CI users, we administered a commonly used clinical CI speech testing battery as well as two popular HRQoL questionnaires in (...) bimodal and bilateral CI users.MethodsThe Glasgow Benefit Inventory, a modified five-factor version of the GBI, and the Nijmegen Cochlear Implant Questionnaire were administered to 25 CI users. Speech perception abilities were measured with the AzBio sentence test in several conditions.ResultsHigher performance scores on the GBI general subscore were related to greater binaural speech perception ability in noise. There were no other relationships between the GBI or NCIQ and speech perception ability under any condition. Scores on many of the GBI-5F factors were substantially skewed and asymmetrical; therefore, correlational analyses could not be applied. Across all participants, binaural speech perception scores were greater than first-ear CI only scores.ConclusionThe GBI general subscore was related to binaural speech perception, which is considered the everyday listening condition of bimodal and bilateral CI users, in noise; while the more CI-specific NCIQ did not relate to speech perception ability in any listening condition. Future research exploring the relationships between the GBI, GBI-5F, and NCIQ considering bimodal and bilateral CI configurations separately is warranted. (shrink)

Objectives To characterize the prevalence and content of pediatric triage policies.Methods We surveyed and solicited policies from U.S. hospitals with pediatric intensive care units. Policies were analyzed using qualitative methods and coded by 2 investigators.Results Thirty-four of 120 institutions (28%) responded. Twenty-five (74%) were freestanding children’s hospitals and 9 (26%) were hospitals within a hospital. Nine (26%) had approved policies, 9 (26%) had draft policies, 5 (14%) were developing policies, and 7 (20%) did not have policies. Nineteen (68%) institutions shared (...) their approved or draft policy. Eight (42%) of those policies included neonates. The polices identified 0 to 5 (median 2) factors to prioritize patients. The most common factors were short- (17, 90%) and long- (14, 74%) term predicted mortality. Pediatric scoring systems included Pediatric Logistic Organ Dysfunction-2 (12, 63%) and Score for Neonatal Acute Physiology and Perinatal Extensions-II (4, 21%). Thirteen (68%) policies described a formal algorithm. The most common tiebreakers were random/lottery (10, 71%) and life cycles (9, 64%). The majority (15, 79%) of policies specified the roles of triage team members and 13 (68%) precluded those participating in patient care from making triage decisions.Conclusions While many institutions still do not have pediatric triage policies, there appears to be a trend among those with policies to utilize a formal algorithm that focuses on short- and long-term predicted mortality and that incorporates age-appropriate scoring systems. Additional work is needed to expand access to pediatric-specific policies, to validate scoring systems, and to address health disparities. (shrink)

This paper explores the analysis of ability, where ability is to be understood in the epistemic sense—in contrast to what might be called a causal sense. There are plenty of cases where an agent is able to perform an action that guarantees a given result even though she does not know which of her actions guarantees that result. Such an agent possesses the causal ability but lacks the epistemic ability. The standard analysis of such epistemic abilities relies on the notion (...) of action types—as opposed to action tokens—and then posits that an agent has the epistemic ability to do something if and only if there is an action type available to her that she knows guarantees it. We show that these action types are not needed: we present a formalism without action types that can simulate analyzes of epistemic ability that rely on action types. Our formalism is a standard epistemic extension of the theory of “seeing to it that”, which arose from a modal tradition in the logic of action. (shrink)

The paper analyzes the factors that brand engagement produces in the growth of a brand, studying the values of creating emotional bonds to retain customers and develop consumer cultures. The PACARI brand is taken as a reference, which has international recognition, managing to position Ecuador as the country where the best chocolate in the world originates. The objective is to analyze the impact of PACARI and its connection in ethical consumption, where the brand has generated impact from the word of (...) mouth marketing that it creates from influencers, and the commitment with its interest groups. (shrink)

We study the notion of weak one-basedness introduced in recent work of Berenstein and Vassiliev. Our main results are that this notion characterizes linearity in the setting of geometric þ-rank 1structures and that lovely pairs of weakly one-based geometric þ-rank 1 structures are weakly one-based with respect to þ-independence. We also study geometries arising from infinite-dimensional vector spaces over division rings.

We explore some topics in the model theory of sheaves of modules. First we describe the formal language that we use. Then we present some examples of sheaves obtained from quivers. These, and other examples, will serve as illustrations and as counterexamples. Then we investigate the notion of strong minimality from model theory to see what it means in this context. We also look briefly at the relation between global, local and pointwise versions of properties related to acyclicity.

Language is highly dynamic: It unfolds over time, and we can use it to achieve a wide variety of communicative goals, from telling a story to trying to persuade another person. One aspect of language that has gained increasing popularity among researchers in the last several decades is the individual language style (LS) represented by an individual’s use of function words (e.g., pronouns, articles). Previous approaches to LS mostly focus on LS of one individual in isolation, paying less attention to (...) the fact that language emerges from interaction with others. The aim of this paper is twofold: First, we integrate LS into a dynamical theoretical framework and present an innovative methodological approach. Second, this paper aims to address how interactive conversation—as an aspect of the communicative setting—changes an individual’s LS. We use recurrence quantification analysis to look at structure in patterns of LS in monologs and conversations of 118 participants. Our results showed that LS significantly differs from monolog to conversation, and post hoc analyses further revealed that the change in LS is greater for conflict than for friendly conversations. The difference between monologs and conversations is reflected more strongly in the dynamics (i.e., structure and complexity) of LS than the proportion of function words used. Theoretical implications and directions for future studies are discussed. (shrink)

Research within the H2020 PROGRESSIVE project has identified good practices in user co-production strategies and methodologies. Early findings from research in the PROGRESSIVE project were shared with relevant stakeholders outside the consortium for consultation and review. The outcomes of that initial investigation highlighted the need to focus on the objectives, processes, and methods used in user and older people co-production. This guide adapts these insights and makes them relevant specifically for standardisation in ICT for active and healthy ageing. This guide (...) was approved by representatives of the PROGRESSIVE project on 22 February 2018. The consortium has requested comments from interested stakeholders in an enquiry from 1 March to 30 April 2018. The PROGRESSIVE guide was approved on 5 June 2018. (shrink)

In this paper, we put forward an interdisciplinary framework describing different levels of self-representations, namely non-conceptual, conceptual and propositional self-representations. We argue that these different levels of self-representation are differently affected by cultural upbringing: while propositional self-representations rely on “theoretical” concepts and are thus strongly influenced by cultural upbringing, non-conceptual self-representations are uniform across cultures and thus universal. This differentiation offers a theoretical specification of the distinction between an independent and interdependent self-construal put forward in cross-cultural psychology. Hence, this does (...) not only allow for a deeper understanding of different self-conceptions, but also for a formulation of new hypotheses regarding the cultural influence on self-representations. As one example, we will highlight the role of the proposed levels of self-representation for emotional experience and formulate some major implications of our interdisciplinary framework for future empirical research. (shrink)

O presente texto parte de um diálogo com um artigo publicado recentemente na revista HOPOS (Journal of the International Society for the History of Philosophy of Science), de autoria dos pesquisadores Fons Dewulf e Massimiliano Simons, intitulado “Positivism in Action: The case of Louis Rougier” (2020). No artigo, os pesquisadores abordam a trajetória pouco frequentada de Louis Rougier, filósofo francês cuja fortuna crítica associou-se à sua participação na rede de intelectuais liberais do pós-guerra e a sua função central na organização (...) do Colóquio Walter Lippmann, ainda em 1938. Os autores abordam a trajetória de Rougier de maneira disciplinarmente inusual: procuram interpretar suas teorias filosóficas à luz de seus comprometimentos políticos, defendendo uma imbricação entre ambas as facetas do pensamento de Rougier. Quero sugerir que uma abordagem disposta a compreender as relações dinâmicas entre uma trajetória intelectual e seu entorno social se beneficia de uma abordagem como essa, às quais pode ser acrescida uma dimensão propriamente institucional das trajetórias intelectuais. Para observá-la, proponho acionar o debate sobre virtudes epistêmicas tal como tem sido pensado por autores como Herman Paul, Lorraine Daston e J. Dongen, com o objetivo de investigar se o debate sobre as non-textual things da atividade intelectual podem ser um caminho para transitar de forma profícua entre texto e contexto. Palavras-chave: Virtudes epistêmicas. História da Filosofia. Louis Rougier. Liberalismo. (shrink)

The present essay analyzes the reflections on the ontology of cinema in the works of Stanley Cavell. In particular, it highlights the way in which Cavell foresees in the philosophy of ordinary language as in Hollywood comedy, as many forms of that effort of redemption from the human condition which he calls skepticism, understood not so much as a philosophical position but rather as an underlying condition, as a reaction to the knowledge conceived as human knowledge, that is, experienced as (...) potentially imperfect. Cinema, therefore, turns into an unveiling of the inadequacy of systematic philosophical frameworks and underlines the insufficiency of the interpretative patterns of research that either end up at an intellectualistic level or return, instead, to a mystic-intuitionist one. (shrink)

Defending first-person introspective access to own mental states, we argue against Carruthers' claim of mindreading being prior to meta-cognition and for a fundamental difference between how we understand our own and others' mental states. We conclude that a model based on one mechanism but involving two different kinds of access for self and other is sufficient and more consistent with the evidence.

Previous research suggested a role of gaze in preference formation, not merely as an expression of preference, but also as a causal influence. According to the gaze cascade hypothesis, the longer subjects look at an item, the more likely they are to develop a preference for it. However, to date the connection between viewing and liking has been investigated predominately with self-paced viewing conditions in which the subjects were required to select certain items from simultaneously presented stimuli on the basis (...) of perceived visual attractiveness. Such conditions might promote a default, but non-mandatory connection between viewing and liking. To explore whether the connection is separable, we examined the evaluative processing of single naturalistic food images in a 2 x 2 design, conducted completely within subjects, in which we varied both the type of exposure (self-paced versus time-controlled) and the type of evaluation (non-exclusive versus exclusive). In the self-paced exclusive evaluation, longer viewing was associated with a higher likelihood of a positive evaluation. However, in the self-paced non-exclusive evaluation, the trend reversed such that longer viewing durations were associated with lesser ratings. Furthermore, in the time-controlled tasks, both with non-exclusive and exclusive evaluation, there was no significant relationship between the viewing duration and the evaluation. The overall pattern of results was consistent for viewing times measured in terms of exposure duration (i.e., the duration of stimulus presentation on the screen) and in terms of actual gaze duration (i.e., the amount of time the subject effectively gazed at the stimulus on the screen). The data indicated that viewing does not intrinsically lead to a higher evaluation when evaluating single food images; instead, the relationship between viewing duration and evaluation depends on the type of task. We suggest that self-determination of exposure duration may be a prerequisite for any influence from viewing time on evaluative processing, regardless of whether the influence is facilitative. Moreover, the purported facilitative link between viewing and liking appears to be limited to exclusive evaluation, when only a restricted number of items can be included in a chosen set. (shrink)

The article argues that there are different ways of justifying suspension of judgement. We suspend judgement not only privatively, that is, because we lack evidence, but also positively, that is, because there is evidence that provides reasons for suspending judgement: suspension is more than the rational fallback position in cases of insufficient evidence. The article applies the distinction to recent discussions about the role of suspension for inquiry, Turri's puzzle about withholding, and formal representations of suspension.

The paper develops an inductive extension of AGM-style belief base revision theory with the aim of formally implementing Freitag’s :254–267, 2015, Dialectica 70:185–200, 2016) solution to Goodman’s paradox. It shows that the paradox dissolves once belief revision takes place on inductively closed belief bases, rather than on belief sets.

The book discusses the central notion of logic: the concept of logical consequence. It shows that the classical definition of consequence as truth preservation in all models must be restricted to all admissible models. The challenge for the philosophy of logic is therefore to supplement the definition with a criterion for admissible models. -/- The problem of logical constants, so prominent in the current debate, constitutes but a special case of this much more general demarcation problem. The book explores the (...) various dimensions of the problem of admissible models and argues that standard responses are unwarranted. As a result, it develops a new vision of logic, suggesting in particular that logic is deeply imbued with metaphysics. (shrink)