BackgroundSocial cognitive impairments adversely affect social functioning in patients with schizophrenia. Although pharmacological interventions have been suggested to provide some benefits on social cognition, little information is available on the comparative efficacy of pharmacotherapy. Thus, the aim of this planned systematic review and network meta-analysis is to perform a quantitative comparison of the effects of various psychotropic drugs, including supplements, on social cognition disturbances of schizophrenia.MethodsThe literature search will be carried out using the PubMed, Embase, Cochrane Central Register of Controlled (...) Trials, PsycINFO, ClinicalTrials.gov, and International Clinical Trials Registry Platform databases from inception onward. Randomized controlled trials that examined the efficacy of drugs in social cognitive disturbances will be included, based on the most recent studies and the broader literature than previously searched. This protocol defines a priori the methods that will be used for study selection, data collection, quality assessment, and statistical syntheses.DiscussionThe findings this work are expected to help promote the development of better therapeutics of social cognitive impairments in schizophrenia and related psychiatric conditions.Systematic Review Registration[www.crd.york.ac.uk/prospero], identifier [CRD42021293224]. (shrink)

In the natural deduction system for classical propositional logic given by G. Gentzen, there are some inference rules with assumptions discharged by the rule. D. Prawitz calls such inference rules improper, and others proper. Improper inference rules are more complicated and are often harder to understand than the proper ones. In the present paper, we distinguish between proper and improper derivations by using sequent systems. Specifically, we introduce a sequent system \(\vdash_{\bf Sc}\) for classical propositional logic with only structural rules, (...) and prove that \(\vdash_{\bf Sc}\) does not allow improper derivations in general. For instance, the sequent \(\Rightarrow p \to q\) cannot be derived from the sequent \(p \Rightarrow q\) in \(\vdash_{\bf Sc}\). In order to prove the failure of improper derivations, we modify the usual notion of truth valuation, and using the modified valuation, we prove the completeness of \(\vdash_{\bf Sc}\). We also consider whether an improper derivation can be described generally by using \(\vdash_{\bf Sc}\). (shrink)

Modal realism -- Time, space, world -- Existence -- Actuality -- Modal realism and modal tense -- Transworld individuals and their identity -- Existensionalism -- Impossibility -- Proposition and relief -- Fictional worlds -- Epistemology.

Hobbs (2010) introduced ‘clause-internal coherence’ (CIC) to describe inferences in, e.g., ‘A jogger was hit by a car,’ where the jogging is understood to have led to the car-hitting. Cohen & Kehler (2021) argue that well-known pragmatic tools cannot account for CIC, motivating an enrichment account familiar from discourse coherence research. An outstanding question is how to compositionally derive CIC from coherence relations. This paper takes strides in answering this question. It first provides experimental support for the existence of CIC (...) via offline evidence that attributive (non-)deverbal adjectives can trigger the same causal inferences within clauses that their predicative counterparts can trigger across clauses, albeit more weakly. To explain the experimental results, we use tools in Segmented Discourse Representation Theory (SDRT), which allows us to show that causal inferences can be derived in various ways, depending on whether deverbal adjectives are used attributively or predicatively. If the former, they are presupposition triggers and the coherence relations Elaboration/Continuation compete with Background; if the latter, Explanation/Result compete with Background. These different competitions -- cashed out in terms of interaction between default axioms -- correlate with the difference in the relative salience of the causal inferences. (shrink)

This paper describes the situation of philosophy in Japan with respect to the question of internationalism. For more than a hundred years, Japan took Western culture as its model and European philosophy as the authentic philosophy. This tendency was paradoxically strengthened by the post‐war humanism. It gave us Japanese philosophers a clear discipline to work in but cut us off from our own native culture, history, and philosophical traditions. In wishing to recover this loss, I argue that it is necessary (...) to distinguish between two forms of internationalism: humanistic and merely fashionable. The latter in fact derives from domestic reasons. (shrink)

『不思議の国のアリス』の数学観から、古代ギリシャから現代への懐疑主義思想との格闘をたどって、数学的知識の成立根拠を探る。.

Those who object to David Lewis' modal realism express qualms about philosophical respectability of the Lewisian notion of a possible world and its correlate notion of an inhabitant of a possible world. The resulting impression is that these two notions either stand together or fall together. I argue that the Lewisian notion of a possible world is otiose even for a good Lewisian modal realist, and that one can carry out a good Lewisian semantics for modal discourse without Lewisian possible (...) worls. I do so by generalizing Lewis' own idea that restrictions on quantification come and go with the pragmatic wind and relativizing possible worlds as shifting domains of discourse. I then suggest a way to soften the infamous incredulous stare. (shrink)

ABSTRACTAnother individual’s gaze automatically shifts an observer’s attention to a location. This reflexive response occurs even when the gaze is presented subliminally over a short period. Another’s gaze also increases the preference level for items in the gaze direction; however, it was previously unclear if this effect occurs when the gaze is presented subliminally. This study showed that the preference levels for nonsense figures looked at by a subliminal gaze were significantly greater than those for items that were subliminally looked (...) away from. Targets that were looked at by a subliminal gaze were detected faster ; however, the participants were unable to detect the gaze direction. These results indicate that another individual’s gaze automatically increases the preference levels for items in the gaze direction without conscious awareness. (shrink)

It seems to be a challenging task for those non-Western scholars who are deeply immersed in European intellectual resources to theorise multiple forms of modernity and deparochialise political theory. What difficulty awaits us in non-Western contexts, when we attempt to throw off these shackles and to open up alternative views of modernity? To address this question, this article attempts to critically examine Maruyama Masao (丸山眞男, 1914–1996), an influential scholar on the history of Japanese political thought, with respect to his view (...) of Japanese modernity, thereby exploring what obstacles await him in pursuing the multiplicity view of modernity and how he actually or potentially overcomes them. In doing so, I develop two arguments. First, Maruyama's move towards multiple modernities remains incomplete because he fails to throw off the shackles of universal history. Second, however, we can identify an alternative way in his own thought that, though not taken by himself, potentially goes beyond universal history towards multiple modernities. (shrink)

Sherlock Holmes is a fictional individual. So is his favorite pipe. Our pre-theoretical intuition says that neither of them is real. It says that neither of them really, or actually, exists. It also says that there is a sense in which they do exist, namely, a sense in which they exist “in the world of” the Sherlock Holmes stories. Our pre-theoretical intuition says in general of any fictional individual that it does not actually exist but exists “in the world of” (...) the relevant fiction. I wish to defend this pretheoretical intuition. To do so, I need to defend two claims: that fictional individuals do not actually exist, and that they exist “in the world of” the relevant fiction. The aim of this paper is to defend the first claim. (shrink)

There are many gene families that are specific to multicellular animals. These have either diverged from ancestral genes that are shared with fungi and/or plants or evolved from an ancestral gene unique to animals. The evolution of gene families involved in cell–cell communication and developmental control has been studied to establish whether the number of member genes increased dramatically immediately prior to or in concert with the Cambrian explosion. A molecular phylogeny‐based analysis of several animal‐specific gene families has revealed that (...) gene diversification by duplication occurred during two active periods interrupted by a long intervening quiescent period. Intriguingly, the Cambrian explosion is situated in the silent period, indicating that there is no direct link between the first burst of gene diversification and the Cambrian explosion itself. The importance of gene recruitment as a possible molecular mechanism for morphological diversity, and its possible role for the Cambrian explosion, are discussed. BioEssays 23:1018–1027, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Mark Jago’s four arguments against Takashi Yagisawa’s extended modal realism are examined and shown to be ineffective. Yagisawa’s device of modal tense renders three of Jago’s arguments harmless, and the correct understanding of predications of modal properties of world stages blocks the fourth one.

This article contributes to the critical engagement with luck egalitarianism by advancing two arguments. Firstly, it questions the cogency of the dichotomies – e.g., luck/choice, person/circumstance, agency/structure – and the accompanying moral ideal of pure voluntarism. This makes it difficult for luck egalitarianism to dissect appropriately the inequalities embedded in social relations, such as social networks and involuntary associations, in which voluntariness and contingency as well as agency and structure are intertwined. Secondly, it suggests that the relational approach, which has (...) been developed, inter alia, in the empirical study of inequality, provides a morally and practically adequate perspective on egalitarian justice. The relational approach achieves this by converging upon those in‐between social relations that are irreducible to the macro‐level structure and to micro‐level agency. Moreover, a relationally sensitive perspective on inequality can adeptly respond to the difficulties that luck‐egalitarian theories encounter. (shrink)

Abstract When the Meiji government allowed Christianity to be proclaimed in Japan in 1873, there aroused heated controversy about how to deal with religion including Christianity. Fukuzawa Yukichi, the most influential thinker and opinion?leader among Japanese intellectuals in those days, participated in the controversy and wrote more than 80 articles concerning religion. At first, he took a critical standpoint against Christianity from the Utilitarian viewpoint. Then he changed his viewpoint of religion and came to admit a Unitarian Christianity for a (...) little while. But he gradually came to be familiar with Pure Land Buddhism and developed his original phibsophy of religion in his later years. In this article I trace the process of change in Fukuzawa's religious viewpoint and clarify his philosophy of religion in his later years, by examining his writings in chronological order. (shrink)

"This book aims to shine light on the scene created by "belief" and "knowledge" and how they influenced the history of ideas at turning points interweaving its important epochs." -- Preface.

DNA with a curved trajectory of its helix axis is called bent DNA, or curved DNA. Interestingly, biologically important DNA regions often contain this structure, irrespective of the origin of DNA. In the last decade, considerable progress has been made in clarifying one role of bent DNA in prokaryotic transcription and its mechanism of action. However, the role of bent DNA in eukaryotic transcription remains unclear. Our recent study raises the possibility that bent DNA is implicated in the “functional packaging” (...) of transcriptional regulatory regions into chromatin. In this article, I review recent progress in bent DNA research in eukaryotic transcription, and summarize the history of bent DNA research and several subjects relevant to this theme. Finally, I propose a hypothesis that bent DNA structures that mimic a negative supercoil, or have a right‐handed superhelical writhe, organize local chromatin infrastructure to help the very first interaction between cis‐acting DNA elements and activators that trigger transcription. BioEssays 23:708–715, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Molecular and biochemical analysis of the biogenesis of peroxisomes has made rapid progress in recent years. Research on the mechanism of targeting of peroxisomal proteins has revealed that many, but not all, peroxisomal proteins have a conserved tripeptide motif in their carboxy‐terminal portions which is required for entry into peroxisomes; the topogenic signal mechanism thus differs in these instances from those employed in mitochondria and endoplasmic reticulum. Other factors involved in peroxisome biogenesis are also coming to light.

This article looks at the past, present, and future of the study of aesthetics. The early modern period, during which aesthetics came into being, was a great historical turning point for civilization. So, too, is our own day. Looked at this way, aesthetics should show a different face than the one we are used to. Aesthetics is generally considered to be the philosophy of art, yet, with art regarded as an autonomous cultural field, aesthetics commonly gives the impression of being (...) isolated from philosophy in general. This article explores a completely different aesthetics. When it was coming into existence, aesthetics was charged with the real and urgent philosophical problem of its time: how to construct a new world. (shrink)