Physicians and other healthcare professionals are increasingly finding ways to use artificial intelligent decision support systems in their work. IBM Watson Health, for example, is a commercially available technology that is providing AI-DDS services in genomics, oncology, healthcare management and more.1 AI’s ability to scan massive amounts of data, detect patterns, and derive solutions from data is vastly more superior than that of humans. AI technology is undeniably integral to the future of healthcare and public health, and thoughtful consideration of (...) the legal, ethical and moral issues surrounding this technology is a must. The authors of the article, Responsibility, Second Opinions, and Peer-Disagreement—Ethical and Epistemological Challenges of Using AI in Clinical Diagnostic Contexts, provide an informed discussion of how AI-DSS may be used, both practically and ethically, to assist healthcare professionals in cooperative diagnostic processes2. The authors propose a process, whereby AI-DSS would provide a physician a second opinion, and when there is a mismatch between opinions, another physician would provide a third opinion. This approach maintains a ‘physician-in-charge’ perspective, and suggests that decision-making must ultimately be made by a person. This approach is also consistent with the ‘physician in-the-loop’ concept, such that even when increasingly autonomous AI-DSSs are put to use, physicians will still be providing checks and overseeing clinical decisions. The authors conceptualise AI as a replacement of human cognitive labour. That is, AI is used to supplant a human professional in particular functions …. (shrink)

Political science faces a challenge from a “Mr. Perestroika,” who decries the hegemony of formal and statistical analysis in the discipline. Although not connected with this movement, Bent Flyvbjerg makes the best case for a renewed dominance for qualitative and case study work throughout the social sciences. This article challenges Flyvbjerg’s call for a phronetic as opposed to an epistemic discipline. It challenges as well the unqualified call for pluralism advocated by many in the perestroika movement. It offers instead an (...) integrated tripartite method in which narrative, statistics, and formal modeling fill in a scientific frame. (shrink)

Controversy has long surrounded the complex relationship between King Victor Emmanuel III and the dictator Benito Mussolini in Fascist Italy. It is clear that the king played decisive roles in bringing Mussolini to power in 1922 and in removing him in 1943. In between, the two coexisted as Italy became a ‘dyarchy’, with two foci of power. The presence of the monarchy at once checked Fascist radicalism and persuaded many conservatives to adhere to the regime. Thanks especially to the monarchy, (...) the innovative thrust of Fascism was channelled in certain delimited directions, toward a statist economy, for example. Still, the relationship between the crown and Mussolini was often rocky, though the king’s reluctance did not prevent alliance with Nazi Germany, anti-Semitism, and war. Tensions were largely papered over by rhetoric and myth-making, as if the elements of Fascism fit together neatly. Despite his opposition to certain particulars, Victor Emmanuel identified with the overall Fascist project to some extent, and he worried that outright opposition to the regime would jeopardize the monarchy. But as the Second World War went badly for Italy, the king finally deposed Mussolini. Nevertheless, Italy soon voted to eliminate the monarchy, discredited by its association with fascism. (shrink)

Informed consent is crucial in most research but written consent is not without its drawbacks. Written consent serves to protect the researcher more than it serves to protect the participant and this can present a barrier to their relationship. In certain circumstances it can undermine the trust important in research. For ‘simple’ studies, where treatments are largely interchangeable or where consent is implied, written consent can be considered not only to be unnecessary, but actually harmful. Research ethics committees should consider (...) removing the requirement for written consent in these studies. (shrink)

For a patient to make an informed decision about participation in research, it is fundamental that they can understand what is involved. COREC has produced a model information sheet and consent form that researchers are encouraged and sometimes forced to use by LRECs. By applying readability statistics to these documents we have shown that the majority of the UK population would not be able to read this proposed text.

Ensuring that research is of high quality and is based on sound ethical principles is not easy; it requires a fine balance between adequate oversight and suitable facilitation. The current state of research ethics governance is an ideal environment to maintain a governance ‘ratchet’ rather than produce a well-organized and carefully thought out ‘dial’.

Following other contributions about the MAX accidents to this journal, this paper explores the role of betrayal and moral injury in safety engineering related to the U.S. federal regulator’s role in approving the Boeing 737MAX—a plane involved in two crashes that together killed 346 people. It discusses the tension between humility and hubris when engineers are faced with complex systems that create ambiguity, uncertain judgements, and equivocal test results from unstructured situations. It considers the relationship between moral injury, principled outrage (...) and rebuke when the technology ends up involved in disasters. It examines the corporate backdrop against which calls for enhanced employee voice are typically made, and argues that when engineers need to rely on various protections and moral inducements to ‘speak up,’ then the ethical essence of engineering—skepticism, testing, checking, and questioning—has already failed. (shrink)

When considering submissions ethics committees should be consistent in all aspects of their review. A wide variation in performance is likely to result in the unfair dismissal of good research on the one hand with inadequate ethical review on the other, neither of which is acceptable. The recent annual reports for UK MRECs suggest that the level of unfavourable opinion ranges from 6.9% to 24.2% Although a certain level of inconsistency is inherent in the system of ethical review there is (...) little research to determine how much of that inconsistency in inevitable and how much of it is the result of poor process. The time has come for high quality research to be done to assess the consistency and hence the validity of ethical review. (shrink)

Describes the features of the Sony Alpha DSLR-A100 camera, with information on such topics as exposure, lighting, lenses, composition, landscape photography, panoramic photography, and editing pictures.

_Draws out numerous affinities between the sophists and Socrates in Plato's dialogues._.

As the latest tool for disseminated information and editorial comment shaping public opinion, blogging is quickly gaining popularity, prominence, and power. One major controversy for the new medium of circulating news and commentary is to what extent or even whether blogs should have codes of ethics. We examined 30 politically-oriented weblogs. Of these, only a few had a code of ethics, stated or implied. Little cohesion existed between the codes of ethics, but a few themes emerged. Qualitative analysis of the (...) codes of ethics shows that what bloggers valued most included accuracy, credibility, and etiquette. We further provide evidence to support the prevailing thought that, while appearing to be “ethical” seems important to bloggers, blogging ethics and credibility are difficult to operationalize. (shrink)

As the latest tool for disseminated information and editorial comment shaping public opinion, blogging is quickly gaining popularity, prominence, and power. One major controversy for the new medium of circulating news and commentary is to what extent or even whether blogs should have codes of ethics. We examined 30 politically-oriented weblogs. Of these, only a few had a code of ethics, stated or implied. Little cohesion existed between the codes of ethics, but a few themes emerged. Qualitative analysis of the (...) codes of ethics shows that what bloggers valued most included accuracy, credibility, and etiquette. We further provide evidence to support the prevailing thought that, while appearing to be "ethical" seems important to bloggers, blogging ethics and credibility are difficult to operationalize. (shrink)

There are presently two modern critical editions of Proclus' commentary on the Parmenides. One, the edition of the Oxford Classical Texts, was completed under the auspices of Carlos Steel in 2009. The other, the Budé edition, under the editorship of Concetta Luna and the late Alain-Philippe Segonds, followed soon after, with the third of the first three books of the commentary having appeared in the early 2012. This most recent two-part volume of the Budé addresses, for the final time it (...) seems, the Budé's criticisms of the OCT edition. The first volume could be well described as a long philippic against the OCT and its editor and contributors, going well beyond the tone of measured academic discourse. Relentlessly, it imprecates the readings of the OCT, the length and tone of which criticisms will not weather time well. However, there is one disagreement between the two editions, perhaps the most textually significant one and certainly the largest, which is noted as a part of a comprehensive list by the Budé, but no discussion ensues. This is all the more curious because Steel had, in a separate article, directly raised objections to their solution to this passage. Why in this single case is the Budé suddenly so taciturn? (shrink)

Here I discuss findings that suggest a universal mechanism for proteins (and RNA) to recognize and interact with various binding partners by selectively binding to different conformations that pre‐exist in the free protein's conformational ensemble. The tandem RNA recognition motif domains of splicing factor U2AF65 fluctuate in solution between a predominately closed conformation in which the RNA binding site of one of the domains is blocked, and a lowly populated open conformation in which both RNA binding pockets are accessible. RNA (...) binding to U2AF65 may thus occur through the weakly populated open conformation, and the binding interaction stabilizes the open conformation. The conformational diversity observed in U2AF65 might also facilitate binding to diverse RNA sequences as found in the polypyrimidine tracts that help define 3′ splice sites. Similar binding pathways in other systems have important consequences in biological regulation, molecular evolution, and information storage. (shrink)

This article assesses Herman Paul's intellectual biography of Hayden White, the most important figure in the philosophy of history of the past half century. Offering a clear overview of White's career and contribution, Paul's account proceeds chronologically from the 1950s to the present, distinguishing the phases of White's career, but convincingly pinpointing an abiding core of concerns around an existentialist and liberationist humanism. In that light, White sought to show the way beyond historiographical realism to more innovative approaches—ideally to serve (...) progressive politics. Paul notes, however, that White failed to connect with most mainstream historians, and Paul's account is not sufficiently probing and critical to explore the gulf. Indeed, following White, Paul is too prone to take White's particular liberationist agenda as the only alternative to a conservative, passive realism—and thereby to gloss over alternative ways of conceiving the postrealist cultural space. Moreover, Paul fails to note White's tendency sometimes to imply that mainstream history claims more than it does, and sometimes to denigrate prejudicially what it in fact does, or could do. Although much of White's challenge could have been especially salutary, he tended toward mischaracterizations that fostered polarization in the historical discipline and reinforced prejudicial understandings of historiography in the wider culture. Paul's overview provides a useful, and in many ways exemplary, introduction to White's legacy, but it is too deferential to provide a convincing overall critical assessment. (shrink)

Philosophers of language have drawn on metamathematical results in varied ways. Extensionalist philosophers have been particularly impressed with two, not unrelated, facts: the existence, due to Frege/Tarski, of a certain sort of semantics, and the seeming absence of intensional contexts from mathematical discourse. The philosophical import of these facts is at best murky. Extensionalists will emphasize the success and clarity of the model theoretic semantics; others will emphasize the relative poverty of the mathematical idiom; still others will question the aptness (...) of the standard extensional semantics for mathematics. In this paper I investigate some implications of the Gödel Second Incompleteness Theorem for these positions. I argue that the realm of mathematics, proof theory in particular, has been a breeding ground for intensionality and that satisfactory intensional semantic theories are implicit in certain rigorous technical accounts. (shrink)

Constructivism is based on the principle that our personalities, behavior, and society are organized by the ways in which we attribute meanings to events, and act upon those meanings. It provides a philosophy, an epistemology, and methods that are especially congruent with the central values of social work, particularly client self-determination. In this volume, Dr. David D.V. Fisher introduces social workers to constructivism, a perspective which is becoming increasingly popular in the social sciences, and which has already been embraced (...) by clinical psychologists, communication researchers, and cyberneticians. Fisher explains constructivism as an epistemology, shows the consequences of adopting a constructivist epistemology in contrast to operating from within the traditional objectivist epistemology, demonstrates the ethical appropriateness and practicality of constructivism for social work, and explicates a number of specific applications of constructivism to social work. The book is divided into two parts. The first part consists of an introduction and then explains and expands the theory of constructivism and its relationship to social work. The second part shows how constructivist principles may be applied in social work practices. Constructivist principles are applied to selected aspects of assessment, intervention, and interviewing--using immediate experience as a guide to action and the creation of professional responsibility. An Introduction to Constructivism for Social Workers will be of particular interest to social workers and psychologists involved in theory and research. (shrink)

There are numerous well-documented problems with the DSM’s polythetic-categorical approach to the delineation of mental disorders. However, the DSM-5 introduces an empirically based dimensional model of personality traits. These traits form a hierarchical structure that represents the organization of dispositions to common mental disorders. We connect emotions to this joint hierarchical structure using a modified set point model, which accommodates major theories linking personality and psychopathology—continuum, risk, scar, and pathoplasty—as well as more dynamic multivariate models. We argue that these traits (...) represent typical causal pathways that can be extracted from a complex web of equifinality and multifinality. Ultimately, research on mood disorders provides a stronger account of their underling traits than the variably endorsed symptoms of their polythetic criteria. (shrink)

Analyzes the ways in which four contemporary novelists depict the rebel and the world that rejects him. Bibliogs.