Child maltreatment not only leads to epigenetic changes, but also increases the risk of related behavioral deficits and mental disorders. These issues presumably are most closely associated with epigenetic changes in the brain, but epigenetic changes in peripheral tissues like blood are often examined instead, due to their accessibility. As such, the reliability of using the peripheral epigenome as a proxy for that of the brain is imperative. Previously, our lab has found aberrant methylation at the Brain-derived neurotrophic factor gene (...) in the prefrontal cortex of rats following aversive caregiving. The current study examined whether aversive caregiving alters Bdnf DNA methylation in the blood compared to the prefrontal cortex. It was revealed that DNA methylation associated with adversity increased in both tissues, but this methylation was not correlated between tissues. These findings indicate that group trends in Bdnf methylation between blood and the brain are comparable, but variation exists among individual subjects. (shrink)

The issue of how to incorporate the individual's first‐hand experience of illness into broader medical understanding is a major question in medical theory and practice. In a philosophical context, phenomenology, with its emphasis on the subject's perception of phenomena as the basis for knowledge and its questioning of naturalism, seems an obvious candidate for addressing these issues. This is a review of current phenomenological approaches to medicine, looking at what has motivated this philosophical approach, the main problems it faces and (...) suggesting how it might become a useful philosophical tool within medicine, with its own individual, but interrelated, contribution to make to current medical debates. After the general background, there is a brief summary of phenomenological ideas and their current usage in a medical context. Next is a critique of four key claims within current phenomenological medical works, concerning both the role phenomenology plays and the supposedly clear divide between phenomenology and other approaches. There are significant problems within these claims, largely because they overlook the complexity of the questions they consider. Finally, there is some more in‐depth examination of phenomenology itself and the true complexity of phenomenological debate concerning subjectivity. The aim is to show that it will be both more productive and truer to phenomenology itself, if we use phenomenology as a philosophical method for explicating and gaining deeper understanding of complex and fundamental problems, which are central to medicine, rather than as providing simple, but flawed solutions. (shrink)

Drawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons. We identify participant-centricity and trustworthiness as the most important features of an MIC and discuss the implications for those seeking to create a sustainable, useful, and widely available collection of linked resources for research and other purposes.

In many animal species, the early development of the embryo follows a stereotypic pattern of cell cleavage, lineage allocation and generation of tissue asymmetry leading to delineation of the body plan with three primary embryonic axes. The mammalian embryo has been regarded as an exception and primary body axes of the mouse embryo were thought to develop after implantation. However, recent findings have challenged this view. Asymmetry in the fertilised oocyte, as defined by the position of the second polar body (...) and the sperm entry point, can be correlated with the orientation of the animal–vegetal and the embryonic–abembryonic axes in the preimplantation blastocyst. Studies of the pattern of morphogenetic movement of cells and genetic activity in the peri‐implantation embryo suggest that the animal–vegetal axis of the blastocyst might presage the orientation of the anterior–posterior axis of the gastrula. This suggests that the asymmetry of the zygote that is established at fertilisation and early cleavage has a lasting impact on the delineation of body axes during embryogenesis. BioEssays 23:508–517, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Does cross-cultural philosophy stand in need of a hermeneutical expansion? In engaging with this question, the symposium focuses upon methodological issues salient to cross-cultural inquiry. Douglas L. Berger lays out the ground for the debate by arguing for a methodological approach, which is able to rectify the discipline’s colonial legacies and bridge the hermeneutical distance with its objects of study. From their own perspectives, Hans-Georg Moeller, Paul Roth and A. Raghuramaraju analyze whether such a processual and hermeneutically-sensitive approach can (...) indeed open up new hermeneutic horizons. Their responses shed light upon cross-cultural philosophy’s continued embedment in Euroamerican professional philosophy and how the locality of its knowledge-seeking endeavors may indeed have repercussions on attempts to bridge temporal and spatial distances. (shrink)

Since Durkheim ([1912] 1965), the concept of ritual has held a privileged position in studies of social life because investigators recurrently have treated it as a source of insight into core issues of human sociality, such as the maintenance of social order. Consequently, studies of ritual have typically focused on rituals' function(s), and, specifically, whether ritual begets social integration or fragmentation. In this frame, students of ritual have tended to ignore other, equally fundamental issues, including (1) how actions, or courses (...) of action, constitute a ritual, and (2) whether ritual is best understood as an aspect of all social action or a specific type of it. Drawing on Durkheim's overlooked contemporary, Van Gennep ([1908] 1960), I argue that analyses of ritual must describe how participants enact an occasion as ritual through distinctive activities and sequences of these. Analysts of ritual must attempt to ground the relevance of their descriptions in the participants' demonstrable orientations, an undertaking with more general implications for the study of social action. (shrink)

Compiled by an archaeologist and philosopher of science, Science at the Frontiers: Perspectives on the History and Philosophy of Science supplements current literature in the history and philosophy of science with essays approaching the traditional problems of the field from new perspectives and highlighting disciplines usually overlooked by the canon. William H. Krieger brings together scientists from a number of disciplines to answer these questions and more in a volume appropriate for both students and academics in the field.

Claims of progress in our ethical or moral beliefs and practices—as well as claims to ethical or moral regression—are commonplace in American social and political conversation. Often, such commentary involves a lamenting of the decline of “traditional” values in contemporary society or alternatively a rejoicing in the ways that we appear to have overcome prior prejudicial values. In this dissertation, I am concerned with the notions of progress and improvement that underlie such commonsense judgments. At a minimum, ethical progress requires (...) the idea that some values or practices are better than others and hence that replacing some beliefs or practices with others can be a genuine improvement. Taking inspiration from the ethical works of John Dewey, I sketch an account of evaluative progress that conceives of this sort of improvement in ethical beliefs or practices in terms of problem-resolving. On my view, resolving a problem involves both offering an adequate conception of the problem and finding a problem-solution which lives up to the world and to the values we reflectively endorse. On my account, resolving problems is not simply a matter of finding the best means to a fixed end; rather, I conceive of problem-resolving as a dynamic process in which ends themselves are typically in flux. The sort of “dynamic deliberation” I have in mind, then, goes beyond mere instrumental reasoning, by not only allowing us to recognize conflicts between ends or means to ends, but in also providing a way to rationally revise or reject ends. Finally, in order for this sort of problem-resolving to make good on the idea of genuine improvement or progress, the process of solving problems must involve some sense of objectivity. I offer a procedural account of objectivity that emphasizes the role of the world in constraining our inquiry, involves a naturalization of ethical epistemology, and allows for objective inquiry to be undertaken by an individual or a community. (shrink)

Teleological explanations (TEs) account for the existence or properties of an entity in terms of a function: we have hearts because they pump blood, and telephones for communication. While many teleological explanations seem appropriate, others are clearly not warranted-for example, that rain exists for plants to grow. Five experiments explore the theoretical commitments that underlie teleological explanations. With the analysis of [Wright, L. (1976). Teleological Explanations. Berkeley, CA: University of California Press] from philosophy as a point of departure, we examine (...) in Experiment 1 whether teleological explanations are interpreted causally, and confirm that TEs are only accepted when the function invoked in the explanation played a causal role in bringing about what is being explained. However, we also find that playing a causal role is not sufficient for all participants to accept TEs. Experiment 2 shows that this is not because participants fail to appreciate the causal structure of the scenarios used as stimuli. In Experiments 3-5 we show that the additional requirement for TE acceptance is that the process by which the function played a causal role must be general in the sense of conforming to a predictable pattern. These findings motivate a proposal, Explanation for Export, which suggests that a psychological function of explanation is to highlight information likely to subserve future prediction and intervention. We relate our proposal to normative accounts of explanation from philosophy of science, as well as to claims from psychology and artificial intelligence. (shrink)

Le terme ktitor accompagne souvent la représentation d'un acte de don dans la peinture murale byzantines et post-byzantines. Même si le terme "ktitor" a été traduit le plus souvent par "fondateur", sémantiquement et historiquement, on retrouve dans le mot le sens de possession. Les ktitores - des propriétaires modaux, offrent leurs dons, dont le destinataire final est Dieu. Les panneaux votifs de Théodore Métochite , du sebastokrator Kalojan , de Stefan Uroš III , de Mircea l'Ancien témoignent des droits, des (...) intentions et de la foi du ktitor. Avec le christianisme, le sens du don s'est inversé et out don humain n'est qu'un contre-don à Dieu pour son sacrifice premier. (shrink)

Despite much research on the relationship between awareness and dementia little can be concluded concerning their relationship and the role of other factors. It is likely that studies capture different phenomena of awareness. This study aimed at identifying and delineating such variation by analysing data from three questionnaires obtained during the longitudinal study of awareness in 101 people with early-stage dementia. The data concerned awareness in relation to memory, activities of daily living and socio-emotional function. Significant differences in patterns of (...) discrepancies were obtained. This suggests that the awareness phenomena involved were structurally different; and that, in turn, this may reflect variation in the intrinsic linking between awareness and its ‘object’ . The identification of such differences is necessary so that appropriate methodologies can be applied to the study of awareness in different contexts. (shrink)

Charland's article suggests that we need to think more about whether decision-making capacity is impaired in severe addiction, working from the idea that drug dealers rely on this understanding of addiction to draw in their clients. Charland argues that it is possible to make a choice without being in control (to make decisions without having decision-making capacity). I argue in support of Charland's ideas by examining the reasons supporting a medical model of addiction and its importance. (For Charland's article and (...) the full set of commentaries, please see the Research Gate link). (shrink)

Taiji – sport, méditation, art martial , préservation de la santé, philosophie de vie et voie de l’illumination – est l’une des caractéristiques du daoïsme chinois les plus connues. Cet article cherche à saisir la portée des notions daoïstes classiques, telles que dao , qi et wuwei , ainsi que leur mise en application dans les principes de Taiji tel que pratiqué aujourd’hui à travers le monde entier. Issues de la première génération du daoïsme , ces notions représentent le point (...) central de ses écrits fondateurs et constituent les bases de la philosophie daoïste qui a réussi à préserver son authenticité, malgré de nombreuses évolutions historiques et influences religieuses pendant mille ans, justement grâce à l’application de ces axiomes. Une pratique régulière de Taiji, avec pour but mens sana in corpore sano, et le respect des principes de dao, qi et wuwei, conduisent à la souplesse, la force et la pondération de l’esprit et du corps, puis mènent vers des niveaux de conscience plus élevés où il est possible d’atteindre l’unité de la perfection physique et mentale. C’est ainsi que le « sport » Taiji revêt sa dimension intégrale et transcendante. (shrink)

La relation d'identité est-elle univoque, ou est-elle au contraire relative au concept sous lequel le jugement est énoncé? Depuis quelques années, parmi les philosophes anglo-américains, partisans et adversaires de la thèse que l'on a appelée « la relativité de l'identité », se sont affrontés sur ce point.

Miguel de Cervantès a ouvert le dossier des rapports de « la vérité » avec le « réel », appliquant à cette question toute sa puissance visionnaire. Dans au moins deux de ses œuvres, il compose une approche très originale de ce questionnement : Le Retable des Merveilles, joué longtemps avant sa date de publication en 1615, et le fameux Don Quichotte. Le réel est-il « vrai » ou répond-il d’une construction mentale confinant à la folie? Le Retable, par la (...) mise en scène hallucinatoire de la pseudo-réalité suggérée, dénonce l’emprise du pouvoir politique sur l’imaginaire collectif, soumis à la domestication qu’impose le Saint-Office, tandis que le Quichotte, irrémédiablement placé sous la direction de la « doctrine dulcinéenne », brave l’oppression du système inquisitorial en créant sa propre épistémologie fondée sur un « code ». En matière de vérité, comme le dit le Chevalier de Lions, ne s’agit-il pas de « peser la chose et la mettre à son vrai point »? Aussi, dans ces deux œuvres, le lecteur est-il constamment invité à transcender toute lecture littéraliste, à surplomber la quiétude des banalisations indéfiniment répétées, pour découvrir ce qui constitue l’épistémologie quichottienne, libératrice du sens. Et si ce « point de vérité » se trouvait précisément dans le nom du Quichotte, audible en une langue bannie de la Péninsule en 1492 dont l’auteur semble être un fin connaisseur? L’histoire du Quichotte devient alors l’histoire de la vérité en mouvement, accompagnée de la grâce tutélaire de Dulcinée, que le lecteur est appelé à suivre, peut-être même à rattraper, pour mieux comprendre combien le réel se code selon une haute folie que le rationalisme ne rejoint pas. (shrink)