With more than half of individuals incarcerated having serious mental health concerns, correctional settings offer excellent opportunities for epidemiological, prevention, and intervention research. However, due to unique ethical and structural challenges, these settings create risks and vulnerabilities for participants not typically encountered in research populations. We surveyed 1,224 researchers, Institutional Review Board members, and IRB prisoner representatives to assess their perceptions of risks and vulnerabilities associated with mental health research conducted in correctional settings. Highest ranked risks were related to privacy, (...) stigma, and confidentiality; lowest ranked risks were related to prisoners’ loss of privileges or becoming targets of violence due to having participated in research. Cognitive impairment, mental illness, lack of autonomy, and limited access to services emerged as the greatest sources of vulnerability; being male, being female, being older than age 60, being a minority, and being pregnant were the lowest ranked sources of vulnerability. Researchers with corrections experience perceived lower risks and vulnerabilities than all other groups, raising the question whether these researchers accurately appraise risk and vulnerability based on experience, or if their lower risk and vulnerability perceptions reflect potential bias due to their vested interests. By identifying areas of particular risk and vulnerability, this study provides important information for researchers and research reviewers alike. (shrink)

Metabolic pathways underlying brain function remain largely unexplored during neurodevelopment, predominantly due to the lack of feasible techniques for use with awake infants. Broadband near-infrared spectroscopy provides the opportunity to explore the relationship between cerebral energy metabolism and blood oxygenation/haemodynamics through the measurement of changes in the oxidation state of mitochondrial respiratory chain enzyme cytochrome-c-oxidase alongside haemodynamic changes. We used a bNIRS system to measure ΔoxCCO and haemodynamics during functional activation in a group of 42 typically developing infants aged between (...) 4 and 7 months. bNIRS measurements were made over the right hemisphere over temporal, parietal and central cortical regions, in response to social and non-social visual and auditory stimuli. Both ΔoxCCO and Δ[HbO2] displayed larger activation for the social condition in comparison to the non-social condition. Integration of haemodynamic and metabolic signals revealed networks of stimulus-selective cortical regions that were not apparent from analysis of the individual bNIRS signals. These results provide the first spatially resolved measures of cerebral metabolic activity alongside haemodynamics during functional activation in infants. Measuring synchronised changes in metabolism and haemodynamics have the potential for uncovering the development of cortical specialisation in early infancy. (shrink)

This paper investigates whether the fundamental linguistic insights and intuitions of Lexical Functional Grammar, which is usually presented as a constraint-based linguistic theory, can be reformulated in a resource sensitive framework using a substructural modal logic. In the approach investigated here, LFG's f-descriptions are replaced with expressions from a multi-modal propositional logic. In effect, the feature structure unification basis of LFG's f-structures is replaced with a very different resource based mechanism. It turns out that some linguistic analyses that required non-monotonic (...) devices in LFG analysis of Icelandic) can be straightforwardly expressed in the framework presented here. Moreover, a Curry– Howard correspondence between proofs in this logic and -terms provides a semantic interpretation as a by-product of the process of showing syntactic well-formedness. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Table of contentsI1 Proceedings of the 4th World Conference on Research IntegrityConcurrent Sessions:1. Countries' systems and policies to foster research integrityCS01.1 Second time around: Implementing and embedding a review of responsible conduct of research policy and practice in an Australian research-intensive universitySusan Patricia O'BrienCS01.2 Measures to promote research integrity in a university: the case of an Asian universityDanny Chan, Frederick Leung2. Examples of research integrity education programmes in different countriesCS02.1 Development of a state-run “cyber education program of research ethics” in (...) KoreaEun Jung Ko, Jin Sun Kwak, TaeHwan Gwon, Ji Min Lee, Min-Ho LeeCS02.3 Responsible conduct of research teachers’ training courses in Germany: keeping on drilling through hard boards for more RCR teachersHelga Nolte, Michael Gommel, Gerlinde Sponholz3. The research environment and policies to encourage research integrityCS03.1 Challenges and best practices in research integrity: bridging the gap between policy and practiceYordanka Krastev, Yamini Sandiran, Julia Connell, Nicky SolomonCS03.2 The Slovenian initiative for better research: from national activities to global reflectionsUrsa Opara Krasovec, Renata SribarCS03.3 Organizational climate assessments to support research integrity: background of the Survey of Organizational Research Climate and the experience with its use at Michigan State UniversityBrian C. Martinson, Carol R. Thrush, C.K. Gunsalus4. Expressions of concern and retractionsCS04.1 Proposed guidelines for retraction notices and their disseminationIvan Oransky, Adam MarcusCS04.2 Watching retractions: analysis of process and practice, with data from the Wiley retraction archivesChris Graf, Verity Warne, Edward Wates, Sue JoshuaCS04.3 An exploratory content analysis of Expressions of ConcernMiguel RoigCS04.4 An ethics researcher in the retraction processMichael Mumford5. Funders' role in fostering research integrityCS05.1 The Fonds de Recherche du Québec’s institutional rules on the responsible conduct of research: introspection in the funding agency activitiesMylène Deschênes, Catherine Olivier, Raphaëlle Dupras-LeducCS05.2 U.S. Public Health Service funds in an international setting: research integrity and complianceZoë Hammatt, Raju Tamot, Robin Parker, Cynthia Ricard, Loc Nguyen-Khoa, Sandra TitusCS05.3 Analyzing decision making of funders of public research as a case of information asymmetryKarsten Klint JensenCS05.4 Research integrity management: Empirical investigation of academia versus industrySimon Godecharle, Ben Nemery, Kris Dierickx5A: Education: For whom, how, and what?CS05A.1 Research integrity or responsible conduct of research? What do we aim for?Mickey Gjerris, Maud Marion Laird Eriksen, Jeppe Berggren HoejCS05A.2 Teaching and learning about RCR at the same time: a report on Epigeum’s RCR poll questions and other assessment activitiesNicholas H. SteneckCS05A.4 Minding the gap in research ethics education: strategies to assess and improve research competencies in community health workers/promoteresCamille Nebeker, Michael Kalichman, Elizabeth Mejia Booen, Blanca Azucena Pacheco, Rebeca Espinosa Giacinto, Sheila Castaneda6. Country examples of research reward systems and integrityCS06.1 Improving systems to promote responsible research in the Chinese Academy of SciencesDing Li, Qiong Chen, Guoli Zhu, Zhonghe SunCS06.4 Exploring the perception of research integrity amongst public health researchers in IndiaParthasarathi Ganguly, Barna Ganguly7. Education and guidance on research integrity: country differencesCS07.1 From integrity to unity: how research integrity guidance differs across universities in Europe.Noémie Aubert Bonn, Kris Dierickx, Simon GodecharleCS07.2 Can education and training develop research integrity? The spirit of the UNESCO 1974 recommendation and its updatingDaniele Bourcier, Jacques Bordé, Michèle LeducCS07.3 The education and implementation mechanisms of research ethics in Taiwan's higher education: an experience in Chinese web-based curriculum development for responsible conduct of researchChien Chou, Sophia Jui-An PanCS07.4 Educating principal investigators in Swiss research institutions: present and future perspectivesLouis Xaver Tiefenauer8. Measuring and rewarding research productivityCS08.1 Altimpact: how research integrity underpins research impactDaniel Barr, Paul TaylorCS08.2 Publication incentives: just reward or misdirection of funds?Lyn Margaret HornCS08.3 Why Socrates never charged a fee: factors contributing to challenges for research integrity and publication ethicsDeborah Poff9. Plagiarism and falsification: Behaviour and detectionCS09.1 Personality traits predict attitude towards plagiarism of self and others in biomedicine: plagiarism, yes we can?Martina Mavrinac, Gordana Brumini, Mladen PetrovečkiCS09.2 Investigating the concept of and attitudes toward plagiarism for science teachers in Brazil: any challenges for research integrity and policy?Christiane Coelho Santos, Sonia VasconcelosCS09.3 What have we learnt?: The CrossCheck Service from CrossRefRachael LammeyCS09.4 High p-values as a sign of data fabrication/falsificationChris Hartgerink, Marcel van Assen, Jelte Wicherts10. Codes for research integrity and collaborationsCS10.1 Research integrity in cross-border cooperation: a Nordic exampleHanne Silje HaugeCS10.3 Research integrity, research misconduct, and the National Science Foundation's requirement for the responsible conduct of researchAaron MankaCS10.4 A code of conduct for international scientific cooperation: human rights and research integrity in scientific collaborations with international academic and industry partnersRaffael Iturrizaga11. Countries' efforts to establish mentoring and networksCS11.1 ENRIO : a network facilitating common approaches on research integrity in EuropeNicole FoegerCS11.2 Helping junior investigators develop in a resource-limited country: a mentoring program in PeruA. Roxana Lescano, Claudio Lanata, Gissella Vasquez, Leguia Mariana, Marita Silva, Mathew Kasper, Claudia Montero, Daniel Bausch, Andres G LescanoCS11.3 Netherlands Research Integrity Network: the first six monthsFenneke Blom, Lex BouterCS11.4 A South African framework for research ethics and integrity for researchers, postgraduate students, research managers and administratorsLaetus OK Lategan12. Training and education in research integrity at an early career stageCS12.1 Research integrity in curricula for medical studentsGustavo Fitas ManaiaCS12.2 Team-based learning for training in the responsible conduct of research supports ethical decision-makingWayne T. McCormack, William L. Allen, Shane Connelly, Joshua Crites, Jeffrey Engler, Victoria Freedman, Cynthia W. Garvan, Paul Haidet, Joel Hockensmith, William McElroy, Erik Sander, Rebecca Volpe, Michael F. VerderameCS12.4 Research integrity and career prospects of junior researchersSnezana Krstic13. Systems and research environments in institutionsCS13.1 Implementing systems in research institutions to improve quality and reduce riskLouise HandyCS13.2 Creating an institutional environment that supports research integrityDebra Schaller-DemersCS13.3 Ethics and Integrity Development Grants: a mechanism to foster cultures of ethics and integrityPaul Taylor, Daniel BarrCS13.4 A culture of integrity at KU LeuvenInge Lerouge, Gerard Cielen, Liliane Schoofs14. Peer review and its role in research integrityCS14.1 Peer review research across disciplines: transdomain action in the European Cooperation in Science and Technology “New Frontiers of Peer Review ”Ana Marusic, Flaminio SquazzoniCS14.2 Using blinding to reduce bias in peer reviewDavid VauxCS14.3 How to intensify the role of reviewers to promote research integrityKhalid Al-Wazzan, Ibrahim AlorainyCS14.4 Credit where credit’s due: professionalizing and rewarding the role of peer reviewerChris Graf, Verity Warne15. Research ethics and oversight for research integrity: Does it work?CS15.1 The psychology of decision-making in research ethics governance structures: a theory of bounded rationalityNolan O'Brien, Suzanne Guerin, Philip DoddCS15.2 Investigator irregularities: iniquity, ignorance or incompetence?Frank Wells, Catherine BlewettCS15.3 Academic plagiarismFredric M. Litto16. Research integrity in EuropeCS16.1 Whose responsibility is it anyway?: A comparative analysis of core concepts and practice at European research-intensive universities to identify and develop good practices in research integrityItziar De Lecuona, Erika Löfstrom, Katrien MaesCS16.2 Research integrity guidance in European research universitiesKris Dierickx, Noémie Bonn, Simon GodecharleCS16.3 Research Integrity: processes and initiatives in Science Europe member organisationsTony Peatfield, Olivier Boehme, Science Europe Working Group on Research IntegrityCS16.4 Promoting research integrity in Italy: the experience of the Research Ethics and Bioethics Advisory Committee of the Consiglio Nazionale delle Ricerche Cinzia Caporale, Daniele Fanelli17. Training programs for research integrity at different levels of experience and seniorityCS17.1 Meaningful ways to incorporate research integrity and the responsible conduct of research into undergraduate, graduate, postdoctoral and faculty training programsJohn Carfora, Eric Strauss, William LynnCS17.2 "Recognize, respond, champion": Developing a one-day interactive workshop to increase confidence in research integrity issuesDieter De Bruyn, Bracke Nele, Katrien De Gelder, Stefanie Van der BurghtCS17.4 “Train the trainer” on cultural challenges imposed by international research integrity conversations: lessons from a projectJosé Roberto Lapa e Silva, Sonia M. R. Vasconcelos18. Research and societal responsibilityCS18.1 Promoting the societal responsibility of research as an integral part of research integrityHelene IngierdCS18.2 Social responsibility as an ethical imperative for scientists: research, education and service to societyMark FrankelCS18.3 The intertwined nature of social responsibility and hope in scienceDaniel Vasgird, Stephanie BirdCS18.4 Common barriers that impede our ability to create a culture of trustworthiness in the research communityMark Yarborough19. Publication ethicsCS19.1 The authors' forum: A proposed tool to improve practices of journal editors and promote a responsible research environmentIbrahim Alorainy, Khalid Al-WazzanCS19.2 Quantifying research integrity and its impact with text analyticsHarold GarnerCS19.3 A closer look at authorship and publication ethics of multi- and interdisciplinary teamsLisa Campo-Engelstein, Zubin Master, Elise Smith, David Resnik, Bryn Williams-JonesCS19.4 Invisibility of duplicate publications in biomedicineMario Malicki, Ana Utrobicic, Ana Marusic20. The causes of bad and wasteful research: What can we do?CS20.1 From countries to individuals: unravelling the causes of bias and misconduct with multilevel meta-meta-analysisDaniele Fanelli, John PA IoannidisCS20.2 Reducing research waste by integrating systems of oversight and regulationGerben ter Riet, Tom Walley, Lex Marius BouterCS20.3 What are the determinants of selective reporting?: The example of palliative care for non-cancer conditionsJenny van der Steen, Lex BouterCS20.4 Perceptions of plagiarism, self-plagiarism and redundancy in research: preliminary results from a national survey of Brazilian PhDsSonia Vasconcelos, Martha Sorenson, Francisco Prosdocimi, Hatisaburo Masuda, Edson Watanabe, José Carlos Pinto, Marisa Palácios, José Lapa e Silva, Jacqueline Leta, Adalberto Vieyra, André Pinto, Mauricio Sant’Ana, Rosemary Shinkai21. Are there country-specific elements of misconduct?CS21.1 The battle with plagiarism in Russian science: latest developmentsBoris YudinCS21.2 Researchers between ethics and misconduct: A French survey on social representations of misconduct and ethical standards within the scientific communityEtienne Vergès, Anne-Sophie Brun-Wauthier, Géraldine VialCS21.3 Experience from different ways of dealing with research misconduct and promoting research integrity in some Nordic countriesTorkild VintherCS21.4 Are there specifics in German research misconduct and the ways to cope with it?Volker Bähr, Charité22. Research integrity teaching programmes and their challengesCS22.1 Faculty mentors and research integrityMichael Kalichman, Dena PlemmonsCS22.2 Training the next generation of scientists to use principles of research quality assurance to improve data integrity and reliabilityRebecca Lynn Davies, Katrina LaubeCS22.3 Fostering research integrity in a culturally-diverse environmentCynthia Scheopner, John GallandCS22.4 Towards a standard retraction formHervé Maisonneuve, Evelyne Decullier23. Commercial research and integrityCS23.1 The will to commercialize: matters of concern in the cultural economy of return-on-investment researchBrian NobleCS23.2 Quality in drug discovery data reporting: a mission impossible?Anja Gilis, David J. Gallacher, Tom Lavrijssen, Malwitz David, Malini Dasgupta, Hans MolsCS23.3 Instituting a research integrity policy in the context of semi-private-sector funding: an example in the field of occupational health and safetyPaul-Emile Boileau24. The interface of publication ethics and institutional policiesCS24.1 The open access ethical paradox in an open government effortTony SavardCS24.2 How journals and institutions can work together to promote responsible conductEric MahCS24.3 Improving cooperation between journals and research institutions in research integrity casesElizabeth Wager, Sabine Kleinert25. Reproducibility of research and retractionsCS25.1 Promoting transparency in publications to reduce irreproducibilityVeronique Kiermer, Andrew Hufton, Melanie ClyneCS25.2 Retraction notices issued for publications by Latin American authors: what lessons can we learn?Sonia Vasconcelos, Renan Moritz Almeida, Aldo Fontes-Pereira, Fernanda Catelani, Karina RochaCS25.3 A preliminary report of the findings from the Reproducibility Project: Cancer biologyElizabeth Iorns, William Gunn26. Research integrity and specific country initiativesCS26.1 Promoting research integrity at CNRS, FranceMichèle Leduc, Lucienne LetellierCS26.2 In pursuit of compliance: is the tail wagging the dog?Cornelia MalherbeCS26.3 Newly established research integrity policies and practices: oversight systems of Japanese research universitiesTakehito Kamata27. Responsible conduct of research and country guidelinesCS27.1 Incentives or guidelines? Promoting responsible research communication through economic incentives or ethical guidelines?Vidar EnebakkCS27.3 Responsible conduct of research: a view from CanadaLynn PenrodCS27.4 The Danish Code of Conduct for Research Integrity: a national initiative to promote research integrity in DenmarkThomas Nørgaard, Charlotte Elverdam28. Behaviour, trust and honestyCS28.1 The reasons behind non-ethical behaviour in academiaYves FassinCS28.2 The psychological profile of the dishonest scholarCynthia FekkenCS28.3 Considering the implications of Dan Ariely’s keynote speech at the 3rd World Conference on Research Integrity in MontréalJamal Adam, Melissa S. AndersonCS28.4 Two large surveys on psychologists’ views on peer review and replicationJelte WichertsBrett Buttliere29. Reporting and publication bias and how to overcome itCS29.1 Data sharing: Experience at two open-access general medical journalsTrish GrovesCS29.2 Overcoming publication bias and selective reporting: completing the published recordDaniel ShanahanCS29.3 The EQUATOR Network: promoting responsible reporting of health research studiesIveta Simera, Shona Kirtley, Eleana Villanueva, Caroline Struthers, Angela MacCarthy, Douglas Altman30. The research environment and its implications for integrityCS30.1 Ranking of scientists: the Russian experienceElena GrebenshchikovaCS30.4 From cradle to grave: research integrity, research misconduct and cultural shiftsBronwyn Greene, Ted RohrPARTNER SYMPOSIAPartner Symposium AOrganized by EQUATOR Network, Enhancing the Quality and Transparency of Health ResearchP1 Can we trust the medical research literature?: Poor reporting and its consequencesIveta SimeraP2 What can BioMed Central do to improve published research?Daniel Shanahan, Stephanie HarrimanP3 What can a "traditional" journal do to improve published research?Trish GrovesP4 Promoting good reporting practice for reliable and usable research papers: EQUATOR Network, reporting guidelines and other initiativesCaroline StruthersPartner Symposium COrganized by ENRIO, the European Network of Research Integrity OfficersP5 Transparency and independence in research integrity investigations in EuropeKrista Varantola, Helga Nolte, Ursa Opara, Torkild Vinther, Elizabeth Wager, Thomas NørgaardPartner Symposium DOrganized by IEEE, the Institute of Electrical and Electronics EngineersRe-educating our author community: IEEE's approach to bibliometric manipulation, plagiarism, and other inappropriate practicesP6 Dealing with plagiarism in the connected world: An Institute of Electrical and Electronics Engineers perspectiveJon RokneP7 Should evaluation of raises, promotion, and research proposals be tied to bibliometric indictors? What the Institute of Electrical and Electronics Engineers is doing to answer this questionGianluca SettiP8 Recommended practices to ensure conference content qualityGordon MacPhersonPartner Symposium EOrganized by the Committee on Freedom and Responsibility in the Conduct of Science of ICSU, the International Council for ScienceResearch assessment and quality in science: perspectives from international science and policy organisationsP9 Challenges for science and the problems of assessing researchEllen HazelkornP10 Research assessment and science policy developmentCarthage SmithP11 Research integrity in South Africa: the value of procedures and processes to global positioningRobert H. McLaughlinP12 Rewards, careers and integrity: perspectives of young scientists from around the worldTatiana Duque MartinsPartner Symposium FOrganized by the Online Resource Center for Ethics Education in Engineering and Science / Center for Engineering, Ethics, and Society of the National Academy of EngineeringP13 Research misconduct: conceptions and policy solutionsTetsuya Tanimoto, Nicholas Steneck, Daniele Fanelli, Ragnvald Kalleberg, Tajammul HusseinPartner Symposium HOrganized by ORI, the Office of Research Integrity; Universitas 21; and the Asia Pacific Research Integrity NetworkP14 International integrity networks: working together to ensure research integrityPing Sun, Ovid Tzeng, Krista Varantola, Susan ZimmermanPartner Symposium IOrganized by COPE, the Committee on Publication EthicsPublication without borders: Ethical challenges in a globalized worldP15 Authorship: credit and responsibility, including issues in large and interdisciplinary studiesRosemary ShinkaiPartner Symposium JOrganized by CITI, the Cooperative Institutional Training InitiativeExperiences on research integrity educational programs in Colombia, Costa Rica and PeruP16 Experiences in PeruRoxana LescanoP17 Experiences in Costa RicaElizabeth HeitmanP18 Experiences in ColumbiaMaria Andrea Rocio del Pilar Contreras NietoPoster Session B: Education, training, promotion and policyPT.01 The missing role of journal editors in promoting responsible researchIbrahim Alorainy, Khalid Al-WazzanPT.02 Honorary authorship in Taiwan: why and who should be in charge?Chien Chou, Sophia Jui-An PanPT.03 Authorship and citation manipulation in academic researchEric Fong, Al WilhitePT.04 Open peer review of research submission at medical journals: experience at BMJ Open and The BMJTrish GrovesPT.05 Exercising authorship: claiming rewards, practicing integrityDésirée Motta-RothPT.07 Medical scientists' views on publication culture: a focus group studyJoeri Tijdink, Yvo SmuldersPoster Session B: Education, training, promotion and policyPT.09 Ethical challenges in post-graduate supervisionLaetus OK LateganPT.10 The effects of viable ethics instruction on international studentsMichael Mumford, Logan Steele, Logan Watts, James Johnson, Shane Connelly, Lee WilliamsPT.11 Does language reflect the quality of research?Gerben ter Riet, Sufia Amini, Lotty Hooft, Halil KilicogluPT.12 Integrity complaints as a strategic tool in policy decision conflictsJanneke van Seters, Herman Eijsackers, Fons Voragen, Akke van der Zijpp and Frans BromPoster Session C: Ethics and integrity intersectionsPT.14 Regulations of informed consent: university-supported research processes and pitfalls in implementationBadaruddin Abbasi, Naif Nasser AlmasoudPT.15 A review of equipoise as a requirement in clinical trialsAdri LabuschagnePT.16 The Research Ethics Library: online resource for research ethics educationJohanne Severinsen, Espen EnghPT.17 Research integrity: the view from King Abdulaziz City for Science and TechnologyDaham Ismail AlaniPT. 18 Meeting global challenges in high-impact publications and research integrity: the case of the Malaysian Palm Oil BoardHJ. Kamaruzaman JusoffPT.19 University faculty perceptions of research practices and misconductAnita Gordon, Helen C. HartonPoster Session D: International perspectivesPT.21 The Commission for Scientific Integrity as a response to research fraudDieter De Bruyn, Stefanie Van der BurghtPT. 22 Are notions of the responsible conduct of research associated with compliance with requirements for research on humans in different disciplinary traditions in Brazil?Karina de Albuquerque Rocha, Sonia Maria Ramos de VasconcelosPT.23 Creating an environment that promotes research integrity: an institutional model of Malawi Liverpool Welcome TrustLimbanazo MatandikaPT.24 How do science policies in Brazil influence user-engaged ecological research?Aline Carolina de Oliveira Machado Prata, Mark William NeffPoster Session E: Perspectives on misconductPT.26 What “causes” scientific misconduct?: Testing major hypotheses by comparing corrected and retracted papersDaniele Fanelli, Rodrigo Costas, Vincent LarivièrePT.27 Perception of academic plagiarism among dentistry studentsDouglas Leonardo Gomes Filho, Diego Oliveira GuedesPT. 28 a few bad apples?: Prevalence, patterns and attitudes towards scientific misconduct among doctoral students at a German university hospitalVolker Bähr, Niklas Keller, Markus Feufel, Nikolas OffenhauserPT. 29 Analysis of retraction notices published by BioMed CentralMaria K. Kowalczuk, Elizabeth C. MoylanPT.31 "He did it" doesn't work: data security, incidents and partnersKatie SpeanburgPoster Session F: Views from the disciplinesPT.32 Robust procedures: a key to generating quality results in drug discoveryMalini Dasgupta, Mariusz Lubomirski, Tom Lavrijssen, David Malwitz, David Gallacher, Anja GillisPT.33 Health promotion: criteria for the design and the integrity of a research projectMaria Betânia de Freitas Marques, Laressa Lima Amâncio, Raphaela Dias Fernandes, Oliveira Patrocínio, and Cláudia Maria Correia Borges RechPT.34 Integrity of academic work from the perspective of students graduating in pharmacy: a brief research studyMaria Betânia de Freitas Marques, Cláudia Maria Correia Borges Rech, Adriana Nascimento SousaPT.35 Research integrity promotion in the Epidemiology and Health Services, the journal of the Brazilian Unified Health SystemLeila Posenato GarciaPT.36 When are clinical trials registered? An analysis of prospective versus retrospective registration of clinical trials published in the BioMed Central series, UKStephanie Harriman, Jigisha PatelPT.37 Maximizing welfare while promoting innovation in drug developmentFarida LadaOther posters that will be displayed but not presented orally:PT.38 Geoethics and the debate on research integrity in geosciencesGiuseppe Di Capua, Silvia PeppoloniPT.39 Introducing the Professionalism and Integrity in Research Program James M. DuBois, John Chibnall, Jillon Van der WallPT.40 Validation of the professional decision-making in research measureJames M. DuBois, John Chibnall, Jillon Van der Wall, Raymond TaitPT.41 General guidelines for research ethicsJacob HolenPT. 42 A national forum for research ethicsAdele Flakke Johannessen, Torunn EllefsenPT.43 Evaluation of integrity in coursework: an approach from the perspective of the higher education professorClaudia Rech, Adriana Sousa, Maria Betânia de Freitas MarquesPT.44 Principles of geoethics and research integrity applied to the European Multidisciplinary Seafloor and Water Column Observatory, a large-scale European environmental research infrastructureSilvia Peppoloni, Giuseppe Di Capua, Laura BeranzoliF1 Focus track on improving research systems: the role of fundersPaulo S.L. Beirão, Susan ZimmermanF2 Focus track on improving research systems: the role of countriesSabine Kleinert, Ana MarusicF3 Focus track on improving research systems: the role of institutionsMelissa S. Anderson, Lex Bouter. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:344 BOOK REVIEWS philosophy-that even seriously disordered individuals always have the possibility of renewing themselves morally. What we need is, first, a detailed specification of the range of goods towards which reason directs us, then, an explanation of how reference to these goods is explicit or implicit in those precepts directive of action upon which prudence has to he able to draw (if it is to function in such (...) a way as to break with the otherwise vicious circle), and, finally, an explanation of how in the concrete circumstances of social life the precepts of reason can become effective. The absence of a systematic treatment of goods, which I noticed earlier, therefore turns out to he an important omission from Cessario's account, since without it a crucial part of his argument remains incomplete. What makes this omission all the more disappointing is the excellence of Cessario's subsequent discussion of the relationship of the theological virtues to the intellectual and moral virtues and of how the habitus of nature are enriched and strengthened by the habitus of grace. Teachers of moral theology could reflect on this discussion with great benefit to their students. It is a mark of how very good a hook Cessario has written that it arouses enormous impatience for a sequel which will not only carry the argument further hut also fill out what is missing in the argument so far. University of Notre Dame Notre Dame, Indiana ALASDAIR MAclNTYRE De vitiis et pecatis: In I-II Summae theologiae Divi Thomae expositio. By JACOBUS (SANTIAGO) M. RAMiREz, O.P. In Jacobus M. Ramirez Opera Omnia, tomus 8, ed. Victorino Rodriguez, O.P. Bihlioteca de Teologos Espafioles, 37 and 38. Salamanca: Editorial San Esteban, 1990. 2 volumes (Pp. xiv + 902). Paper: 5,000 pesetas (=approx. $47.00 U.S.). After a dormancy of some sixteen years, and fittingly on the eve of the centenary of its author's birth, the publication of Santiago Maria Ramirez's (t 1967) Opera Omnia continued in 1990 with the appearance of volume 8, De vitiis et peccatis: In I-II Summae theologiae Divi Thomae expositio. When completed, the Opera Omnia will contain not only vast writings on analogy and the nature of philosophy hut also the single most thorough, and arguably most profound, exposition of the Secunda pars of St. Thomas Aquinas's Summa theologiae ever written. The present installment covers qq. 71-85 of the Prima secundae. BOOK REVIEWS 345 Although the Spanish province of the Dominican Order has taken over the publication and distribution of Ramirez's Opera Omnia from the Consejo Superior de lnvestigaciones Cientificas, who began the series and oversaw the publication and distribution of all previous volumes, the new volumes' physical constitution is identical to that of the earlier volumes, since the actual printing is done at the same house. The volumes read easily, not only because they are in octavo form, hut also because the publishers have done the printing on an off.white paper, with leisurely spacing of the 11 point type. The second volume contains four indices: an index of names, biblical references, references to Thomas's writings, and a schematized index of the contents of both volumes. In a project of this magnitude one is prepared to find printing mistakes, and there are occasional typographical errors and formatting errors such as mis-italicization. In one place there is an omission of an entire line. (In vol. 2, p. 537, no. 373, the citation from Innocent III, after the words ' visionis Dei,' should be completed with the following: " (= damni tantum), actualis vero poena peccati est gehennae perpetuae cruciatus.") But these are minor imperfections, and the editor Fr. Rodriguez once again deserves our thanks for making such learning tools available to us in so useful a format. Rodriguez has informed me that the next volume to appear will be De gratia in 1991, despite the fact that a treatment De lege would of course be in keeping with the order of the Prima secundae. The quantity of Ramirez's writing on the treatise on law did not justify a separate volume, so it will be included along with De iure gentium and De... (shrink)

The now-classic Metaphors We Live By changed our understanding of metaphor and its role in language and the mind. Metaphor, the authors explain, is a fundamental mechanism of mind, one that allows us to use what we know about our physical and social experience to provide understanding of countless other subjects. Because such metaphors structure our most basic understandings of our experience, they are "metaphors we live by"--metaphors that can shape our perceptions and actions without our ever noticing them. In (...) this updated edition of Lakoff and Johnson's influential book, the authors supply an afterword surveying how their theory of metaphor has developed within the cognitive sciences to become central to the contemporary understanding of how we think and how we express our thoughts in language. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:A Note on Thomas and the Divine MercyMark JohnsonA PUZZLING THING about the topic of the divine mercy as presented in the early part of the Prima pars, especially in light of the detailed commentaries presented by Cessario and Cuddy, 1 is how relatively little Thomas speaks about it. Pope Francis devoted the entire 2016 year to a Jubilee of Mercy. The Catholic Theological Society of America followed suit (...) by devoting its 2016 conference to the topic. Yet Thomas does not devote a single Scholastic question to it in the Summa. The topic of the divine names gets question 13 (12 articles), the divine knowledge gets question 14 (16 articles), and the divine will gets question 19 (12 articles). Our anchor text, question 21, is a four-article-long question that emerges from the larger issue of God’s will in itself (absolute). Yet the question is not about the divine mercy on its own, but is rather about features or properties of the divine act of love, a topic to which the whole of question 20 is devoted. God’s justice and mercy are considered in question 21 as quasi-virtues that perfect the divine act of love (question 20), which in turn is the proper act of God’s will (question 19).2 The divine will of question 19 [End Page 355] is Halley’s Comet, and mercy is the tail of dust trailing in its wake. When God’s mercy does appear it seems to vie with God’s justice for our attention.Cessario and Cuddy help us understand why this is, both with their two-part structure and with the sources they employ, the commentators. My focus here will be on the original text in its own light, before the varnish of the commentators. Thomas’s original is a dense chiaroscuro, which both raises questions and offers opportunities.First, while Thomas is still well within the consideration of the divine being and action (STh I, qq. 3–26), he is sensitive to our human understanding. For us humans an element of suffering seems to be built into any consideration of mercy. It is the first hurdle that needs to be jumped in question 21, article 3; objection 1 frets about mercy because it is a subset, a species, of sorrow—and that cannot be in God. In the body of the article, Thomas alludes to sorrow via a consideration of the quid nominis of mercy. The term misericordia means having a miserum cor, a heart afflicted by the sufferings of another. Thomas dismisses this right away; in the body of the article he says “being saddened at the misery of another does not befit God” (tristari... de miseria alterius non competit Deo). He does not say more. Similarly, in addressing the first objection he notes that the objection was invoking mercy as a kind of “being affected by suffering” (obiectio illa procedit de misericordia, quantum ad passionis affectum). Again, he gives no further commentary.3 [End Page 356]With the concern about God’s “co-suffering” with us dispatched, Thomas addresses a second objection, the satisfying of which will allow for the existence and procedure of the next article (a. 4). The objection focuses upon the divine justice and worries that mercy seems to mean some kind of “loosening up” of the divine justice (relaxatio iustitiae), in which God seems to act contrary to himself, to his utterances or dictates (dicta sua). Thomas addresses this concern head-on; there is no loss or relaxation of the divine justice, but rather a fulfilling and indeed exceeding of the dictates of divine justice. An example both explains and foreshadows: the man who owes someone a hundred dollars but who fulfills the debt when he pays him two hundred dollars of his own money, has both met the demands of justice and acted with liberality and mercy. He has acted above and beyond justice (supra iustitiam operando). 4 Remembering that objection 2 had included a concern about acting against one’s own self and dictates, Thomas adds that remitting an offense made against oneself by another—he may have had peccatum originale originans in mind—has the... (shrink)

"There are books—few and far between—which carefully, delightfully, and genuinely turn your head inside out. This is one of them. It ranges over some central issues in Western philosophy and begins the long overdue job of giving us a radically new account of meaning, rationality, and objectivity."—Yaakov Garb, _San Francisco Chronicle_.

Using path-breaking discoveries of cognitive science, Mark Johnson argues that humans are fundamentally imaginative moral animals, challenging the view that morality is simply a system of universal laws dictated by reason. According to the Western moral tradition, we make ethical decisions by applying universal laws to concrete situations. But Johnson shows how research in cognitive science undermines this view and reveals that imagination has an essential role in ethical deliberation. Expanding his innovative studies of human reason in Metaphors We (...) Live By and The Body in the Mind, Johnson provides the tools for more practical, realistic, and constructive moral reflection. (shrink)

In _The Meaning of the Body_, Mark Johnson continues his pioneering work on the exciting connections between cognitive science, language, and meaning first begun in the classic _Metaphors We Live By_. Johnson uses recent research into infant psychology to show how the body generates meaning even before self-consciousness has fully developed. From there he turns to cognitive neuroscience to further explore the bodily origins of meaning, thought, and language and examines the many dimensions of meaning—including images, qualities, emotions, and (...) metaphors—that are all rooted in the body’s physical encounters with the world. Drawing on the psychology of art and pragmatist philosophy, Johnson argues that all of these aspects of meaning-making are fundamentally aesthetic. He concludes that the arts are the culmination of human attempts to find meaning and that studying the aesthetic dimensions of our experience is crucial to unlocking meaning's bodily sources. Throughout, Johnson puts forth a bold new conception of the mind rooted in the understanding that philosophy will matter to nonphilosophers only if it is built on a visceral connection to the world. “Mark Johnson demonstrates that the aesthetic and emotional aspects of meaning are fundamental—central to conceptual meaning and reason, and that the arts show meaning-making in its fullest realization. If you were raised with the idea that art and emotion were external to ideas and reason, you must read this book. It grounds philosophy in our most visceral experience.”—George Lakoff, author of _Moral Politics_. (shrink)

All too often, we think of our minds and bodies separately. The reality couldn’t be more different: the fundamental fact about our mind is that it is embodied. We have a deep visceral, emotional, and qualitative relationship to the world—and any scientifically and philosophically satisfactory view of the mind must take into account the ways that cognition, meaning, language, action, and values are grounded in and shaped by that embodiment. This book gathers the best of philosopher Mark Johnson’s essays (...) addressing questions of our embodiment as they deal with aesthetics—which, he argues, we need to rethink so that it takes into account the central role of body-based meaning. Viewed that way, the arts can give us profound insights into the processes of meaning making that underlie our conceptual systems and cultural practices. Johnson shows how our embodiment shapes our philosophy, science, morality, and art; what emerges is a view of humans as aesthetic, meaning-making creatures who draw on their deepest physical processes to make sense of the world around them. (shrink)

Mark Johnson is one of the great thinkers of our time on how the body shapes the mind. This book brings together a selection of essays from the past two decades that build a powerful argument that any scientifically and philosophically satisfactory view of mind and thought must ultimately explain how bodily perception and action give rise to cognition, meaning, language, action, and values. A brief account of Johnson’s own intellectual journey, through which we track some of the most (...) important discoveries in the field over the past forty years, sets the stage. Subsequent chapters set out Johnson’s important role in embodied cognition theory, including his cofounding of conceptual metaphor theory and, later, their theory of bodily structures and processes that underlie all meaning, conceptualization, and reasoning. A detailed account of how meaning arises from our physical engagement with our environments provides the basis for a nondualistic, nonreductive view of mind that he sees as most congruous with the latest cognitive science. A concluding section explores the implications of our embodiment for our understanding of knowledge, reason, and truth. The resulting book will be essential for all philosophers dealing with mind, thought, and language. (shrink)

The need for ethical naturalism -- Moral problem-solving as an empirical inquiry -- Where are our values bred? : sources of moral norms -- Intuitive processes of moral cognition -- Moral deliberation as cognition, imagination, and feeling -- The nature of "reasonable" moral deliberation -- There is no moral faculty -- Moral fundamentalism is immoral -- The making of a moral self.

In lieu of an abstract, here is a brief excerpt of the content:508 BOOK REVIEWS Margerie tells us that Augustine surely held that Genesis contains such a plural sense, with the added affirmation that Moses, whom Augustine considers to be the author ofthe Pentateuch, thanks to a transient beatific vision, personally foresaw and intended all the interpretations that would later be given. In keeping with his careful and cautious approach, near the end of the book Father de Margerie admits the (...) limitations of Augustine, limitations which Augustine himself often perceived. "First, Augustine's strictly exegetical works are rather limited.... His sustained commentaries are few, those which have reached us concern Genesis, Job, the Letters to the Galatians and part of that to the Romans, the Gospel, and the First Letter of John" (126). Secondly, Augustine had only a slight knowledge of Biblical Greek. He usually worked from the Latin Bible. He seldom referred systematically to the Greek. Further, he had "but a smattering of Hebrew, acquired indirectly through his familiarity with Punic" (126). Finally-a very large admission- "he, along with nearly all the Fathers, failed to analyze adequately the literal meaning of numerous texts he sought to interpret" (126). In spite of such limitations, Augustine and the other Fathers do provide us with many insights into sound doctrine. This is especially useful since so many of the errors of today, advertised as new, are merely ancient mistakes rejected centuries ago by the Fathers. Therefore we are all indebted to Father de Margerie for helping to call us back to what is so very good in the Fathers. Father de Margerie has rendered a singular service to scholarship in his first two volumes of study of Patristic exegesis. The present volume, the third, is a worthy successor to the first two. Notre Dame Institute Alexandria, Virginia WILLIAM G. MOST The Primacy of Love: An Introduction to the Ethics of Thomas Aquinas. By PAUL J. WADELL, C.P. Mahwah, N.J.: Paulist Press, 1992. Pp. 162. $11.95. Friends of God: Virtues and Gifts in Aquinas. By PAUL J. WADELL, C.P. American University Studies, Series VII: Theology and Religion, vol. 76. New York: Peter Lang, 1991. Pp. x + 148. Drawing from the virtue-ethics orientation of his earlier work, Friendship and the Moral Life (Notre Dame: University of Notre Dame Press, 1990), Paul Wadell has written two books that seek to accomplish two distinctly different BOOK REVIEWS 509 objectives: to produce a work that can serve as a general introduction to Thomas Aquinas's teaching about ethics, and to produce a monograph that urges a different approach to the interpretation of Thomas's ethical teaching. But both books share a common interest of Wadell's: showing that Thomas's ethics is an ethics of genuine affection. Whether he is judged to have reached the two objectives is a question that is likely to be answered differently by moralists, depending upon the issues and approaches that shape their own understanding of Thomistic moral theology. At the very least, Wadell has produced two well-crafted books that are trend-setting works in a long and promising career, works whose approach is surely to become familiar as more and more writers emphasize virtue ethics with regard to the moral teaching of Aquinas. And at most, Wadell has shown himself to be both a fine teacher of Thomas's ethical thought and an incisive scholar in identifying the subterranean movements of the Common Doctor's thought. I shall consider The Primacy ofLove first, which, although it appeared second, is a good intelligible backdrop for presenting the more sophisticated and important argument of Friends ofGod. Waddell's introduction to Thomas's ethics is not really a synopsis of the Secunda pars of the Summa theologiae, though the lion's share of the material he employs is from there, and in something of its original order. It is rather a sympathetic, almost affectionate, portrait of Thomas's ethical teaching. The book does not introduce the reader to the technicalities of Thomas's thought, or to the bewildering debates surrounding the practical syllogism and natural law that have characterized the secondary literature in the second half of this century. Wadell-and others, I imagine-would consider this a strength... (shrink)

Book reviewed: O’Connor, Peg, Oppression and Responsibility: a Wittgensteinian Approach to Social Practices and Moral Theory, The Pennsylvania State University Press, 2002, 151 pp., ISBN 0‐271‐02202‐7.

Because of the ease of their implementation, attribute-value based theories of grammar are becoming increasingly popular in theoretical linguistics as an alternative to transformational accounts and in computational linguistics. This book provides a formal analysis of attribute-value structures, their use in a theory of grammar and the representation of grammatical relations in such theories of grammar. It provides a classical treatment of disjunction and negation, and explores the linguistic implications of different representations of grammatical relations. Mark Johnson is assistant (...) professor in cognitive and linguistic sciences at Brown University. He was a Fairchild postdoctoral fellow at the Massachusetts Institute of Technology during the 1987-88 academic year. (shrink)

What are the processes, from conception to adulthood, that enable a single cell to grow into a sentient adult? Neuroconstructivism is a pioneering 2 volume work that sets out a whole new framework for considering the complex topic of development, integrating data from cognitive studies, computational work, and neuroimaging.

Rich with historical and cultural value, these works are published unaltered from the original University of Minnesota Press editions.

Several research groups have identified a network of regions of the adult cortex that are activated during social perception and cognition tasks. In this paper we focus on the development of components of this social brain network during early childhood and test aspects of a particular viewpoint on human functional brain development: “interactive specialization.” Specifically, we apply new data analysis techniques to a previously published data set of event-related potential ~ERP! studies involving 3-, 4-, and 12-month-old infants viewing faces of (...) different orientation and direction of eye gaze. Using source separation and localization methods, several likely generators of scalp recorded ERP are identified, and we describe how they are modulated by stimulus characteristics. We then review the results of a series of experiments concerned with perceiving and acting on eye gaze, before reporting on a new experiment involving young children with autism. Finally, we discuss predictions based on the atypical emergence of the social brain network. (shrink)

Provides an overview of Mark Sharlow's philosophical work with summaries of his positions. Includes references and links to his writings.

Abstract Recent empirical studies of categorization, concept development, semantic structure, and reasoning reveal the inadequacies of all theories that regard knowledge as static, propositional, and sentential. These studies show that conceptual structure and reason are grounded in patterns of bodily experience. Structures of our spatial/temporal orientations, perceptual interactions, and motor programs provide an imaginative basis for our knowledge of, and reasoning about, more abstract domains. Such a view transcends both foundationalism and extreme relativism or scepticism.

In the past thirty years, face perception has become an area of major interest within psychology. The Oxford Handbook of Face Perception is the most comprehensive and commanding review of the field ever published.For anyone looking for the definitive review of this burgeoning field, this is the essential book.

Actions to prepare for and prevent pandemics are a common topic for bioethical analysis. However, little attention has been paid to global catastrophic biological risks more broadly, including pandemics with artificial origins, the creation of agents for biological warfare, and harmful outcomes of human genome editing. What’s more, international policy discussions often focus on economic arguments for state action, ignoring a key potential set of reasons for states to mitigate global catastrophic biological risks: moral reasons. In this paper, I frame (...) the mitigation of such risks as a global public good, and I explore three possible categories of moral reasons that might motivate states to provide this global public good: nationalism, cosmopolitanism, and interstate obligations. Whilst there are strong objections to moral nationalism as a reason for states to act, moral cosmopolitanism may provide a broad reason which is further supplemented for individual states through the elaboration of interstate moral obligations. The obligations I consider are moral leadership, fairness, and reciprocity. Moral reasons for individual states action may more effectively or more appropriately motivate states to mitigate global catastrophic biological risks. (shrink)

The effectiveness of case-based learning in ethics education varies widely regarding how cases are presented. Case process instruction may impact case-based ethics education to promote sensemaking processes, ethical sensemaking strategy use, and ethical decision making (EDM) quality. This study examined two teaching techniques, notes and review, and participants completed note-taking and review activities examining a case-based scenario during an ethics education course. Results suggest that providing case notes in outline form improves sensemaking processes, strategy use, and EDM quality. In addition, (...) combining processes of provided notes and passive review results in incremental, additive performance via certain ethical sensemaking strategies and EDM quality. (shrink)

The emergence of linguistic pragmatism has given rise to a lively debate over whether philosophy should focus on language or experience. But the experience vs. language dichotomy is just another type of dualism of the sort that pragmatists ought to be wary of. We need to appreciate that, insofar as pragmatism aspires to elucidate and transform our meaningful experience, it must recognize that meaning goes deeper than language. What linguistic pragmatists hope to do with language cannot be done without meaning (...) resources that are not themselves linguistic. Meaning, understanding, thinking, and valuing all have to be enacted as embodied processes. Moreover, no use or analysis of language is possible without an experience of meaning, and so we can never avoid experience in our philosophical undertakings, even granting that there is no perspective-free take on what some thing or event means. (shrink)

What exactly is complexity science? Two's company, three is complexity ; Disorder rules, OK? ; Chaos and all that jazz ; Mob mentality ; Getting connected -- What can complexity science do for me? Forecasting financial markets ; Tackling traffic networks and climbing the corporate ladder ; Looking for Mr./Mrs. Right ; Coping with conflict : next-generation wars and global terrorism -- Catching a cold, avoiding super-flu and curing cancer ; The mother of all complexities : our nanoscale quantum world (...) ; To infinity and beyond. (shrink)