At least since the seminal work of the (US) National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research in the 1970s, a fundamental distinction between research and practice has underwritten both conceptual work in research ethics and regulations governing research involving human subjects. Notwithstanding its undoubted historical importance, I believe the distinction is problematic because it misrepresents clinical inquiry. In this essay, I aim to clarify the character of clinical inquiry by identifying crucial contextual constraints on (...) justification constitutive of clinical science. This analysis shows that, from an epistemological point of view, clinical research and clinical practice are not sharply distinct but intimately intertwined. This result is important in its own right—an enriched understanding of the epistemology of clinical research is valuable in and of itself. But this result is also important because it has profound implications for the ethics of human subjects research. (shrink)

As it is known, there is no rule satisfying Additivity in the complete domain of bankruptcy problems. This paper proposes a notion of partial Additivity in this context, to be called µ-additivity. We find that µ-additivity, together with two quite compelling axioms, anonymity and continuity, identify the Minimal Overlap rule, introduced by Neill (1982).

This commentary explores biological models of analogical and associative learning in support of Illusion 1 and Illusion 4 in D. Noble’s target article. The intent is to support Noble’s theses of emergent higher level functionality from lower level stochastic dynamics and his etiological claim that “there is no privileged level of causation” through a biosemiotic lens. Upon these arguments, a case for creative agency via higher-dimensional constraints will also be made in support of Noble’s claim that organismic behavior is actively (...) directed by an agent. (shrink)

Isaac Newton's closest approach to a system of the world in the critical period 1681–84 is provided in a set of untitled propositions concerning comets. They drastically revise his position maintained against Flamsteed in 1681 and may signal his adoption of a single comet solution for the appearances of 1680/1. Points of agreement and difference with the key pre-Principia texts of 1684–85 are analysed. He shows substantial control of the phenomena of tails which change very little in mechanical detail throughout (...) his subsequent work. An emerging theory of gravitation brings planets, their satellites, and comets under the same laws of motion, yet retains a celestial vortex and includes a singular proposition in lieu of the usual formulation of Keplers area law. The analysis raises questions on a number of issues of recent Newtonian scholarship ranging from his achievement following his correspondence with Robert Hooke in 1679 to his veneration of the wisdom of the ancients. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 61.3 (2000) 381-395 [Access article in PDF] Minds, Forms, and Spirits: The Nature of Cartesian Disenchantment Han van Ruler What is Descartes's contribution to Enlightenment? Undoubtedly, Cartesian philosophy added to the conflict between philosophical and theological views which divided intellectual life in the Dutch Republic towards the end of its "Golden Age." 1 Although not everyone was as explicit as Lodewijk Meyer, who (...) said that his theological doubts were inspired by Descartes's philosophical method, Cartesianism along with Copernicanism, Socinianism, and Cocceianism played an important part in the growing skepticism towards the authority of Scripture. 2 Apart from Descartes's general method, however, specific Cartesian ideas encouraged a new view towards nature and towards God's role in governing it. In physics and physiology the new philosophy replaced the image of mind working on matter with the image of a self sufficient mechanism. This new causal metaphor led to a typically Cartesian form of "disenchantment." In this article I argue that on account of their approval of a Cartesian theory of causality, even authors with sincere religious motives came close to accepting radical and nearly Spinozistic ideas. I start with disenchantment in a very literal sense: Balthasar Bekker's denial of the activities of devils, angels, and other spirits. A comparison of Bekker's arguments with those of another Cartesian, Arnold Geulincx will, I hope, bring out the nature and importance of what I shall present as [End Page 381] Descartes's "mechanical reduction" in physics. Finally, I argue that the Cartesian separation of mind and body gave rise to a form of disenchantment that reached far beyond contemporary debates. Devils, Ghosts, and God's Omnipotence Balthasar Bekker's classic book The World Bewitched (1691-93) does not so much deal with the practice of sorcery as with its theory. Bekker offers a wide range of theological and philosophical arguments in order to combat the idea that ghosts, devils, and angels influence natural or historical events. In particular Bekker draws some important conclusions from the philosophy of Descartes. Yet it is immediately clear to the reader that the motives for his critique are religious rather than philosophical. 3 The World Bewitched is not written as a scientific assault on superstition. Bekker, at the time serving as a Calvinist minister in Amsterdam, presents his work as a new and perhaps final phase in the perfection of Christianity. For two centuries it had been a goal of the Protestant Reformation to accentuate God's majesty and to establish the idea of His absolute power over creation. Bekker's World again expresses this idea. His denial that ghosts and devils are active in the world is a logical consequence of the belief that there is no room for demigods in nature. Bekker thus adds a final touch to the project of the Reformation. The World Bewitched will testify to the fact "that I return as much of the honor of His Power and Wisdom to the Almighty, as they took from Him who gave it to the Devil. I ban [the Devil] from the World and I bind him in Hell." 4 Removing devils and spirits from nature, Bekker aims to distinguish superstition from true faith. The battle against superstitious beliefs had formed a characteristic element of Protestant tactics. Dutch Calvinists, for instance, took offense at the continuing practices of blessings and incantations. 5 Bekker wanted to go even further. The Protestantization of Christian dogma could only be completed by making everything in nature's course depend on God's unique power and providence. 6 "Science" in our sense of the word was a subsidiary matter. 7 Still, Bekker saw the new scientific theories of his day as useful allies. In particular it was the new philosophy of Descartes that attracted him. Following Descartes, Bekker reasons "that I think, that I will, [End Page 382] [and] that I understand something," without any part of my body being involved in this type of consciousness. Mind and body in fact have nothing in common: My... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:AMERICAN OATHOLlC THEOLOGY AT CENTURY'S END: POS'I100NCIL!IAR, POSTMODERN, POST...THOMISTIC * J. A. D1No1A, O.P. Domiinican House of Studies Washiington, D.O. I N CENTURY'S END-.a iascinaiting recent hook describing the decades at the turn of the centuries from the 990s throiUgh the 1990s-cultural historian Hillel Schwartz writes: "The millennial year ~000 has gravitamona1l tides of maximal reach. Its entire precedirng hundred years, our century, has come to he felt as (...) a final epoch, a time of grotesque·extremity...." 1 Along with other modern intellectual inquiries, American Catholic theology has felt the pull of the app :voaching miHenium. Any interpretation of its current stateas well as of the 'l:"ole that the ·thought of St. Thomas Aquinas may continue to play in it--'ll.eeds to take account of long range intellectual and theological trends. Clearly, the main currents in fate 20th century American Catholic theology result at least in part from the play of large tides reaching over the past hundred years and hey;ond. Among the most significant of these is Ohrist]anity's continuing endeavor to meet the pl'leS'sing surge of modernity. This endeavor engaged the energies of Catholics and Protestants for nearly two centuries, :before reaching 1someth:ing orf a climax in the Second Vatican C01Uncil. Assimilating the 1Work of several *A version of this paper was presented on May 4, 1990 in Rome at an Angelicum University symposium on the role of St. Thomas in contemporary thought. 1.Hillel.Schwartz, Oentury's End: A Oultural History of the Fiin de Siecle from the 990s through the 1990s (New York: Doubleday, 1990), p. 239. 499 500 J. A. DI NOIA1 O.P. generrutions of,bishops and theologians, the Council oombined a reaffirmation of the Catholic Christian identity of the Church with a positive, a:lbeit critical, approach to modernity. Now, just when disagreements about the conciliar stance to modernity preoccupy and divide eurrent American Catholic theologians, the advent of " :postmodernity " is being hailed in a1,chitecbure, literary oriticism, science, philosophy, and other fields. No wonder the decades ushering in the 21st century have seemed to many "a final epoch, a time of grotesque extremity " in theology an:d in Church life. The condition of late 20th century American theology is intelligible, I shall af'gue here, only when viewed in the perspective of the complex responses of Catholic and Protestant Christianity to the once swelling and now receding tides of modernity. The fortunes of the study of Aquinas ha,V'e shifted in tandem with these :fluctuations. In both Aquinas's late 19th century 11evival and, at least in American CathoJic circles, his late 20th century eclipse, alternative Christian assessments of the challenge of moderniity figured prominently. But the situation is again in flux. There is a recovery of Aquinas underway, in connection with theological developments that encompass at least a measure of the refreshing postmodern agenda. It is here, I shall suggest, that we can identify some of the most creative currents at work in present-day American theology. I Although united in their appeal to the authority of Vatican II, rival American Catholic theological positions are divided by two opposed readings of the nature of the conciliar response to modernity and its implioataions for the theo1ogica:l a:genida. Acco1 •ding to one reading, the Coundl is understood to commend,a strong reaffirmation o.f Catho·lic Christian identity, taking the broadest view of its historic traditions, yet open to the cultural and religious pluralism characteristic of our times. But in the eyes of a numerous and influential group of American theologians, such a reading reverses the true priorities of AMERICAN CATHOLIC THEOLOGY 501 the Council. It was not resfomtion, ibut modernization, dialogue, a.nd social oommitment that V:atican IT chiefly sought to culti¥ate in the contemporary Church. To a. large extent, the state of theology in the U.S. (and perhaps elsewhere as well) refLects the predominance of the second interpreta.tion of the Council. Ressourcement or aggiornamento? As the conciliar documents reveal, both of these progmms were ruddressed and embraced by Viatican II. But which of them has priority? The documents themselrves... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 61.3 (2000) 381-395 [Access article in PDF] Minds, Forms, and Spirits: The Nature of Cartesian Disenchantment Han van Ruler What is Descartes's contribution to Enlightenment? Undoubtedly, Cartesian philosophy added to the conflict between philosophical and theological views which divided intellectual life in the Dutch Republic towards the end of its "Golden Age." 1 Although not everyone was as explicit as Lodewijk Meyer, who (...) said that his theological doubts were inspired by Descartes's philosophical method, Cartesianism along with Copernicanism, Socinianism, and Cocceianism played an important part in the growing skepticism towards the authority of Scripture. 2 Apart from Descartes's general method, however, specific Cartesian ideas encouraged a new view towards nature and towards God's role in governing it. In physics and physiology the new philosophy replaced the image of mind working on matter with the image of a self sufficient mechanism. This new causal metaphor led to a typically Cartesian form of "disenchantment." In this article I argue that on account of their approval of a Cartesian theory of causality, even authors with sincere religious motives came close to accepting radical and nearly Spinozistic ideas. I start with disenchantment in a very literal sense: Balthasar Bekker's denial of the activities of devils, angels, and other spirits. A comparison of Bekker's arguments with those of another Cartesian, Arnold Geulincx will, I hope, bring out the nature and importance of what I shall present as [End Page 381] Descartes's "mechanical reduction" in physics. Finally, I argue that the Cartesian separation of mind and body gave rise to a form of disenchantment that reached far beyond contemporary debates. Devils, Ghosts, and God's Omnipotence Balthasar Bekker's classic book The World Bewitched (1691-93) does not so much deal with the practice of sorcery as with its theory. Bekker offers a wide range of theological and philosophical arguments in order to combat the idea that ghosts, devils, and angels influence natural or historical events. In particular Bekker draws some important conclusions from the philosophy of Descartes. Yet it is immediately clear to the reader that the motives for his critique are religious rather than philosophical. 3 The World Bewitched is not written as a scientific assault on superstition. Bekker, at the time serving as a Calvinist minister in Amsterdam, presents his work as a new and perhaps final phase in the perfection of Christianity. For two centuries it had been a goal of the Protestant Reformation to accentuate God's majesty and to establish the idea of His absolute power over creation. Bekker's World again expresses this idea. His denial that ghosts and devils are active in the world is a logical consequence of the belief that there is no room for demigods in nature. Bekker thus adds a final touch to the project of the Reformation. The World Bewitched will testify to the fact "that I return as much of the honor of His Power and Wisdom to the Almighty, as they took from Him who gave it to the Devil. I ban [the Devil] from the World and I bind him in Hell." 4 Removing devils and spirits from nature, Bekker aims to distinguish superstition from true faith. The battle against superstitious beliefs had formed a characteristic element of Protestant tactics. Dutch Calvinists, for instance, took offense at the continuing practices of blessings and incantations. 5 Bekker wanted to go even further. The Protestantization of Christian dogma could only be completed by making everything in nature's course depend on God's unique power and providence. 6 "Science" in our sense of the word was a subsidiary matter. 7 Still, Bekker saw the new scientific theories of his day as useful allies. In particular it was the new philosophy of Descartes that attracted him. Following Descartes, Bekker reasons "that I think, that I will, [End Page 382] [and] that I understand something," without any part of my body being involved in this type of consciousness. Mind and body in fact have nothing in common: My... (shrink)

This article discusses Descartes’s preferred focus on morally and theologically neutral subjects and points out the impact of this focus on the scientific status of theology. It does so by linking Descartes’s method to his transformation of the notion of substance. Descartes’s _Meditations_ centred around epistemological questions rather than non-human intelligences or the life of the mind beyond this world. Likewise, in his early works, Descartes consistently avoided referring to causal operators. Finally, having first redefined the notion of substance in (...) the _Principia,_ Descartes would completely abandon making use of this notion in his later years. Indeed, in contrast to many authors before and after him, Descartes never showed any interest in the long-established metaphysical interpretation of substances as being causal factors of natural change. With God, nature, and mind commonly serving as instances of substantial causality, Descartes’s philosophy had a huge impact on the place of God in science and discreetl. (shrink)

I summarize recent discussion in this journal and in Woolcock(1999) of the relevance of evolution to the question of thereality of moral rightness and wrongness. I show thata satisfactory version of Ruse-type evolutionaryethics has been adequately defended.

In a previous article an elementary semantic analysis showed that, logically, analogical terms and expressions must be treated as homonyms, though of a special type. The latter qualification is necessitated by the concomitant element of similarity that is found to be involved in all comparisons of the analogical type. Further, it was pointed out that the special types of similarity in question cannot be isolated through a purely semantic analysis. This is, in particular, a consequence of the fact that analogy (...) is itself an analogical notion and term. The kind of similarity involved may, therefore, vary in the different forms of analogy and it may prove impossible to abstract from these something like a common element, e.g., a particular type of resemblance. This implies that the full philosophical significance of a particular form of analogy can be gleaned only from a contextual examination of its rôle in relation to a particular problem. Nevertheless, some significant conclusions may emerge from a partial analysis of certain forms of resemblance which are usually associated with analogy. (shrink)

If the priest is always a sign of transcendence in some form or other, what is his function in the academic community for which he labors?

Amyloid-beta peptide plaque in the brain is the primary diagnostic criterion of Alzheimer's disease . The physiological role of Abeta are poorly understood. We have previously determined an Abeta interacting domain in the promoters of AD-associated genes . This AbetaID interacts in a DNA sequence-specific manner with Abeta. We now demonstrate novel Abeta activity as a possible transcription factor. Herein, we detected Abeta-chromatin interaction in cell culture by ChIP assay. We observed that human neuroblastoma cells treated with FITC conjugated Abeta1-40 (...) localized Abeta to the nucleus in the presence of H2O2-mediated oxidative stress. Furthermore, primary rat fetal cerebrocortical cultures were transfected with APP and BACE1 promoter-luciferase fusions, and rat PC12 cultures were transfected with polymorphic APP promoter-CAT fusion clones. Transfected cells were treated with different Abeta peptides and/or H2O2. Abeta treatment of cell cultures produced a DNA sequence-specific response in cells transfected with polymorphic APP clones. Our results suggest the Abeta peptide may regulate its own production through feedback on its precursor protein and BACE1, leading to amyloidogenesis in AD. (shrink)

The author examines and discusses berkeley's statement: "the absolute existence of unthinking things are words without a meaning or which include a contradiction." (staff).

It will, I suppose, be readily agreed that questions concerning the scope of moral principles are of vital importance for the moral philosopher. If we are to accept a view, such as Professor Hare's, that there are formal criteria for any morality if it is to count as a morality, then it is necessary to know what is left outside the fence. Are Egoism and Caste Morality to count as moralities, restricted to the interests of one and of a limited (...) group of persons respectively; or is there a logical absurdity in calling them moralities at all? Hare's thesis of ‘prescriptive universalisability’, as definitive of the formal structure of any moral system, rules out such restricted ‘moralities’. Using ‘ought’ as a key-concept in moral discourse, Hare suggests that the word has two basic functions: to prescribe: meaning to commend courses of action sincerely to oneself and others. to prescribe consistently, or universalisably; that is, in the same way, on relevantly similar occasions, to anyone, including oneself, unless valid reasons for discrimination of persons can be offered. (shrink)

B erkeley wrote of ‘the absolute existence of unthinking things’ as being, ‘words which are without meaning and including a contradiction’. There are few philosophers today who do not regard Berkeley as having been mistaken in this view, in that it is regarded as clearly not meaningless to suppose that there might be many objects about which no one happens to be thinking. Nor is it the aim of this paper entirely to resurrect such a view, though it is my (...) purpose to try to show the subtlety of the logical and ontological issues involved in the problem of independent things. (shrink)