Hepatitis B virus infects about 200 million people worldwide yearly. The consequences of the infection range from mild, self‐limiting hepatitis with full recovery and immunity to chronic infection with liver disease of varying severity, including fulminant hepatitis and death. Alternatively, individuals may become healthy carriers of the virus and thus serve as a reservoir of infection. In addition, all chronic carriers of the virus are also at risk for development of primary hepatocellular carcinoma later in life. Efforts to combat this (...) disease on a global scale require an inexpensive vaccine. Studies of the hepatitis B viral coat protein (HBsAg) have permitted the development of two generations of vaccine to date, and detailed structural studies of its antigenic sites may eventually allow the development of a completely synthetic (and therefore inexpensive) vaccine in the future. (shrink)

It is appropriate to open an essay in honor of someone by commemorating that person. When I think of Dallas Willard I think of someone who has not been afraid to point to Jesus and spiritual commitment in an age when most people are committed to themselves. Dallas has been very clear in all of his writings that knowing Jesus is not a hobby, a business transaction one makes and forgets, nor an add-on to life; it is an entry into (...) a journey God is to direct in the context of the uniqueness of His person and the enablement of His rule and presence. The Father leads, Jesus mediates and exemplifies, and the Spirit enables. This commitment to Jesus is the goal of this article. It deals with unique claims about Jesus within the Second Temple Judaism of the first century, as well as looking at what religious life was like in the first century Greco-Roman world. Such background might seem distant in a journal on spiritual formation, but let me warn you that is not the case. To understand the world in which “decisions” for Jesus were made is to appreciate what it took to receive Jesus and begin the journey with Him. The study hopes to show that Willard's emphasis that genuine faith in Jesus is life-changing came with the first century territory. I proceed in three parts: the Jewish context, the Greco-Roman context, and then the application. (shrink)

How to Read the Old Testament. By Etienne Charpentier. Pp.124, London, SCM Press, 1982, £3.95. How to Read the New Testament. By Etienne Charpentier. Pp.129, London, SCM Press, 1982. £3.95. Beginning Old Testament Study. Edited by John Rogerson. Pp.vi, 157, London, SPCK, 1982, £3.95. Welt aus der die Bibel kommt Welt aus der die Bibel kommt: Biblische Hil ‘swissenschaften’. By Mechthild Kellermann, Stanisław Medala, Michele Piccirillo and Eugene Sitarz. Pp.263, Kevelaer, Butzon und Bercker; Stuttgart, Verlag Katholisches Bibelwerk, 1982, DM 28. (...) The Structure of Biblical Myths. The Structure of Biblical Myths. By Heinz Westman. Pp.xxii, 477, Dallas, Spring Publications, 1983, no price given. Toward Old Testament Ethics. Toward Old Testament Ethics. By Walter C. Kaiser, Pp.xii, 345, Grand Rapids, Academie Books, 1983, £13.95. Das Evangelium and die Evangelien. Das Evangelium and die Evangelien. Edited by Peter Stuhlmacher. Pp.viii, 454, Tubingen, J.C.B. Mohr, 1983, DM 178. Once More Astonished Once More Astonished: The Parables of Jesus. By Jan Lambrecht. Pp.xiv, 245, New York, Crossroad Publishing, 1983, $9.95. Mark: The Gospel as Story. Mark: The Gospel as Story. By Ernest Best. Pp.vii, 155, Edinburgh, T & T. Clark, 1983, £8.95. The ‘Son of Man’ as The Son of God. The ‘Son of Man’ as The Son of God. By Seyoon Kim. Pp.x, 118, Tübingen, J.C.B. Mohr, 1983, DM 48. Paul and the Law. Paul and the Law. By Heikki Räisänen. Pp.xi, 320, Tübingen, J.C.B. Mohr, 1983, DM 108. Pauline Christianity. Pauline Christianity. By John Ziesler, Pp.ix, 157, Oxford University Press, 1983, £3.50. God as the Mystery of the World God as the Mystery of the World: On the Foundations of the Theology of the Crucified One in the Dispute between Theism and Atheism. By Eberhard Jüngel, translated by Darrell L. Guder.Pp. xvi, 414, Edinburgh, T. and T. Clark, 1983, £14.95. Theologia: The Fragmentation and Unity of Theological Education. Theologia: The Fragmentation and Unity of Theological Education. By Edward Farley. Pp.xiv, 206, Philadelphia, Fortress Press, 1983, $14.50. Unity in Theology Unity in Theology: Lonergan's Framework for Theology in its New Context. By Michael C. O'Callaghan. Pp.xlii, 553, Lanham, University Press of America, 1980, $24.50, $16.75. Understanding Karl Rahner, vol.1: A Theologian in Search of a Philosophy. Understanding Karl Rahner, vol.1: A Theologian in Search of a Philosophy. By George Vass. Pp.xix, 153, London, Sheed and Ward, 1985, £8.50. Understanding Karl Rahner, vol.2: The Mystery of Man and the Foundations of a Theological System. By George Vass. Pp.xvii, 200, London, Sheed and Ward, 1985, £9.50. Ignatius von Loyola Ignatius von Loyola: Die Exerzitien. By Lothar Lies, Pp. 142, Innsbruck‐Vienna, Tyrolia Verlag, 1983, DM 26. The Name of Christ The Name of Christ: The Names of Jesus Used by the Early Cristians, The Development of the Jesus Prayer. By Irenée Hausherr. Pp.viii, 358, Kalamazoo, Cistercian Publications, 1978, $8.00. The Easter Sermons of Gregory of Nyssa. The Easter Sermons of Gregory of Nyssa. Edited by Andreas Spira and Christopher Klock. Pp.x, 384, Cambridge, The Philadelphia Patristic Foundation, 1981, $10.00. Anonymus in Ecclesiasten Commentarius qui dicitur Catena Trium Patrum. Anonymus in Ecclesiasten Commentarius qui dicitur Catena Trium Patrum. Edited by Santo Lucá. Pp.lvi, 139, Turnhout, Brepols, and Leuven, University Press, 1983, no price given. The Medieval Inquistion. The Medieval Inquistion. By Albert Clement Shannon. Pp viii, 153, Washington D.C., Augustinian College Press, 1983, $10.00. John Calvin. John Calvin. Edited by G.R. Potter and M. Greengrass. Pp.xvi, 176, London, Edward Arnold, 1983, £4.95. When Fathers Ruled. Family Life in Reformation Europe. When Fathers Ruled. Family Life in Reformation Europe. By Steven Ozment. Pp.x, 238, Cambridge, Harvard University Press, 1983, £14.85. The Apocalypse in English Renaissance Thought and Literature. The Apocalypse in English Renaissance Thought and Literature. Edited by C.A. Patrides and Joseph Wittreich. Pp. ix, 452, Manchester University Press, 1984, £37.50. The Contribution of British Writers between 1560 and 1830 to the Interpretation of Revelation 13.16–18. By David Brady, Pp.vii, 335, Tubingen, J.C.B. Mohr, 1983, DM 98. Typologies in England, 1650–1820. Typologies in England, 1650–1820. By Paul J. Korshin. Pp.xvii, 437, Princeton University Press, 1982, £26.10. The Great Debate on Miracles. The Great Debate on Miracles. By R.M. Burns. Pp.305, Lewisburg, Bucknell University Press, 1981, £12.00. Coleridge's Religious Imagination. Coleridge's Religious Imagination. By Stephen Happel. Pp.xii, 943, Salzburg, Institut für Anglistik und Amerikanistik, 1983, no price given. Jacques Maritain and the French Catholic Intellectuals. Jacques Maritain and the French Catholic Intellectuals. By Bernard Doering, Pp.x, 268, Notre Dame, University of Notre Dame Press, 1983, £18.25. Dorothy Day: A Biography. Dorothy Day: A Biography. By William D. Miller. Pp.xv, 527, New York, Harper and Row, 1982, $18.00, $10.50. For God and Clarity: New Essays in Honour of Austin Farrer. For God and Clarity: New Essays in Honour of Austin Farrer. Edited by Jeffrey C. Easton and Ann Loades. Pp.xiii, 205, Allison Park, Pickwick Publications; Edinburgh, T. & T. Clark, 1983, £11.75. God, Free Will, and Morality. God, Free Will, and Morality. By Robert J. Richman. Pp.xi, 195, Dordrecht, D. Reidel, 1983, $36.95. God and Skepticism: A Study in Skepticism and Fideism. God and Skepticism: A Study in Skepticism and Fideism. By Terence Penelhum. Pp.xii, 186, Dordrecht, D. Reidel, 1983, $34.00. Religious Belief and Religious Skepticism. Religious Belief and Religious Skepticism. By Gary Gutting. Pp.xi, 192, Notre Dame, University of Notre Dame Press, 1982, £11.20. A Philosopher's Search for the Infinite. A Philosopher's Search for the Infinite. By Jules M. Brady. Pp.94, New York, Philosophical Library, 1983, $10.00 Realism and Reason: Philosophical Papers, Vol.3. Realism and Reason: Philosophical Papers, Vol.3. By Hilary Putnam. Pp.xviii, 312, Cambridge University Press, 1983, £22.50. Perception, Learning and the Self. Perception, Learning and the Self. By D.W. Hamlyn. Pp.viii, 311, London, Routledge and Kegan Paul, 1982, £14.95. Science and Speculation: Studies in Hellenistic Theory and Practice. Science and Speculation: Studies in Hellenistic Theory and Practice. Edited by Jonathan Barnes. Pp.xxvii, 351, Cambridge University Press, 1983, £25.00. Plato: Hippias Major. Plato: Hippias Major. Translated with a commentary and essay by Paul Woodruff. Pp.xvi, 211, Oxford, Basil Blackwell 1983, £12.50. Max Scheler: The Man and his Work. Max Scheler: The Man and his Work. By John H. Nota, translated by T. Plantinga and J. Nota. Pp.vii, 213, Chicago, Franciscan Herald Press, 1983, $12.00. Searching: Practices and Beliefs of the Religious Cults and Human Potential Groups. Searching: Practices and Beliefs of the Religious Cults and Human Potential Groups. By Harriet S. Mosatche. Pp.432, New York, Straven Educational Press, 1983, £10.95. (shrink)

Increasing global economic integration and recent military interventions in the name of human rights have forced questions of global justice into political discussions. Is the unequal distribution of wealth across the globe just? What's wrong with imperialism? Are the most indebted countries obligated to pay back their loans to international financ.

In a recent contribution to Grazer Philosophische Studien, Booth argues that for S to have an epistemic reason to ψ means that if S ψ's then he will have more true beliefs and less false beliefs than if he does not ψ. After strengthening this external account in response to the objection that one can improve one's epistemic state in other fashions, e.g. by having a gain in true beliefs which outweighs one's gain in false beliefs, I provide a challenge (...) to it. My main objection, which I advance with the aid of several examples, is that such epistemic reasons could not motivate any action whatsoever. I close by developing an alternative account, which avoids this problem by appeal to internal considerations. (shrink)

In this paper I argue that hope is best understood as a compound psychological state. When we take hope according to the details of this account, we are in a good position to understand why it is a political virtue of persons. I also argue that securing the institutional bases of hope is a virtue of state institutions, particularly in states in transition from severe injustice. And, finally, when the bases are secure, a person who fails to hope for the (...) political future is in that regard prima facie blameworthy. (shrink)

After briefly surveying the mission and principles of the World Trade Organization (WTO), I argue that international trade may be assessed from the perspective of justice, and that the correct account of justice for these purposes is egalitarian in fundamental principle. I then consider the merits of the WTO's basic commitment to liberalized trade in the light of egalitarian considerations. Finally, I discuss the justice of several WTO policies. While noting the complexity of the empirical issues relating to the effects (...) of trade institutions and policies, I conclude that egalitarians have reasons to object to certain of the principles and policies of the WTO. (shrink)

"A climate crisis and other pressures on planetary ecology are causing profound anxieties. Climate change threatens to trap hundreds of millions of people in dire poverty and to separate further an already deeply divided world. However, a new generation of activists is offering inspiration, serving as a hope-maker. This book offers an accessible and empirically informed philosophical discussion of climate change, global poverty, justice, and the importance of political responses, both internationally and domestically, that offer hope. There are reasons enough (...) to worry that the era of pervasive human planetary impact, the Anthropocene, could produce terrible global injustices and massive environmental destruction. But that need not be so. Since the Industrial Revolution growth in productive capacity and the egalitarian struggles to share its benefits widely have made another world possible. We still have reason to hope for a world in which international cooperation to manage Earth systems sustainably prevails, in which the natural treasures of the Earth are valued, in which a vision of prosperity is realized and the scourges of disease, ignorance, and poverty are overcome, in which powerful lobbies defending private interests that threaten sustainability are minimized and contained, and in which democratic politics responding to the values of an educated public prevail. The work of bringing about such a world is the work of mobilizing hope"--. (shrink)

This article discusses two doctrines of jus ex bello concerning whether and how to end wars. In Section I, I defend the claim that there is a distinct morality of ending wars. Section II rebuts a challenge that the account is too permissive of war. Section III rejects a forward-looking conception of proportionality for jus ex bello. In Section IV, I allow an exception in cases in which the just cause for the war has changed. In Section V, I defend (...) five principles governing how to end a war. (shrink)

This book examines the threat that climate change poses to the projects of poverty eradication, sustainable development, and biodiversity preservation. It offers a careful discussion of the values that support these projects and a critical evaluation of the normative bases of climate change policy. This book regards climate change policy as a public problem that normative philosophy can shed light on. It assumes that the development of policy should be based on values regarding what is important to respect, preserve, and (...) protect. What sort of climate change policy do we owe the poor of the world who are particularly vulnerable to climate change? Why should our generation take on the burden of mitigating climate change that is caused, in no small part, by emissions from people now dead? What value is lost when natural species go extinct, as they may well do en masse because of climate change? This book presents a broad and inclusive discussion of climate change policy, relevant to those with interests in public policy, development studies, environmental studies, political theory, and moral and political philosophy. (shrink)

Although the Ca2+‐dependent proteinase (calpain) system has been found in every vertebrate cell that has been examined for its presence and has been detected in Drosophila and parasites, the physiological function(s) of this system remains unclear. Calpain activity has been associated with cleavages that alter regulation of various enzyme activities, with remodeling or disassembly of the cell cytoskeleton, and with cleavages of hormone receptors. The mechanism regulating activity of the calpain system in vivo also is unknown. It has been proposed (...) that binding of the calpains to phospholipid in a cell membrane lowers the Ca2+ concentration, [Ca2+], required for the calpains to autolyze, and that autolysis converts an inactive proenzyme into an active protease. Recent studies, however, show that the calpains bind to specific proteins and not to phospholipids, and that binding to cell membranes does not affect the [Ca2+] required for autolysis. It seems likely that calpain activity is regulated by binding of Ca2+ to specific sites on the calpain molecule, with binding to each site eliciting a response (proteolytic activity, calpastatin binding, etc.) specific for that site. Regulation must also involve an, as yet, undiscovered mechanism that increases the affinity of the Ca2+‐binding sites for Ca2+. (shrink)

Thomas Aquinas, one of the "founding fathers" of just war theory, offers an account of virtuous warfare in practice. The author argues that Aquinas's approach to warfare, with its emphasis on justice and charity, is helpful in providing a coherent moral account of war to which Christians can subscribe. Particular attention is given to the role of charity, since this virtue is the distinguishing characteristic of the Christian soldier. Charity compels him to soldier justly, and by fighting justly, he is (...) elevated by God to friendship with God. Notable features of this approach are its emphasis on the criteria for judging whether a war is just and its relativizing of the criteria for proper combat behavior. (shrink)

Abstract:Enlightenment era optimism that technological and educational developments offer a progressive path to plenty and liberation supports a hope that human toil may be progressively reduced. The Development Thesis defended by G. A. Cohen is a piece of that Enlightenment optimism. The Development Thesis holds that productive forces tend to develop throughout history. The tendency for such an increase in productive forces to occur is, according to Cohen’s argument, due to persistent facts about human nature. If Cohen is correct, there (...) is a tendency toward progress of an important sort, and this progress is due in significant part to human nature. But the development of productive forces also destroys nonhuman natural value. In the era of the Anthropocene this is occurring on a planetary scale. The simultaneous development and destruction entails that claims of progress must rely on an all-things-considered judgment. But due to the plurality of the relevant values, which cannot be compared according to a common metric, rational disagreement about the existence of progress and our progressive nature can be expected to persist. (shrink)

Popper’s Critical Rationalism presents Popper’s views on science, knowledge, and inquiry, and examines the significance and tenability of these in light of recent developments in philosophy of science, philosophy of probability, and epistemology. It develops a fresh and novel philosophical position on science, which employs key insights from Popper while rejecting other elements of his philosophy.

Treaty Norms and Climate Change MitigationDarrel MoellendorfCurrently the international community is discussing the regulatory framework to replace the Kyoto Protocol after 2012. The unveiling of the new framework is scheduled to occur at the December 2009 COP in Copenhagen. The stakes are high, since any treaty will affect the development prospects of per capita poor countries and will determine the climate change–related costs borne by poor people for centuries to come. Failure to arrive at an agreement would have grave effects (...) on the development prospects of poor countries, many of which will experience the most severe effects of climate change. The original UNFCCC treaty recognizes these kinds of concerns and requires that further treaty negotiation pay them heed. Any agreement will be required to conform to UNFCCC norms related to sustainable development and the equitable distribution of responsibilities. In this paper I argue that UNFCCC norms tightly constrain the range of acceptable agreements for the distribution of burdens to mitigate climate change. I conclude that any legitimate treaty must put much heavier mitigation burdens on industrialized developed countries. Of the various proposals that have received international attention, two in particular stand out as possibly satisfying UNFCCC norms regarding the distribution of responsibilities. (shrink)