Surgical resection of a primary tumour is often not sufficient to cure a patient. Even when no residual cancer can be detected at time of surgery, metastases may appear in the following years, which indicates that the primary tumour had apparently spread before surgery. Following surgery, systemic chemotherapy may be used to eradicate micro‐metastatic disease. Here we present two unconventional strategies that implement new insights into tumour biology and tumour immunology in the treatment of patients with cancer. Both experimental strategies (...) use the individual characteristics of the patient's primary tumour to optimise the control of life‐threatening micro‐metastases. We aim to modulate the patient's adaptive immune system, targeting it towards the patient's own tumour cells to eradicate residual disease following local treatment. In one approach, this is done by autologous tumour cell vaccinations as adjuvant treatment for colon cancer patients and, in a second approach, by giving chemo‐imunotherapy before local treatment to women with locally advanced breast cancer. BioEssays 25:79–86, 2003. © 2002 Wiley Periodicals, Inc. (shrink)

The study of conscious experience has seen remarkable strides in the last ten years, reflecting important technological breakthroughs and the enormous efforts of researchers in disciplines as varied as neuroscience, cognitive science, and philosophy. Although still embroiled in debate, scientists are now beginning to find common ground in their understanding of consciousness, which may pave the way for a unified explanation of how and why we experience and understand the world around us. Written by eminent psychologist Bernard J. Baars, (...) In the Theater of Consciousness: The Workspace of the Mind brings us to the frontlines of this exciting discipline, offering the general reader a fascinating overview of how top scientists currently understand the processes underlying conscious experience. Combining psychology with brain science, Baars brilliantly brings his subject to life with a metaphor that has been used to understand consciousness since the time of Aristotle--the mind as theater. Here consciousness is seen as a "stage" on which our sensations, perceptions, thoughts, and feelings play to a vast, silent audience. Behind the scenes, silent context operators shape conscious experience; they include implicit expectations, self systems, and scene setters. Using this framework, Baars presents compelling evidence that human consciousness rides on top of biologically ancient mechanisms. In humans it manifests itself in inner speech, imagery, perception, and voluntary control of thought and action. Topics like hypnosis, absorbed states of mind, adaptation to trauma, and the human propensity to project expectations on uncertainty, all fit into the expanded theater metaphor. As Baars explores our present understanding of the mind, he takes us to the top laboratories around the world, where we witness some of the field's most exciting breakthroughs and discoveries. And throughout the book, Baars has sprinkled numerous and often highly amusing on-the-spot demonstrations that illuminate the ideas under discussion. Understanding consciousness is perhaps the most difficult puzzle facing the sciences today. In the Theater of Consciousness offers an invaluable introduction to the field, brilliantly weaving together the various theories that have emerged as scientists continue their quest to uncover the profound mysteries of the mind--and of human nature itself. (shrink)

I: Environmental aesthetics -- A phenomenological aesthetics of environment -- Aesthetic dimensions of environmental design -- Down the garden path -- The wilderness city : a study of metaphorical experience -- Aesthetics of the coastal environment -- The world from the water -- Is there life in virtual space? -- Is greasy lake a place? -- Embodied music -- II: Social aesthetics -- The idea of a cultural aesthetic -- The social evaluation of art -- Subsidization of art as social (...) policy -- Morality and the artist : toward an ethics of art -- Getting along beautifully : ideas for a social aesthetics. (shrink)

Written by eminent psychologist Bernard J. Baars, this book brings us to the frontlines of the consciousness debate, offering the general reader a fascinating overview of how top scientists currently understand the processes underlying conscious experience. The study of conscious experience has seen remarkable strides in the last ten years, reflecting important technological breakthroughs and the enormous efforts of researchers in disciplines as varied as neuroscience, cognitive science, and philosophy. Scientists are just now beginning to find common ground in (...) their understanding of consciousness, which may pave the way for a unified explanation of how and why we experience and understand the world around us. This book offers an invaluable introduction to the field, brilliantly weaving together the various theories that have emerged as scientists continue their quest to uncover the profound mysteries of the mind--and of human nature itself. (shrink)

ABSTRACT:In a series of reports the United Nations Special Representative on the issue of Human Rights and Transnational Corporations has emphasized a tripartite framework regarding business and human rights that includes the state “duty to protect,” the TNC “responsibility to respect,” and “appropriate remedies” for human rights violations. This article examines the recent history of UN initiatives regarding business and human rights and places the tripartite framework in historical context. Three approaches to human rights are distinguished: moral, political, and legal. (...) It is argued that the tripartite framework’s grounding of the responsibility of TNCs to respect human rights is properly understood as moral and not merely as a political or legal duty. A moral account of the duty of TNCs to respect basic human rights is defended and contrasted with a merely strategic approach. The main conclusion of the article is that only a moral account of the basic human rights duties of TNCs provides a sufficiently deep justification of “the corporate responsibility to respect human rights” feature of the tripartite framework. (shrink)

Conscious experience is one of the most difficult and thorny problems in psychological science. Its study has been neglected for many years, either because it was thought to be too difficult, or because the relevant evidence was thought to be poor. Bernard Baars suggests a way to specify empirical constraints on a theory of consciousness by contrasting well-established conscious phenomena - such as stimulus representations known to be attended, perceptual, and informative - with closely comparable unconscious ones - such (...) as stimulus representations known to be preperceptual, unattended, or habituated. Adducing data to show that consciousness is associated with a kind of global workplace in the nervous system, and that several brain structures are known to behave in accordance with his theory, Baars helps to clarify many difficult problems. (shrink)

Conscious events interact with memory systems in learning, rehearsal and retrieval (Ebbinghaus 1885/1964; Tulving 1985). Here we present hypotheses that arise from the IDA computional model (Franklin,Kelemen and McCauley 1998; Franklin 2001b) of global workspace theory (Baars 1988, 2002). Our primary tool for this exploration is a flexible cognitive cycle employed by the IDA computational model and hypothesized to be a basic element of human cognitive processing. Since cognitive cycles are hypothesized to occur five to tentimes a second and (...) include interaction between conscious contents and several of the memory systems, they provide the means for an exceptionally fine-grained analysis of various cognitive tasks. We apply this tool to the small effect size of subliminal learning compared to supraliminal learning, to process dissociation, to implicit learning, to recognition vs. recall, and to the availability heuristic in recall. The IDA model elucidates the role of consciousness in the updating of perceptual memory, transient episodic memory, and procedural memory. In most cases, memory is hypothesized to interact with conscious events for its normal functioning. The methodology of the paper is unusual in that the hypotheses and explanations presented are derived from an empirically based, but broad and qualitative computational model of human cognition. (shrink)

C’est en grande partie grâce à sa connaissance de l’œuvre de la prophétesse Antoinette Bourignon (1616-1680) que le cartésien Pierre Poiret est devenu un fervent défenseur de la mystique. Après leur rencontre en 1676, Poiret devint son disciple le plus dévoué et l’éditeur en chef de ses écrits. Cependant, à l’époque de leur première rencontre il n’était pas du tout prévu qu’il assume ce rôle. En fait, de nouvelles recherches montrent que pendant deux ans, Bourignon a continué à mettre Poiret (...) à l’épreuve. Les épreuves auxquelles Bourignon l’a soumis ne l’ont pas détourné d’elle, ce qui ne fait que montrer à quel point il la croyait vraiment prophétesse de Dieu. Cet article se concentre d’une part sur l’importance de Bourignon pour Poiret, et d’autre part sur la question de son rôle dans la postérité de cette femme mystique. Qu’est-ce qui l’a poussé à passer dix ans de sa vie au service de Bourignon? (shrink)

When “divided attention” methods were discovered in the 1950s their implications for conscious experience were not widely appreciated. Yet when people process competing streams of sensory input they show both selective processesandclear contrasts between conscious and unconscious events. This paper suggests that the term “attention” may be best applied to theselection and maintenanceof conscious contents and distinguished from consciousness itself. This is consistent with common usage. The operational criteria for selective attention, defined in this way, are entirely different from those (...) used to assess consciousness. To illustrate the scientific usefulness of the distinction it is applied to Posner's brain model of visual attention. It seems that features that are often attributed to attention—like limited capacity—may more accurately be viewed as properties of consciousness. (shrink)

The currently leading cognitive theory of consciousness, Global Workspace Theory,1,2 postulates that the primary functions of consciousness include a global broadcast serving to recruit internal resources with which to deal with the current situation and to modulate several types of learning. In addition, conscious experiences present current conditions and problems to a "self" system, an executive interpreter that is identifiable with brain structures like the frontal lobes and precuneus.1Be it human, animal or artificial, an autonomous agent3 is said to be (...) functionally conscious if its control structure (mind) implements Global Workspace Theory and the LIDA Cognitive Cycle, which includes unconscious memory and control functions needed to integrate the conscious component of the system. We would therefore consider humans, many animals4 and even some virtual or robotic agents5,6 to be functionally conscious. Such entities may approach phenomenal consciousness, as found in human and other biological brains, as additional brain-like features are added.Here we argue that adding mechanisms to produce a stable, coherent perceptual field7 in a LIDA controlled mobile robot might provide a small but significant step toward phenomenal consciousness in machines.>8 We also propose that implementing several of the various notions of self in such a LIDA controlled robot may well prove another step toward phenomenal consciousness in machines. (shrink)

In humans, conscious perception and cognition depends upon the thalamocortical complex, which supports perception, explicit cognition, memory, language, planning, and strategic control. When parts of the T-C system are damaged or stimulated, corresponding effects are found on conscious contents and state, as assessed by reliable reports. In contrast, large regions like cerebellum and basal ganglia can be damaged without affecting conscious cognition directly. Functional brain recordings also show robust activity differences in cortex between experimentally matched conscious and unconscious events. This (...) basic anatomy and physiology is highly conserved in mammals and perhaps ancestral reptiles. While language is absent in other species, homologies in perception, memory, and motor cortex suggest that consciousness of one kind or another may be biologically fundamental and phylogenetically ancient. In humans we infer subjective experiences from behavioral and brain evidence. This evidence is quite similar in other mammals and perhaps some non-mammalian species. On the weight of the biological evidence, therefore, subjectivity may be conserved in species with human-like brains and behavior. (shrink)

In this book, Arnold Davidson elaborates a method for considering the history of concepts and the nature of scientific knowledge, a method he calls "historical epistemology." He applies this to the history of sexuality, with consequences for our understanding of desire, abnormality, and sexuality.

Using a knowledge-based approach, we derive a protocol, MACOM1, for the sequence transmission problem from one agent to a group of agents. The protocol is correct for communication media where deletion and reordering errors may occur. Furthermore, it is shown that after k rounds the agents in the group attain depth k general knowledge about the members of the group and the values of the messages. Then, we adjust this algorithm for multi-agent communication for the process of teamwork. MACOM1 solves (...) the sequence transmission problem from one agent to a group of agents, but does not fully comply with the type of dialogue communication needed for teamwork. The number of messages being communicated per communication between the initiator and the other agents from the group can differ. Furthermore, the teamwork process can require the communication algorithm to handle changes of initiator. We show the adjustments that have to be made to MACOM1 to handle these properties of teamwork. For the new multi-agent communication algorithm, MACOM2, it is shown that the gaining of knowledge required for a successful teamwork process is still guaranteed. (shrink)

Global Workspace Theory (GWT) can be compared to a theater of mind, in which conscious contents resemble a bright spot on the stage of immediate memory, selected by a spotlight of attention under executive guidance. Only the bright spot is conscious; the rest of the theater is dark and unconscious. GWT has been implemented in a number of explicit and testable global workspace models (GWM's). These specific GW models suggest that conscious experiences recruit widely distributed brain functions that are mostly (...) unconscious (unreportable). A large body of new findings support that view. For example, brain experiments show that while unconscious visual stimuli evoke high activity in visual cortex, identical conscious stimuli reveal an additional spread of high brain activity to frontal and parietal lobes (Dehaene, 2001). Similar results have been found for hearing, touch, pain, and sensorimotor skills (Baars, 2002). The conscious waking state supports such fast, flexible, and widespread brain interactions, while unconscious states do not (Baars et al, 2004). These findings illustrate the ability of the GW framework to suggest novel and falsifiable hypotheses. (shrink)

After suggesting an operational definition for fringe experiences—as opposed to clearly conscious and clearly unconscious phenomena—we examine three empirical cases: The tip-of-the-tongue experience, the fringe experience of "wrongness," and the case of conscious focus on abstract, hard-to-image conscious contents. In each case, Mangan′s four major claims are explored in some detail. Most tasks seem to involve a combination of conscious experiences, complex unconscious representations, and multiple fringe experiences. The chief disagreement from this analysis involves vague experiences that are generally believed (...) to be focal: The case of currently topical abstract concepts, which are not reported as conscious images or percepts. In the interest of caution, it may be better to speak of "conscious access" to focal abstract concepts, rather than "conscious experience" of such concepts. There may be other vague but focally conscious phenomena, such as an intention to act, the signal for executing a prepared action, and so on. Mangan′s points are generally supported, with some qualifications. (shrink)

Being able to self-regulate one’s learning is essential for academic success but is also very difficult for students. Especially first year students can be overwhelmed with the high study load and autonomy in higher education. To face this challenge, students’ monitoring and self-regulated learning processes are crucial. Yet, often students are not aware of effective SRL strategies or how to use them. In this study, the use of a mobile application with gamification elements to support first-year university students’ SRL processes (...) was investigated. In Study 1a, the Ace your self-study app was implemented in a first-year psychology course, and students’ SRL skills, motivation, self-efficacy, app use and satisfaction, and performance were measured. The results showed a significant increase in autonomous motivation, controlled motivation, and metacognitive self-regulation skills across the 5-week course. Moreover, students who used the mobile application with gamified elements showed higher autonomous motivation. Nevertheless, most students used the app only for a limited number of self-study sessions. In Study 1b, students’ self-study experiences were captured using focus group interviews to shed some more light on why students did or did not use the app. The results show that if students feel they do not need support for their SRL processes during self-study, they are less inclined to use the app. Specifically, regarding using study strategies, it was found that only if students’ strategies do not work well in their perception, they feel the need to change their way of studying and choose another strategy. These results are discussed in the context of theory on SRL and how to support it. (shrink)

Since the advent of behaviorism the question of volition or "will" has been largely neglected. We consider evidence indicating that two identical behaviors may be quite distinct with respect to volition: For instance, with practice the details of predictable actions become less and less voluntary, even if the behavior itself does not visibly change. Likewise, people can voluntarily imitate involuntary slips they have just made. Such examples suggest that the concept of volition applies not to visible behavior per se, but (...) to the control system that guides behavior. Involuntary events include both automatisms and counter voluntary actions such as slips . An adequate theory of voluntary control must account for the entire set of such pairs of voluntary/involuntary contrasts. The problem of volition highlights core psychological issues. Voluntary acts are consistent with one′s current dominant goals. Volition and consciousness are intimately related. Consciousness of an action seems to recruit unconscious resources that help in planning, executing, and monitoring a voluntary act. Conversely, losing conscious access to an action seems to produce a loss of voluntary control. However, voluntary actions are not wholly conscious. It appears that we only need conscious access to nonroutine choice-points in the flow of control; routine aspects are handled unconsciously. The goals that guide voluntary acts often encounter conflict, either from reality or from other goals, and emotions are widely believed to result from appraisals of such conflicts . Finally, there is a close connection between countervoluntary slips and the symptoms of clinical pathology, which involve a loss of voluntary control over speech, action, feeling, imagery, or thought. A modern version of William James′ ideomotor theory is proposed, based on Global Workspace theory . The theory shows how a conscious goal image could activate unconscious plans and automatisms that shape a voluntary act. Conscious feedback from the act serves to communicate success or failure to many unconscious routines, which may then adapt cooperatively to shape future actions. (shrink)

The standard behavioral index for human consciousness is the ability to report events with accuracy. While this method is routinely used for scientific and medical applications in humans, it is not easy to generalize to other species. Brain evidence may lend itself more easily to comparative testing. Human consciousness involves widespread, relatively fast low-amplitude interactions in the thalamocortical core of the brain, driven by current tasks and conditions. These features have also been found in other mammals, which suggests that consciousness (...) is a major biological adaptation in mammals. We suggest more than a dozen additional properties of human consciousness that may be used to test comparative predictions. Such homologies are necessarily more remote in non-mammals, which do not share the thalamocortical complex. However, as we learn more we may be able to make “deeper” predictions that apply to some birds, reptiles, large-brained invertebrates, and perhaps other species. (shrink)

After suggesting an operational definition for fringe experiences—as opposed to clearly conscious and clearly unconscious phenomena—we examine three empirical cases: The tip-of-the-tongue experience, the fringe experience of "wrongness," and the case of conscious focus on abstract, hard-to-image conscious contents. In each case, Mangan′s four major claims are explored in some detail. Most tasks seem to involve a combination of conscious experiences, complex unconscious representations, and multiple fringe experiences. The chief disagreement from this analysis involves vague experiences that are generally believed (...) to be focal: The case of currently topical abstract concepts, which are not reported as conscious images or percepts. In the interest of caution, it may be better to speak of "conscious access" to focal abstract concepts, rather than "conscious experience" of such concepts. There may be other vague but focally conscious phenomena, such as an intention to act, the signal for executing a prepared action, and so on. Mangan′s points are generally supported, with some qualifications. (shrink)

Aesthetic sensibility rests on perceptual experience and characterizes not only our experience of the arts but our experience of the world. _Sensibility and Sense_ offers a philosophically comprehensive account of humans' social and cultural embeddedness encountered, recognized, and fulfilled as an aesthetic mode of experience. Extending the range of aesthetic experience from the stone of the earth's surface to the celestial sphere, the book focuses on the aesthetic as a dimension of social experience. The guiding idea of pervasive interconnectedness, both (...) social and environmental, leads to an aesthetic critique of the urban environment, the environment of daily life, and of terrorism, and has profound implications for grounding social and political values. The aesthetic emerges as a powerful critical tool for appraising urban culture and political practice. (shrink)

Can we make progress exploring consciousness? Or is it forever beyond human reach? In science we never know the ultimate outcome of the journey. We can only take whatever steps our current knowledge affords. This paper explores today's evidence from the viewpoint of Global Workspace theory. First, we ask what kind of evidence has the most direct bearing on the question. The answer given here is ‘contrastive analysis’ -- a set of paired comparisons between similar conscious and unconscious processes. This (...) body of evidence is already quite large, and constrains any possible theory . Because it involves both conscious and unconscious events, it deals directly with our own subjective experience, as anyone can tell by trying the demonstrations in this article. (shrink)

Environmental aesthetics is an emerging discipline that explores the meaning and influence of environmental perception and experience on human life. Arguing for the idea that environment is not merely a setting for people but is fully integrated and continuous with us, The Aesthetics of Environment explores the aesthetic dimensions of the human-environmental continuum in both theoretical terms and concrete situations. From outer space to the museum, from architecture to landscape, from city to countryside to wilderness, this book discovers in the (...) aesthetic perception of environment the reciprocity that constitutes both person and place. (shrink)

This article applies the Kantian doctrine of respect for persons to the problem of sweatshops. We argue that multinational enterprises are properly regarded as responsible for the practices of their subcontractors and suppliers. We then argue that multinationalenterprises have the following duties in their off-shore manufacturing facilities: to ensure that local labor laws are followed; to refrain from coercion; to meet minimum safety standards; and to provide a living wage for employees. Finally, we consider and reply to the objection that (...) improving health and safety conditions and providing a living wage will cause greater harm than good. (shrink)

Auch seine letzte Monographie Moral und Hypermoral sah Gehlen in der direkten Nachfolge seines anthropologischen Hauptwerkes Der Mensch. Insofern verstand er seinen Entwurf einer pluralistischen Ethik als Konkretisierung seiner Lehre vom Menschen. In diesem Buch, das eine Genealogie der Moralen entwickeln will, stellte sich Gehlen die Aufgabe, Anthropologie, Verhaltensforschung und Soziologie so zu verbinden, dass vier voneinander nicht ableitbare Ethosformen empirisch freigelegt werden konnten: von einem aus der aGegenseitigkeit entwickelten Ethos uber Eudaimonismus und Humanitarismus bis hin zu einem Ethos der (...) Institutionen einschliesslich des Staates. Gehlen wollte der abstrakten Ethik der Aufklarung widersprechen, wie sie beispielsweise in Voltaires Diktum zum Ausdruck kam, nach welchem es nur eine Moral gebe, so wie es nur eine Geometrie gibt. Systematisch geht es in erster Linie um eine anthropologische Begrundung der Ethik, d.h. um eine Mehrheit moralischer Instanzen und Sozial-Regulationen. Diese werden nicht evolutionar interpretiert, d.h. als Fortschritt von der Nahethik zu einer schliesslich weltumspannenden Moralitat. Manche Moralen konnen als instinktnah angenommen werden, andere ergeben sich aus den Notwendigkeiten bestimmter Institutionen. Immer jedoch sind sie kulturell geformt und zugleich auf unterschiedlichen Ebenen der Abstraktion angesiedelt. Es bleibt im Zuge einer neuerlichen Rezeption von Moral und Hypermoral die These zu prufen, ob die Modellvorstellung eines unversohnlichen Pluralismus moralischer Normen eine Dimension des Ethischen zum Ausdruck bringt, die in den evolutiven Konzepten der ethischen Anpassung an je hohere gesellschaftliche Synthesen unterschatzt wird. Insofern gehort dieses Buch in den Zusammenhang einer philosophisch-soziologischen Grundlagenforschung, wie sie seit Max Scheler und Helmuth Plessner als Philosophische Anthropologie durchgefuhrt wurde und welche Arnold Gehlen - von den Elementarbestanden der menschlichen Existenz bis zur Analyse der modernen Malerei - mit so viel Sachhaltigkeit weiterverfolgt hat. (shrink)

Containing the debate between Michel Foucault and Noam Chomsky on epistemology and politics, this book also features the most significant essays by the most important French thinkers who influenced and were influenced by Foucault. Foucault's teachers, colleagues, and collaborators take up his major claims, from his first to final works, and provide us with the authoritative context in which to understand Foucault's writings. This volume also includes several important works by Foucault previously unpublished in English. The other contributors are Georges (...) Canguilhem, Gilles Deleuze, Jacques Derrida, Pierre Hadot, Michel Serres, and Paul Veyne. Here for the first time is the French Foucault. This volume offers lucid and important texts that will appeal to students and professors at every level of study. It is essential reading for all scholars of twentieth-century philosophy and critical theory. (shrink)

Most early studies of consciousness have focused on human subjects. This is understandable, given that humans are capable of reporting accurately the events they experience through language or by way of other kinds of voluntary response. As researchers turn their attention to other animals, “accurate report” methodologies become increasingly difficult to apply. Alternative strategies for amassing evidence for consciousness in non-human species include searching for evolutionary homologies in anatomical substrates and measurement of physiological correlates of conscious states. In addition, creative (...) means must be developed for eliciting behaviors consistent with consciousness. In this paper, we explore whether necessary conditions for consciousness can be established for species as disparate as birds and cephalopods. We conclude that a strong case can be made for avian species and that the case for cephalopods remains open. Nonetheless, a consistent effort should yield new means for interpreting animal behavior. (shrink)

"Arnold Geulincx (1624-1669) est un philosophe flamand, connu en son temps pour ses enseignements dans les universités de Louvain puis de Leyde. Sa pensée, occasionnaliste, est explicitement située dans la ligne tracée par Descartes, mais présente la singularité d'associer une priorité donnée à l'éthique et la thèse d'une influence minimale de l'action humaine dans le monde. Dans son oeuvre dont la notoriété est essentiellement due à une Éthique publiée en 1665 en latin puis traduite par l'auteur en flamand, la (...) Métaphysique, objet quant à elle d'une publication posthume en 1691, occupe une place décisive : Geulincx y développe une métaphysique du sujet originale, centrée sur l'expérience d'une humanité saisie dans ses limites."--Page 4 de la couverture. (shrink)

Kritische analyse van een aantal misvattingen in het huidige economische denken.

The essays, collected by Berleant in this volume all express the impulse to reject the received wisdom of modern aesthetics: that art demands a mode of experience sharply different from others and unique to the aesthetic situation, and that the identity of the aesthetic lies in keeping it distinct from other kinds of human experience, such as the moral, the practical, and the social. Berleant shows, on the contrary, that the value, the insight, the force of art and the aesthetic (...) are all enhanced. (shrink)