Beta‐oxidation of fatty acids and detoxification of reactive oxygen species are generally accepted as being fundamental functions of peroxisomes. Additionally, these pathways might have been the driving force favoring the selection of this compartment during eukaryotic evolution. Here we performed phylogenetic analyses of enzymes involved in beta‐oxidation of fatty acids in Bacteria, Eukaryota, and Archaea. These imply an alpha‐proteobacterial origin for three out of four enzymes. By integrating the enzymes' history into the contrasting models on the origin of eukaryotic cells, (...) we conclude that peroxisomes most likely evolved non‐symbiotically and subsequent to the acquisition of mitochondria in an archaeal host cell. (shrink)

At first glance the three eukaryotic protein translocation machineries – the ER‐associated degradation (ERAD) transport apparatus of the endoplasmic reticulum, the peroxisomal importomer and SELMA, the pre‐protein translocator of complex plastids – appear quite different. However, mechanistic comparisons and phylogenetic analyses presented here suggest that all three translocation machineries share a common ancestral origin, which highlights the recycling of pre‐existing components as an effective evolutionary driving force.Editor's suggested further reading in BioEssays ERAD ubiquitin ligases Abstract.

ZusammenfassungMit den Fortschritten im Bereich der psychiatrisch-genetischen Forschung gehen auch intensive Diskussionen bezüglich der daraus erwachsenden Implikationen einher. Hoffnungen wie Befürchtungen gegenüber der neuen Technologie und deren Folgen werden gleichermaßen zum Ausdruck gebracht. Über die Einstellung der Bevölkerung und insbesondere der Patienten mit affektiven oder schizophrenen Erkrankungen und ihrer Angehörigen in Deutschland war bisher allerdings wenig bekannt. Daher führten wir im Rahmen des Deutschen Humangenomprojektes erstmals eine Studie durch, um die Einstellungen und ihre beeinflussenden Faktoren zu erfassen. Wir entwickelten einen (...) Fragebogen zur Erfassung der Erwartungen, Hoffnungen und Befürchtungen sowie der die Einstellung beeinflussenden Faktoren. Hiermit wurde eine repräsentative Stichprobe von 3077 Personen aus der Allgemeinbevölkerung am Telefon befragt. Weiterhin wurden mit 316 Patienten und 163 Angehörigen persönliche standardisierte Interviews anhand des Fragebogens durchgeführt. Die Mehrzahl der Befragten hatte eine positive Einstellung zu psychiatrisch-genetischer Forschung, äußerte jedoch gleichzeitig ethische Bedenken. Übereinstimmend waren die Befragten der Ansicht, dass Informationen aus genetischen Untersuchungen vertraulich behandelt werden sollten. Kleine, aber signifikante Unterschiede zwischen den Gruppen zeigten sich bezüglich der Einstellung zu präsymptomatischer genetischer Diagnostik. Unsere Ergebnisse weisen auf eine Ambivalenz der Befragten gegenüber der psychiatrisch-genetischen Forschung und Untersuchung hin: Neben einer überwiegend positiven Einstellung wurden auch moralische Bedenken geäußert. (shrink)

Studies have shown that in the mammalian neuromuscular system stretch reflexes are localized within individual muscles. Neuromuscular compartmentalization, the partitioning of sensory output from muscles, and the partitioning of segmental pathways to motor nuclei have also been demonstrated. This evidence indicates that individual motor nuclei and the muscles they innervate are not homogeneous functional units. An analysis of the functional significance of reflex localization and partitioning suggests that segmental control mechanisms are based on subdivisions of motor nuclei–muscle complexes. A partitioned (...) organization of segmental control mechanisms could utilize (1) the potential functional diversity of muscle fiber types, (2) the variety of mechanical actions of individual muscles arising from their distributed origins and insertions, and (3) diverse architectural features such as intramuscular variations in pinnation and complex in-series and in-parallel arrangements of muscle fibers. The differentiated activity observed in some muscles during natural movements also calls for localized segmental control mechanisms. Partitioning may also play a role in mechanical interactions between contracting motor units and in increasing the stability of neuromuscular systems. The functional advantages of reflex localization and partitioning suggest they are probably common features of segmental systems, whose organization reflects the structure and function of their associated neuromuscular systems. (shrink)

Objectives:Social isolation is increasing in aging societies and several studies have shown a relation with worse cognition in old age. However, less is known about the association in the oldest-old (85+); the group that is at highest risk for both social isolation and dementia. Methods:Analyses were based on follow-up 5 to 9 of the longitudinal German study on aging, cognition, and dementia in primary care patients (AgeCoDe) and the study on needs, health service use, costs, and health-related quality of life (...) in a large sample of oldest-old primary care patients (AgeQualiDe), a multi-center population-based prospective cohort study. Measurements included the Lubben Social Network Scale (LSNS-6), with a score below 12 indicating social isolation, as well as the Mini-Mental Status Examination (MMSE) as an indicator of cognitive function. Results:Dementia-free study participants (n = 942) were M = 86.4 (SD = 3.0) years old at observation onset, 68.2% were women. One third (32.3%) of them were socially isolated. Adjusted linear hybrid mixed effects models revealed significantly lower cognitive function in individuals with smaller social networks (β = 0.5, 95% CI = 0.3-0.7, p <.001). Moreover, changes in an individual's social network size were significantly associated with cognitive changes over time (β = 0.2, 95% CI = 0.1-0.4, p =.003), indicating worse cognitive function with shrinking social networks. Conclusion:Social isolation is highly prevalent among oldest-old individuals, being a risk factor for decreases in cognitive function. Consequently, it is important to maintain a socially active lifestyle into very old age. Likewise, this calls for effective ways to prevent social isolation. (shrink)

BackgroundBiobanking biospecimens and consent are common practice in paediatric research. We need to explore children and young people’s (CYP) knowledge and perspectives around the use of and consent to biobanking. This will ensure meaningful informed consent can be obtained and improve current consent procedures.MethodsWe designed a survey, in co-production with CYP, collecting demographic data, views on biobanking, and consent using three scenarios: 1) prospective consent, 2) deferred consent, and 3) reconsent and assent at age of capacity. The survey was disseminated (...) via the Young Person’s Advisory Group North England (YPAGne) and participating CYP’s secondary schools. Data were analysed using a qualitative thematic approach by three independent reviewers (including CYP) to identify common themes. Data triangulation occurred independently by a fourth reviewer.ResultsOne hundred two CYP completed the survey. Most were between 16–18 years (63.7%, N = 65) and female (66.7%, N = 68). 72.3% had no prior knowledge of biobanking (N = 73).Acceptability of prospective consent for biobanking was high (91.2%, N = 93) with common themes: ‘altruism’, ‘potential benefits outweigh individual risk’, 'frugality', and ‘(in)convenience’.Deferred consent was also deemed acceptable in the large majority (84.3%, N = 86), with common themes: ‘altruism’, ‘body integrity’ and ‘sample frugality’. 76.5% preferred to reconsent when cognitively mature enough to give assent (N = 78), even if parental consent was previously in place. 79.2% wanted to be informed if their biobanked biospecimen is reused (N = 80).ConclusionProspective and deferred consent acceptability for biobanking is high among CYP in the UK. Altruism, frugality, body integrity, and privacy are the most important themes. Clear communication and justification are paramount to obtain consent. Any CYP with capacity should be part of the consenting procedure, if possible. (shrink)

Widowhood is common in old age, can be accompanied by serious health consequences and is often linked to substantial changes in social network. Little is known about the impact of social isolation on the development of depressive symptoms over time taking widowhood into account. We provide results from the follow-up 5 to follow-up 9 from the longitudinal study AgeCoDe and its follow-up study AgeQualiDe. Depression was measured with GDS-15 and social isolation was assessed using the Lubben Social Network Scale (LSNS-6). (...) The group was aligned of married and widowed people in old age and education through entropy balancing. Linear mixed models were used to examine the frequency of occurrence of depressive symptoms for widowed and married elderly people depending on the risk of social isolation. Our study shows that widowhood alone does not lead to an increased occurrence of depressive symptoms. However, "widowed oldest old", who are also at risk of social isolation, have significantly more depressive symptoms than those without risk. In the group of "married oldest old", women have significantly more depressive symptoms than men, but isolated and non-isolated do not differ. Especially for people who have lost a spouse, the social network changes significantly and increases the risk for social isolation. This represents a risk factor for the occurrence of depressive symptoms. (shrink)

Why do we engage in folk psychology, that is, why do we think about and ascribe propositional attitudes such as beliefs, desires, intentions etc. to people? On the standard view, folk psychology is primarily for mindreading, for detecting mental states and explaining and/or predicting people’s behaviour in terms of them. In contrast, McGeer (1996, 2007, 2015), and Zawidzki (2008, 2013) maintain that folk psychology is not primarily for mindreading but for mindshaping, that is, for moulding people’s behavior and minds (e.g., (...) via the imposition of social norms) so that coordination becomes easier. Mindreading is derived from and only as effective as it is because of mindshaping, not vice versa. I critically assess McGeer’s, and Zawidzki’s proposal and contend that three common motivations for the mindshaping view do not provide sufficient support for their particular version of it. I argue furthermore that their proposal underestimates the role that epistemic processing plays for mindshaping. And I provide reasons for favouring an alternative according to which, in social cognition involving ascriptions of propositional attitudes, neither mindshaping nor mindreading is primary but both are complementary in that effective mindshaping depends as much on mindreading as effective mindreading depends on mindshaping. (shrink)

The English language now dominates scientific communications. Yet, many scientists have English as their second language. Their English proficiency may therefore often be more limited than that of a ‘native speaker’, and their scientific contributions (e.g. manuscripts) in English may frequently contain linguistic features that disrupt the fluency of a reader’s, or listener’s information processing even when the contributions are understandable. Scientific gatekeepers (e.g. journal reviewers) sometimes cite these features to justify negative decisions on manuscripts. Such justifications may rest on (...) the prima facie plausible assumption that linguistic characteristics that hinder fast and easy understandability of scientific contributions are epistemically undesirable in science. I shall raise some doubts about this assumption by drawing on empirical research on processing fluency and its biasing effects. I also argue that directing scientists with English as a foreign language toward approaching ‘native-level’ English can have the negative consequence of reducing their potential to make scientific belief formation more reliable. These points suggest that one seemingly compelling justification for linguistically discriminating against scientific contributions in ‘non-native’ English is questionable and that the common insistence by scientific gatekeepers on ‘native-like’ English may be epistemically harmful to science. (shrink)

Teleosemantics explains mental representation in terms of biological function and selection history. One of the main objections to the account is the so-called ‘Swampman argument’ (Davidson 1987), which holds that there could be a creature with mental representation even though it lacks a selection history. A number of teleosemanticists reject the argument by emphasising that it depends on assuming a creature that is fi ctitious and hence irrelevant for teleosemantics because the theory is only concerned with representations in real-world organisms (...) (Millikan 1996, Neander 1996, 2006, Papineau 2001, 2006). I contend that this strategy doesn’t succeed. I off er an argument that captures the spirit of the original Swampman objection but relies only on organisms found in the actual world. Th e argument undermines the just mentioned response to the Swampman objection, and furthermore leads to a particular challenge to strong representationalist theories of consciousness that endorse teleosemantics such as, e.g., Dretske’s (1995) and Tye’s (1995, 2000) accounts. On these theories, the causal effi cacy of consciousness in actual creatures will be undermined. (shrink)

Suppose we know our own attitudes, e.g. judgments and decisions, only by unconsciously interpreting ourselves. Would this undermine the assumption that there are conscious attitudes? Carruthers has argued that if the mentioned view of selfknowledge is combined with either of the two most common approaches to consciousness, i.e. the higher-order state account or the global workspace theory , then the conjunction of these theories implies that there are no conscious attitudes. I shall show that Carruthers' argument against the existence of (...) conscious attitudes doesn't succeed, and mention studies on autism and logical reasoning under cognitive load that suggest that there are conscious attitudes. (shrink)

O tema deste artigo é um texto apócrifo de W. G. Sebald, o ensaio "Europäische Peripherien" [Periferias Europeias], baseado em uma palestra proferida em fevereiro de 1992, em Tübingen. Esse ensaio ocupa um lugar especial na obra de Sebald, pois nele o autor se expressa mais resolutamente do que em qualquer outra ocasião sobre questões políticas, no que diz respeito tanto ao processo de unificação europeia quanto aos problemas fundamentais das sociedades ocidentais na transição para o século XXI. A partir (...) de uma leitura mais atenta, chego à conclusão de que esse ensaio, supostamente secundário, revela-se um importante pilar para reconstruir a interpretação profundamente melancólica que Sebald faz da história com base no conceito de uma “história natural da destruição”. Ao mesmo tempo, “Europäische Peripherien” permite reconhecer a importância de Mutation der Menschheit [Mutação da Humanidade], de Pierre Bertaux, como influência fundamental, até então não reconhecida, para o desenvolvimento da obra de Sebald.Palavras-chave: W.G. Sebald. Europa. “História natural da destruição”. Pierre Bertaux. AbstractThis article discusses the essay "Europäische Peripherien", a hitherto overlooked text by W.G. Sebald based on a lecture given in Tübingen in February 1992. The essay occupies a special position in Sebald's oeuvre, as the author positions himself more pronouncedly than anywhere else on political issues, both with regard to the process of European unification and to fundamental challenges of Western societies in the transition to the twenty-first century. In my close reading the supposedly insignificant essay proves to be an important text for a reconstruction of Sebald's deeply melancholic view of history as expressed in the concept of a "natural history of destruction". At the same time, "European Peripheries" allows us to acknowledge the importance of Pierre Bertaux’ Mutation der Menschheit as an undiscovered influence on the development of Sebald's oeuvre.Keywords: W.G. Sebald. Europa. “Natural history of destruction”. Pierre Bertaux. ORCIDhttps://orcid.org/0000-0002-4825-1912. (shrink)

Quotation exhibits characteristics of both use and mention. I argue against the recently popular pragmatic reductions of quotation to mere language use (e.g. Recanati 2001), and in favor of a truly hybrid account synthesizing and extending Potts (2007) and Geurts & Maier (2005), using a mention logic and a dynamic semantics with presupposition to establish a context-driven meaning shift. The current paper explores a `quotebreaking' extension to solve the problems posed by non-constituent quotation, and anaphora, ellipsis and quantifier raising (...) across quotation marks. (shrink)

English direct discourse is easily recognized by e.g. the lack of a complementizer, the quotation marks (or the intonational contour they induce), and verbatim (`shifted') pronouns. Japanese employs the same complementizer for all reports, does not have a consistent intonational quotation marking, and tends to drop pronouns where possible. Some have argued that this just shows many Japanese reports are ambiguous: despite the lack of explicit marking, the underlying distinction is just as hard. On the basis of a number of (...) `mixed' examples, I claim that the line between direct and indirect is blurred and I propose a unified analysis of speech reporting in which a general mechanism of mixed quotation replaces the classical two-fold distinction. (shrink)

Many ethical frameworks require artificial intelligence (AI) systems to be explainable. Explainable AI (XAI) models are frequently tested for their adequacy in user studies. Since different people may have different explanatory needs, it is important that participant samples in user studies are large enough to represent the target population to enable generalizations. However, it is unclear to what extent XAI researchers reflect on and justify their sample sizes or avoid broad generalizations across people. We analyzed XAI user studies (N = (...) 220) published between 2012 and 2022. Most studies did not offer rationales for their sample sizes. Moreover, most papers generalized their conclusions beyond their target population, and there was no evidence that broader conclusions in quantitative studies were correlated with larger samples. These methodological problems can impede evaluations of whether XAI systems implement the explainability called for in ethical frameworks. We outline principles for more inclusive XAI user studies. (shrink)

The short version of the Bielefeld Partnership Expectations Questionnaire assesses the partner-related attachment dimensions fear of rejection, readiness for self-disclosure, and conscious need for care. The presented study investigated the factor structure in two samples and evaluated the convergent validity of scales. The sample included N = 175 patients with panic disorder and/or agoraphobia and N = 143 healthy controls. Besides, the BPEQ, the Experiences in Close Relationships Questionnaire, and the Brief Symptom Inventory were assessed as well, and the Adult (...) Attachment Prototype Rating was conducted. A confirmatory factor analysis of the three factor model revealed an acceptable model fit for the entire sample, patients and controls in terms of low RMSEA and SRMR. We found metric, scalar, and strict measurement invariance for the presence of anxiety disorder. However, only for fear of rejection and readiness for self-disclosure the reliability was acceptable, and convergent validity in terms of large correlations with the ECR scales was found in both samples. The scale conscious need for care had a questionable reliability and correlated only slightly with ECR-R scales. We conclude that fear of rejection and readiness for self-disclosure of the BPEQ-12 are reliable and valid scales for measuring partner-related attachment in healthy and clinical samples. (shrink)

Confirmation bias is one of the most widely discussed epistemically problematic cognitions, challenging reliable belief formation and the correction of inaccurate views. Given its problematic nature, it remains unclear why the bias evolved and is still with us today. To offer an explanation, several philosophers and scientists have argued that the bias is in fact adaptive. I critically discuss three recent proposals of this kind before developing a novel alternative, what I call the ‘reality-matching account’. According to the account, confirmation (...) bias evolved because it helps us influence people and social structures so that they come to match our beliefs about them. This can result in significant developmental and epistemic benefits for us and other people, ensuring that over time we don’t become epistemically disconnected from social reality but can navigate it more easily. While that might not be the only evolved function of confirmation bias, it is an important one that has so far been neglected in the theorizing on the bias. (shrink)

Language- and music-readiness are demonstrated as related within comparative neuroprimatology by elaborating three hypotheses concerning music-readiness (MR): The (musicological) rhythm-first hypothesis (MR-1), the combinatoriality hypothesis (MR-2), and the socio-affect-cohesion hypothesis (MR-3). MR-1 states that rhythm precedes evolutionarily melody and tonality. MR-2 states that complex imitation and fractionation within the expanding spiral of the mirror system/complex imitation hypothesis (MS/CIH) lead to the combinatorial capacities of rhythm necessary for building up a musical lexicon and complex structures; and rhythm, in connection with repetition (...) and variation, scaffolds both musical form and content. MR-3 states that music’s main evolutionary function is to self-induce affective states in individuals to cope with distress; rhythm, in particular isochrony, provides a temporal framework to support movement synchronization, inducing shared affective states in group members, which in turn enhances group cohesion. This document reviews current behavioural and neurocognitive research relevant to the comparative neuroprimatology of music-readiness. It further proposes to extend MS/CIH through the evolution of the relationship of the language- and music-ready brain, by comparing “affective rhythm” and prosody – i.e. by comparatively approaching the language- and music-emotion link in neuroprimatology. (shrink)

We propose to analyze well-known cases of "imaginative resistance" from the philosophical literature (Gendler, Walton, Weatherson) as involving the inference that particular content should be attributed to either: (i) a character rather than the narrator or, (ii) an unreliable, irrational, opinionated, and/or morally deviant "first person" narrator who was originally perceived to be a typical impersonal, omniscient, "effaced" narrator. We model the latter type of attribution in terms of two independently motivated linguistic mechanisms: accommodation of a discourse referent (Lewis, Stalnaker, (...) Kamp) and 'cautious' updating as a model of non-cooperative information exchange (Eckardt). (shrink)

Das Handbuch Kritische Theorie beleuchtet aus ganz unterschiedlicher Perspektive, was Kritische Theorie heute bedeuten kann. Das Handbuch reklamiert, trotz seines Umfangs, keine eindeutige oder definitorische Antwort auf die Frage, was Kritische Theorie heute ist oder zu sein hat. Die Programmatiken Kritischer Theorie sind in den letzten 85 Jahren weder konstant geblieben noch lässt sich Kritische Theorie auf die Interpretation eines Kanons von Texten festlegen. Gleichwohl sind Kritische Theorie und die Bezugnahmen auf sie nicht beliebig, sondern, so die Überzeugung der Herausgeber*in, (...) bei allen Auseinandersetzungen um die richtige Interpretation und institutionelle Praxis, mehr als eine „bloße Metapher“. Im Zentrum steht nach wie vor die Diskrepanz zwischen dem Ausmaß an real vorhandenen und in gesellschaftliche Institutionen gegossenen Herrschaftsverhältnissen einerseits und den Möglichkeiten der Verringerung von Herrschaft von Menschen über sich, über andere und über Natur andererseits. In diesem Grundverständnis sind sich – bei aller Heterogenität – die im Handbuch versammelten Beiträge und Beitragenden einig. (shrink)