\noindent\textbf{Introduction} Online interventions hold great potential for Therapeutic Change Process Research (TCPR), a field that aims to relate in-therapeutic change processes to the outcomes of interventions. Online a client is treated essentially through the language their counsellor uses, therefore the verbal interaction contains many important ingredients that bring about change. TCPR faces two challenges: how to derive meaningful change processes from texts, and secondly, how to assess these complex, varied and multi-layered processes? We advocate the use text mining and multi-level (...) models (MLMs): the former offers tools and methods to discovers patterns in texts; the latter can analyse these change processes as outcomes that vary at multiple levels. \noindent\textbf{Method} We (re-)used the data from \cite{Lamers2015} because it includes outcomes and the complete online intervention for clients with mild depressive symptoms. We used text mining to obtain basic text-variables from e-mails, that we analysed through MLMs. \noindent\textbf{Results} We found that we could relate outcomes of interventions to variables containing text-information. We conclude that we can indeed bridge text mining and MLMs for TCPR as it was possible to relate text-information (obtained through text mining) to multi-levelled TCPR outcomes (using a MLM). \noindent\textbf{Discussion} Text mining can be helpful to obtain change processes, which is also the main challenge for TCPR. We showed how MLMs and text mining can be combined, but our proposition leaves open how to obtain the most relevant textual operationalization of TCPR concepts. That requires interdisciplinary collaboration and discussion. The future does look bright: based on our proof-of-concept study we conclude that MLMs and text mining can indeed advance TCPR. (shrink)

In this paper, reduction and its pragmatics are discussed in light of the development in computer science of languages to describe processes. The design of higher-level description languages within computer science has had the aim of allowing for description of the dynamics of processes in the (physical) world on a higher level avoiding all (physical) details of these processes. The higher description levels developed have dramatically increased the complexity of applications that came within reach. The pragmatic attitude of a (scientific) (...) practitioner in this area has become inherently anti-reductionist, but based on well-established reduction relations. The paper discusses how this perspective can be related to reduction in general, and to other domains where description of dynamics plays a main role, in particular, biological and cognitive domains. (shrink)

The contribution that Professor Pieter M. Venter has made to the study of the Old Testament during his academic and ecclesiastic career is reviewed. After a brief biographical introduction, the article surveys the development of his research interests, focusing specifically on his contributions to the study of wisdom literature, narratives and narratology, second temple literature, the formation of the canon, and Old Testament Theology. The review concludes with reference to his way of practising critical theology, taking full cognisance of research (...) into the linguistic, historical critical, narratological and ideological aspects of Old Testament texts, but always with a sensitivity for the needs of the church as interpretive community. (shrink)

As of October 23, 2020, almost 42 million cases of COVID-19 have been reported globally. Although many different treatments have been applied in infected...

Conserved upstream open reading frames (uORFs) are found within many eukaryotic transcripts and are known to regulate protein translation. Evidence from genetic and bioinformatic studies implicates disturbed uORF‐mediated translational control in the etiology of human diseases. A genetic mouse model has recently provided proof‐of‐principle support for the physiological relevance of uORF‐mediated translational control in mammals. The targeted disruption of the uORF initiation codon within the transcription factor CCAAT/enhancer binding protein β (C/EBPβ) gene resulted in deregulated C/EBPβ protein isoform expression, associated (...) with defective liver regeneration and impaired osteoclast differentiation. The high prevalence of uORFs in the human transcriptome suggests that intensified search for mutations within 5′ RNA leader regions may reveal a multitude of alterations affecting uORFs, causing pathogenic deregulation of protein expression. (shrink)

I argue that there are at least four different ways in which the term ‘function’ is used in connection with the study of living organisms, namely: function as activity, function as biological role, function as biological advantage, and function as selected effect. Notion refers to what an item does by itself; refers to the contribution of an item or activity to a complex activity or capacity of an organism; refers to the value for the organism of an item having a (...) certain character rather than another; refers to the way in which a trait acquired and has maintained its current share in the population. The recognition of a separate notion of function as biological advantage solves the problem of the indeterminate reference situation that has been raised against a counterfactual analysis of function, and emphasizes the importance of counterfactual comparison in the explanatory practice of organismal biology. This reveals a neglected problem in the philosophy of biology, namely that of accounting for the insights provided by counterfactual comparison. (shrink)

I argue that there are at least four different ways in which the term ‘function’ is used in connection with the study of living organisms, namely: function as activity, function as biological role, function as biological advantage, and function as selected effect. Notion refers to what an item does by itself; refers to the contribution of an item or activity to a complex activity or capacity of an organism; refers to the value for the organism of an item having a (...) certain character rather than another; refers to the way in which a trait acquired and has maintained its current share in the population. The recognition of a separate notion of function as biological advantage solves the problem of the indeterminate reference situation that has been raised against a counterfactual analysis of function, and emphasizes the importance of counterfactual comparison in the explanatory practice of organismal biology. This reveals a neglected problem in the philosophy of biology, namely that of accounting for the insights provided by counterfactual comparison. (shrink)

Fictional realists maintain that fictional characters are part of the world’s ontology. In an influential article, Anthony Everett argues that the fictional realist is thereby committing herself to problematic entities. Among these are entities that are indeterminately identical. Recently, Ross Cameron and Richard Woodward have answered Everett’s worry using the same strategy. They argue that the fictional realist can bypass the problematic identities by contending that they are merely semantically indeterminate. This paper concisely surveys Everett’s original argument, Cameron’s and Woodward’s (...) responses, and then argues that the strategy employed by Cameron and Woodward fails to satisfactorily answer Everett’s worries. (shrink)

The expression that professionals should be led by their moral or ethical compass is increasingly used by academics, policy makers, professionals, and educational institutes. Dutch universities of applied sciences (UAS), for example, explicitly aim to educate their students to become professionals equipped with a moral compass. This moral or ethical compass is a metaphor of which people intuitively grasp its meaning, but our literature review also shows that various interpretations are possible. We found three clusters of proposed ethical compasses expressing (...) its a) content, b) form, or c) use, which we present in this article. Thereafter, we evaluate which compass can meaningfully assist (young) professionals and, therefore, should be part of the aims and content of education provided by UAS. Based on this evaluation, we describe the possibilities and boundaries of UAS’ contribution to the development of their students’ ethical compass. (shrink)

Ludwig Wittgenstein (1889-1951) was an extraordinarily original thinker, whose influence on twentieth-century thinking far outside the bounds of philosophy alone. In this engaging Introduction, A.C. Grayling makes Wittgenstein's thought accessible to the general reader by explaining the nature and impact of Wittgenstein's views. He describes both his early and later philosophy, the differences and connections between them, and gives a fresh assessment of Wittgenstein's continuing influence on contemporary thought.

There is a strong intuition that we can listen to works of music, yet musical ontologies on which works of music are abstract objects, perhaps most notably, type theories of music, seem to imply that this is impossible. This problem has received relatively little attention in the literature. I here explore and develop a solution suggested by Julian Dodd and argue that it has at least two problematic consequences, namely (i) that some works of music cannot be listened to unless (...) one has already studied the relevant score or through a similar process learned roughly what the work requires of its performances and (ii) that it is possible for two people to listen to different musical works while listening to the same performance. (shrink)

It is well known that Carnap, early in his philosophical career, took most of metaphysics to consist of meaningless pseudostatements. In contrast to this meaning-theoretic critique of metaphysics, we develop what we take to be Carnap’s later value-based critique. We argue that this later critique is forceful against several central contemporary metaphysical debates, its origin in the principle of tolerance notwithstanding.

Philosopher Roger Scruton offers a wide-ranging perspective on philosophy, from logic to aesthetics, written in a lively and engaging way that is sure to stimulate debate. Rather than producing a survey of an academic discipline, Scruton reclaims philosophy for worldly concerns.

Bertrand Russell (1872-1970) is one of the most famous and important philosophers of the twentieth century. In this account of his life and work A.C. Grayling introduces both his technical contributions to logic and philosophy, and his wide-ranging views on education, politics, war, andsexual morality. Russell is credited with being one of the prime movers of Analytic Philosophy, and with having played a part in the revolution in social attitudes witnessed throughout the twentieth-century world. This introduction gives a clear survey (...) of Russell's achievements across their wholerange. (shrink)

The 1981 Dahlem conference was a catalyst for contemporary evolutionary developmental biology (Evo-devo). This introductory chapter rehearses some of the details of the history surrounding the original conference and its associated edited volume, explicates the philosophical problem of conceptual change that provided the rationale for a workshop devoted to evaluating the epistemic revisions and transformations that occurred in the interim, explores conceptual change with respect to the concept of evolutionary novelty, and highlights some of the themes and patterns in the (...) different contributions to the present volume, Conceptual Change in Biology: Scientific and Philosophical Perspectives on Evolution and Development. (shrink)

'The unconsidered life is not worth living' - Socrates. Thinking about life, what it means and what it holds in store does not have to be a despondent experience, but rather can be enlightening and uplifting. A life truly worth living is one that is informed and considered so a degree of philosophical insight into the inevitabilities of the human condition is inherently important and such an approach will help us to deal with real personal dilemmas. This book is an (...) accessible, lively and thought-provoking series of linked commentaries, based on A. C. Grayling's 'The Last Word' column in the Guardian. Its aim is not to persuade readers to accept one particular philosophical point of view or theory, but to help us consider the wonderful range of insights which can be drawn from an immeasurably rich history of philosophical thought. Concepts covered include courage, love, betrayal, ambition, cruelty, wisdom, passion, beauty and death. This will be a wonderfully stimulating read and act as an invaluable guide as to what is truly important in living life, whether facing success, failure, justice, wrong, love, loss or any of the other profound experience life throws out. (shrink)

In this benchmark five-volume study, originally published between 1922 and 1955, Surendranath Dasgupta examines the principal schools of thought that define Indian philosophy. A unifying force greater than art, literature, religion, or science, Professor Dasgupta describes philosophy as the most important achievement of Indian thought, arguing that an understanding of its history is necessary to appreciate the significance and potentialities of India's complex culture. Volume I offers an examination of the Vedas and the Brahmanas, the earlier Upanisads, and the six (...) systems of Indian philosophy. (shrink)

"A distinctive voice somewhere between Mark Twain and Michel Montaigne" is how Psychology Today described A.C. Grayling. In Life, Sex, and Ideas: The Good Life Without God, readers have the pleasure of hearing this distinctive voice address some of the most serious topics in philosophy--and in our daily lives--including reflections on guns, anger, conflict, war; monsters, madness, decay; liberty, justice, utopia; suicide, loss, and remembrance. A civilized society, says Grayling, is one which never ceases having a discussion with itself about (...) what human life should best be. In this book, Grayling adds to this discussion a series of short informal essays about ethics, ideas, and culture. A recurring theme is religion, of which he writes "there is no greater social evil." He argues, for instance, that liberal education is better than religion for inculcating moral values. "Education in literature, history, and appreciation of the arts," he says, "opens the possibility for us to live more reflectively and knowledgeably, especially about the nature and variety of human experience. That in turn increases our capacity for understanding others better, so that we can treat them with respect and sympathy, however different their outlook on life." Thought provoking rather than definitive, these essays don't tell readers what to think, but only note what has been thought about how it is best to live. A person who does not think about life, the author reminds us, is like a stranger mapless in a foreign land. These brief and suggestive essays offer us the outlines of a map, with avenues of thought that are a pleasure to wander down. (shrink)

A traditional approach to teaching medical ethics aims to provide knowledge about ethics. This is in line with an epistemological view on ethics in which moral expertise is assumed to be located in theoretical knowledge and not in the moral experience of healthcare professionals. The aim of this paper is to present an alternative, contextual approach to teaching ethics, which is grounded in a pragmatic-hermeneutical and dialogical ethics. This approach is called moral case deliberation. Within moral case deliberation, healthcare professionals (...) bring in their actual moral questions during a structured dialogue. The ethicist facilitates the learning process by using various conversation methods in order to find answers to the case and to develop moral competencies. The case deliberations are not unique events, but are a structural part of the professional training on the work floor within healthcare institutions. This article presents the underlying theory on ethics and illustrates this approach with an example of a moral case deliberation project in a Dutch psychiatric hospital. The project was evaluated using the method of responsive evaluation. This method provided us with rich information about the implementation process and effects the research process itself also lent support to the process of implementation. (shrink)

In mathematics, the deductive method reigns. Without proof, a claim remains unsolved, a mere conjecture, not something that can be simply assumed; when a proof is found, the problem is solved, it turns into a “result,” something that can be relied on. So mathematicians think. But is there more to mathematical justification than proof?The answer is an emphatic yes, as I explain in this chapter. I argue that non-deductive justification is in fact pervasive in mathematics, and that it is in (...) good epistemic standing. (shrink)

"ACT Administrative Appeals Tribunal Decisions." Ethos: Official Publication of the Law Society of the Australian Capital Territory, (200), pp. 42.

In mathematics, the deductive method reigns. Without proof, a claim remains unsolved, a mere conjecture, not something that can be simply assumed; when a proof is found, the problem is solved, it turns into a “result,” something that can be relied on. So mathematicians think. But is there more to mathematical justification than proof? -/- The answer is an emphatic yes, as I explain in this article. I argue that non-deductive justification is in fact pervasive in mathematics, and that it (...) is in good epistemic standing. (shrink)

This a general account of the school of Mo-tzu, its social basis as a movement of craftsmen, its isolated place in the Chinese tradition, and the nature of its later contributions to logic, ethics, and science. It assesses the relation of Mohist thinking to the structure of the Chinese language, and grapples with the textual dynamics of later Mohist writings, particularly in regard to grammar and style, technical terminology, the use and significance of stock examples, and overall organization. Includes edited (...) and annotated Chinese text with an English translation and commentary, a glossary, and a photographic reproduction of the unemended text from the Taoist Patrology. (shrink)

Cutting across boundaries of art and science, evolution is a fundamental process that has beguiled thinkers through the ages. This collection draws together world renowned thinkers and communicators with their own intriguing insights. In these essays they offer a feast of dazzling thoughts and ideas to challenge and enthrall the reader. Why and how do civilisations and societies change over time? Why do our cells develop the way they do? Why are some villages still villages while others have grown into (...) vast cities? Can we learn from our evolutionary past to plan a better future for our health and society? Tracing a line from the history of biological evolution, through the evolution of cultures, society, science and the universe, Evolution brings together intriguing parallels from all levels of life. From the evolution of the developing embryo to the evolution of a developing star, common threads develop into a fascinating story. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Scientia propter quid nobis—The Epistemic Independence of Metaphysics and Theology in the Quaestio de cognitione Dei attributed to Duns Scotus by Wouter GorisClaus A. AndersenGORIS, Wouter. Scientia propter quid nobis—The Epistemic Independence of Metaphysics and Theology in the Quaestio de cognitione Dei attributed to Duns Scotus. Münster: Aschendorff, 2022. viii + 296 pp. Paper, € 49.00The central claim of Wouter Goris's new book is that (...) the Quaestio de cognitione Dei traditionally (both in one late medieval manuscript and in some modern scholarship) attributed to John Duns Scotus not only is inauthentic but in fact represents an early reaction against Scotus's teaching on the scientific nature of metaphysics. The Quaestio in particular explores Scotus's distinction between a science "in itself" and one "for us" and, going beyond Scotus's own doctrine, shows how this distinction is applicable to metaphysics.The book is divided into three parts. Part 1 offers a critical edition of the Quaestio de cognitione Dei, which has hitherto been available in a plain transcription published by C. R. S. Harris in 1927. Harris's text was based on a single manuscript from the fifteenth century (Oxford, Merton College, Ms. 90); Goris bases his edition on a manuscript from the early fourteenth century (Assisi, Biblioteca Comunale, Ms. 172), one that does not attribute the text to Scotus. Goris highlights that the text has significant parallels in the prologue of John of Reading's Scriptum on the first book of the Sentences; there is presently not sufficient evidence for claiming that Reading is the author of the De cognitione Dei, but it does seem clear that either Reading or some other Franciscan friar relying on Reading's Scriptum authored the text between 1316 and 1325. The Quaestio itself consists of two articles. Two appendices to the edition document longer passages from Reading's Scriptum.Part 2 investigates the use of the distinction between a science in itself and one for us in Duns Scotus and some of the early Scotists. Scotus's doctrine developed over time. At Oxford Scotus taught that theology in se is about the divine essence in its particularity; theology for us is about the most perfect concept of God attainable for human beings by natural means, that is, the concept "infinite being." It falls to metaphysics to prove that there is such a kind of being. At Paris Scotus rather taught that both theology in se and theology for us are about the divine essence in its [End Page 549] particularity. The implication is that a strictly demonstrative science about God is possible for human beings in this present life, a knowledge of God that is completely independent of metaphysics. Goris argues that this shift in the view of theology explains the absence of Scotus's famous "twin doctrines" of the univocal concept of being and of being as the first adequate object of the intellect from his theological epistemology of the Parisian period. Not too surprisingly, in the wake of Scotus we find several authors grappling with the relationship between theology and metaphysics. The positions investigated by Goris vary considerably. Richard of Conington distinguishes between human metaphysical knowledge of being and God's own metaphysical knowledge of being; the latter represents a more perfect knowledge of both God himself and creatures as included under the concept of being. Francis of Marchia employs a distinction between a general metaphysics (about being as being) and a special metaphysics (about divine being), but on the level of science for us the special part of metaphysics is subordinated to the general one. Nicolas Bonetus, by contrast, advocates a sharp distinction between metaphysical knowledge of being and natural theology; he structures his metaphysics as a purely ontological discipline and treats natural theology as a separate science; Goris sees this reorganization as Bonetus's most decisive contribution to the history of metaphysics.Part 3 analyzes the fundamental doctrines defended in the Quaestio de cognitione Dei and compares them with those of Scotus and John of Reading. The first article of the Quaestio introduces two important distinctions, the first of which is between metaphysics in itself and metaphysics for us; these two... (shrink)

_Sonoran Desert, Stuart Hameroff and Alwyn Scott awoke from their_ _siestas to take margaritas in the shade of a ramada. On a nearby_ _table, a tape recorder had accidentally been left on and the following_ _is an unedited transcript of their conversation._.

The Compactness Theorem The compactness theorem is a fundamental theorem for the model theory of classical propositional and first-order logic. As well as having importance in several areas of mathematics, such as algebra and combinatorics, it also helps to pinpoint the strength of these logics, which are the standard ones used in mathematics and arguably … Continue reading Compactness →.

In the light of increasing public mistrust, there is an urgent need to clarify the moral status of the medical profession and of the relationship of the clinician to his/her patients. In addressing this question, I first establish the coherence, within moral philosophy generally, of the concept of supererogation . I adopt the notion of an act of “unqualified” supererogation as one that is non-derivatively good, praiseworthy, and freely undertaken for others' benefit at the risk of some cost to the (...) agent. I then argue that committing oneself to the profession of clinical medicine is an act of this kind. This is the case, not because the aim of medicine is to help patients, but because of the open ended commitment of time and the vulnerability to the consequences of failure that the clinician must accept. (shrink)