The limbus is a narrow band of tissue that encircles the cornea, the transparent ‘window’ into the eye. The outermost layer of the cornea is the epithelium, which is necessary for clear vision. The limbus acts as a ‘reservoir’ for limbal stem cells which maintain and regenerate the corneal epithelium. It also functions as a barrier to the conjunctiva and its blood vessels. Limbal stem cell deficiency is a general term for diseases which are characterised by the impairment of the (...) limbus, limbal stem cells and their ability to replenish the corneal epithelium through proliferation and differentiation. Consequently, sufferers experience chronic pain and progressive blindness. This paper will highlight the salient milestones of limbal stem cell biology and potential future treatments for limbal stem cell deficiency. (shrink)

We investigate the timing of pre-answer inbreaths in order to shed light on the time course of response planning and execution in conversational turn-taking. Using acoustic and inductive plethysmography recordings of seven dyadic conversations in Dutch, we show that pre-answer inbreaths in conversation typically begin briefly after the end of questions. We also show that the presence of a pre-answer inbreath usually co-occurs with substantially delayed answers, with a modal latency of 576 vs. 100 ms for answers not preceded by (...) an inbreath. Based on previously reported minimal latencies for internal intercostal activation and the production of speech sounds, we propose that vocal responses, either in the form of a pre-utterance inbreath or of speech proper when an inbreath is not produced, are typically launched in reaction to information present in the last portion of the interlocutor's turn. We also show that short responses are usually made on residual breath, while longer responses are more often preceded by an inbreath. This relation of inbreaths to answer length suggests that by the time an inbreath is launched, typically during the last few hundred milliseconds of the question, the length of the answer is often prepared to some extent. Together, our findings are consistent with a two-stage model of response planning in conversational turn-taking: early planning of content often carried out in overlap with the incoming turn, and late launching of articulation based on the identification of turn-final cues. (shrink)

Depois de estabelecer as características do corpo político ou soberano e destacar a função excepcional do legislador no Livro segundo do Contrato social, e no livro seguinte analisada a incumbência do governo na ordem política, Rousseau, no livro quarto da obra referida, se mobiliza para demonstrar a importância fundamental de algumas instituições para a manutenção dos valores republicanos. Entre as diversas instituições apresentadas pelo filósofo genebrino que visam cumprir esses objetivos, o presente artigo se concentra no exame de três delas: (...) o tribunato, a ditadura e a censura - instituições claramente inspiradas nas instituições romanas no período da Roma republicana. Em vista disso, indagamos: em que consiste o tribunato, a ditadura e a censura no arcabouço teórico de Rousseau? Quais são suas características? Como elas podem contribuir para a conservação da República? Partindo dessas indagações, pretende-se investigar as definições das três instituições elencadas bem como suas particularidades e a maneira como elas operam e podem contribuir para a preservação da República em longo prazo. (shrink)

O problema da desigualdade se apresenta como um constante objeto de reflexão na filosofia de Rousseau, perpassando diversas de suas obras. Buscando analisar a relação entre a desigualdade social e a corrupção política no pensamento rousseauniano mediante a defesa da hipótese de que a desigualdade social se configura em um fenômeno responsável pelo advento da corrupção política, pretende-se, nesse artigo, primeiro: examinar as distinções entre a desigualdade natural e a desigualdade social, ou seja, demarcar suas especificidades e como Rousseau compreende (...) cada uma delas; segundo, avaliar como a desigualdade social pode produzir a corrupção política, isto é, entender porque a desigualdade de riquezas ao produzir o luxo pode consequentemente engendrar a corrupção política, e, terceiro, ambiciona-se demonstrar quais são as consequências mais drásticas da desigualdade social na república. Com isso, almeja-se instaurar um frutífero debate e uma consistente reflexão. (shrink)

No presente trabalho buscou-se realizar uma pesquisa a respeito de algumas características elementares do humanismo na tradição marxista - particularmente reveladas por Marx nas suas obras de juventude - e bem assim procurou-se efetuar um levantamento da crítica que lhe tem sido oposta por autores comprometidos com uma visão antropológica cristã.

Neste artigo visa-se demarcar os intercursos da ética do discurso de Habermas e da psicologia genética de Lawrence Kohlberg. Se, por um lado, para o filósofo alemão a sua proposta ética pode contribuir para suprir os déficits da psicologia genética em relação ao desenvolvimento moral, por outro lado, a ética do discurso se apoia nas pesquisas empíricas realizadas pelos teóricos da psicologia e, com isso, reforçam a tese da universalidade ética defendida por Habermas e Carl Otto-Apel. No entanto, há limites (...) na demarcação da filosofia e da psicologia por se tratar de campos nos quais as metodologias não se identificam e por assumirem perspectivas epistemológicas distintas, descritiva para a psicologia do desenvolvimento e prescritiva para a ética do discurso. Ainda assim, a filosofia de Habermas pretende estabelecer uma relação com campos distintos de saberes, a partir dos quais garante a interdisciplinaridade e a abertura para o diálogo constante entre saberes diversos. (shrink)

O pensamento de Cícero inaugura o republicanismo romano e se apresenta como uma reflexão política que busca analisar questões primordiais para a República, tendo Roma Antiga como referência. Amiúde, verifica-se nesse pensamento a utilização de exemplos da vida política real com o intuito de formular uma crítica ao regime romano. O presente artigo tem como propósito central, por meio da investigação de um problema de gravidade incontestável: a corrupção política, examinar o republicanismo de Cícero mediante suas noções fundamentais. Assim, teremos (...) três objetivos: primeiro, compreender a concepção de República alicerçada na virtude, no interesse comum e na justiça; o segundo, avaliar as razões pelas quais a igualdade e a liberdade se inscrevem como suportes indispensáveis no referido regime político; e, o terceiro, analisar como Cícero define a corrupção política, a maneira como ela penetra na República e suas prováveis consequências. (shrink)

Resumo Ao encerrar a sua explicação concernente à noção de Lei, no capítulo VI do segundo livro do Contrato social, Jean-Jacques Rousseau apresenta algumas inquietações referentes à capacidade de uma população prematura elaborar um sistema de legislação. Tais inquietações conduzem o pensador genebrino a preconizar a necessidade de uma figura polêmica e excepcional, na engrenagem política republicana: o legislador. Considerando a excepcionalidade dessa figura, o presente artigo sustentará a hipótese de que, mais do que alguém hábil em formular um conjunto (...) de leis para um determinado povo, a função republicana primordial de um legislador é a de contribuir para engendrar um espírito público em cada cidadão pertencente à república. A hipótese aventada será defendida a partir de três objetivos: primeiro, examinar-se-ão as razões pelas quais Rousseau julga ser necessário um legislador na ordenação republicana; segundo, analisar-se-á por que a construção de um espírito público pelo legislador pode ser considerada uma função republicana; terceiro, perscrutar-se-ão quais são as condições necessárias para um povo receber uma boa legislação.In closing his explanation concerning the notion of law, in chapter VI of the second book of the Social contract, Jean-Jacques Rousseau has some concerns about the ability of a premature population to develop a legislation system. Such concerns lead the Genevan thinker to advocate the need for a controversial and exceptional personage in the republican political machinery: The legislator. Considering the exceptionality of this personage, this article will support the hypothesis that, more than being one skilled at presenting a set of laws to a particular people, the primary republican function assigned to the legislator is to contribute to engender a public spirit in every citizen belonging to the republic. The hypothesis presented will be defended from three objectives: first, I shall examine the reasons why Rousseau deems it necessary to have a legislator in the republican order; Second, I shall analyze why the construction of a public spirit by the legislator may be considered a republican function; third, I shall look into the conditions necessary for a people to receive a good legislation. (shrink)

A virtude cívica representa uma peça de fundamental importância na engrenagem política republicana e pode desempenhar uma função decisiva na manutenção da república. Mas, como a virtude cívica se apresenta no republicanismo de Rousseau? Como tornar os cidadãos virtuosos e de que maneira cidadãos dotados dessa aptidão ou disposição podem contribuir para a preservação da república em longo prazo? Tais questões servirão de fio condutor para analisarmos a noção de virtude no arcabouço teórico rousseauísta. Para tanto, nossa análise será dividida (...) em três momentos: primeiro, examinaremos como o conceito de virtude se inscreve no pensamento de Rousseau; segundo, avaliaremos o meio ou meios possíveis para se formar cidadãos virtuosos; terceiro, perscrutaremos como a virtude cívica pode contribuir para a manutenção da república. (shrink)

The core niche for language use is in verbal interaction, involving the rapid exchange of turns at talking. This paper reviews the extensive literature about this system, adding new statistical analyses of behavioral data where they have been missing, demonstrating that turn-taking has the systematic properties originally noted by Sacks et al. (1974 ; hereafter SSJ). This system poses some significant puzzles for current theories of language processing: the gaps between turns are short (of the order of 200 ms), but (...) the latencies involved in language production are much longer (over 600 ms). This seems to imply that participants in conversation must predict (or ‘project’ as SSJ have it) the end of the current speaker’s turn in order to prepare their response in advance. This in turn implies some overlap between production and comprehension despite their use of common processing resources. Collecting together what is known behaviorally and experimentally about the system, the space for systematic explanations of language processing for conversation can be significantly narrowed, and we sketch some first model of the mental processes involved for the participant preparing to speak next. (shrink)

El siguiente trabajo se enmarca en una investigación acerca de las fuentes históricofilosóficas que dan cuenta de los fundamentos de la tendencia de la filosofía a interpretarse a sí misma como una ciencia. Hemos tomado algunos de los diálogos socráticos de Platón para pesquisar cómo opera esto ahí, cuál es su motivación última y cuál su sentido. El supuesto básico es que cabe, en algún sentido, pensar la actividad filosófica como un “saber del saber”. El hilo conductor lo constituye el (...) examen de ciertos pasajes ejemplares en donde aparece la llamada “analogía del arte”, a través de la cual se ponen al descubierto ciertos caracteres esenciales del saber. Finalmente se concluye que la motivación de un “saber referido al saber” no puede ser “epistemológica” sino fundada en la preocupación por alcanzar una vida de excelencia. (shrink)

The data showed in this review exposes basic aspects that define organic foods and some factors that influence consumption by the population, ie, its production in the country and the motivations for the consumption of food produced in this system. This way of production, originated in the early decades in the 20th century, nowadays involves environmental, social and health aspects. Although the environment is a more evident aspect than other ones, economic output and potential beneficial to health are discussed further (...) in this description about organic foods. Brazil, has excelled in the growth of this type of farming, however holds the 6th position in the world and 2nd producer in Latin America, with grains and vegetables being the main products, although the livestock reaches the largest area. The consumption of these products is primarily motivated by the perception of organic food as healthier than other kinds of food. However, there are no conclusive studies about better nutritional value, where nutrient concentrations are often unchanged. In contrast the presence of more phytochemicals compounds and reduced pesticides’ content in vegetables, and lipid profile in animal products can justify the health benefits of the products obtained from the organic production system. (shrink)

This article proposes to analyse some aspects of the appropriation of New School thinking in Brazil, particularly Deweyan pragmatism, in the 1950s and 1960s. The analysis is based on the assumption that the developmentalist ideology that punctuated the debate on the economic, political and social restructuring of the country in these two decades constituted fertile ground for the return and expansion of pragmatist thinking amongst Brazilian educators, articulating itself, sometimes in contradictory ways, with this ideology. The focus of the analysis (...) will be on the writings of the group of educators which circulated around the figure of Anísio Teixeira, at the time director of the National Institute for Pedagogic Studies, an organ linked to the Ministry of Education and Culture, which set itself the task of producing research that would support public policy in the field of education, as well as constituting itself as a center for teacher education and the stimulus and development of innovative experiences in the public school system. The appropriation of Deweyan pragmatism, in this context, had a triple perspective: pragmatism as scientific method, implying a specific conception of science, particularly the social sciences, with emphasis on the application of scientific knowledge in the solution of practical problems; as a way of democratic life; and as a synonym for experimentalism, in the sphere of schooling. (shrink)

Traces scholarly thought from the nineteenth-century birth of evolutionary biology to the mapping of the human genome through forty-eight essays, arranged in chronological order, each preceded by a one-page essay that explains the significance of the chosen work.

Traces scholarly thought from the nineteenth-century birth of evolutionary biology to the mapping of the human genome through forty-eight essays, arranged in chronological order, each preceded by a one-page essay that explains the significance of the chosen work.

The Concussion in Sport Group guidelines have successfully brought the attention of brain injuries to the global medical and sport research communities, and has significantly impacted brain injury-related practices and rules of international sport. Despite being the global repository of state-of-the-art science, diagnostic tools and guides to clinical practice, the ensuing consensus statements remain the object of ethical and sociocultural criticism. The purpose of this paper is to bring to bear a broad range of multidisciplinary challenges to the processes and (...) products of sport-related concussion movement. We identify lacunae in scientific research and clinical guidance in relation to age, disability, gender and race. We also identify, through multidisciplinary and interdisciplinary analysis, a range of ethical problems resulting from conflicts of interest, processes of attributing expertise in sport-related concussion, unjustifiably narrow methodological control and insufficient athlete engagement in research and policy development. We argue that the sport and exercise medicine community need to augment the existing research and practice foci to understand these problems more holistically and, in turn, provide guidance and recommendations that help sport clinicians better care for brain-injured athletes. (shrink)

In his pioneering work in the field of inductive inference, Gold (Inf Control 10:447–474, 1967) proved that a set containing all finite languages and at least one infinite language over the same fixed alphabet is not identifiable in the limit (learnable in the exact sense) from complete texts. Gold’s work paved the way for computational learning theories of language and has implications for two linguistically relevant classes in the Chomsky hierarchy (cf. Chomsky in Inf Control 2:137–167, 1959, Chomsky in Knowledge (...) of language: its nature, origin, and use, Praeger, 1986; Shieber in Linguist Philos 8:333–343, 1985; Heinz in Linguist Inq 41:623–661, 2010). Within that same framework, Angluin (Inf Control 45:117–135, 1980) provided a complete characterization for the learnability of language families. Mathematically, the concept of identification in the limit from that classical setting can be seen as the use of a particular type of metric for learning in the limit (Wharton in Inf Control 26:236–255, 1974). In this research note, I use Niyogi’s extended version of a theorem by Blum and Blum (Inf Control 28:125–155, 1975) on the existence of locking data sets to prove a necessary condition for learnability in the limit of any family of languages with the Gold property in any given metric. This recovers the most general version of Gold’s Theorem as a particular case. Moreover, when the language family is further assumed to contain all finite languages, the same condition also becomes sufficient for learnability in the limit. Finally, we discuss questions that are left open and outline a research program regarding language learnability in the limit from other input types and cognitive feasibility. (shrink)

How can a work of art give us clues about scientific aspects? How can chemistry help a painter enhance his creativity and, above all, preserve the original characteristics of his work? Does an artist require scientific knowledge to innovate or, at least, not to be faked? Other symbiotic fields between art and science are: tattoos, as body art with physical and chemical consequences; pigments, as basic materials with interesting historiographical preparations; spectroscopy diagnosis, as very broad and thorough method of analysis (...) ; biosensors, as one of the applications of new pigments. Note also the interconnection between the several possible paths of science and art, which reflect new challenges with enormous potential investigated through a literature review and the application as a case study in an educational inquiry module. (shrink)

El siguiente trabajo se enmarca en una investigación acerca de las fuentes históricofilosóficas que dan cuenta de los fundamentos de la tendencia de la filosofía a interpretarse a sí misma como una ciencia. Hemos tomado algunos de los diálogos socráticos de Platón para pesquisar cómo opera esto ahí, cuál es su motivación última y cuál su sentido. El supuesto básico es que cabe, en algún sentido, pensar la actividad filosófica como un “saber del saber”. El hilo conductor lo constituye el (...) examen de ciertos pasajes ejemplares en donde aparece la llamada “analogía del arte”, a través de la cual se ponen al descubierto ciertos caracteres esenciales del saber. Finalmente se concluye que la motivación de un “saber referido al saber” no puede ser “epistemológica” sino fundada en la preocupación por alcanzar una vida de excelencia. (shrink)

RESUMEN: El presente artículo se centra en algunos de los aspectos centrales de la concepción heideggeriana de la indicación formal. Como es sabido, el filósofo toma como punto de partida en una de las más tempranas exposiciones de este metaconcepto, una explicación delimitativa frente a otras operaciones conceptuales. Se revisará críticamente la explicación que Heidegger hace de la generalización a diferencia de la formalización, destacando especialmente que no se trata aquí de una mera distinción entre generalización y formalización, sino de (...) una estructura de fundamentación. En segundo lugar se argumenta que la crítica de Heidegger no se dirige directamente contra la formalización, sino contra el contexto metódico al cual sirve. Por último, a modo de conclusión, se intenta mostrar que para Heidegger concebir la indicación formal como principio de la investigación fenomenológica, supone que ella es, por vía negativa, una radicalización de la tendencia a lo formal.ABSTRACT: The aim of this article is to focus on central aspects of Heidegger's conception of the formal indication. An early Heideggerian exposition of this meta-concept take as starting point a differentiation from others conceptual operations. First, it will be critical discuss the exposition of the generalization. The main point is that the distinction of generalization and formalization is rather a foundational structure than a simple difference. This premise leads to the view that the Heidegger's critical attempt is not addressed to the formalization as such, but rather to the methodological context to which the formalization serves. Finally, based on this, it will be claimed that is a necessary condition for the determination of the formal indication as a methodological principle of the phenomenological investigation, that this meta-concept is a radical tendency toward the formal. (shrink)

Bernard Suits’ groundbreaking work, The Grasshopper: Games, Life, and Utopia, has profoundly shaped the philosophy of sport. Its sequel, Return of the Grasshopper: Games, Leisure, and the Good Life in the Third Millennium, released in October 2022, enriches scholarly understandings of Suits’ views on games, emphasizing the normative aspects of gameplay and its impact on people’s pursuit of the good life. In this book symposium, world-leading Suits scholars analyze the Suitsian conception of gameplay and its relevance to his views on (...) Utopia outlined in the sequel, covering a wide range of topics. Filip Kobiela explores counterfactual situations in Suits’ oeuvre. Christopher Bartel and Gwen Bradford scrutinize the ethical nature and ramifications of Suits’ claim that life is an unconscious game. R. Scott Kretchmar and John S. Russell present thoughtful critiques of Suits’ musing on Utopia. William J. Morgan’s contribution integrates contemporary work studies to illuminate Suits’ utopia. The symposium concludes with the editors, Francisco Javier Lopez Frias and Christopher Yorke, offering their perspectives on Suitsian Utopia, ethics, and metaethics. (shrink)

s for the Second Workshop on Implementing Machine Ethics.

System analyses deal with interrelationships between different variables that keep the system in balance. In many analysis of complex thinking, a system is viewed as a complex unit in which the ‘whole’ is not reduced to the ‘sum’ of its parts; the system becomes an ambiguous item because it consists of several entities that interact with unforeseen results or, in other words, it is situated at a transdisciplinary level, it is impossible for an area to have a complete reading of (...) its complexity. It was also mentioned that the concept of the open system best describes complexity by stating that ‘the laws of the organization are not equilibrium, but an imbalance that is restored or compensated for by stabilized dynamics’. This idea originated from the field of thermodynamics and the second law, in which the imbalance that it maintains allows the system for an apparent balance. This fragile steady state has something of a paradox, since the structures remain the same, but their constituents are changeable. The concept of open system undoes the door to a theory of evolution that can only derive from the interactions between a system and its ecosystem. Within this systemic approach, the focus of the analysis takes into account the ambiguity, multidisciplinary and complexity associated with system adjustment, i.e. it is intended to qualify an employee job based on their experience and knowledge as a measure of their impact on the organization performance. (shrink)

Maps and territory suggest problems which have to do with the opening of pathways in some poorly explored domain.

We expose the main ideas, concepts and results about Jakowski's discussive logic, and apply that logic to the concept of pragmatic truth and to the Dalla Chiara-di Francia view of the foundations of physics.

We expose the main ideas, concepts and results about Jaśkowski's discussive logic, and apply that logic to the concept of pragmatic truth and to the Dalla Chiara-di Francia view of the foundations of physics.

We present some recent technical results of us on the incompleteness of classical analysis and then discuss our work on the Arnol'd decision problems for the stability of fixed points of dynamical systems.

We present some recent technical results of us on the incompleteness of classical analysis and then discuss our work on the Arnol'd decision problems for the stability of fixed points of dynamical systems.