Autophagy promotes both health and disease, depending on tissue types and genetic contexts, yet the regulatory mechanism remain incompletely understood. Our recent publication has uncovered a coherent FOXO‐SNAI feed‐forward loop in autophagy, which is evolutionarily conserved from Drosophila to human. In addition, it's revealed that DNA binding plays a critical role in intracellular localization of nucleocytoplasmic shuttling proteins. Based on these findings, herein we further integrate mechanistic insights of FOXO‐SNAI regulatory interplay in autophagy and unravel the potential link of FOXO‐induced (...) autophagy with SNAI in diseases. Besides, the generality of DNA‐retention mechanism on transcription factor nuclear localization is illustrated with wide‐ranging discussion, and more functions potentially regulated by FOXO‐SNAI feedforward loop are provided. Elucidation of these unsolved paradigms will expand the understanding of FOXO‐SNAI interplay and facilitate the development of new therapeutics targeting FOXO‐SNAI axis in diseases. (shrink)

Students with learning disabilities (LDs) suffer from executive function deficits and impaired prospective memory (PM). Yet the specificity of deficits associated with different types of LDs is still unclear. The object of the present research was to compare subgroups of students with different forms of LDs (<25th percentile) on executive function and PM. Students with a mathematics disability (MD,n= 30), reading disability (RD,n= 27), both (RDMD,n= 27), or neither (typically developing, TD,n= 30) were evaluated on a set of executive functioning (...) tasks (e.g., updating, inhibition, and shifting) and on PM. The results showed that students with MDs and RDMDs suffered from PM deficits. Among the subtypes of LDs, the deficit is different. The students with RDMDs showed a wide range of defects in PM, shifting, inhibition, and updating. In comparison, students with MDs experienced deficits in PM and shifting, while students with RDs experienced a deficit only in updating. For the RD group, the RDMD group and the TD group, updating, and shifting significantly predicted PM. For the MD group, only shifting significantly predicted PM performance, but PM deficits were not completely confined to shifting deficits. (shrink)

Grounded on the social exchange theory (SET), social cognitive theory (SCT), and self-determination theory (SDT), this study aims to explore the mediating role of self-efficacy (SE) and work engagement (WE) on the effect of social support (SS) on job satisfaction (JS) among Chinese ethnic minority kindergarten teachers (KTs). The results show that: (1) SS has a directly significant effect on JS; (2) WE mediates the relationship between SS and JS; and (3) SE mediates the relationship between SS and WE. Although (...) the mediation of SE on the relationship between SS and JS is not found, the posited multiple mediations of SE and WE on the relationship between SS and JS are totally accepted. The results reveal that SS mainland Chinese ethnic minority KTs received can not only have a direct effect on JS but also have an indirect impact through the one-path mediating role of WE and the chain mediating role of SE and WE. The results suggest that governments, supervisors, and sponsors should work together to provide ethnic minority KTs with more prioritized SS from both cultural psychology and financial material and opportunities for facilitating professional knowledge and skills in order to enhance their SE, inspire their WE, and eventually accumulate their JS. (shrink)

In the contextual cueing task, visual search is faster for targets embedded in invariant displays compared to targets found in variant displays. However, it has been repeatedly shown that participants do not learn repeated contexts when these are irrelevant to the task. One potential explanation lays in the idea of associative blocking, where salient cues block the learning of invariant associations in the task-irrelevant subset of items. An alternative explanation is that the associative blocking rather hinders the allocation of attention (...) to task-irrelevant subsets, but not the learning per se. The current work examined these two explanations. In two experiments, participants performed a visual search task under a rapid presentation condition in Experiment 1, or under a longer presentation condition in Experiment 2. In both experiments, the search items within both old and new displays were presented in two colors which defined the irrelevant and task-relevant items within each display. The participants were asked to search for the target in the relevant subset in the learning phase. In the transfer phase, the instructions were reversed and task-irrelevant items became task-relevant. In line with previous studies, the search of task-irrelevant subsets resulted in no cueing effect post-transfer in the longer presentation condition; however, a reliable cueing effect was generated by task-irrelevant subsets learned under the rapid presentation. These results demonstrate that under rapid display presentation, global attentional selection leads to global context learning. However, under a longer display presentation, global attention is blocked, leading to the exclusive learning of invariant relevant items in the learning session. (shrink)

The goal of the present study is to explore whether the affective states of a pedagogical agent in an online multimedia lesson yields different learning processes and outcomes, and whether the effects of affective PAs depend on the learners’ emotion regulation strategies and their prior knowledge. In three experiments, undergraduates were asked to view a narrated animation about synaptic transmission that included either a happy PA or a neutral PA and subsequently took emotions, motivation, cognitive outcomes tests. Across three experiments, (...) the happy PA group reported more positive emotions and higher level of motivation than the neutral PA group. Moreover, the happy PA prompted higher germane load than a neutral PA in Experiment 3. However, adding a happy PA to the screen did not improve learning performance. In addition, in Experiment 2, learners’ usage of emotion regulation strategies moderated the effectiveness of affective PA on positive emotions in learners. Specifically, happy PAs increased the positive emotions of students who used expressive suppression strategy but not those who used cognitive reappraisal strategy. In Experiment 3, the effectiveness of affective PAs was not moderated by learners’ prior knowledge. Results support the cognitive affective theory of learning with media that students are happier and more motivated when they learn from happy PAs than from neutral PAs. (shrink)

BackgroundThe Coronavirus 2019 outbreak has led to a considerable proportion of adverse psychological symptoms in different subpopulations. This study aimed to investigate the status of anxiety and depression and their associated factors in the adult, working-age population in Mainland China at the early remission stage of the COVID-19 pandemic.MethodsAn online study was conducted among 1,863 participants in 29 provinces in Mainland China from March 23 to 31, 2020. Their mental health was evaluated by the generalized anxiety disorder scale and the (...) patient health questionnaire. Descriptive analysis, Chi-square, and multiple logistic regressions were applied.ResultsAbout 44.5% of the participants had anxiety, 49.2% had depression, and 37.9% showed a combination of depression and anxiety. Around 83.7% of the participants claimed that the pandemic had a negative impact on their medical needs, which was the primary predictor of mental health, the degree of impact being positively related to the prevalence of anxiety and depression. More chronic diseases, moderate to bad self-rated health, severe perceived infection risk, and younger age group were the common risk factors for anxiety and depression. Having no children, unemployment, and a college-level educational background were associated with higher anxiety prevalence, whereas unmarried participants were correlated with higher depression prevalence.ConclusionThe working-age population showed a relatively high risk of anxiety and depression in Mainland China at the early remission stage of the pandemic. To improve medical services capacity for routine and delayed medical service needs should be a part of policy-makers’ priority agenda during this period of crisis. (shrink)

In the past few decades, a lot of optimization methods have been applied in estimating the parameter of photovoltaic models and obtained better results, but these methods still have some deficiencies, such as higher time complexity and poor stability. To tackle these problems, an enhanced success history adaptive DE with greedy mutation strategy is employed to optimize parameters of PV models to propose a parameter optimization method in this paper. In the EBLSHADE, the linear population size reduction strategy is used (...) to gradually reduce population to improve the search capabilities and balance the exploitation and exploration capabilities. The less and more greedy mutation strategy is used to enhance the exploitation capability and the exploration capability. Finally, a parameter optimization method based on EBLSHADE is proposed to optimize parameters of PV models. The different PV models are selected to prove the effectiveness of the proposed method. Comparison results demonstrate that the EBLSHADE is an effective and efficient method and the parameter optimization method is beneficial to design, control, and optimize the PV systems. (shrink)

With the rapid development of renewable generators such as distributed photovoltaic and profound changes of the power structure, this paper analyzes the frequency characteristics of the power system with high penetration of renewable generations in the process of low-frequency load shedding and discusses the influence of the distributed renewable generator frequency endurance capabilities on the implementation effect of low-frequency load shedding in detail. Finally, the influences of the distributed renewable generator frequency endurance capability and the capacities of the distributed renewable (...) generator on frequency response characteristics of an actual Hunan power grid are simulated. The simulation results show that more distributed photovoltaic capacity without frequency endurance capability leads to deeper frequency drops after the disturbance and requires more basic rounds of load shedding. When the penetration rate of distributed photovoltaic is too high, it may cause load shedding, resulting in power grid load losses and, at the same time, leading to an overshoot phenomenon in the process of frequency recovery. Therefore, the influence of distributed photovoltaic on the control of low-frequency load shedding should be considered when designing low-frequency load shedding schemes for the power grid with high penetration of distributed photovoltaic. (shrink)

Was ist Leben? Im vorliegenden Sammelband wird der Akzent von dieser allgemeinen Frage nach dem Was auf die grundlegende nach dem Wie, nach der Entfaltung des menschlichen Lebens, verschoben. Dabei wird das Leben in seiner Bewegung verfolgt: als Leben, das auf Widerstand stößt, stetig transzendiert, sich als zeitlich erfährt und in Welt und Praxis verwirklicht. Der Band versammelt begriffsgeschichtliche Aufsätze, philosophisch-phänomenologische Untersuchungen (im Zwiegespräch u. a. mit Husserl, Heidegger und Scheler) sowie an der konkreten Praxis (wie der Demenzforschung und Schulbildung) (...) orientierte Beiträge. (shrink)

The human serum protein α1‐antitrypsin is the major source of antiprotease activity found in the blood. The protein is synthesised primarily by liver cells but, to a lesser extent, by at least one other cell type. Expression of the gene has provided a paradigm for studies on transcriptional regulation in liver and of tissue‐specific promoter activity. The pleiomorphic nature of the gene has given rise to a variety of α1‐antitrypsin variants some of which are clinically important. These abnormal variants may (...) be poorly synthesised, rapidly degraded or inefficiently secreted; studies on the molecular mechanisms which underly these events are providing interesting insights into the general processes of protein transport and intracellular protein degradation. (shrink)

本书分上下两篇，上篇分析“命”的意义结构以重读《中庸》首句“天命之谓性”；下篇则从“诚”这一概念来重读《中庸》中对诚的系统论述。.

‘‘Time’’, Berlioz wrote, ‘‘is a great teacher, but unfortunately it kills all its pupils.’’ Not only has time taught a great many (and killed all), but it has also spawned many great teachers of time—and of space. In fact, thinking about space and time has driven important parts of philosophy since antiquity and continues to be at the forefront of advances in fundamental physics. This has naturally led to many authors attempting to convey either the physics of space and time (...) or their philosophical reflection to the interested non-specialist. Not few of them, however, wreck their ships navigating the narrow passage between oversimplification and inaccessibility. Others navigate this passage successfully, yet focus exclusively on either the physical or the philosophical aspects and often fail to acknowledge— let alone mine—the fruitful interaction between them. In the book under review, Nick Huggett invites us on a journey surveying the land of space, time and motion. What a delight then, when I found that not only does he steer clear of the treacherous shallows of oversimplification and the inscrutable abysses of inaccessibility but that he also masterfully weaves together the philosophical with the physical thread and forcefully shows how they cross-fertilize. This weaving mostly occurs at the end of each chapter when Huggett explains how the material in the corresponding chapter illustrates the fruitful interaction between physics and philosophy and thus offers a lesson worth reminding of also the specialists. The first chapter starts out from the ‘paradox of change’, i.e. the issue of whether or not a thing can change over time yet remain that same one thing that undergoes the change. For there to be change at all, it seems as if a thing must be the same and different: if it were not different, it would not have changed, yet if it were not the same, it would be impossible to say that it is this thing that changed. Apart from a historical excursus on how Aristotle, Descartes and Newton conceived of change and a very brief introduction to spacetime, this chapter offers a powerful and.... (shrink)

There has been a lack of research into candidate selection outside the developed world. In this paper we attempt to fill this gap, with a detailed examination of the factors leading to the introduction of party primaries, their operations and their future prospects, in a third wave democracy, Taiwan. Although Taiwan is a late democratizer, the high degree of party institutionalization makes it more appropriate to compare its nomination system with those of older political parties, we particularly contrast it with (...) the leading German and British political parties. Our discussion also finds many similar trends with developments of intra-party democracy in European parties, particularly in terms of a decentralization of candidate selection and reduced mediation between party centre and members. In addition, despite technical changes in electoral campaigning, parties in Taiwan have not abandoned the mass membership model. In Taiwan, direct primary elections have been a controversial subject. By analyzing relevant data, we argue that the core problem of the party primary was its lack of fairness, because party cadres tried to monopolize the candidate selection and thus failed to remain neutral. We find signs that leaders in all parties are wary of allowing inner party democracy to go too far and losing their control over nomination. When the party centre fears the wrong candidates will be selected, they are prepared to manipulate the rules in their favour or re-centralize the selection process. (shrink)

This introductory article begins by presenting the author's impression of contemporary Western philosophy as having become too professionalized to perform the functions of moral guidance and spiritual supervision. Herein lies a reason for the search for Oriental wisdom by some people in the West. The author then points out some fallacies often incurred in the pursuit of Chinese philosophy: the fallacy of ?craving for cash value?, the fallacy of ?the Procrustean bed?, and the fallacy of ?the misplaced hamburger?. In the (...) second half of the paper the author attempts a characterization of Chinese philosophy as a whole. As he interprets it, Chinese philosophy as a distinct tradition possesses five characteristics: (1) human centrality, (2) unity of theory and practice, (3) pedagogic universality, (4) methodological simplicity, and (5) dynamic harmony. (shrink)

This article is currently available as a free download on ingentaconnect.

Homologous recombination (HR) is essential for the accurate repair of DNA double‐strand breaks and damaged replication forks. However, inappropriate or aberrant HR can also result in genome rearrangements. The maintenance of cell viability is, therefore, a careful balancing act between the benefits of HR (the error‐free repair of DNA strand breaks) and the potential detrimental outcomes of HR (chromosomal rearrangements). Two papers have recently provided a mechanistic insight into how HR may be tempered by RecQ helicases to prevent genome instability (...) and diseases that are a consequence of this, such as cancer.1,2 BioEssays 30:291–295, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

When Wordsworth was eighteen he embarked on a series of translations from Virgil's Georgics. All that survives of them today is a series of rough drafts and jottings, among which is a short note in which he attempts to resolve the well-known crux at 4.228–30 Suppose we read it thus – ‘prius haustu parcus aquarum / Ora fove, etc.’ – and construe it thus: First sparingly steep the mouth of the hive in water.

Fan (2010) did a good job in applying his interpretation of Confucian ethics of giftedness to genetic enhancement. To him, it is God-like Heaven that gives lives to us and our ancestors as gifts th...

本书介绍了刑法理念批判、刑法解释问题研究综述、刑法解释的目标:由主观主义到客观主义、刑法解释的主体:由多元到一元等关于刑法解释理论的相关内容。.

本书包括两类:一类是从各个不同角度研究王阳明的生平事迹与思想学说,评论其学说宗旨、思想性质与历史影响的论文;另一类则主要是探讨阳明后学各家各派对阳明心学的继承、丰富、修正、扬弃的演变轨迹与思想特色.