The article is focused on one of the first large armed conflicts between Japan and Soviet Union, the Battle of Lake Khasan, which took place in July, 31 - August, 11 1938. In this article, the author analyzes the data of the military casualties of the USSR and Japan in the result of the Battle of Lake Khasan, considering the documentary sources of both countries. To analyze the losses of the Red Army, the data given in the revised sources data (...) is recalculated and revised. By studying the casualties of the countries participating in the conflict, the author points out a great difference between the contemporary information of Russian historical researches on a problem and that of historians in the USSR. In addition, the author points out the mistakes of the Japanese researchers regarding the losses of the USSR and corrects them. It is shown in the article, which types of weapons were more effective considering the nature of the injuries, for example, artillery was very effective, but the bombing of Soviet aviation was almost inconclusive. The effectiveness of Japanese use of cold weapons during hand-to-hand fighting is shown, which is also evident through the nature of injuries. For the first time in Russia, all losses of the Japanese army were tabulated on the basis of the data of the Japan Ministry of Defense. This analysis gives an opportunity to evaluate the Battle of the Lake Khasan from the new side. (shrink)

In 1981, the Atlantic Council's Energy Policy Committee, in collaboration with the Japanese Committee for Energy Policy Promotion and the Japanese Institute of Energy Economics, published a joint policy paper entitled 'U.S.-Japan Energy Relationships in the 1980s.'.

This study is aimed to address the problems associated with questionnaire-based research. Twelve hypothetical cases are presented and checked for ethical validity. The problems are categorized under seven headings: Whether the participation of the subject is truly voluntary; whether consent to participate in the study has been obtained or proxy consent is required; whether consent to participate has been obtained from "authentic" participants and their privacy is protected; whether participants are fully informed before they consent to participate; whether the validity (...) of questionnaire-based research has been determined in terms of its possible harm; how the roles of the research ethics committee are defined; and what content should be presented in reports and articles. It is important that the ethics of questionnaire-based research should be reviewed with consideration to maintaining a balance between the protection of a subject's human rights and the promotion of research for the improvement of medical science and health care. (shrink)

The identification of Smad proteins as molecular components of the transforming growth factor-β (TGF-β) signaling cascade has enhanced our understanding of how ligand-mediated activation of TGF-β receptors leads to modulation of target gene transcription. Recent studies have identified a distinct, structurally related class of Smads which inhibits, rather than transduces, TGF-β family signals. The molecular mechanism of action and the exact signaling pathways that are targeted by antagonistic Smads are not completely understood. These proteins appear to participate in autoregulatory negative (...) feedback loops in which signaling initiated by specific TGF-β family ligands induces the expression of an inhibitory Smad that then functions to modulate the amplitude or duration of signaling. Negative feedback circuits such as these play important roles in fine-tuning the activity of multifunctional signaling molecules during embryonic patterning and in response to pathologic stimuli in adults. BioEssays 21:382–390, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

Specificities of enzymes involved in plant specialized metabolism, including flavonoid biosynthesis, are generally promiscuous. This enzyme promiscuity has served as an evolutionary basis for new enzyme functions and metabolic pathways in land plants adapting to environmental challenges. This phenomenon may lead, however, to inefficiency in specialized metabolism and adversely affect metabolite‐mediated plant survival. How plants manage enzyme promiscuity for efficient specialized metabolism is, thus, an open question. Recent studies of flavonoid biosynthesis addressing this issue have revealed a conserved strategy, namely, (...) a homolog of chalcone isomerase with no catalytic activity binds to chalcone synthase, a key flavonoid pathway enzyme, to narrow (or rectify) the enzyme's highly promiscuous product specificity. Reducing promiscuity via specific protein–protein interactions among metabolic enzymes and proteins may be a solution adopted by land plants to achieve efficient operation of specialized metabolism, while the intrinsic promiscuity of enzymes has likely been retained incidentally. (shrink)

Изложено понимание рассуждения как метода рационального познания, рассмотрены его разновидности: аргументативные, интерпретативные, прогностические, квалификационные и вычислительные. Для аспирантов и соискателей.

Thomas Kuhn's The Structure of Scientific Revolutions has sold more than one million copies since its publication in 1962, is one of the most cited academic books of all time, and continues to be read and studied today. This volume of new essays evaluates the significance of Kuhn's classic book in its changing historical context, including its initial reception and its lasting effects. The essays explore the range of ideas which Kuhn made popular with his influential philosophy of science, including (...) paradigms, normal science, paradigm changes, scientific revolutions, and incommensurability; and they also look at less-studied themes in his work, including scientific measurement, science education, and science textbooks. Drawing on the latest scholarship as well as unpublished material in the Thomas Kuhn Archives at MIT, this volume offers a comprehensive way into Kuhn's philosophy and demonstrates the continuing relevance of his ideas for our understanding of science. (shrink)

In Nicolaus Cusanus on Faith and the Intellect: A Case Study in 15th-Century Fides-Ratio Controversy, K.M. Ziebart presents an account of the Cusan epistemology as a fascinating late-medieval attempt to definitively harmonize faith and reason.

Trata-se de uma resenha da tradução de Celi Hirata das Questões sobre a Liberdade, a Necessidade e o Acaso de Thomas Hobbes.