The discovery of induced pluripotent stem (iPS) cells in 2006 was heralded as a major breakthrough in stem cell research. Since then, progress in iPS cell technology has paved the way towards clinical application, particularly cell replacement therapy, which has refueled debate on the ethics of stem cell research. However, much of the discourse has focused on questions of moral status and potentiality, overlooking the ethical issues which are introduced by the clinical testing of iPS cell replacement therapy. First-in-human trials, (...) in particular, raise a number of ethical concerns including informed consent, subject recruitment and harm minimisation as well as the inherent uncertainty and risks which are involved in testing medical procedures on humans for the first time. These issues, while a feature of any human research, become more complex in the case of iPS cell therapy, given the seriousness of the potential risks, the unreliability of available animal models, the vulnerability of the target patient group, and the high stakes of such an intensely public area of science. Our paper will present a detailed case study of iPS cell replacement therapy for Parkinson's disease to highlight these broader ethical and epistemological concerns. If we accept that iPS cell technology is fraught with challenges which go far beyond merely refuting the potentiality of the stem cell line, we conclude that iPS cell research should not replace, but proceed alongside embryonic and adult somatic stem cell research to promote cross-fertilisation of knowledge and better clinical outcomes. (shrink)

In The Ethics of Food, Gregory E. Pence brings together a collection of voices who share the view that the ethics of genetically modified food is among the most pressing societal questions of our time. This comprehensive collection addresses a broad range of subjects, including the meaning of food, moral analyses of vegetarianism and starvation, the safety and environmental risks of genetically modified food, issues of global food politics and the food industry, and the relationships among food, evolution, and human (...) history. (shrink)

Using the emerging technology of large-scale textual analysis, this study examines the use of the term ‘customer satisfaction’ and its variants in the annual reports issued by publicly traded U.S. corporations and filed with the Securities and Exchange Commission as Form 10-K. We document the frequency of the term’s occurrence in 10-Ks over the 1995–2013 period and the differences in usage across industries. We then relate the term’s usage in 10-Ks to subsequent scores from the American Customer Satisfaction Index to (...) determine whether management’s discussion of customer satisfaction in financial disclosures is credible. The commitment of management to shareholders versus, more broadly, stakeholders is a central question in business ethics, and the integrity of management communication is a fundamental construct in the American Marketing Association’s Statement of Ethics. We document a complex relation between management’s discussion of customer satisfaction and subsequently reported satisfaction. We find that the general use of customer satisfaction in 10-K documents is negatively correlated with subsequent ACSI scores. However, for retail firms, when the phrase is located near words indicating measurement or monitoring of the phenomenon, the empirical relation is reversed and becomes positive. (shrink)

The treatise was in origin a polemic against the Erasistrateans in Rome whom Galen found to be in opposition to his own views. It is of interest not only for Galen's views on venesection but also for the fragments of the writings of Erastistratus contained in it. The text has not yet appeared in a modern critical edition. The Kühn edition of 1826 is the most recent, but Kühn did not go beyond the work of the Renaissance editors in dealing (...) with the numerous corruptions of the text. The emendations proposed below are occasioned by the want of a satisfactory reading anywhere in the tradition. (shrink)

The widespread potential for somatic fusion among different conspecific multicellular individuals suggests that such fusion is adaptive. However, because recognition of non‐kin (allorecognition) usually leads to a rejection response, successful somatic fusion is limited to close kin. This is consistent with kin‐selection theory, which predicts that the potential cost of fusion and the potential for somatic parasitism decrease with increasing relatedness. Paradoxically, however, Crozier1 found that, in the short term, positive‐frequency‐dependent selection eliminates the required genetic polymorphism at allorecognition loci. The (...) ‘Crozier paradox’ may be solved if allorecognition is based on extrinsically balanced polymorphisms, for example at immune loci. Alternatively, the assumption of most models that self fusion is mutually beneficial is wrong. If fusion is on average harmful, selection will promote unconditional rejection. However, we propose that fusion within individuals is beneficial, selecting for the ability to fuse, but fusion between individuals on average costly, selecting for non‐self recognition (rather than non‐kin recognition). We discuss experimental data on fungi that are consistent with this hypothesis. BioEssays 30:1193–1203, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

This book is a readers' companion to Simone Weil's The Need for Roots. It includes comprehensive and illuminating essays from recognized Weil scholars from the United States, Canada, England, France, and Germany, addressing the most pressing historical and contemporary aspects of Weil's thought and striking proposals. These include her substituting obligations for rights as the moral basis of society, her critique of our uprootedness and her proposals for rootedness, her critique of our dangerous understanding of greatness, the importance of work (...) for society, and her critique of modern science. This companion reader relies on the latest and most reliable work on the history of the Weil manuscript as provided by French scholars. It is unique in its thorough examination of the book's issues, which center around a spiritual renewal, first of France, but more broadly of western democracies. It includes a comprehensive introduction to the issues important to understanding The Need for Roots. Also included in the appendices are a new translation of Weil's preliminary study of obligations that was meant as an introduction to her work (but always published separately) as well as a translation of an address by Free French leader Andre Philippe-an address that helped set the moral issues that Weil would come to address. The book is both a scholarly contribution to understanding Weil's book and a striking set of conversations about many of the most pressing contemporary issues surrounding the possibilities of a spiritual and moral renewal of Western norms. The ultimate point of this companion is to stress the importance of Weil's The Need for Roots. In a time of clashing ideologies, politics of identity, and a desire, somehow in all that, to find a path to community and a way of respecting all human beings, The Need for Roots is now, more than ever, a timely book and one that needs careful examination and reflection. (shrink)

The notion of stakeholder salience based on attributes (e.g., power, legitimacy, urgency) is applied in the family business setting. We argue that where principal institutions intersect (i.e., family and business); managerial perceptions of stakeholder salience will be different and more complex than where institutions are based on a single dominant logic. We propose that (1) whereas utilitarian power is more likely in the general business case, normative power is more typical in family business stakeholder salience; (2) whereas in a general (...) business context legitimacy is socially constructed; for family stakeholders, legitimacy is based on heredity; and (3) whereas temporality and criticality are somewhat independent in general-business urgency, they are linked in the family business case because of family ties and family-centered non-economic goals. We apply this theoretical framework to position and integrate the contributions to this special section of Business Ethics Quarterly on “Stakeholder Theory, Ethics, Corporate Social Responsibility, and Family Enterprise.”. (shrink)

The notion of stakeholder salience based on attributes (e.g., power, legitimacy, urgency) is applied in the family business setting. We argue that where principal institutions intersect (i.e., family and business); managerial perceptions of stakeholder salience will be different and more complex than where institutions are based on a single dominant logic. We propose that (1) whereas utilitarian power is more likely in the general business case, normative power is more typical in family business stakeholder salience; (2) whereas in a general (...) business context legitimacy is socially constructed; for family stakeholders, legitimacy is based on heredity; and (3) whereas temporality and criticality are somewhat independent in general-business urgency, they are linked in the family business case because of family ties and family-centered non-economic goals. We apply this theoretical framework to position and integrate the contributions to this special section of Business Ethics Quarterly on “Stakeholder Theory, Ethics, Corporate Social Responsibility, and Family Enterprise.”. (shrink)

The consensus among legal philosophers is probably that rule-based legal expert systems leave much to be desired as aids in legal decision-making. Why? What can we do about it? A bureaucrat administering some set of complex rules will ascertain the facts and apply the rules to them in order to discover their consequences for the case in hand. This process of deductive reasoning is characteristically bureaucratic.

The anecdotal and historical literature describing intoxication in elephants from fermented fruit or alcoholic beverages is reviewed. Seven African elephants readily self-administered 7% unflavored alcohol solutions; the results included separation from herd groupings and changes in the frequency and/or duration of several behaviors as scored according to a quantitative observational system. Alcohol decreased feeding, drinking, bathing, and exploration for most animals. Inappropriate behaviors such as lethargy and ataxia increased for all elephants. Results are discussed in terms of stress-induced drinking and (...) intoxication. (shrink)

In his Ruffin Lecture on stakeholder value and the entrepreneurial process, Professor S. Venkataraman asserted that two processes: value creation, and value sharing, are common ground for both the field of business ethics and the field of entrepreneurship (Venkataraman, 1999). In this article I further explore the connections between entrepreneurship and stakeholder theory raised in the Lecture, as they relate to both the production and the distribution of wealth in society. Through the application of transaction cognition theory, which suggests that (...) a type of stakeholder-centered expert transacting script can integrate entrepreneurship and stakeholder theory through concepts from its sub-specialty, expert information processing theory, I employ a cognitive theory lens to suggest a set of integrating ideas and implications that attempt to complement and expand on Professor Venkataraman’s thesis. Implications for research and education conclude the article. (shrink)

In his Ruffin Lecture on stakeholder value and the entrepreneurial process, Professor S. Venkataraman asserted that two processes: value creation, and value sharing, are common ground for both the field of business ethics and the field of entrepreneurship (Venkataraman, 1999). In this article I further explore the connections between entrepreneurship and stakeholder theory raised in the Lecture, as they relate to both the production and the distribution of wealth in society. Through the application of transaction cognition theory, which suggests that (...) a type of stakeholder-centered expert transacting script can integrate entrepreneurship and stakeholder theory through concepts from its sub-specialty, expert information processing theory, I employ a cognitive theory lens to suggest a set of integrating ideas and implications that attempt to complement and expand on Professor Venkataraman’s thesis. Implications for research and education conclude the article. (shrink)

In his Ruffin Lecture on stakeholder value and the entrepreneurial process, Professor S. Venkataraman asserted that two processes: value creation, and value sharing, are common ground for both the field of business ethics and the field of entrepreneurship (Venkataraman, 1999). In this article I further explore the connections between entrepreneurship and stakeholder theory raised in the Lecture, as they relate to both the production and the distribution of wealth in society. Through the application of transaction cognition theory, which suggests that (...) a type of stakeholder-centered expert transacting script can integrate entrepreneurship and stakeholder theory through concepts from its sub-specialty, expert information processing theory, I employ a cognitive theory lens to suggest a set of integrating ideas and implications that attempt to complement and expand on Professor Venkataraman’s thesis. Implications for research and education conclude the article. (shrink)

This article investigates whether there is an underlying morality in the ways that human beings seek to obtain economic security within our imperfect economy, which can be illuminated through evolutionary biology research. Two research questions are the focus of the analysis: (1) What is the transaction cognitive machinery that is specialized for the entrepreneurial task of exchange-based security-seeking? and, (2) What are the moral implications of the acquisition and use of such transaction cognitions?Evolutionary biology research suggests within concepts that are (...) more Darwin- v. Huxley-based, an underlying morality supportive of algorithm-governed economizing arising from the behaviors that are most worthy of long-term reproduction. Evolutionarily stable algorithm-enhanced security-seeking is argued to be a new view of entrepreneurship, but one that, somewhat ironically, is grounded in a primordially-based entrepreneurial morality that is at the core of economic security. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Valla Grammaticus, Agostino Steuco, and the Donation of ConstantineRonald K. DelphRecent studies dealing with Lorenzo Valla's treatise on the Donation of Constantine have provided us with a profound understanding of the revolutionary nature of this work. Scholars have rightly seen the De falso credita et ementita Constantini donatione (1440) as one of Valla's earliest attempts to apply the principles of Quintilian's rhetoric to textual scholarship. Valla followed Quintilian both (...) in the structure of his arguments against the authenticity of the actions described in the Donation, as well as in the critical tools that he employed while attacking the language found in the text itself.1 In his use of philology and grammar as analytical tools and in his perception that historical development was reflected by changes in linguistic style and word meaning, Valla closely followed Quintilian.2 [End Page 55]The scholarly methodology employed in this work helped Valla lay the foundations for his radical reorientation of the ars rhetorica in which he established philology, grammar, and historical perspective as essential components of his textual scholarship. Using the principles of rhetoric that Quintilian laid out in his Institutio oratoria, Valla sought to broaden the scope of humanist critical activity and present humanists with several key elements with which to engage in linguistic and textual studies.3 The significance of what he had accomplished was clear to the Roman humanist. In December 1443 he boasted to Giovanni Aurispa that "I have never written anything more oratorical than my oration" on the Donation of Constantine.4 Valla here expressed his belief that his treatise had succeeded in incorporating the strictures and theories espoused in Quintilian's work into a viable humanist program of textual and linguistic scholarship.Valla's De Constantini donatione is of undeniable importance for understanding his early development as a humanist textual critic and language philosopher. But what has escaped most historians is the oration's problem of methodology, and the deficiencies of philology and grammar as tools of textual criticism in this work. To put it bluntly, scholars, while focusing on the promising innovations found there, have consistently ignored what by later standards would be considered the serious methodological flaws in Valla's treatise. The Vallian ars rhetorica as articulated in this work by no means presented a model from which later humanists would derive the foundations of modern textual criticism. By the late fifteenth and early sixteenth centuries, textual scholars had shown the inadequacies of the methodology Valla employed in this treatise. In fact the best humanist scholars of the period approached the task of textual criticism and manuscript emendation using procedures that were essentially at odds with the philological, grammatical critique used in this work.5While most modern historians have overlooked the scholarly shortcomings of Valla's treatise, the sixteenth century produced one critic who raised serious questions about the scholarship underlying the critique of the Donation. Twice in his lifetime, the Italian humanist Agostino Steuco (1497-1548) [End Page 56] published significant replies to Valla. First in his Pro religione christiana adversus Lutheranos (1530), and then in his Contra Laurentium Vallam de falso donatione Constantini libri duo (1547), Steuco raised substantial objections to a number of Valla's philological, grammatical, and historical arguments against the authenticity of the edict.6In each treatise Steuco's textual scholarship on the Donation formed part of a larger effort on his part to defend the cultic practices, institutions, and hierarchy of the late medieval church against the reformers. As he made clear in both works, he believed that Valla's attacks upon the papacy and Donation put him in league with Luther and Erasmus in undermining respect for the papacy in the early sixteenth century. While these two works recently have proved to be of great interest to historians of religion and reform in sixteenth-century Italy, I shall confine the present analysis to Steuco's scholarship on the Donation.Taking direct aim at Valla's philological and grammatical analysis of the language of the Donation, Steuco repeatedly characterized Valla as being nothing more than a "grammarian."7 Valla had blundered badly in his analysis, Steuco pointed out, by ignoring the first... (shrink)

The confirmation process and the virtues of duplicity -- How to be aggressive and passive ... and great -- Recusal and the vices of impartiality -- The use and misuse of the politics of personality -- Fortuna : the role of chance in choosing cases -- When and why to avoid a case -- Carpe diem : when to embrace a case -- Tactical tools : using procedure to one's advantage -- Oral arguments : what to say and how -- (...) When to lose a case and win a cause -- In defense of unprincipled decision making -- How to manipulate the rule of law -- When precedents are to be honored (if only formally) -- When to take command and make demands -- The boldest moves : when and how to make them -- On writing : when style should trump substance -- When it is wise to write a separate opinion -- Law clerks : when and how to use them -- How to play to the media -- Cameras in the courtroom : seizing the future -- On television : the medium is not the message -- On publishing books : when and of what kind -- The threat of impeachment and how best to avoid it -- When it is best to retire -- Directing history : a justice's working papers and what to do with them -- How to best secure an enduring legacy. (shrink)

A quick look at what is happening in the corporate world makes it clear that the stakeholder idea is alive, well, and flourishing; and the question now is not “if ” but “how” stakeholder theory will meet the challenges of its success. Does stakeholder theory’s “arrival” mean continued dynamism, refinement, and relevance, or stasis? How will superior stakeholder theory continue to develop? In light of these and related questions, the authors of these essays conducted an ongoing dialogue on the current (...) state and future of stakeholder thinking. Beginning with a review of research and theory that has developed since the major stakeholder theorizing efforts of the 1990s, the authors individually offer their perspectives on the key issues relevant today to stakeholder thinking, and to suggest possible approaches that might lead toward and enable the continuing development of superior stakeholder theory. (shrink)

¿The authors argue that queer, black, brown, and foreign bodies, and the so-called threats they represent, such as immigration reform and same-sex marriage, have been effectively linked with terrorism. These awful conflations¿ are enduring and help to explain the contradictions of contemporary U.S. politics. We are far from a post post-9/11 world.¿ Ronald R. Sundstrom, Associate Professor, Department of Philosophy, The University of San Francisco, United States ¿If you want to understand how a new biopolitics of citizenship is containing (...) bodies of the nation by re-inscribing sex and race into it and how this new biopolitics is being resisted you must read this book.¿ Engin F. Isin, Professor, Department of Politics and International Studies, The Open University, United Kingdom. (shrink)

In the management and business ethics literatures, stakeholder engagement has been demonstrated to lead to more ethical management practices. However, there may be limits on the extent to which stakeholder engagement can, as currently conceptualized, resolve some of the more difficult ethical challenges faced by managers. In this paper we argue that stakeholder engagement, when seen as a way of reducing five types of knowledge problems—risk, ambiguity, complexity, equivocality, and a priori irreducible uncertainty—can aid managers in resolving such ethical challenges. (...) Using a practical illustration of the ethical challenges surrounding the development and application of genetic modification technologies, we demonstrate how stakeholder engagement enables managers to better address these knowledge problems, thereby to manage more ethically. In this way, we suggest that stakeholder engagement has an even more crucial role to play in business ethics research and practice. (shrink)

Guanxi (literally interpersonal connections) is in essence a network of resource coalition-based stakeholders sharing resources for survival, and it plays a key role in achieving business success in China. However, the salience of guanxi stakeholders varies: not all guanxi relationships are necessary, and among the necessary guanxi participants, not all are equally important. A hierarchical stakeholder model of guanxi is developed drawing upon Mitchell et al.’s (1997) stakeholder salience theory and Anderson’s (1982) constituency theory. As an application of instrumental stakeholder (...) theory, the model dimensionalizes the notion of stakeholder salience, and distinguishes between and among internal and external guanxi, core, major, and peripheral guanxi, and primary and secondary guanxi stakeholders. Guanxi management principles are developed based on a hierarchy of guanxi priorities and management specializations. The goal of this application of instrumental stakeholder theory is to construct, for Western business firms in China, a means to reliably identify guanxi partners by employing the principles of effective guanxi. These principles are described in the form of testable propositions that advance social scientific research in this area of international business ethics. (shrink)

Teaching ethics poses a dilemma for professors of business. First, they have little or no formal training in ethics. Second, they have established ethical values that they may not want to impose upon their students. What is needed is a well-recognized, yet non-sectarian model to facilitate the clarification of ethical questions. Gestalt theory offers such a framework. Four Gestalt principles facilitate ethical clarification and another four Gestalt principles anesthetize ethical clarification. This article examines each principle, illustrates that principle through current (...) business examples, and offers exercises for developing each principle. (shrink)

laudationem ferculum est insecutum plane non pro expectatione magnum: novitas tamen omnium convertit oculos. rotundum enim repositoriurr duodecim habebat signa in orbe disposita, super quae proprium convenien. temque materiae structor imposuerat cibum: super arietem cicer arietinum, super taurum bubulae frustum, super geminos testiculos ac rienes, supei cancrum coronam, super leonem ficum Africanam, super virginem steriliculam super libram stateram in cuius altera parte scriblita erat, in altera placenta super scorpionem † pisciculum marinum, super sagittarium oclopetam, supei capricornum locustam marinam,† super pisces (...) duos mullos. in medio autem caespes cum herbis excisus favum sustinebat. (shrink)

Those who deny the usefulness of the concept of “motive” for psychology commonly bring two arguments in support of theirview. The first is that the whole notion of “motive” is “animistic” and “folklorish”, since a motive cannot be directly observed. The second is that “motives” cannot be accurately observed, and therefore are beyond the scope of scientific study, because they are “the secret of the agent”, and the agenthimself has no indubitable knowledge of his “motives”. In a recent article, Professor (...) MacIver defends the view that the imputation of “motives” is necessary to a complete explanation of behaviour. To the first of the above criticisms, he replies that such a view neglects a part of reality and that since “motives” exist they should be studied by psychology. This reply does nothing to demonstrate the necessity of imputing motives in order to obtain a complete explanation of behaviour. To the second criticism he replies “motives” are not the secret of the agent, and we can only assert that the agent has mistaken his “motive” if we can gain indepen-dent knowledge of it. We can do this, Professor MacIver asserts, by observing typical behaviour in typical circum-stances, and making inferences from the coherence of total situations. Professor MacIver's replies to the second of the above criticisms are valid only if “motive” is defined as equivalent to “need”, so that we can say “under such-and-such conditions, such-and-such behaviour occurs”. A statement of this type says nothing about the agent's awareness of his goal. When the term “consciousness” is carefully defined along the lines suggested by Boring, the methods of imputation described by Professor MacIver can be seen to lead us only to the agent's “drives”, or “needs”, defined without reference to the agent's awareness of his goal. Professor MacIver uses “motives” to mean “awareness of the goal”, but gives us no clue as to how they may be imputed, and adduces no proof that their imputation is necessary. A possible criterion of the presence of a “motive” is the degree of direction observable in the organism's varied reac-tions in response to frustration, though the more precise definition of such a criterion must await further experiment. In view of the ambiguity of the term “motive” and its penumbra of false suggestion, it is desirable that the term be dropped from psychology. (shrink)