Results for 'Aubrey de Grey'

961 found
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  1.  4
    The Curate's Egg of Anti‐Anti‐Aging Bioethics.Aubrey de Grey - 2013 - In Max More & Natasha Vita‐More (eds.), The Transhumanist Reader. Oxford: Wiley. pp. 215–219.
    As a leader of the crusade to defeat aging, working to demonstrate both its feasibility and its desirability, I am often seen as an implacable opponent of all arguments that defend aging and criticize this crusade. This is an oversimplification.
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  2.  8
    Is human aging still mysterious enough to be left only to scientists?Aubrey D. N. J. de Grey, John W. Baynes, David Berd, Christopher B. Heward, Graham Pawelec & Gregory Stock - 2002 - Bioessays 24 (7):667-676.
    The feasibility of reversing human aging within a matter of decades has traditionally been dismissed by all professional biogerontologists, on the grounds that not only is aging still poorly understood, but also many of those aspects that we do understand are not reversible by any current or foreseeable therapeutic regimen. This broad consensus has recently been challenged by the publication, by five respected experimentalists in diverse subfields of biogerontology together with three of the present authors, of an article (Ann NY (...)
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  3.  2
    A proposed refinement of the mitochondrial free radical theory of aging.Aubrey D. N. J. De Grey - 1997 - Bioessays 19 (2):161-166.
    Over recent years, evidence has been accumulating in favour of the free radical theory of aging, first proposed by Harman. Despite this, an understanding of the mechanism by which cells might succumb to the effects of free radicals has proved elusive. This paper proposes such a mechanism, based on a previously unexplored hypothesis for the proliferation of mutant mitochondrial DNA: that mitochondria with reduced respiratory function, due to a mutation or deletion affecting the respiratory chain, suffer less frequent lysosomal degradation, (...)
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  4.  2
    Forces maintaining organellar genomes: is any as strong as genetic code disparity or hydrophobicity?Aubrey Dnj de Grey - 2005 - Bioessays 27 (4):436-446.
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  5.  11
    Biologists abandon Popper at their peril.Aubrey D. N. J. de Grey - 2000 - Bioessays 22 (2):206.
  6.  4
    Fear of misrepresentation cannot justify silence about foreseeable life‐extension biotechnology.Aubrey de Grey - 2003 - Bioessays 25 (1):94-95.
  7.  3
    More on mitochondria and senescence.Aubrey de Grey - 1997 - Bioessays 19 (6):533-534.
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  8.  10
    Popular gerontology comes of age.Aubrey de Grey - 1999 - Bioessays 21 (9):802-803.
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  9.  4
    More on mitochondria and senescence.David Gershon & Aubrey De Grey - 1997 - Bioessays 19 (6):533-534.
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  10.  1
    Book review: Ageless Quest. [REVIEW]Aubrey D. N. J. de Grey - 2004 - Bioessays 26 (1):108-109.
  11.  4
    More on mitochondria and senescence. [REVIEW]Aubrey de Grey - 1997 - Bioessays 19 (6):533-534.
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  12.  1
    Forces maintaining organellar genomes: is any as strong as genetic code disparity or hydrophobicity?Aubrey D. N. J. De Grey - 2005 - Bioessays 27 (4):436-446.
  13. In Silico Approaches and the Role of Ontologies in Aging Research.Georg Fuellen, Melanie Börries, Hauke Busch, Aubrey de Grey, Udo Hahn, Thomas Hiller, Andreas Hoeflich, Ludger Jansen, Georges E. Janssens, Christoph Kaleta, Anne C. Meinema, Sascha Schäuble, Paul N. Schofield, Barry Smith & Others - 2013 - Rejuvenation Research 16 (6):540-546.
    The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means. A particular focus was on ontologies, as these are a key technology to systematically integrate heterogeneous information about the aging process. Related topics were databases and data integration. Other talks tackled modeling issues and applications, the latter including talks focussed on marker development and cellular stress as well as on diseases, in particular on diseases of kidney (...)
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  14.  11
    Is human aging still mysterious enough to be left only to scientists?Aubrey D. N. J. De Grey, John W. Baynes, David Berd, Christopher B. Heward, Graham Pawelec & Gregory Stock - 2002 - Bioessays 24 (7):667-676.
    The feasibility of reversing human aging within a matter of decades has traditionally been dismissed by all professional biogerontologists, on the grounds that not only is aging still poorly understood, but also many of those aspects that we do understand are not reversible by any current or foreseeable therapeutic regimen. This broad consensus has recently been challenged by the publication, by five respected experimentalists in diverse subfields of biogerontology together with three of the present authors, of an article (Ann NY (...)
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  15.  4
    On Futuristic Gerontology: A Philosophical Evaluation of Aubrey de Grey’s SENS Project.Fernando Suárez Müller - 2007 - International Journal of Applied Philosophy 21 (2):225-239.
    This article is an ethical evaluation of the SENS bio-engineering program of Aubrey de Grey. After a general introduction, section 2 is a refutation of the claim that not to cure aging is immoral. It analyses the conceptual identification made by de Grey between “aging” and “disease.” This identification has important moral implications. It is argued that from a physiological standpoint the identification makes sense but from an evolutionary point of view it is highly questionable. Section 3 (...)
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  16.  10
    Response to Jonathan Bard and Aubrey de Grey.Robin Holliday - 2000 - Bioessays 22 (2):207-207.
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  17.  7
    Medical Nanorobotics: Breaking the Trance of Futility in Life Extension Research (A Reply to de Grey).Robert A. Freitas - 2007 - Studies in Ethics, Law, and Technology 1 (1).
    Biogerontologist Aubrey de Grey has suggested that one of the reasons we as a society invest so little in research on combating aging is because we are in an intellectual trance. We think the effort will be futile: aging is immutable, so why try? A healthy skepticism can be a good thing but it is a major mistake to bet against the irresistible force of inexorable technological progress. Over the next few decades, nanotechnology will come to play a (...)
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  18.  21
    Life extension, human rights, and the rational refinement of repugnance.A. D. N. J. de Grey - 2005 - Journal of Medical Ethics 31 (11):659-663.
    On the ethics of extending human life: healthy people have a right to carry on livingHumanity has long demonstrated a paradoxical ambivalence concerning the extension of a healthy human lifespan. Modest health extension has been universally sought, whereas extreme health extension has been regarded as a snare and delusion—a dream beyond all others at first blush, but actually something we are better off without. The prevailing pace of biotechnological progress is bringing ever closer the day when humanity will be able (...)
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  19.  87
    Humanity's End: Why We Should Reject Radical Enhancement.Nicholas Agar - 2013 - Bradford.
    Proposals to make us smarter than the greatest geniuses or to add thousands of years to our life spans seem fit only for the spam folder or trash can. And yet this is what contemporary advocates of radical enhancement offer in all seriousness. They present a variety of technologies and therapies that will expand our capacities far beyond what is currently possible for human beings. In _Humanity's End,_ Nicholas Agar argues against radical enhancement, describing its destructive consequences. Agar examines the (...)
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  20. Ageless Quest Leonard Guarente.Adnj de Grey - 2004 - Bioessays 26 (1):108-109.
     
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  21. Popular gerontology comes of age By Kirkwood TBL. Weidenfeld and Nicolson.A. De Grey - 1999 - Bioessays 21:802-803.
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  22.  2
    Reasons and methods for promoting our duty to extend healthy life indefinitely.Adnj de Grey - 2008 - Journal of Evolution and Technology 18 (1):50-5.
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  23.  9
    Humanity’s End: Why We Should Reject Radical Enhancement.Nicholas Agar - 2010 - Bradford.
    Proposals to make us smarter than the greatest geniuses or to add thousands of years to our life spans seem fit only for the spam folder or trash can. And yet this is what contemporary advocates of radical enhancement offer in all seriousness. They present a variety of technologies and therapies that will expand our capacities far beyond what is currently possible for human beings. In _Humanity's End,_ Nicholas Agar argues against radical enhancement, describing its destructive consequences. Agar examines the (...)
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  24. Gute Gene sind alles? Der genetisch codierte Mensch im Transhumanismus.Anna Puzio - 2024 - In Mariano Delgado & Klaus Vellguth (eds.), Der bessere Mensch. Religionswissenschaftliche, ethische und theologische Perspektiven. Ostfildern: Grünewald. pp. 165–192.
    Mit den Fortschritten in Generativer Künstlicher Intelligenz, Large Language Models, Brain-Computer Interfaces und genetischen Eingriffen gewinnt auch der Transhumanismus an Relevanz. Der Transhumanismus ist ein beliebtes Thema der Medien und wird in Tages- und Wochenzeitungen sowie im Fernsehen gerne aufgegriffen. Außerdem gibt es inzwischen viele Filme, die den Transhumanismus thematisieren, z. B. die Dokumentation „Endlich unendlich“ (2021, Regie: Stephan Bergmann). Der Transhumanismus wurde in Österreich auch Gegenstand einer Verschwörungserzählung, über die der Bayrische Rundfunk aufgeklärt hat. Auf den Wahlplakaten der „Partei (...)
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  25.  52
    On Futuristic Gerontology.Fernando Suárez Müller - 2007 - International Journal of Applied Philosophy 21 (2):225-239.
    This article is an ethical evaluation of the SENS bio-engineering program of Aubrey de Grey. After a general introduction, section 2 is a refutation of the claim that not to cure aging is immoral. It analyses the conceptual identification made by de Grey between “aging” and “disease.” This identification has important moral implications. It is argued that from a physiological standpoint the identification makes sense but from an evolutionary point of view it is highly questionable. Section 3 (...)
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  26.  5
    Propuesta preventiva en gerencia del servicio para los pequeños comerciantes tenderos de Pereira y Dosquebradas.Luz Stella Restrepo de Ocampo, F. Morales & Greys Patricia - forthcoming - Scientia.
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  27.  11
    Three maps and three misunderstandings: A digital mapping of climate diplomacy.Kari De Pryck, Vinciane Zabban, Ian Gray, Jean-Philippe Cointet, Nicolas Baya Laffite & Tommaso Venturini - 2014 - Big Data and Society 1 (2).
    This article proposes an original analysis of the international debate on climate change through the use of digital methods. Its originality is twofold. First, it examines a corpus of reports covering 18 years of international climate negotiations, a dataset never explored before through digital techniques. This corpus is particularly interesting because it provides the most consistent and detailed reporting of the negotiations of the United Nations Framework Convention on Climate Change. Second, in this paper we test an original approach to (...)
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  28.  31
    The TMS Motor Map Does Not Change Following a Single Session of Mirror Training Either with Or without Motor Imagery.Mark van de Ruit & Michael J. Grey - 2017 - Frontiers in Human Neuroscience 11.
  29.  1
    Six great thinkers: Socrates, St. Augustine, Lord Bacon, Rousseau, Coleridge, John Stuart Mill.Aubrey De Sélincourt - 1977 - Folcroft, Pa.: Folcroft Library Editions.
  30.  5
    Russell y la Elegía de Gray.Max Fernández de Castro & Rosa María Espinoza - 2022 - Tópicos: Revista de Filosofía 65:11-48.
    El pasaje de la Elegía de Gray (PEG) en “On Denoting” es extremadamente obscuro y ha sido objeto de muy diversas interpretaciones. Aparentemente contiene una crítica devastadora contra la teoría de los conceptos denotativos que el propio Russell había postulado en The Principles of Mathematics (PM) (1903). En este artículo exponemos sucintamente dicha teoría semántica, examinamos detalladamente el pasaje en cuestión y exploramos algunas de las interpretaciones que pretenden desentrañar su sentido. Con ello mostramos, en primer lugar, que la crítica (...)
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  31.  5
    Considerações acerca de uma dignidade não limitada ao ser humano: serão também dignos os animais?Anamaria Gonçalves Feijó, Natália De Campos Grey & Cleópas Isaías Santos - 2011 - Filosofia Unisinos 12 (2).
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  32.  60
    A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus).Ezgi Tanriver-Ayder, Laura J. Gray, Sarah K. McCann, Ian M. Devonshire, Leigh O’Connor, Zeinab Ammar, Sarah Corke, Mahmoud Warda, Evandro Araújo De-Souza, Paolo Roncon, Edward Christopher, Ryan Cheyne, Daniel Baker, Emily Wheater, Marco Cascella, Savannah A. Lynn, Emmanuel Charbonney, Kamil Laban, Cilene Lino de Oliveira, Julija Baginskaite, Joanne Storey, David Ewart Henshall, Ahmed Nazzal, Privjyot Jheeta, Arianna Rinaldi, Teja Gregorc, Anthony Shek, Jennifer Freymann, Natasha A. Karp, Terence J. Quinn, Victor Jones, Kimberley Elaine Wever, Klara Zsofia Gerlei, Mona Hosh, Victoria Hohendorf, Monica Dingwall, Timm Konold, Katrina Blazek, Sarah Antar, Daniel-Cosmin Marcu, Alexandra Bannach-Brown, Paula Grill, Zsanett Bahor, Gillian L. Currie, Fala Cramond, Rosie Moreland, Chris Sena, Jing Liao, Michelle Dohm, Gina Alvino, Alejandra Clark, Gavin Morrison, Catriona MacCallum, Cadi Irvine, Philip Bath, David Howells, Malcolm R. Macleod, Kaitlyn Hair & Emily S. Sena - 2019 - Research Integrity and Peer Review 4 (1).
    BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.MethodsIn a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication (...)
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  33.  6
    Aubrey de Vere, Tennyson and Alice Meynell.Sister M. Paraclita - 1946 - Thought: Fordham University Quarterly 21 (1):109-126.
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  34.  5
    La maturité de la pensée scientifique en GrèceAbel Rey.Aubrey Diller - 1940 - Isis 32 (1):167-168.
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  35.  20
    Les opuscules mathematiques de Didyme, Diophane, et Anthemius, suivis du fragment mathematique de Bobbio. Paul Ver Eecke.Aubrey Diller - 1942 - Isis 33 (5):639-640.
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  36.  7
    Touching God: Vertigo, Exactitude, and Degrees of Devekut in the Contemporary Nondual Jewish Mysticism of R. Yitzhaq Maier Morgenstern.Aubrey L. Glazer - 2011 - Journal of Jewish Thought and Philosophy 19 (2):147-192.
    Whether extrovertive, introvertive, or some further hybrid, the process of the soul touching the fullness of its divine origins is itself undergoing transformation in the twenty-first-century cultural matrices of Israel. A remarkable exemplar of devotional Hebrew cultures can be found within the hybrid networks of haredi worlds in Israel today. R. Yitzhaq Maier Morgenstern, author of Yam ha-okhmah, Netiv ayyim, and De'i okhmah le-nafshekha, is arguably the most innovative mystical voice in Israel. Why are his works resonating so strongly both (...)
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  37.  7
    De Lamennais.R. J. Gray - 1928 - Modern Schoolman 4 (4):52-53.
    This is a section of Mr. Gray's recent paper read before The Philosophers' Academy covering "The Catholic Movement in France (1830-1850) and the Philosophy of de Lamennais".Complete ignorance of the system of the Medieval Schoolmen seems responsible for the contempt in which he held Scholasticism, and indirectly for the vagaries of his own philosophy, and the ultimate shipwreck of his faith.
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  38.  12
    De Lamennais.R. J. Gray - 1928 - Modern Schoolman 4 (4):52-53.
    This is a section of Mr. Gray's recent paper read before The Philosophers' Academy covering "The Catholic Movement in France (1830-1850) and the Philosophy of de Lamennais".Complete ignorance of the system of the Medieval Schoolmen seems responsible for the contempt in which he held Scholasticism, and indirectly for the vagaries of his own philosophy, and the ultimate shipwreck of his faith.
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  39.  12
    Dictionnaire etymologique de la langue latine: histoire des mots.Louis H. Gray, A. Ernout & A. Meillet - 1942 - American Journal of Philology 63 (3):374.
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  40.  8
    Die Frauenheilkunde der alten Welt. Paul Diepgen.Aubrey Diller - 1938 - Isis 28 (1):123-126.
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  41.  6
    Der Friedensgedanke in der antiken Welt.Aubrey Diller & Wilhelm Nestle - 1940 - American Journal of Philology 61 (2):254.
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  42.  8
    Mindfulness and De-Automatization.Yoona Kang, June Gruber & Jeremy R. Gray - 2013 - Emotion Review 5 (2):1754073912451629.
    Some maladaptive thought processes are characterized by reflexive and habitual patterns of cognitive and emotional reactivity. We review theoretical and empirical work suggesting that mindfulness—a state of nonjudgmental awareness of the present moment—can facilitate the discontinuation of such automatic mental operations. We propose a framework that suggests a series of more specific mechanisms supporting the de-automatizing function of mindfulness. Four related but distinct elements of mindfulness (awareness, attention, focus on the present, and acceptance) can each contribute to de-automatization through subsequent (...)
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  43.  10
    Spinoza: Moral Philosophy.John Grey - 2015 - Internet Encyclopedia of Philosophy.
    Spinoza: Moral Philosophy Like many European philosophers in the early modern period, Benedict de Spinoza developed a moral philosophy that fused the insights of ancient theories of virtue with a modern conception of humans, their place in nature, and their relationship to God. Unlike many other authors in this period, however, Spinoza was strongly … Continue reading Spinoza: Moral Philosophy →.
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  44.  12
    De Lamennais.R. J. Gray - 1928 - Modern Schoolman 4 (4):64-65.
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  45.  28
    Le socrate de Xénophon et la démocratie.Vivienne J. Gray - 2004 - Les Etudes Philosophiques 2 (2):141-176.
    Le Socrate de Xénophon et la démocratie présente une interprétation nuancée du témoignage de Xénophon sur l’attitude de Socrate à l’endroit de la démocratie athénienne. Cette étude conteste les interprétations qui ont été trop restrictives dans le choix des témoignages et trop négatives dans leurs conclusions. Elle tient compte, d’une part, des différents paramètres qui permettent de définir la démocratie ; d’autre part, des réalités de la démocratie athénienne. Les principaux textes pertinents proviennent des Mémorables. Nous traitons de la nature (...)
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  46.  9
    Principes de grammaire generale.Louis H. Gray & Louis Hjelmslev - 1931 - American Journal of Philology 52 (1):77.
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  47.  9
    La formation des noms en grec ancien.Louis H. Gray & Pierre Chantraine - 1934 - American Journal of Philology 55 (3):278.
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  48. Radical enhancement as a moral status de-enhancer.Jesse Gray - 2020 - Monash Bioethics Review 1 (2):146-165.
    Nicholas Agar, Jeff McMahan and Allen Buchanan have all expressed concerns about enhancing humans far outside the species-typical range. They argue radically enhanced beings will be entitled to greater and more beneficial treatment through an enhanced moral status, or a stronger claim to basic rights. I challenge these claims by first arguing that emerging technologies will likely give the enhanced direct control over their mental states. The lack of control we currently exhibit over our mental lives greatly contributes to our (...)
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  49.  4
    Recognition and the Harms of “Cheer Up”.Fiona Vera-Gray & Bianca Fileborn - 2018 - Philosophical Journal of Conflict and Violence 2 (1).
    A philosophical frame for violence against women and girls creates unique opportunities to deepen our understanding of the embodied consequences of men’s violence. Using the seemingly innocuous example of being told to “cheer up” or “smile”, we draw on Simone de Beauvoir and Franz Fanon’s work on recognition to suggest that a phenomenological approach to sexual violence may help to voice previously inarticulable harms. The dual frame of Beauvoir and Fanon also highlights the need for philosophical work on sexual violence (...)
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  50. Onveranderlijkheid en verschil. De bijdrage van Isaiah Berlin aan het geestelijk leven.John N. Gray - 1995 - Nexus 12.
    Ondanks de grote diversiteit van Berlins werken, die een groot cultuurhistorisch bereik hebben, gaat hij uit van een moreel minimum als constante horizon van de mensheid, ondanks alle culturele verschillen.
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