Using long-term anthropological observations at the Center for Biological and Environmental Nanotechnology in Houston, Texas, the article demonstrates in detail the creation of new objects, new venues and new modes of veridiction which have reoriented the disciplines of materials chemistry and nanotoxicology. Beginning with the confusion surrounding the meaning of ‘implications’ and ‘applications’ the article explores the creation of new venues (CBEN and its offshoot the International Council on Nanotechnology); it then demonstrates how the demands for a responsible, safe (...) or ethical science were translated into new research and experiment in and through these venues. Finally it shows how ‘safety by design’ emerged as a way to go beyond implications and applications, even as it introduced a whole new array of controversies concerning its viability, validity and legitimacy. (shrink)

The Belousov-Zhabotinsky reaction is a far-from-equilibrium reaction involving bromine and citric acid that results in the establishment of a nonlinear chemical oscillator. In addition to providing a paradigmatic chemical model of nonequilibrium biological phenomena, the mathematical models of the BZ reaction are theoretically interesting. The present article concentrates on the personal trajectory of Boris Pavlovich Belousov ; it attempts to explain what, in his routine work in applied and industrial chemistry, could have induced his discovery. The second section describes (...) Belousov’s reaction as presented in his short paper in the proceedings of the institute where he was employed , this being the only paper on his reaction that he was able to publish during his lifetime. The third section presents Belousov’s biography. I then discuss Belousov’s biography in the light of the paper representing his reaction. I have tried to find the prerequisites of Belousov’s discovery in his research in analytical chemistry and in toxicology and radiation medicine . The sixth section attempts an explanation of the ideological underpinning of Belousov’s reaction—the dialectics of continuity and discontinuity popular among Soviet scholars at that time. (shrink)

The multiple environmental crises our planet is experiencing forces us to change the ways we engage with it, especially the ones developed by scientific disciplines such as toxicology. In particular, widespread degradation should lead us to develop scientific practices that take environmental ruination as a framework condition, not only as an object of analysis. In doing so, we should take into account the practice of science at laboratories located in the peripheries of global science, institutions that have coexisted with extensive (...) environmental and material decay from their very onset. Contributing to this task, this paper analyzes the case of Centro Nacional del Medio Ambiente, an environmental chemistry laboratory located in Santiago, Chile. Established in mid-1990s, decades of continual budget cuts left it in a state of almost terminal ruin. In its struggle to remain relevant, CENMA developed an alternative kind of scientific practice, ruination science. Although always precarious, ruination science also tends to be well adapted to engage with impurity, resilient but fragile, and ethically entangled, prioritizing attachment and compromises over the application of certain standard recipes or procedures. Beyond its particularities, CENMA’s ruination science provides us with several valuable keys to better deal with worlds facing multiple kinds of anthropogenic degradation. (shrink)

This personal account traces a series of studies that led from DNA physical chemistry to anticancer drug mechanisms. Chemical crosslinking as a basis for anticancer drug actions had been suspected since the time of the first clinical reports of the effectiveness of nitrogen mustard in 1946. After the elucidation of the DNA helix‐coil transition, several nearly concurrent findings in the early 1960s established the paradigm of DNA interstrand crosslinking. The DNA filter elution phenomenon was discovered in the early 1970s, (...) and lent itself to the development of practical assays for DNA crosslinks and other DNA lesions in mammalian cells. The assays allowed studies of the effects of DNA damaging agents at pharmacologically or toxicologically relevant doses, and have been widely applied in studies of mutagenic and chemotherapeutic agents. During the period 1979–1986, DNA filter elution studies led to the paradigm of DNA topoisomerases as targets of anticancer drug action, and this has become one of the most active areas of anticancer drug development. (shrink)

The ArgumentJohann von Justi, the foremost literary cameralist of his generation, served as chief police commissioner in Göttingen between 1755 and 1757. While in Göttingen, Justi offered lectures at the university on the “œconomic, police and cameral sciences.” He also arrested vagrants, wrote on chemistry, disciplined unruly students, conducted chemical experiments, supervised the pricing of Göttingen's staple goods, engaged in a public controversy with a prominent Berlin chemist, edited and published a bi-weekly periodical (Göttingische Policey-Amts Nachrichien), and worked with (...) the university's curator to refashion the academic structure of the sciences. Taken together, these various activities reflected his broad vision for social and academic change, a vision with important implications for the form and content of the sciences. Drawing on archival material in Göttingen, on articles from thePolicey-Amts Nachrichten, and on Justi's other cameralist and chemical writings, I use his everyday experiences as a local police official to explore the meaning of his chemical work. I argue that Justi's chemistry was suffused with the cameralist dreams and ambitions of a small-town police commissioner. It is what I call police chemistry. (shrink)

This article examines the way in which public controversies affect regulatory science. It describes the controversy that unfolded in Europe around the use of the ninety-day rat-feeding tests for the risk assessment of genetically modified plants. This type of test had been criticized for almost two decades by toxicologists, nongovernmental organizations, and industry alike for its inability to capture the specific health effects of GM plants. But GM risk assessment experts showed great reluctance to move toward a more systematic use (...) of other tests, such as chronic two-year studies or toxicogenomic techniques, and made sure that official guidance continues to recommend the use of the ninety-day rat-feeding study. The article shows that these tactics of standardization are a defining feature of regulatory science, and a resource for toxicity experts to defend their authority and credibility against competing expertises that arise during controversies. (shrink)

Inmaculada de Melo-Martín and Kristen Intemann consider whether, from the perspective of the argument from inductive risk, ethical and political values might be logically, epistemically, pragmatically, or ethically necessary in the “core” of scientific reasoning. In each case, they argue that there are significant conceptual problems. In this comment, employing regulatory uses of high-throughput toxicology at the US Environmental Protection Agency as a case study, I respond to some of their claims about the notion of “pragmatic necessity.” I conclude that, (...) while an inductive risk framework has some significant limitations, it is still conceptually and rhetorically valuable. (shrink)

If scientists rely on assumptions rather than logic, empirical confirmation, and falsification, they are no longer doing science but ideology – which is, by definition, unethical. As a recent US National Academy of Sciences report put it, “bad science is always unethical.”1 This article discusses several ways in which toxicologists can fall into ideology – bad, therefore unethical, science. In part because of the increasing expense of pollution control, some toxicologists have been reexamining pollution dose-response curves that are non-monotonic, that (...) is, curves in which the direction of some response changes with increasing or decreasing dose.2 Ethanol is a classic example of a non-monotonic dose-response curve because moderate drinking is associated with lower risks of heart disease, whereas heavy drinking is associated with higher risks.3,4 If some low-dose pollutants exhibit adaptive or “beneficial effects,”5 this might suggest re-thinking pollution regulations which presuppose linear no-threshold (LNT) dose-response curves. (shrink)

Chemistry and physics are two sciences that are hard to connect. Yet there is significant overlap in their aims, methods, and theoretical approaches. In this book, the reduction of chemistry to physics is defended from the viewpoint of a naturalised Nagelian reduction, which is based on a close reading of Nagel's original text. This naturalised notion of reduction is capable of characterising the inter-theory relationships between theories of chemistry and theories of physics. The reconsideration of reduction also (...) leads to a new characterisation of chemical theories. This book is primarily aimed at philosophers of chemistry and chemists with an interest in philosophy, but is also of interest to the general philosopher of science. (shrink)

. Computational chemistry grew in a new era of “desktop modeling,” which coincided with a growing demand for modeling software, especially from the pharmaceutical industry. Parameterization of models in computational chemistry is an arduous enterprise, and we argue that this activity leads, in this specific context, to tensions among scientists regarding the epistemic opacity transparency of parameterized methods and the software implementing them. We relate one flame war from the Computational Chemistry mailing List in order to assess (...) in detail the relationships between modeling methods, parameterization, software and the various forms of their enclosure or disclosure. Our claim is that parameterization issues are an important and often neglected source of epistemic opacity and that this opacity is entangled in methods and software alike. Models and software must be addressed together to understand the epistemological tensions at stake. (shrink)

In 1931 eminent chemist Fritz Paneth maintained that the modern notion of “element” is closely related to (and as “metaphysical” as) the concept of element used by the ancients (e.g., Aristotle). On that basis, the element chlorine (properly so-called) is not the elementary substance dichlorine, but rather chlorine as it is in carbon tetrachloride. The fact that pure chemicals are called “substances” in English (and closely related words are so used in other European languages) derives from philosophical compromises made by (...) grammarians in the late Roman Empire (particularly Priscian [fl. ~520 CE]). When the main features of the constitution of isotopes became clear in the first half of the twentieth century, the formal (IUPAC) definition of a “chemical element” was changed. The features that are “essential” to being an element had previously been “transcendental” (“beyond the sphere of consciousness”) but, by the mid-twentieth century the defining characteristics of elements, as such, had come to be understood in detail. This amounts to a shift in a “horizon of invisibility” brought about by progress in chemistry and related sciences. Similarly, chemical insight is relevant to currently-open philosophical problems, such as the status of “the bundle theory” of the coherence of properties in concrete individuals. (shrink)

Chemistry and dynamics are closely related in G.W. Leibniz's thinking, from the corpuscularism of his youth to the theory of conspiracy movements that he proposes in his later years. Despite the importance of chemistry and chemical thought in Leibniz's philosophy, interpreters have not paid enough attention to this subject, especially in the recent decades. This work aims to contribute to filling this gap in Leibnizian studies. In this first part of the work I will expose the theory of (...) matter that the young Leibniz conceives under the influence of chemical corpuscularism. Leibniz uses R. Boyle's interpretation of the Aristotelian idea of form in order to give an explanation of the unity and cohesion of bodies. As opposed to the Cartesians, Leibniz puts forth the idea of a dependence between the variables of extension, movement and figure, without losing analytical clarity and with the aim of extending the explanatory power of physics to natural phenomena difficult to approach by Cartesian mechanics. (shrink)

This is an attempt to take a look at chemistry from the point of view of practical realism. Besides its social–historical and normative aspects, the latter involves a direct reference to experimental research. According to Edward Caldin chemistry depends on our being able to isolate pure substances with reproducible properties. Thus, the very basis of chemistry is practical. Even the laws of chemistry are not stable but are subject to correction. At the same time, these statements (...) do not necessarily make Edward Caldin a predecessor of practical realism. The latter has other predecessors, like Rom Harré’s policy realism or Sami Pihlström’s pragmatic realism. Chemistry is an experimental science. The experiment is a purposeful and critically theory-guided constructive, manipulative, material interference with nature according to Rein Vihalemm, the founder of practical realism. Chemistry is physics-like science but just partly so. This is an important point in the context of the current paper. (shrink)

Summary Opinion is divided as to whether chemistry is reducible to physics. The problem can be given a satisfactory solution provided three conditions are met: that a science not be identified with its theories; that several notions of theory dependence be distinguished; and that quantum chemistry, rather than classical chemistry, be compared with physics. This paper proposes to perform all three tasks. It does so by analyzing the methodological concepts concerned as well as by examining the way (...) a chemical rate constant is derivable with the help of the quantum atomic theory. The conclusion is that chemistry, and in particular quantum chemistry, is not a part of physics although it is certainly based on the latter. (shrink)

Using the Public Value Mapping framework, I address the values successes and failures of chemistry as compared to the emerging field of green chemistry, in which the promoters attempt to incorporate new and expanded values, such as health, safety, and environmental sustainability, to the processes of prioritizing and conducting chemistry research. I document how such values are becoming increasingly public. Moreover, analysis of the relations among the multiple values associated with green chemistry displays a greater internal (...) coherence and logic than for conventional chemistry. Although traditional chemistry research has successfully contributed to both economic and values gains, there have been public values failures due to imperfect values articulations, failure to take a longer-term view, and inertia within a system that places too much emphasis on science values. Green chemistry, if implemented effectively, has potential to remedy these failures. (shrink)

In 1931 eminent chemist Fritz Paneth maintained that the modern notion of “element” is closely related to (and as “metaphysical” as) the concept of element used by the ancients (e.g., Aristotle). On that basis, the element chlorine (properly so-called) is not the elementary substance dichlorine, but rather chlorine as it is in carbon tetrachloride. The fact that pure chemicals are called “substances” in English (and closely related words are so used in other European languages) derives from philosophical compromises made by (...) grammarians in the late Roman Empire (particularly Priscian [fl. ~520 CE]). When the main features of the constitution of isotopes became clear in the first half of the twentieth century, the formal (IUPAC) definition of a “chemical element” was changed. The features that are “essential” to being an element had previously been “transcendental” (“beyond the sphere of consciousness”) but, by the mid-twentieth century the defining characteristics of elements, as such, had come to be understood in detail. This amounts to a shift in a “horizon of invisibility” brought about by progress in chemistry and related sciences. Similarly, chemical insight is relevant to currently-open philosophical problems, such as the status of “the bundle theory” of the coherence of properties in concrete individuals. (shrink)

Recently, philosophers have come forth with approaches to chemistry based on its actual practice, imparting to it a proper aim and character of its own. These approaches add to the currently growing movement of pluralist philosophies of science. We draw on recent pluralist accounts from chemistry and analyse three notions from modern chemical practice and theory in terms of these accounts, in order to complement the so far more general pluralist approaches with specific evidence. Our survey reveals that (...) the concept of element indicates conceptual pluralisms in chemistry. that electronegativity illustrates methodological pluralism in determining one and the same concept, and that acidity is an instance of plurality hidden behind ‘one notion’. (shrink)

This book reflects on the significant and highly original scientific contributions of Hans Primas. A professor of chemistry at ETH Zurich from 1962 to 1995, Primas continued his research activities until his death in 2014. Over these 50 years and more, he worked on the foundations of nuclear magnetic resonance spectroscopy, contributed to a number of significant issues in theoretical chemistry, helped to clarify central topics in quantum theory and the philosophy of physics, suggested innovative ways of addressing (...) interlevel relations in the philosophy of science, and introduced cutting-edge approaches in the flourishing young field of scientific studies of consciousness. His work in these areas of research and its continuing impact is described by noted experts, colleagues, and collaborators of Primas. All authors contextualize their contributions to facilitate the mutual dialog between these fields. (shrink)

Along with exploring some of the necessary conditions for the chemistry of our world given what we know about quantum mechanics, I will also discuss a different reductionist challenge than is usually considered in debates on the relationship of chemistry to physics. Contrary to popular belief, classical physics does not have a reductive relationship to quantum mechanics and some of the reasons why reduction fails between classical and quantum physics are the same as for why reduction fails between (...) chemistry and quantum physics. However, a neoreductionist can accept that classical physics has some amount of autonomy from quantum mechanics, but still try to maintain that classical+quantum physics taken as a whole reduces chemistry to physics. I will explore some of the obstacles lying in the neoreductionist’s path with respect to quantum chemistry and thereby hope to shed more light on the conditions necessary for the chemistry of our world. (shrink)

This is an attempt to take a look at chemistry from the point of view of practical realism. Besides its social–historical and normative aspects, the latter involves a direct reference to experimental research. According to Edward Caldin chemistry depends on our being able to isolate pure substances with reproducible properties. Thus, the very basis of chemistry is practical. Even the laws of chemistry are not stable but are subject to correction. At the same time, these statements (...) do not necessarily make Edward Caldin a predecessor of practical realism. The latter has other predecessors, like Rom Harré’s policy realism or Sami Pihlström’s pragmatic realism. Chemistry is an experimental science. The experiment is a purposeful and critically theory-guided constructive, manipulative, material interference with nature according to Rein Vihalemm, the founder of practical realism. Chemistry is physics-like science but just partly so. This is an important point in the context of the current paper. (shrink)

During the second half of the nineteenth century, electronegativity has been one of the most relevant chemical concepts to explain the relationships between chemical substances and their possible reactions. Specifically, EN is a property of the substances that allows them to attract external electrons in bonding situations. The problem arises because EN cannot be measured directly. Indeed, the only way to measure it is through different properties that do can be directly measured, for instance enthalpy, ionization energies or electron affinities. (...) What is particularly troubling about this case in quantum chemistry is that the different models used to describe and quantify EN are incompatible but, in a certain sense, equivalent because the same EN scale results in all of them. By analyzing Linus Pauling’s and Robert Mulliken’s models of EN, it will be argued that, if we remain cling to a traditional representative conception of models, we cannot understand the meaning of the information provided by those models. Indeed, if we do not want to adopt an instrumentalist point of view concerning chemical knowledge, we should reconsider by virtue of what a model represents the system, or, in other words, which the factors that determine the representative power of a model are. I will propose a new perspective that incorporates the role of experimental techniques in the very notion of representation; this perspective allows us to understand how supposedly incompatible models of the same target system can be both simultaneously representative. (shrink)

By a close examination of changes in analytical chemistry between the years 1920 and 1950, I document the case that natural science has undergone and continues to undergo a major revolution. The central feature of this transformation is the rise in importance of scientific instrumentation. Prior to 1920, analytical chemists determined the chemical constitution of some unknown by treating it with a series of known compounds and observing the kind of reactions it underwent. After 1950, analytical chemists determined the (...) chemical constitution of an unknown by using a variety of instruments which allow one to discriminate chemicals in terms of their physical properties. This transformation involved changes in the practice of analytical chemistry. It involved the development of a new family of scientific instrument-making companies, and a new level of capital expenditure necessary to do analytical chemistry. It involved the development of new means to disseminate information about scientific instruments. While I do not document the broader case, these changes have been widespread throughout the natural sciences. It is the rise in the importance of instrumentation which is the key conceptual change in what has been identified as the fourth big scientific revolution. (shrink)

Are there circumstances under which scientists and engineers doing their ordinary jobs can be thought of as participants in a social movement? The technoscientists analyzed in this article are at the forefront of a new way of doing chemistry; they are attempting to redesign chemical products and synthesis pathways to significantly reduce health effects and environmental damage from industrial chemicals. Green chemistry practitioners and entrepreneurs now constitute a small minority of chemists and chemical engineers in the university, government, (...) and corporate sectors, but the innovators gradually are institutionalizing their efforts and winning converts. Drawing on concepts from social movement theory, the authors argue that examining green chemistry as a social movement sheds light on the intentional social organization of emerging scientific and engineering disciplines, advances thinking about the role of expertise in social change, and uncovers a possible pathway toward reconstructing chemical technologies on a more environmentally sustainable basis. The article closes with questions about potential coalitions among green chemists and engineers, regulators, and activist sectors of civil society. (shrink)

In his Metaphysische Anfangsgründe der Naturwissenschaft (MAN), Kant claims that chemistry is an improper, though rational science. The chemistry to which Kant confers this status is the phlogistic chemistry of, for instance, Georg Stahl. In his Opus Postumum (OP), however, Kant espouses a broadly Lavoiserian conception of chemistry. In particular, Kant endorses Antoine Lavoisier's elements, oxygen theory of combustion, and role for the caloric. As Lavoisier's lasting contribution to chemistry, according to some histories of the (...) science, was his emphasis on quantitative methods, Kant's assimilation of the chemical revolution raises the question: did Kant continue to think of chemistry as an improper, though rational, science in OP? In this paper, I answer this question affirmatively. I explain that a proper science requires a priori laws for the mathematical construction of its objects: the mere use of quantitative measurements is insufficient for the satisfaction this requirement. Further, I argue, contra Burkhard Tuschling, that in OP Kant retains a central role for mathematical construction in the foundations of proper natural science. Finally, I contend that the prominent a priori components of chemistry discussed in OP—the aether and the enumeration of the elements—do not make chemistry into a proper science. (shrink)

The paper deals with the philosophy of science and technology from a new perspective. The analysis connects closely to the novel approach to scientific research called practical realism of the late Estonian philosopher of science and chemistry Rein Vihalemm. From his perspective, science is not only theoretical but even more clearly a practical activity. This kind of practice-based approach puts chemistry rather than physics into the position of the most typical science as chemistry has a dual character (...) resting on both constructive-hypothetico-deductive and classifying-historico-descriptive types of cognition. Chemists deal with finding out the laws of nature just like the physicists do. However, in addition to this chemistry deals with substances or stuff that is rather an activity typical to natural history. The analysis of the dual character of chemistry brings forward the need to analyse philosophically also the reasons why physics has held the position of the model science so far. The problem unfolds in the context of practical realism. However, some earlier observations concerning the dual character of chemistry influenced us as well, i.e. by Friedrich Paneth, Michael Polanyi and Edward Caldin. More recently, Bernadette Bensaude-Vincent and Jonathan Simon have given their own explanation of why and how chemistry has a dual character. From their perspective, chemistry is a perfect technical science as it aims at applications, literally at producing something new. Bensaude-Vincent and Simon call their approach operational realism. The latter, however, does not differ from practical realism. (shrink)

The birth of a new discipline, called 'physical chemistry', is sometimes related to the names OSTWALD, ARRHENIUS and VAN'T HOFF and dated back to the year 1887, when OSTWALD founded the Zeitschrift für physikalische Chemie.[1] But as many historians have pointed out, the phrase 'physical chemistry' was widely used before that and the topics under investigation partially go back to Robert BOYLE's attempts to connect chemistry with concepts of mechanical philosophy.[2] The idea of a sudden birth of (...) physical chemistry in 1887 seems to be a founder myth.[3] But there is no doubt that in the late nineteenth-century there was a rapid growth of research in fields now understood as physical chemistry: chemical thermodynamics, electrochemistry, photochemistry, spectroscopy, chemical kinetics etc. (shrink)

In this paper I reply to Olimpia Lombardi’s comment on my recent book Reducing Chemistry to Physics: Limits, Models, Consequences.

At first glance twentieth-century philosophy of science seems virtually to ignore chemistry. However this paper argues that a focus on chemistry helped shape the French philosophical reflections about the aims and foundations of scientific methods. Despite patent philosophical disagreements between Duhem, Meyerson, Metzger and Bachelard it is possible to identify the continuity of a tradition that is rooted in their common interest for chemistry. Two distinctive features of the French tradition originated in the attention to what was (...) going on in chemistry.French philosophers of science, in stark contrast with analytic philosophers, considered history of science as the necessary basis for understanding how the human intellect or the scientific spirit tries to grasp the world. This constant reference to historical data was prompted by a fierce controversy about the chemical revolution, which brought the issue of the nature of scientific changes centre stage.A second striking—albeit largely unnoticed—feature of the French tradition is that matter theories are a favourite subject with which to characterize the ways of science. Duhem, Meyerson, Metzger and Bachelard developed most of their views about the methods and aims of science through a discussion of matter theories. Just as the concern with history was prompted by a controversy between chemists, the focus on matter was triggered by a scientific controversy about atomism in the late nineteenth-century.Keywords: France; Epistemology; Chemistry; Revolution; Atomism; Realism. (shrink)

Chemistry laboratories, as buildings, have been surprisingly little studied by historians of science; interest has been focused on them more as sites of specific scientific activity, with particular emphasis on the personalities who worked within them. This has overshadowed aspects of laboratories such as their specification, design, construction, fitting-out, adaptation, replacement, status as civic and academic structures, and so on. Systematic study of them would be aided by an agreed taxonomy of laboratory types, according to their purpose, and a (...) scheme is proposed here. Practically no pre-1800 chemical laboratories survive, and there are very few dating from earlier than 1900, at least in their original state. Encouragingly, there have been several recent archaeological excavations which have turned up interesting evidence of early examples from various cultures. Little interest has been shown in the preservation of laboratories as significant architectural or historical structures, certainly when compared with other building types. The paper closes by considering those English laboratories which enjoy some level of legal protection but questioning the criteria adopted in deciding the programme of preservation. (shrink)

In 1904 Joachim published an influential paper dealing with 'Aristotle's Conception of Chemical Combination' which has provided the basis of much more recent studies. About the same time, Duhem developed what he regarded as an essentially Aristotelian view of chemistry, based on his understanding of phenomenological thermodynamics. He does not present a detailed textual analysis, but rather emphasises certain general ideas. Joachim's classic paper contains obscurities which I have been unable to fathom and theses which do not seem to (...) be fully explained, or which at least seem difficult for the modern reader to understand. An attempt is made here to provide a systematic account of the Aristotelian theory of the generation of substances by the mixing of elements by reconsidering Joachim's treatment in the light of the sort of points which most interested Duhem.The work described in this paper was undertaken with a view to providing a basis for presenting, evaluating and criticising Duhem's understanding of what was for him modern chemistry. This latter project will be taken up on another occasion. I hope the present paper will be of some value to a broader philosophical readership in so far as it provides a fairly clear conception of matter which might be called Aristotelian, even if it is not precisely Aristotle's, and raises certain clear problems of interpretation. It may also be of interest to historians of chemistry in suggesting an analysis of the old chemical notion of a mixt independent of atomic theories. (shrink)

This chapter shows that the combination of mathematical and chemical thinking in particular, as evidenced by Charles Sanders Peirce’s chemical training at Harvard, formed a solid conceptual basis for his account of diagrams. The connection between the Lawrence school and the chemical tradition established by Justus von Liebig in Giessen is of crucial importance to understand the context of Peirce’s own chemistry training. A completely different picture emerges if one pays greater attention to the nature of the chemistry (...) curriculum in Harvard at the time, and in particular to the pedagogical innovations introduced by Peirce’s chemistry teacher, Josiah Parsons Cooke. Historians of science have investigated the rise of institutional scientific laboratories from a range of perspectives. The chapter concludes with some suggestions for further investigation into the role of chemistry in Peirce’s philosophical system more broadly and the potential this new avenue of inquiry might have for the direction of Peirce scholarship. (shrink)

Dissatisfied with the descriptive and speculative methods of evolutionary biology of his time, the physiologist Jacques Loeb , best known for his “engineering” approach to biology, reflected on the possibilities of artificially creating life in the laboratory. With the objective of experimentally tackling one of the crucial questions of organic evolution, i.e., the origin of life from inanimate matter, he rejected claims made by contemporary scientists of having produced artificial life through osmotic growth processes in inorganic salt solutions. According to (...) Loeb, the answer to the question of whether or not life could be created artificially had to come from macro-molecular chemistry, in particular from the research on the recently discovered DNA. He was convinced that a prerequisite for making living matter from inanimate substances was the chemical synthesis of nuclear material capable of self-replication. Moreover, Loeb, experimentally refuting some vitalistic explanations as well as colloidal chemists’ far-reaching claims that biologically relevant macromolecules follow colloidal rather than chemical laws, pioneered research on the physical and chemical explanations of biological phenomena. (shrink)

Plato's geometrical theory of what we now call chemistry, set out in the Timaeus, uses triangles, his stoicheia, as the fundamental units with which he constructs his four elements. A paper claiming that these triangles can be divided indefinitely is criticized; the claim of an error here in the commentary by F.M. Cornford is unfounded. Plato's constructions of the elements are analyzed using simple point group theory. His procedure generates fully symmetric polyhedra, but Cornford's 'simpler' alternatives generate polyhedra with (...) low symmetries and multiple isomeric forms. However, Cornford's principle of constructing larger triangles by assembling smaller ones is still valid. (shrink)

Crossing the boundaries - between nature and artifact and between inanimate and living matter - is a major feature of the convergence between nanotechnology and biotechnology. This paper points to two symmetric ways of crossing the boundaries: chemists mimicking nature's structures and processes, and synthetic biologists mimicking synthetic chemists with biological materials. However to what extent are they symmetrical and do they converge toward a common view of life and machines? The question is addressed in a historical perspective. Both biomimetic (...) chemistry and synthetic biology can be described as descendants of an ambitious program developed by Stéphane Leduc who coined the phrase 'synthetic biology' in the early twentieth century. The main intention of this genealogy is to emphasize that although making life in a test tube is a recurrent project there are subtle nuances in the underlying metaphysical assumptions. This comparison is meant to contribute to a better understanding of the cultural issues at stake in the convergence between nano and biotechnologies. It suggests that the demarcation line between life and inanimate matter remains a hot issue, and that all traffics across the borders do not proceed from the same metaphysical assumptions. (shrink)

How do we teach chemistry as a different science from physics? This paper looks into a fundamental distinguishing property of chemistry as a science. It is characterized in this paper that chemistry, unlike many other sciences that are largely descriptive, is primarily creative. In this sense, the various fields of chemistry may seek to create as an end goal, and not merely to create as a means to an end as commonly seen in allied sciences. This (...) distinction is important as it elevates the importance of chemical synthesis above being a small detail of the field. I argue in this paper that synthesis is a largely defining character of chemistry as a structured science, and must be given importance to when attempting to define chemistry as a separate study from similar fields. Awareness of the importance of synthesis can elucidate on the manner and trends of normal chemical research as well as predict possible circumstances that will arise for the field of chemistry. (shrink)

This article examines the chemistry of race at the turn of the nineteenth century. Physicians, philosophers, and intellectuals from Benjamin Rush to Everard Home defined the skin color of Africans as resulting from the changes of the body's humors. Radical physicians like Benjamin Rush believed that he could “cure” African slaves of what he identified as indicative of sickness, their skin color, as they were essentially sick white people in his mind. Overall, the study seeks to explain the medical (...) and chemical understanding of race and the potential for “curing” blackness. Often these cures were linked to balancing and unblocking the fluids. A justification for these ideas comes from cases where people seemed to have spontaneously turned black and experiments where black people were turned white. (shrink)

In this paper we wish to raise the following question: which conceptual obstacles need to be overcome to arrive at a scientific and theoretical understanding of the mind? In the course of this examination, we shall encounter methodological and explanatory challenges and discuss them from the point of view of the philosophy of chemistry and quantum mechanics. This will eventually lead us to a discussion of emergence and metaphysics, thereby focusing on the status of objects. The question remains whether (...) this could be interpreted in terms of a re-description or dissolution of seemingly troubling problems in the philosophy of mind, or whether it further emphasizes the problematic: the ubiquitous and irreducible role of mind and consciousness in scientific activities. (shrink)

How do chemists assign numbers to chemicals properties? What do these numbers refer to? To answer these questions, we will first point out both the context-dependence of chemicals and the epistemic limitations of chemistry. We will then investigate how chemists use various procedures to stabilize measurements and how they use mixtures of samples as “references” in order to determine the amount of different chemicals in a sample. This study will enable us to query how it is possible for chemists (...) to change one factor while holding others constant at each step of the measurement procedure. This part of our work which will lead us to query the meaning of the ceteris paribus clause and the very possibility of making holistic inferences in the domain of chemistry. To conclude, we will highlight how methodological pluralism developed by chemists makes it possible for a relational type of consistency to emerge. (shrink)

It is often assumed that chemistry was a typical positivistic science as long as chemists used atomic and molecular models as mere fictions and denied any concern with their real existence. Even when they use notions such as molecular orbitals chemists do not reify them and often claim that they are mere models or instrumental artefacts. However a glimpse on the history of chemistry in the longue durée suggests that such denials of the ontological status of chemical entities (...) do not testify for any specific allegiance of chemists to positivism. Rather it suggests that the dilemma positivism vs realism is inappropriate for characterizing the ontology of chemistry. This alternative shaped at the turn of the twentieth century in the context of controversies about atomic physics does not take into account the major concern of chemists, i.e. making up things. Only by considering what matters for chemists, their matters of concern rather than their matter theories, can we expect to get an insight on their ontological assumptions. The argumentation based on historical data is twofold. It is wellknown that generating new substances out of initial ingredients which is the raison d'être of chemistry raised a vexing puzzle which has been alternatively solved with the Aristotelian notion of mixt and the Lavoisieran notion of compound. I argue that an essential tension remains intrinsic in chemistry between the two conceptual frameworks. The second section tries to make sense of the long tradition in chemistry of ontological noncommitment. I argue that what is usually considered as a denial of the existence of the basic units of matter would be better characterized as a focus on more important actors on the chemical stage. (shrink)

Hybrid scientific fields consist of a collection of knowledge-producing and -utilising organisations, fulfilling a dual role of providing specific knowledge services as well as contributing to increased scientific understanding. In this article, the processes that govern scientific knowledge production in hybrid scientific fields are explored. While such sets of organisations are targeted in science policy as receivers of resources, as well as providers of services and other knowledge products, attention in science studies is all but lacking. Data from a study (...) on toxicology as a representative of public health sciences are used. The author will focus on the effects on scientific research and its organisational relations by discussing three social processes relevant to knowledge production, problem choice, resource distribution, and reputational control. (shrink)

The many-faced relationship between chemistry and physics is one of the most discussed topics in the philosophy of chemistry. In his recent book Reducing Chemistry to Physics. Limits, Models, Consequences, Hinne Hettema conceives this relationship as a reduction link, and devotes his work to defend this position on the basis of a “naturalized” concept of reduction. In the present paper I critically review three kinds of issues stemming from Hettema’s argumentation: philosophical, scientific and methodological.

The focus of this contribution lies on eighteenth-century chemistry up to Lavoisier’s anti-phlogistic chemical system. Some main features of chemistry in this period will be examined by discussing classificatory practices and the understanding of the substances these practices imply. In particular, the question will be discussed of whether these practices can be regarded as natural historical practices and, hence, whether chemistry itself was a special natural history (part I). Furthermore, discussion of the famous Methode de nomenclature chimique (...) (1787) raises the question of what modes of classification tell us about chemists’ understanding of the substances they deal with (part II). Finally, in investigating what taxonomic orders reveal about deep structures of chemists’ understanding of the world of substances, the contribution will examine the question of whether Lavoisier’s anti-phlogistic chemical system was a revolution on the level of a deep structure or a revision within the untouched frame of such a structure (part III). (shrink)

Differing views on reduction are briefly reviewed and a suggestion is made for a working definition of 'approximate reduction'. Ab initio studies in quantum chemistry are then considered, including the issues of convergence and error bounds. This includes an examination of the classic studies on CH2 and the recent work on the Si2C molecule. I conclude that chemistry has not even been approximately reduced.