Braitenberg et al.'s target article presents the best current integration of anatomical and physiological data, and provides a qualitative description of cerebellar function in terms of the dynamics of processes based on the geometry of the cerebellar cortex. We compare the proposed model to our own quantitative model based on the concept of Purkinjeunit.

This paper inquires the systematical consequences in the Nietzschean critics of the biological determination of life. We proposed an analysis about central topics of this determination: the finalism, the life and chaos. This approach allows us to relieve a systematical conception of what Nietzsche understands by “necessity”. This conception of necessity is not metaphysic in the traditional sense, but implies a subversion of all special metaphysic. Beyond this, it entails a critical to the transcendental and normative version, own of Kantian (...) thought, about the question of life. These confrontations seek to clarify the gnoseological and ontological areas put in check, on the status of the concept of life. (shrink)

Recent studies of early development in a number of ivertebrate and vertebrate species have suggested that growth factors and their receptors may play important roles in differentiation as well as cell proliferation. In the mouse embryo, the expression of the receptors for insulin and insulin‐like growth factors I and II (IGF‐I and ‐II) are temporally regulated. The ontogeny of receptor and ligand expression within the insulin and IGF gene family suggests that the very earliest stages of mammalian embryogenesis may be (...) subject to regulation by autocrine and paracrine factors from maternal and embryonic sources. (shrink)

It's not always the person who is right who wins the arguments, more often it's the person who argues best. Gilbert's practical, clever guide--which also serves as a text for his popular seminars on the art of arguing--shows readers how to hone their polemical skills, and how to counter the verbal weapons that may be in an opponent's arsenal.

Ontologies, as the term is used in informatics, are structured vocabularies comprised of human- and computer-interpretable terms and relations that represent entities and relationships. Within informatics fields, ontologies play an important role in knowledge and data standardization, representation, integra- tion, sharing and analysis. They have also become a foundation of artificial intelligence (AI) research. In what follows, we outline the Coronavirus Infectious Disease Ontology (CIDO), which covers multiple areas in the domain of coronavirus diseases, including etiology, transmission, epidemiology, pathogenesis, diagnosis, (...) prevention, and treatment. We emphasize CIDO development relevant to COVID-19. (shrink)

Este artículo intenta rastrear una de las vértebras centrales del pensamiento Nietzscheano que ha sido tratada de modo tangencial, a saber, sus interpretaciones sobre la formación humana. En ese orden de ideas aborda una lectura de algunas de las críticas y propuestas sobre la educaciónque se encuentran en Schopenhauer como educador y El futuro de nuestras instituciones educativas,conferencias presentadas por Nietzsche entre enero y marzo de 1872, desde una perspectivapsicológica que se expresa en la doctrina de los impulsos nietzscheana. La (...) primera parte del artículose adentra a una interpretación detenida de la propuesta formativa de carácter psicológico delindividuo como unidad de estilo que Nietzsche presenta en la segunda sección del Schopenhauereducador. La segunda parte pone de relieve el valor crítico y propositivo que tiene la tesis con cabeza de Jano, con la cual Nietzsche articula su interpretación de la tarea cultural de la educación en Sobre el futuro de nuestras instituciones educativas. Este proyecto que Nietzsche presenta a laeducación resulta abrirse campo hasta nuestros días y resulta ser aún una perspectiva valiosa y crítica para interpretar las altas tareas culturales de nuestra educación, así como también permitiría fundamentar una base plausible de interpretación para rastrear el papel de la educación en ladoctrina de Nietzsche. (shrink)

IntroductionCardiology is characterized by its state-of-the-art biomedical technology and the predominance of Evidence-Based Medicine. This predominance makes it difficult for healthcare professionals to deal with the ethical dilemmas that emerge in this subspecialty. This paper is a first endeavor to empirically investigate the axiological foundations of the healthcare professionals in a cardiology hospital. Our pilot study selected, as the target population, cardiology personnel not only because of their difficult ethical deliberations but also because of the stringent conditions in which they (...) have to make them. Therefore, there is an urgent need to reconsider clinical ethics and Value-Based Medicine. This study proposes a qualitative analysis of the values and the virtues of healthcare professionals in a cardiology hospital in order to establish how the former impact upon the medical and ethical decisions made by the latter.ResultsWe point out the need for strengthening the roles of healthcare personnel as educators and guidance counselors in order to meet the ends of medicine, as well as the need for an ethical discernment that is compatible with our results, namely, that the ethical values developed by healthcare professionals stem from their life history as well as their professional education.ConclusionWe establish the kind of actions, communication skills and empathy that are required to build a stronger patient-healthcare professional relationship, which at the same time improves prognosis, treatment efficiency and therapeutic adhesion. (shrink)

Cultured meat, like any new technology, raises inevitable ethical issues. For example, on animal ethics grounds, it may be argued that reformed livestock farming in which animals’ lives are worth living constitutes a better alternative than cultured meat, which, along with veganism, implies the extinction of farm animals. Another ethical argument is that, just as we would undermine human dignity by producing and consuming meat that is grown from human cells, eating meat that is grown from nonhuman animal cells would (...) violate animal dignity because it is a way to create an us and them, which would make veganism the only ethical option. The present study challenges this argument. First, I examine the fundamental issue of whether cultured meat provides such an attack on animal dignity. The second issue is whether, assuming that it is true that cultured meat undermines animal dignity, it would be acceptable to reject cultured meat even though this implies sacrificing nonhuman animals. (shrink)

Positions in dialogic dispute are presented enthymematically. It is important to explore the position the disputant holds. A model is offered which relies on the presentation of a counter-example to an inferred missing premiss. The example may be: [A+J embraced as falling under the rule; [A-] rejected as basically changing the position; or, [R] rejected as changing the proffered missing premiss. In each case the offered model indicates the next appropriate action. The focus of the model is on uncovering the (...) position actually held by the disputant as opposed to identifying the "logically correct" enthymematic premiss. (shrink)

This paper begins the development of a pragmatics of emotion based on the pragma-dialectical programme, Externalization, Socialization, Functionalization, and Dialectification, applied to the emotional mode of argumentation. The first step points out a systematic equivocation within pragma-dialectics between the notion of argument and that of 'dialectics.' With this cleared, it is shown that each of the first three main assumptions can be altered to accommodate a non-logical mode of communication. However, dialectification, insofar as it is actually defining of the dialectical (...) mode, must be created anew. A defining assumption for emotionality is presented as a replacement for dialectification. (shrink)

Holobionts, consisting of a host and diverse microbial symbionts, function as distinct biological entities anatomically, metabolically, immunologically, and developmentally. Symbionts can be transmitted from parent to offspring by a variety of vertical and horizontal methods. Holobionts can be considered levels of selection in evolution because they are well-defined interactors, replicators/reproducers, and manifestors of adaptation. An initial mathematical model is presented to help understand how holobionts evolve. The model offered combines the processes of horizontal symbiont transfer, within-host symbiont proliferation, vertical symbiont (...) transmission, and holobiont selection. The model offers equations for the population dynamics and evolution of holobionts whose hologenomes differ in gene copy number, not in allelic or loci identity. The model may readily be extended to include variation among holobionts in the gene identities of both symbionts and host. (shrink)

Coalescent argumentation is a normative ideal that involves the joining together of two disparate claims through recognition and exploration of opposing positions. By uncovering the crucial connection between a claim and the attitudes, beliefs, feelings, values and needs to which it is connected dispute partners are able to identify points of agreement and disagreement. These points can then be utilized to effect coalescence, a joining or merging of divergent positions, by forming the basis for a mutual investigation of non-conflictual options (...) that might otherwise have remained unconsidered. The essay proceeds by defining and discussing ‘argument’, ‘position’ and ‘understanding’. These notions are then brought together to outline the concept of coalescent reasoning. (shrink)

Adolescence is an important yet vulnerable period of transition from childhood to adulthood. An increasing number of studies support the traditional Catholic view, which sees teens as prone to making poor decisions when influ­enced by emotions or peer pressure but capable of thriving when guided by parents and religion. However, newer policies of medical societies undermine the traditional supports of family and faith with a permissive approach toward sexual exploration. To counter this unhealthy trend, which seems to be based more (...) on postmodern ideology than robust science, Catholic physicians should become experts in adolescent behavior and sexual health. Physicians should be sensitive to opposing viewpoints but participate only in treatments which are ethical and beneficial for their patients. Specifically, Catholic physicians must avoid contraceptives, abortion, and “gender-affirming” therapies. By using good science and emulating the models of service, Socratic dialogue, and accompaniment, physicians can guide adolescents toward a virtuous, healthy adulthood. (shrink)

Global health experiences during medical education can have a profound effect on physicians-in-training. This reflection was written to capture a meaningful moment during the author’s experience in medical school—one that made real the contrast between children from different social circumstances. Now a resident physician in pediatrics, the author carries with him the lessons learned from his time in rural India.

Although international security studies tend to focus on the nature of armed conflict and how nations fare in the face of such conflicts, our attention has been drawn to the challenge of managing the peace.

This research assessed how the performance and team skills of three-person teams working with an Intelligent Team Tutoring System on a virtual military surveillance task were affected by feedback privacy, participant role, task experience, prior team experience, and teammate familiarity. Previous work in Intelligent Tutoring Systems has focused on outcomes for task skill training for individual learners. As research extends into intelligent tutoring for teams, both task skills and team skills are necessary for good team performance. This work includes a (...) brief review of previous research on ITTSs, feedback, teams, and teamwork, including the recounting of two categories of a framework of teamwork performance, Communication and Cognition, which are relevant to the present study. This research examines the effects of an intelligent agent, as well as features of the team, its members, and the task being undertaken, on team communication and team situation awareness. Thirty-seven teams of three participants, each at their own computer running a multiplayer surveillance simulation, were given just-in-time private or public performance feedback during four 5-min trials. In the fourth trial, two of the three participants switched roles. Feedback type, teamwork experience, and teammate familiarity had no statistically significant effect on communication or team situation awareness. However, higher levels of role experience and task experience showed significant and medium-sized effects on communication performance. Results, based on performance data and structured interview responses, also revealed areas of improvement in future feedback design and a potential benchmark for feedback frequency in an action-oriented serious game-based ITTS. Among the conclusions are six design objectives for future ITTSs, establishing a foundation for future research on designing effective ITTSs that train interpersonal skills to nascent teams. (shrink)

This chapter directs attention to calls to integrate compassion training in curricula throughout the education system. Following a review of current Higher Education aims and objectives, and the potential psychological impacts that these can have on staff and students, we outline a case for compassion based initiatives in education. We discuss the nature and functions of compassion, as well as how compassion can heighten prosocial competencies. We then consider how compassion based approaches can be - and have been - implemented (...) in education settings, including HE, to promote the health and well-being of staff and students, as well as academic performance. We argue that elements of compassion should underpin the training of lecturers, as well as students, if UK institutes of learning truly embrace the various core values they advertise. (shrink)

This essay begins with a critique of the Critical-Logical model dominant in contemporary argumentation theory. The concerns raised stem primarily from considerations brought by several feminist thinkers including Carol Gilligan, Karen Warren, Deborah Tannen and, most especially, Andrea Nye. It is argued that, in light of these considerations, and concerns of essentialism or non-essentialism notwithstanding, that the Critical-Logical model is liable to dis-enfranchise a significant part of the population with regard to modes and styles of reasoning. The solution is found (...) in coalescent reasoning, an approach to argumentation that focuses on finding agreement rather than emphasizing disagreement and criticism. (shrink)

The main stream of formal and informal logic as well as more recent work in discourse analysis provides a way of understanding certain arguments that particularly lend themselves to rational analysis. I argue, however, that these, and allied modes of analysis, be seen as heuristic models and not as the only proper mode of argument. This article introduces three other modes of argumen tation that emphasize distinct aspects of human communication, but that, at the same time, must be considered for (...) the full understanding of argumentation. These modes are (1) the emotional, which relates to the realm of feelings, (2) the visceral, which stems from the area of the physical, and (3) the kisceral, which covers the intuitive and non-sensory arenas. At its most extreme the view holds that arguments may be given (almost) wholly within one mode and not be at all susceptible to those methods of argument analysis previously used. A more cautious statement allows that any interactive argument will (possibly) contain elements from various modes, and that to attempt to reduce these all to the rational is prejudiced reductionism. (shrink)

Predictive coding models of brain processing propose that top-down cortical signals promote efficient neural signaling by carrying predictions about incoming sensory information. These “priors” serve to constrain bottom-up signal propagation where prediction errors are carried via feedforward mechanisms. Depression, traditionally viewed as a disorder characterized by negative cognitive biases, is associated with disrupted reward prediction error encoding and signaling. Accumulating evidence also suggests that depression is characterized by impaired local and long-range prediction signaling across multiple sensory domains. This review highlights (...) the electrophysiological and neuroimaging evidence for disrupted predictive processing in depression. The discussion is framed around the manner in which disrupted generative predictions about the sensorium could lead to depressive symptomatology, including anhedonia and negative bias. In particular, the review focuses on studies of sensory deviance detection and reward processing, highlighting research evidence for both disrupted generative predictions and prediction error signaling in depression. The role of the monoaminergic and glutamatergic systems in predictive coding processes is also discussed. This review provides a novel framework for understanding depression using predictive coding principles and establishes a foundational roadmap for potential future research. (shrink)

Throughout his life, John Tyler Bonner contributed to major transformations in the fields of developmental and evolutionary biology. He pondered the evolution of complexity and the significance of randomness in evolution, and was instrumental in the formation of evolutionary developmental biology. His contributions were vast, ranging from highly technical scientific articles to numerous books written for a broad audience. This historical vignette gathers reflections by several prominent researchers on the greatness of John Bonner and the implications of his work.

Surveying nearly seven decades of habitual and obsessive reading, I consider how my character and psychology used reading to shape philosophical questions that move me into forms in which I could pursue them by reading. This became both the method and the substance of my philosophical work. It preserved some core emotional issues but also gave me the way to integrate them into scholarship and into my life.

Over the past 60 years there have been tremendous advances made in Argumentation Theory. One crucial advance has been the move from the investigation of static arguments to a concern with dialogic interactions in concrete contexts. This focus has entailed a slow shift toward involving both non-logical and non-discursive elements in the analysis of an argument. I argue that the traditional attitude Informal Logic has displayed toward emotion can be and ought be moderated. In particular, I examine the role of (...) emotion in everyday argumentation, and how Informal Logic can encompass it alongside the more traditional logical mode of communication. (shrink)

“I hate war,” de Fontenelle confessed, “for it spoils conversation.” And does it spoil philosophy too, which is always a kind of conversation? Or can philosophers write about war, as now we surely must, in a way that keeps the conversation going without belligerence? Only so, perhaps, can philosophy shed light on this dark field; but how to do it is itself obscured by the passions that wars evoke. Ted Honderich advocates advocacy, “an advocacy of arguments and judgements. A decent (...) philosopher dealing with moral and political questions … is in a line of life higher than that of a trial lawyer, but not out of sight of that line of life. If there is what can be called moral truth, it is not ordinary truth. Desire sits onto it” . Honderich's book may be viewed in this light as a sustained speech for the prosecution in the impeachment of Tony Blair and George W. Bush for waging terrorist war and supporting the terrorist wars of others. It is, then, a polemical work, but, unlike a lawyer's, founded on Honderich's own convictions, which are themselves rooted in philosophical belief. (shrink)

This is a new release of the original 1949 edition.