Cell and tissue-based products, such as autologous adult stem cells, are being prescribed by physicians across the world for diseases and illnesses that they have neither been approved for or been demonstrated as safe and effective in formal clinical trials. These doctors often form part of informal transnational networks that exploit differences and similarities in the regulatory systems across geographical contexts. In this paper, we examine the regulatory infrastructure of five geographically diverse but socio-economically comparable countries with the aim of (...) identifying similarities and differences in how these products are regulated and governed within clinical contexts. We find that while there are many subtle technical differences in how these regulations are implemented, they are sufficiently similar that it is difficult to explain why these practices appear more prevalent in some countries and not in others. We conclude with suggestions for how international governance frameworks might be improved to discourage the exploitation of vulnerable patient populations while enabling innovation in the clinical application of cellular therapies. (shrink)

At the very beginning of Lavallee’s article on addictive craving, they note that they will avoid using the term addict in an attempt to avoid essentializing the identities of people who experience addiction. Neuroscientific approaches to the study of mental disorders could benefit from a similar level of caution with regard to discouraging essentialism. Zachar characterized psychological essentialism as the “cognitive predisposition to view entities as possessing underlying natures that make them be the kind of things that they are”. The (...) view that the brain is the underlying “essence” of the person has been dubbed neuroessentialism. Neuroessentialism entails that mental disorders have an inherent... (shrink)

Important philosophical work has gone into debunking thoroughly entrenched positivist notions that objective science proceeds in a value neutral manner. Dr. Tamara Kayali Browne's article "A Role for Philosophers, Sociologists, and Bioethicists in Revising the DSM" admirably takes the next step. Given the evaluative elements that permeate, in this case, the science of nosology—how do we deal responsibly with those evaluative elements? She correctly, in my opinion, concludes that dealing with evaluative issues responsibly is tantamount to dealing with them ethically. (...) But, as her concrete example of the ethics of premenstrual dysphoric disorder demonstrates, dealing with the ethics of the science of... (shrink)

I would like to thank Scott Waterman for sharing what must have been very challenging personal circumstances. Waterman's reflections touched upon many complex issues. For my part, I would like to explore how Waterman's experience underscores the importance of epistemic humility regarding the limits of scientific knowledge and our sense of the meaning of scientific knowledge while still recognizing the significance and power of scientific knowledge. The first epistemic challenge presented by Scott Waterman's experience of "patienthood" that demonstrates the limits (...) of scientific knowledge is the ability to know pain. Of course, we have all known pain, but such firstperson knowledge would not qualify as scientific... (shrink)

In face of the multiple controversies surrounding the DSM process in general and the development of DSM-5 in particular, we have organized a discussion around what we consider six essential questions in further work on the DSM. The six questions involve: 1) the nature of a mental disorder; 2) the definition of mental disorder; 3) the issue of whether, in the current state of psychiatric science, DSM-5 should assume a cautious, conservative posture or an assertive, transformative posture; 4) the role (...) of pragmatic considerations in the construction of DSM-5; 5) the issue of utility of the DSM – whether DSM-III and IV have been designed more for clinicians or researchers, and how this conflict should be dealt with in the new manual; and 6) the possibility and advisability, given all the problems with DSM-III and IV, of designing a different diagnostic system. Part 1 of this article took up the first two questions. Part 2 took up the second two questions. Part 3 now deals with Questions 5 & 6. Question 5 confronts the issue of utility, whether the manual design of DSM-III and IV favors clinicians or researchers, and what that means for DSM-5. Our final question, Question 6, takes up a concluding issue, whether the acknowledged problems with the earlier DSMs warrants a significant overhaul of DSM-5 and future manuals. As in Parts 1 & 2 of this article, the general introduction, as well as the introductions and conclusions for the specific questions, are written by James Phillips, and the responses to commentaries are written by Allen Frances. (shrink)

In the conclusion to this multi-part article I first review the discussions carried out around the six essential questions in psychiatric diagnosis – the position taken by Allen Frances on each question, the commentaries on the respective question along with Frances’ responses to the commentaries, and my own view of the multiple discussions. In this review I emphasize that the core question is the first – what is the nature of psychiatric illness – and that in some manner all further (...) questions follow from the first. Following this review I attempt to move the discussion forward, addressing the first question from the perspectives of natural kind analysis and complexity analysis. This reflection leads toward a view of psychiatric disorders – and future nosologies – as far more complex and uncertain than we have imagined. (shrink)

In face of the multiple controversies surrounding the DSM process in general and the development of DSM-5 in particular, we have organized a discussion around what we consider six essential questions in further work on the DSM. The six questions involve: 1) the nature of a mental disorder; 2) the definition of mental disorder; 3) the issue of whether, in the current state of psychiatric science, DSM-5 should assume a cautious, conservative posture or an assertive, transformative posture; 4) the role (...) of pragmatic considerations in the construction of DSM-5; 5) the issue of utility of the DSM - whether DSM-III and IV have been designed more for clinicians or researchers, and how this conflict should be dealt with in the new manual; and 6) the possibility and advisability, given all the problems with DSM-III and IV, of designing a different diagnostic system. Part I of this article will take up the first two questions. With the first question, invited commentators express a range of opinion regarding the nature of psychiatric disorders, loosely divided into a realist position that the diagnostic categories represent real diseases that we can accurately name and know with our perceptual abilities, a middle, nominalist position that psychiatric disorders do exist in the real world but that our diagnostic categories are constructs that may or may not accurately represent the disorders out there, and finally a purely constructivist position that the diagnostic categories are simply constructs with no evidence of psychiatric disorders in the real world. The second question again offers a range of opinion as to how we should define a mental or psychiatric disorder, including the possibility that we should not try to formulate a definition. The general introduction, as well as the introductions and conclusions for the specific questions, are written by James Phillips, and the responses to commentaries are written by Allen Frances. (shrink)

In face of the multiple controversies surrounding the DSM process in general and the development of DSM-5 in particular, we have organized a discussion around what we consider six essential questions in further work on the DSM. The six questions involve: 1) the nature of a mental disorder; 2) the definition of mental disorder; 3) the issue of whether, in the current state of psychiatric science, DSM-5 should assume a cautious, conservative posture or an assertive, transformative posture; 4) the role (...) of pragmatic considerations in the construction of DSM-5; 5) the issue of utility of the DSM - whether DSM-III and IV have been designed more for clinicians or researchers, and how this conflict should be dealt with in the new manual; and 6) the possibility and advisability, given all the problems with DSM-III and IV, of designing a different diagnostic system. Part I of this article took up the first two questions. Part II will take up the second two questions. Question 3 deals with the question as to whether DSM-V should assume a conservative or assertive posture in making changes from DSM-IV. That question in turn breaks down into discussion of diagnoses that depend on, and aim toward, empirical, scientific validation, and diagnoses that are more value-laden and less amenable to scientific validation. Question 4 takes up the role of pragmatic consideration in a psychiatric nosology, whether the purely empirical considerations need to be tempered by considerations of practical consequence. As in Part 1 of this article, the general introduction, as well as the introductions and conclusions for the specific questions, are written by James Phillips, and the responses to commentaries are written by Allen Frances. (shrink)

I argue that a common philosophical approach to the interpretation of physical theories—particularly quantum field theories—has led philosophers astray. It has driven many to declare the quantum field theories employed by practicing physicists, so-called ‘effective field theories’, to be unfit for philosophical interpretation. In particular, such theories have been deemed unable to support a realist interpretation. I argue that these claims are mistaken: attending to the manner in which these theories are employed in physical practice, I show that interpreting effective (...) field theories yields a robust foundation for a more refined approach to scientific realism in the context of quantum field theory. The paper concludes by briefly sketching some general morals for interpretive practice in the philosophy of physics. (shrink)

Argumentation, which can be abstractly defined as the interaction of different arguments for and against some conclusion, is an important skill to learn for everyday life, law, science, politics and business. The best way to learn it is to try it out on real instances of arguments found in everyday conversational exchanges and legal argumentation. The introductory chapter of this book gives a clear general idea of what the methods of argumentation are and how they work as tools that can (...) be used to analyze arguments. Each subsequent chapter then applies these methods to a leading problem of argumentation. Today the field of computing has embraced argumentation as a paradigm for research in artificial intelligence and multi-agent systems. Another purpose of this book is to present and refine tools and techniques from computing as components of the methods that can be handily used by scholars in other fields. (shrink)

This monograph poses a series of key problems of evidential reasoning and argumentation. It then offers solutions achieved by applying recently developed computational models of argumentation made available in artificial intelligence. Each problem is posed in such a way that the solution is easily understood. The book progresses from confronting these problems and offering solutions to them, building a useful general method for evaluating arguments along the way. It provides a hands-on survey explaining to the reader how to use current (...) argumentation methods and concepts that are increasingly being implemented in more precise ways for the application of software tools in computational argumentation systems. It shows how the use of these tools and methods requires a new approach to the concepts of knowledge and explanation suitable for diverse settings, such as issues of public safety and health, debate, legal argumentation, forensic evidence, science education, and the use of expert opinion evidence in personal and public deliberations. (shrink)

This book provides an argumentation model for means-end reasoning, a distinctive type of reasoning used for problem-solving gand decision-making. Means-end reasoning is modeled as goal-directed argumentation from an agent's goals and known circumstances, and from an action selected as a means, to a decision to carry out the action. Goal-based reasoning for argumentation provides an argumentation model for this kind of reasoning, showing how it is employed in settings of intelligent deliberation where agents try to collectively arrive at a conclusion (...) on what they should do to move forward in a set of circumstances. The book explains how this argumentation model can help build more realistic computational systems of deliberation and decision-making and shows how such systems can be applied to solve problems posed by goal-based reasoning in numerous fields, from social psychology and sociology, to law, political science, anthropology, cognitive science, artificial intelligence, multi-agent systems, and robotics." -- Back cover. (shrink)

This reader-friendly book examines philosophies and philosophers using an engaging, non-condescending approach that speaks to you at your level.

Douglas Wadle celebrates the juxtaposition of art and science while examining music's influence on humanity's understanding of our place in the universe. Tracing the millennia-old love affair between music and science, Wadle chronicles the surprising ubiquity of musical training among history's greatest thinkers. He shines a spotlight on the intertwining stories of pattern and form and how they complement one another in our search for creativity and insight. Einstein's Violin relies on extensive research to tell the story of how (...) music impacts the pattern recognition software in our brains, facilitating more creative problem solving. Without digression into technical treatise, it focuses on the historical stories that best display music's beautiful interaction with mind and universe"--Back cover. (shrink)

This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1986.

An award-winning author explores how the world works in our age of "continuous now" Back in the 1970s, futurism was all the rage. But looking forward is becoming a thing of the past. According to Douglas Rushkoff, "presentism" is the new ethos of a society that's always on, in real time, updating live. Guided by neither history nor long term goals, we navigate a sea of media that blend the past and future into a mash-up of instantaneous experience. Rushkoff (...) shows how this trend is both disorienting and exhilarating. Without linear narrative we get both the humiliations of reality TV and the associative brilliance of The Simpsons. With no time for long term investing, we invent dangerously compressed derivatives yet also revive sustainable local businesses. In politics, presentism drives both the Tea Party and the Occupy movement. In many ways, this was the goal of digital technology--outsourcing our memory was supposed to free us up to focus on the present. But we are in danger of squandering this cognitive surplus on trivia. Rushkoff shows how we can instead ground ourselves in the reality of the present tense. (shrink)

A comprehensive look at the decline of the United States offers non-ideological remedies on how to overcome national self-doubt, reclaim optimism, and secure a prosperous future for American citizens.

Design and analysis of algorithms can be a difficult subject for students due to its sometimes-abstract nature and its use of a wide variety of mathematical tools. Here the author, an experienced and successful textbook writer, makes the subject as straightforward as possible in an up-to-date textbook incorporating various new developments appropriate for an introductory course. This text presents the main techniques of algorithm design, namely, divide-and-conquer algorithms, greedy algorithms, dynamic programming algorithms, and backtracking. Graph algorithms are studied in detail, (...) and a careful treatment of the theory of NP-completeness is presented. In addition, the text includes useful introductory material on mathematical background including order notation, algorithm analysis and reductions, and basic data structures. This will serve as a useful review and reference for students who have covered this material in a previous course. Features The first three chapters provide a mathematical review, basic algorithm analysis, and data structures. Detailed pseudocode descriptions of the algorithms along with illustrative algorithms are included. Proofs of correctness of algorithms are included when appropriate. The book presents a suitable amount of mathematical rigor. After reading and understanding the material in this book, students will be able to apply the basic design principles to various real-world problems that they may encounter in their future professional careers. (shrink)

Extraterrestrial Altruism examines a basic assumption of the Search for Extraterrestrial Intelligence (SETI): that extraterrestrials will be transmitting messages to us for our benefit. This question of whether extraterrestrials will be altruistic has become increasingly important in recent years as SETI scientists have begun contemplating transmissions from Earth to make contact. Technological civilizations that transmit signals for the benefit of others, but with no immediate gain for themselves, certainly seem to be altruistic. But does this make biological sense? Should we (...) expect altruism to evolve throughout the cosmos, or is this only wishful thinking? Is it dangerous to send messages to other worlds, as Stephen Hawking has suggested, or might humankind benefit from an exchange with intelligence elsewhere in the galaxy? Would extraterrestrial societies be based on different ethical principles, or would we see commonalities with Earthly notions of morality? Extraterrestrial Altruism explores these and related questions about the motivations of civilizations beyond Earth, providing new insights that are critical for SETI. Chapters are authored by leading scholars from diverse disciplines—anthropology, astronomy, biology, chemistry, computer science, cosmology, engineering, history of science, law, philosophy, psychology, public policy, and sociology. The book is carefully edited by Douglas Vakoch, Director of Interstellar Message Composition at the SETI Institute and professor of clinical psychology at the California Institute of Integral Studies. The Foreword is by Frank Drake. This interdisciplinary book will benefit everybody trying to understand whether evolution and ethics are unique to Earth, or whether they are built into the fabric of the universe. (shrink)

Excerpt from Epictetus and the New Testament I gladly accept the opportunity of offering a foreword to my old pupil's study of contracts between Epictetus and the New Testament. It was on my suggestion that he took up this subject for linguistic research; but the arrival of the proofs of a book was a surprise to me. A very rapid glance over the pages has made the surprise a welcome one. In grammatical as well as lexical questions, as this book (...) well shows, Epictetus has much to teach us. I might remark in this connexion that Mr. Sharp (p. 61) remembers my obiter dicta better than I do. I do not now feel so sure about the use ws suggested there, but I must look into it further. A wider circle than those who study New Testament Greek will find much interest in the few pages which present parallels in Epictetus' thought. They should send some English readers to the accessible discourses of a very noble 'heathen, ' whose 'feeling after God' was assuredly not without reward. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

Fragmented thinking, broken world -- Toward recovery of wholeness: the radical humanities and traditional wisdom -- Toward recovery of wholeness: another look at science -- Insight-imagination -- Living thinking, living world: toward an education of insight-imagination.

The Theory of Multidimensional Reality is the latest development of this information theory of existence by the Author. The book applies the theory to explain what causes light, gravity, time, Planck's constant, and other phenomena found in physics. The Theory provides a foundation philosophy for all of science to explain some of the hardest phenomenon found.

The recent discovery of the Higgs at 125 GeV by the ATLAS and CMS experiments at the LHC has put significant pressure on a principle which has guided much theorizing in high energy physics over the last 40 years, the principle of naturalness. In this paper, I provide an explication of the conceptual foundations and physical significance of the naturalness principle. I argue that the naturalness principle is well-grounded both empirically and in the theoretical structure of effective field theories, and (...) that it was reasonable for physicists to endorse it. Its possible failure to be realized in nature, as suggested by recent LHC data, thus represents an empirical challenge to certain foundational aspects of our understanding of QFT. In particular, I argue that its failure would undermine one class of recent proposals which claim that QFT provides us with a picture of the world as being structured into quasi-autonomous physical domains. (shrink)

Not until the twentieth century did science come to be regarded as fundamentally technical in nature. A technical field, after all, meant not just a difficult one, but one relying on concepts and vocabulary that matter only to specialists. The alternative, to identify science with an ideal of public reason, attained its peak of influence in the late nineteenth century. While the scale and applicability of science advanced enormously after 1900, scientists have more and more preferred the detached objectivity of (...) service to bureaucratic experts over the cultivation of an engaged public. This reshaping of science, which has been both celebrated and condemned, provided a stimulus to the incipient field of history of science, and it remains a key historical problem. (shrink)

My aim in this paper is twofold: to distinguish two notions of naturalness employed in beyond the standard model physics and to argue that recognizing this distinction has methodological consequences. One notion of naturalness is an “autonomy of scales” requirement: it prohibits sensitive dependence of an effective field theory’s low-energy observables on precise specification of the theory’s description of cutoff-scale physics. I will argue that considerations from the general structure of effective field theory provide justification for the role this notion (...) of naturalness has played in BSM model construction. A second, distinct notion construes naturalness as a statistical principle requiring that the values of the parameters in an effective field theory be “likely” given some appropriately chosen measure on some appropriately circumscribed space of models. I argue that these two notions are historically and conceptually related but are motivated by distinct theoretical considerations and admit of distinct kinds of solution. (shrink)

This is an introduction to renormalization group methods in quantum field theory aimed at philosophers of science. review path integral methods, the relationship between early renormalization theory and renormalization group methods, and conceptual shifts in thinking about quantum field theory spurred by the development of renormalization group methods.

Commonsense Consequentialism is a book about morality, rationality, and the interconnections between the two. In it, Douglas W. Portmore defends a version of consequentialism that both comports with our commonsense moral intuitions and shares with other consequentialist theories the same compelling teleological conception of practical reasons. Broadly construed, consequentialism is the view that an act's deontic status is determined by how its outcome ranks relative to those of the available alternatives on some evaluative ranking. Portmore argues that outcomes should (...) be ranked, not according to their impersonal value, but according to how much reason the relevant agent has to desire that each outcome obtains and that, when outcomes are ranked in this way, we arrive at a version of consequentialism that can better account for our commonsense moral intuitions than even many forms of deontology can. What's more, Portmore argues that we should accept this version of consequentialism, because we should accept both that an agent can be morally required to do only what she has most reason to do and that what she has most reason to do is to perform the act that would produce the outcome that she has most reason to want to obtain.Although the primary aim of the book is to defend a particular moral theory, Portmore defends this theory as part of a coherent whole concerning our commonsense views about the nature and substance of both morality and rationality. Thus, it will be of interest not only to those working on consequentialism and other areas of normative ethics, but also to those working in metaethics. Beyond offering an account of morality, Portmore offers accounts of practical reasons, practical rationality, and the objective/subjective obligation distinction. (shrink)

What happens to the causal structure of a world when time is reversed? At first glance it seems there are two possible answers: the causal relations are reversed, or they are not. I argue that neither of these answers is correct: we should either deny that time-reversed worlds have causal relations at all, or deny that causal concepts developed in the actual world are reliable guides to the causal structure of time-reversed worlds. The first option is motivated by the instability (...) of time-reversed dynamical evolutions under interventions. The second option is motivated by a recognition of how contingent structural features of the actual world shape our causal concepts and reasoning strategies. (shrink)

It is often claimed that one cannot locate a notion of causation in fundamental physical theories. The reason most commonly given is that the dynamics of those theories do not support any distinction between the past and the future, and this vitiates any attempt to locate a notion of causal asymmetry—and thus of causation—in fundamental physical theories. I argue that this is incorrect: the ubiquitous generation of entanglement between quantum systems grounds a relevant asymmetry in the dynamical evolution of quantum (...) systems. I show that by exploiting a connection between the amount of entanglement in a quantum state and the algorithmic complexity of that state, one can use recently developed tools for causal inference to identify a causal asymmetry—and a notion of causation—in the dynamical evolution of quantum systems. (shrink)

Contribution to a PPR book symposium on Mark Wilson's Physics Avoidance.

This article explores datafication as a speculative discourse that fundamentally and instrumentally misunderstands data, not as a representational system, but as an ontology. This analysis of datafication takes a semiotic and media-archaeological approach to datafication, understanding it as an imaginary media system, and the article looks to supplementary discourses in data visualization and big data to clarify and expand an understanding of datafication as a prescriptive and speculative idea. This critique is sharpened through the exploration of a detailed study of (...) the early visualizations and unpublished fictions of W. E. B. Du Bois, whose imagined technology of the “megascope” gives a remarkable blueprint for contemporary discourses in data visualization and data science. Du Bois’s liberatory perspective is contrasted to a more paranoid example coming from the self-documented delusional system of Daniel Paul Schreber, who provides a much different vision of a totalizing media system in the form of an Aufschreibesysteme, which seems to presage another side of datafication as a surveillance system. Taken together, datafication, the megascope, and the Aufschreibesysteme work as three speculative media that imagine themselves as different instances or visions of a totalizing media system, a notion that has become especially significant in the technological, cultural, and economic systems of the twenty-first century. (shrink)

How should we teach controversial issues? And which issues should we teach as controversies? In this paper, I argue that educators should heed what I call a ‘psychological condition’ in their practical efforts to address these questions. In defending this claim, I engage with the various decision criteria that have been advanced in the controversial issues literature: the epistemic criterion, behavioral criterion, political criterion and politically authentic criterion. My argument is that the supporters of these various criteria have focused too (...) closely on the socio-political and epistemic qualities of controversial issues in deriving their controversial issues pedagogies and have thereby overlooked the necessary subjective conditions for teaching controversial issues. If our pedagogical efforts to cultivate students’ reason by means of controversial issues are to be successful, then we must understand controversy as fundamentally a psychological phenomenon consisting in an intellectual tension in the minds of students. In the final pages, I conclude by recommending several forms of directive teaching that promise to be instrumental for creating such intellectual tension. (shrink)

ABSTRACT In this wide-ranging interview Professor Douglas V. Porpora discusses a number of issues. First, how he became a Critical Realist through his early work on the concept of structure. Second, drawing on his Reconstructing Sociology, his take on the current state of American sociology. This leads to discussion of the broader range of his work as part of Margaret Archer’s various Centre for Social Ontology projects, and on moral-macro reasoning and the concept of truth in political discourse.

It is a great privilege to have been invited to speak on this occasion. I shall not talk about Janet Semple's life, since I did not know Janet Semple well. I first came across her work when the Oxford University Press sent me a copy of her Ph.D. thesis, asking for my opinion as to its publishability. I groaned—yet another study of the panopticon! I opened it, started reading—and read it straight through. It was so clear, insightful, powerful in its (...) interpretation and beautifully written. I am delighted to see that it has appeared as Bentham's Prison. I was, at a later stage, equally pleased to be involved in persuading Janet to publish some of her research on Bentham's medical and health interests. I shall not try to evaluate her work today. I think I might best honour her by trying to reflect upon some of the wider issues that surround Bentham's concerns with prisons and hospitals—issues raised by her work. (shrink)

The Empire of Chance tells how quantitative ideas of chance transformed the natural and social sciences, as well as daily life over the last three centuries. A continuous narrative connects the earliest application of probability and statistics in gambling and insurance to the most recent forays into law, medicine, polling and baseball. Separate chapters explore the theoretical and methodological impact in biology, physics and psychology. Themes recur - determinism, inference, causality, free will, evidence, the shifting meaning of probability - but (...) in dramatically different disciplinary and historical contexts. In contrast to the literature on the mathematical development of probability and statistics, this book centres on how these technical innovations remade our conceptions of nature, mind and society. Written by an interdisciplinary team of historians and philosophers, this readable, lucid account keeps technical material to an absolute minimum. It is aimed not only at specialists in the history and philosophy of science, but also at the general reader and scholars in other disciplines. (shrink)