It has been suggested that hierarchically structured symbols, a remarkable feature of human language, are produced via the operation of recursive combination. Recursive combination is frequently observed in human behavior, not only in language but also in action sequences, mind-reading, technology, et cetera.; in contrast, it is rarely observed in animals. Why is it that only humans use this operation? What is the adaptability of recursive combination? We aim (1) to identify the environmental feature(s) in which recursive combination is effective (...) for survival and reproduction, and that has facilitated the evolution of this ability, and (2) to demonstrate the possible evolutionary processes of recursive combination. To achieve this, we constructed an evolutionary simulation of agents that generated products using recursive combination and used the results to explore the types of fitness functions (that reflect the kinds of adaptive environments) that give rise to this ability. We identified two types of adaptability of the recursive combination: (1) diversifiability of production and (2) diversifiability of products. Through the former, recursive combination promotes robustness against failure of production caused by inaccurate manipulations or irreversible changes. In an environment in which diversified products are preferable, sharing a portion of the production process for these products entails producing multiple products in which recursive combination plays a key role. We suppose that recursive combination works as a driving force of material culture. Finally, we discuss the possible evolutionary scenarios of recursive combination that is later generalized to encompass many aspects of human cognition, including human language. (shrink)

BackgroundSocial cognitive impairments adversely affect social functioning in patients with schizophrenia. Although pharmacological interventions have been suggested to provide some benefits on social cognition, little information is available on the comparative efficacy of pharmacotherapy. Thus, the aim of this planned systematic review and network meta-analysis is to perform a quantitative comparison of the effects of various psychotropic drugs, including supplements, on social cognition disturbances of schizophrenia.MethodsThe literature search will be carried out using the PubMed, Embase, Cochrane Central Register of Controlled (...) Trials, PsycINFO, ClinicalTrials.gov, and International Clinical Trials Registry Platform databases from inception onward. Randomized controlled trials that examined the efficacy of drugs in social cognitive disturbances will be included, based on the most recent studies and the broader literature than previously searched. This protocol defines a priori the methods that will be used for study selection, data collection, quality assessment, and statistical syntheses.DiscussionThe findings this work are expected to help promote the development of better therapeutics of social cognitive impairments in schizophrenia and related psychiatric conditions.Systematic Review Registration[www.crd.york.ac.uk/prospero], identifier [CRD42021293224]. (shrink)

江戸時代の儒学者・宗教者である山崎闇斎の思想を、心理学・文化人類学・現代哲学等を取り入れた学際的なアプローチで解明する。.

Sherlock Holmes is a fictional individual. So is his favorite pipe. Our pre-theoretical intuition says that neither of them is real. It says that neither of them really, or actually, exists. It also says that there is a sense in which they do exist, namely, a sense in which they exist “in the world of” the Sherlock Holmes stories. Our pre-theoretical intuition says in general of any fictional individual that it does not actually exist but exists “in the world of” (...) the relevant fiction. I wish to defend this pretheoretical intuition. To do so, I need to defend two claims: that fictional individuals do not actually exist, and that they exist “in the world of” the relevant fiction. The aim of this paper is to defend the first claim. (shrink)

Deep theorizing about possibility requires theorizing about possible objects. One popular approach regards the notion of a possible object as intertwined with the notion of a possible world. There are two widely discussed types of theory concerning the nature of possible worlds: actualist representationism and possibilist realism. They support two opposing views about possible objects. Examination of the ways in which they do so reveals difficulties on both sides. There is another popular approach, which has been influenced by the philosophy (...) of Alexius Meinong. The Meinongian approach is relevant to theorizing about possible objects because it attempts to construct a general theory of objects other than ordinary concrete existing objects. Independently of the debate about the nature of possible worlds or about Meinongianism, it is not always as straightforward as it may at first appear to determine whether putative possible objects are indeed possible. Another category of object similar to that of a possible object is the category of a fictional object. Although initially attractive, the idea that fictional objects are possible objects should not be accepted blindly. An important instance of theoretical usefulness of possible objects is their central role in the validation of two controversial theorems of a simple quantified modal logic. (shrink)

I propose and defend a surprisingly simple yet useful analysis of existence according to which existence is a relation between a thing and a set: a thing x bears the relation of existence to a set S if and only if x is a member of S . This simple set-theoretic analysis of existence demystifies existence and is powerful and flexible enough to serve important theoretical purposes.

Modal realism -- Time, space, world -- Existence -- Actuality -- Modal realism and modal tense -- Transworld individuals and their identity -- Existensionalism -- Impossibility -- Proposition and relief -- Fictional worlds -- Epistemology.

Those who object to David Lewis' modal realism express qualms about philosophical respectability of the Lewisian notion of a possible world and its correlate notion of an inhabitant of a possible world. The resulting impression is that these two notions either stand together or fall together. I argue that the Lewisian notion of a possible world is otiose even for a good Lewisian modal realist, and that one can carry out a good Lewisian semantics for modal discourse without Lewisian possible (...) worls. I do so by generalizing Lewis' own idea that restrictions on quantification come and go with the pragmatic wind and relativizing possible worlds as shifting domains of discourse. I then suggest a way to soften the infamous incredulous stare. (shrink)

Modal Dimensionalism is a metaphysical theory about possible worlds that is naturally suggested by the often-noted parallelism between modal logic and tense logic. It says that the universe spreads out not only in spatiotemporal dimensions but also in a modal dimension. It regards worlds as nothing more or less than indices in the modal dimension in the way analogous to the way in which Temporal Dimensionalism regards temporal points and intervals as indices in the temporal dimension. Despite its naturalness and (...) intuitive appeal. Modal Dimensionalism has been largely ignored while the debates between David Lewis and his critics have dominated the discourse on the nature of possible worlds. It is high time that we took Modal Dimensionalism seriously as a viable alternative. (shrink)

Biological forms are very complex, and mechanisms of pattern formation are not well understood. Although developmental biology deals with the mechanistic explanation of patterns, currently we do not know how to understand the mechanisms of pattern formation from huge amounts of molecular information. In this article, I present one useful tool, mathematical modeling, to obtain a mechanistic understanding of biological pattern formation, and show an actual example in lung branching morphogenesis. In this example, mathematical modeling plays an indispensable role in (...) understanding the biological phenomena. The model successfully reproduces the basic features of morphogenesis in vitro, but mechanism in vivo still remains to be elucidated. (shrink)

There are many gene families that are specific to multicellular animals. These have either diverged from ancestral genes that are shared with fungi and/or plants or evolved from an ancestral gene unique to animals. The evolution of gene families involved in cell–cell communication and developmental control has been studied to establish whether the number of member genes increased dramatically immediately prior to or in concert with the Cambrian explosion. A molecular phylogeny‐based analysis of several animal‐specific gene families has revealed that (...) gene diversification by duplication occurred during two active periods interrupted by a long intervening quiescent period. Intriguingly, the Cambrian explosion is situated in the silent period, indicating that there is no direct link between the first burst of gene diversification and the Cambrian explosion itself. The importance of gene recruitment as a possible molecular mechanism for morphological diversity, and its possible role for the Cambrian explosion, are discussed. BioEssays 23:1018–1027, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

DNA with a curved trajectory of its helix axis is called bent DNA, or curved DNA. Interestingly, biologically important DNA regions often contain this structure, irrespective of the origin of DNA. In the last decade, considerable progress has been made in clarifying one role of bent DNA in prokaryotic transcription and its mechanism of action. However, the role of bent DNA in eukaryotic transcription remains unclear. Our recent study raises the possibility that bent DNA is implicated in the “functional packaging” (...) of transcriptional regulatory regions into chromatin. In this article, I review recent progress in bent DNA research in eukaryotic transcription, and summarize the history of bent DNA research and several subjects relevant to this theme. Finally, I propose a hypothesis that bent DNA structures that mimic a negative supercoil, or have a right‐handed superhelical writhe, organize local chromatin infrastructure to help the very first interaction between cis‐acting DNA elements and activators that trigger transcription. BioEssays 23:708–715, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Molecular and biochemical analysis of the biogenesis of peroxisomes has made rapid progress in recent years. Research on the mechanism of targeting of peroxisomal proteins has revealed that many, but not all, peroxisomal proteins have a conserved tripeptide motif in their carboxy‐terminal portions which is required for entry into peroxisomes; the topogenic signal mechanism thus differs in these instances from those employed in mitochondria and endoplasmic reticulum. Other factors involved in peroxisome biogenesis are also coming to light.

Mark Jago’s four arguments against Takashi Yagisawa’s extended modal realism are examined and shown to be ineffective. Yagisawa’s device of modal tense renders three of Jago’s arguments harmless, and the correct understanding of predications of modal properties of world stages blocks the fourth one.

Macroautophagy is a major degradation mechanism of cell components via the lysosome. Macroautophagy greatly contributes to not only cell homeostasis but also the prevention of various diseases. Because macroautophagy proceeds through multi‐step reactions, researchers often face a persistent question of how macroautophagic activity can be measured correctly. To make a straightforward determination of macroautophagic activity, diverse monitoring assays have been developed. Direct measurement of lysosome‐dependent degradation of radioisotopically labeled cell proteins has long been applied. Meanwhile, indirect monitoring procedures have been (...) developed. In these assays, autophagosome marker proteins, microtubule‐associated proteins 1A/1B light chain 3B‐II (LC3B‐II) and gamma‐aminobutyric acid receptor‐associated protein‐II (GABARAP‐II) have been analyzed and the validity of the assays strongly depends on appropriate assessment of the fluctuation of LC3‐II and/or GABARAP‐II levels in the presence or absence of lysosomal inhibitors. This article describes these monitoring methods, paying special attention to the principles and characteristics of each procedure. (shrink)

Meaning Solipsism says that it is possible for there to be a meaningful state without any other meaningful state. The meaning of such a solo meaningful state should be non-natural. The best strategy for establishing Meaning Solipsism is to argue for the determination of the meaning of a possible solo meaningful state via the set of entities the meaning of the state fits. Embracing merely possible and impossible entities is the most straightforward way to do so. Also, a good way (...) to honor analayticities the meaning of a solo meaningful state gives rise to is to insist on certain facts about impossible entities as non-negotiable brute facts. (shrink)