Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Anubav Vasudevan characterized van Fraassen’s “Infomin” solution to the Judy Benjamin Problem (i.e. the solution by way of minimizing the Kullback-Leibler divergence between the posterior and prior) as an implementation of a “brand of epistemic charity” taking “the form of an assumption on the part of Judy Benjamin that her informant’s evidential report leaves out no relevant information”. After an analysis of the example that led Vasudevan to this way of thinking about Infomin, as well as of a new (...) one that supports the rival position of Douven and Romeijn in favor of minimizing the inverse Kullback-Leibler divergence between the posterior and the prior, we come to a different and more enlightening characterization of Infomin’s implicit assumptions. (shrink)

At the centenary of Frank H. Knight’s Risk, Uncertainty, and Profit, we explore the continuing relevance of Knightian uncertainty to the theory and practice of entrepreneurship. There are three challenges facing such assessment. First, RUP is complex and difficult to interpret. The key but neglected element of RUP is that Knight’s account is not solely about risk and uncertainty as states of nature, but about how an agent’s beliefs about uncertain outcomes and confidence in those beliefs guide their choices. Second, (...) RUP is Knight’s only effort in this area. His subsequent career led elsewhere, so he did not engage with subsequent interpretations of this work. Third, much of the current literature emphasizes that decisions must be different under the two states of nature with a consequent misunderstanding of entrepreneurial agency. This paper addresses each challenge in sequence. First, we explicate Knight’s approach and explain why that approach is murky. Second, as a complement to Knight’s interpretation, we examine Frank P. Ramsey’s approach to subjective probabilities to help clarify Knight’s murky approach. What links Knight and Ramsey is a shared pragmatism about entrepreneurial agency under uncertainty that depends upon the beliefs about, and confidence in, their judgments of possible outcomes. This Knight-Ramsey approach does not require actor’s behaviors to be determined by the class of uncertain environment they face. We focus on the response by the entrepreneur to the existence of uncertainty in all its forms. We argue that this reductive account provides a foundation to examine common problems in management, including managerial hubris, the interaction between entrepreneurs and venture capitalists, and the need for experimentation in advance of new product and venture launches. Third, we critique current literature that favors epistemic purism about the ontology of risk and uncertainty and ignores Knight-Ramsey pragmatism in meeting uncertainty, such as using formal and informal institutions for uncertainty mitigation. Our account locates Frank Knight’s subtleties in entrepreneurial behavior firmly in the literature on entrepreneurial agency a century later. (shrink)

The edited collection Rorty and Beyond assesses and moves beyond Rorty’s legacy, bringing together leading international philosophers. The collection covers diverse territory, from his views about what we may hope for to his personal character, and everything in between.

2 Enoch 58–59 provides an esoteric and somewhat eccentric delineation of attitudes toward the mistreatment of animals within some sect of Egyptian Judaism, in all probability. Three attitudes, having to do with the mistreatment of animals in failing to feed them properly, the wrongful binding of animals for sacrifice, and possible secret sexual exploitation of animals, are delineated along with warnings regarding the effects of such treatment on the human soul at the great judgment. This linking of how humans treat (...) animals with how humans will be judged in “the great age” is unique in the literature of this period and demonstrates a deep concern for animal welfare that has been largely dormant in many facets of religion until more recent times. (shrink)

Josiah Royce (1855?-1916) has had a major influence on American intellectual life, both popular movements and cutting-edge thought, but his name often went unmentioned while his ideas marched forward. The leading American proponent of absolute idealism, Royce has come back into fashion in recent years. With several important new books appearing, the formation of a Josiah Royce Society, and the re-organization of the Royce papers at Harvard, the time is ripe for Time, Will, and Purpose. Randall Auxier delves into (...) the primary texts written by Royce. (shrink)

Global security cannot be achieved until people view the world as a global community. Until such time, differences will continue to be perceived as threatening. These perceived “threats” are the primary threat to global security. This volume proposes methods for minimizing the “us versus them” mentality so that we can build a sense of global community.

Religion is often criticized for failing to uphold animal concerns, yet Zoroastrianism, an ancient religion that underlies the Abrahamic traditions as well as Eastern religions, offers some strikingly contemporary concerns regarding the kinship of human and nonhuman animals. Human and nonhuman animals alike have souls, free will, and life after death. In the middle of the second millennium BCE, Zoroaster called attention to the treatment of animals as necessary to the divine order and righteousness that has been disturbed by evil (...) and sin. How humans treat animals also affects their own well-being in this world and the next. (shrink)

The various efforts to put the idea of humanity on a secure ethical, political, and social base have not succeeded. The various post-humanist and transhumanist programs are inadequate. Our deep-seated suspicion of our deepest selves and motives is understandable in light of the barbarity of the twentieth century, but humanism is not to blame. The thought of Ernst Cassirer holds a framework for a new humanism, once it is rid of certain colonialist, triumphalist, and Eurocentric ideas that distorted Cassirer’s understanding (...) of the European role in creating the problems of civilization, especially its mistake of thinking that science was a progressive symbolic form of culture. I set out the basis of a new humanism based upon not the problem of knowledge, but the problem of genuine self-situating socialty, a personalist point of view. (shrink)

This paper aims to consider Peirce and Eco’s approach to signs and semiotics in order to assess their relation to Peirce’s mature pragmatism. Both thinkers attempted to set out a truly general theory of signs, and ran into difficulties on similar points. I show that the responses of Peirce and Eco to the difficulties that arose in seeking a truly general theory of signs were quite different. And yet, the differences are not so deep as to prevent us from thinking (...) of both Peirce and Eco as pragmatists, and perhaps of a similar stripe. (shrink)

Arthur Danto is the Johnsonian Professor Emeritus of Philosophy at Columbia University and the most influential philosopher of art in the last half century. As an art critic for The Nation for 25 years and frequent contributor to other widely read outlets such as the New York Review of Books, Danto also has become one of the most respected public intellectuals of his generation. He is the author of some two dozen important books, along with hundreds of articles and reviews (...) which have been the center of both controversy and discussion. In this volume Danto offers his intellectual autobiography and responds to essays by 27 of the keenest critics of his thought from the worlds of philosophy and the arts. The book includes 16 pages of color art reproductions. Danto is the author dozens of books on art, philosophy, the philosophy of art, and art criticism. He is a rare philosopher who is also a public intellectual. (shrink)

This volume consists of an intellectual autobiography by world-renowned philosopher Hilary Putnam, 26 critical or descriptive essays, 26 replies by Arthur C. Danto, and a bibliography listing all of Putnam's published writings.

_The Quantum of Explanation_ advances a bold new theory of how explanation ought to be understood in philosophical and cosmological inquiries. Using a complete interpretation of Alfred North Whitehead’s philosophical and mathematical writings and an interpretive structure that is essentially new, Auxier and Herstein argue that Whitehead has never been properly understood, nor has the depth and breadth of his contribution to the human search for knowledge been assimilated by his successors. This important book effectively applies Whitehead’s philosophy to problems (...) in the interpretation of science, empirical knowledge, and nature. It develops a new account of philosophical naturalism that will contribute to the current naturalism debate in both Analytic and Continental philosophy. Auxier and Herstein also draw attention to some of the most important differences between the process theology tradition and Whitehead’s thought, arguing in favor of a Whiteheadian naturalism that is more or less independent of theological concerns. This book offers a clear and comprehensive introduction to Whitehead’s philosophy and is an essential resource for students and scholars interested in American philosophy, the philosophy of mathematics and physics, and issues associated with naturalism, explanation and radical empiricism. (shrink)

"Essays explore philosophical themes in the Wizard of Oz saga, comprising the books by L. Frank Baum, the 1939 film, the novel Wicked, and related films and ...

Preview: Bergson noted that the cinematographic image does not really move. It is, then as now, a series of still photographs. The real motion in such images is produced by machinery, which imparts a kinesis, an energy of movement, to the succession of fixed images. Our perception then endows such images with their “life,” insofar as they can be said to possess life. It is an illusion, it is “virtual” both as space and time. The real duration, as generated by (...) the machinery or as lived by the perceiver is part of a broader system of images that includes those still photographs and their succession. Images of images of images, by the time they are processed by our bodies and appear to our mind’s eye as inhibited acts we have not enacted. (shrink)

Philosophers analyze the last of the great rock stars.

In 1922 Charles Hartshorne, then an aspiring young philosopher, wrote to Edgar Sheffield Brightman, a preeminent philosopher of religion for twenty-three subsequent years and, remarkably, almost every letter was preserved. In their introductory essays, editors Randall Auxier and Mark Davies place the unusually rich and intensive correspondence in its intellectual context and address the relationship between personalism and process philosophy/theology in metaphysics, epistemology, ethics, and social philosophy.

BOOK REVIEWS 3~3 reaction to them into account. The actual historical dialectic involving Moore, Mal- colm, and Wittgenstein is a good deal more complicated, and more interesting, than the story told here by Stroll. Moving on to Stroll's discussion of Wittgenstein, I should now acknowledge that, so far as I can judge, Stroll offers a largely reliable account of On Certainty. In particular, in the best chapter of the book, on "Wittgenstein's Foundationalism," he makes a convincing case for the view (...) that Wittgenstein, unlike Moore, separates propositional knowledge from the kind of "non-propositional" certainty concerning what "stands fast" for us and which is primarily evinced in our ways of acting. What is less clear to me is just what kind of response to sceptical arguments this amounts to: Stroll says that although at some points Wittgenstein is prepared to countenance, in a relativist spirit which closely adjoins scepticism, radical changes in what is thus cer- tain, by and large towards the end of On Certainty Wittgenstein advances an "absolut- ist" position which rules out such changes. But if this is so , we surely need some arguments why it has to be so. But much here depends on the broader context within which Wittgenstein's position is developed and discussed. Despite noting Wittgenstein's invocation of the conception of man as a "primitive.. (shrink)