Philosophy and Neuroscience: A Ruthlessly Reductive Account is the first book-length treatment of philosophical issues and implications in current cellular and molecular neuroscience. John Bickle articulates a philosophical justification for investigating "lower level" neuroscientific research and describes a set of experimental details that have recently yielded the reduction of memory consolidation to the molecular mechanisms of long-term potentiation (LTP). These empirical details suggest answers to recent philosophical disputes over the nature and possibility of psycho-neural scientific reduction, including the multiple (...) realization challenge, mental causation, and relations across explanatory levels. Bickle concludes by examining recent work in cellular neuroscience pertaining to features of conscious experience, including the cellular basis of working memory, the effects of explicit selective attention on single-cell activity in visual cortex, and sensory experiences induced by cortical microstimulation. (shrink)

A kind of “ruthless reductionism” characterized the experimental practices of the first two decades of molecular and cellular cognition. More recently, new research tools have expanded experimental practices in this field, enabling researchers to image and manipulate individual molecular mechanisms in behaving organisms with an unprecedented temporal, sub-cellular, cellular, and even circuit-wide specificity. These tools dramatically expand the range and reach of experiments in MCC, and in doing so they may help us transcend the worn-out and counterproductive debates about “reductionism” (...) and “emergence” that divide neuroscientists and philosophers alike. We describe examples of these new tools and illustrate their practical power by presenting an exemplary recent case of MCC research using them. From these tools and results, we provide an initial sketch of a new image of the behaving organism in its full causal-interactive complexity, with its molecules, cells, and circuits combined within the single system that it is. This new image stands in opposition to the traditional “levels” image of the behaving organism, and even the initial sketch we provide of it here offers hope for avoiding the dreary metaphysical debates about “emergence” and “downward causation,” and even the reduction vs. anti-reduction dispute, all dependent upon the familiar “levels” image. (shrink)

I critically evaluate Bickle’s version of scientific theory reduction. I press three main points. First, a small point, Bickle modifies the new wave account of reduction developed by Paul Churchland and Clifford Hooker by treating theories as set-theoretic structures. But that structuralist gloss seems to lose what was distinctive about the Churchland-Hooker account, namely, that a corrected theory must be specified entirely by terms and concepts drawn from the basic reducing theory. Set-theoretic structures are not terms or concepts (...) but the structures that they describe. Second, and more serious, a familiar problem for classical positivist account of reduction resurfaces within this newest wave of thinking, namely, commitment to property identities and inter-theoretic bridge laws (a problem I discussed at more length in "Collapse of the New Wave"). Indeed, this problem is exacerbated by Bickle’s conciliatory treatment of property plasticity, since he is willing to grant that a large number of special science terms denote multiply realized properties, at least if realistically construed. Still, in the end, Bickle sidesteps the reduction of properties by appealing to Hooker’s "function-to-structure token reduction." This is an interesting move with an intriguing concept of reduction. But problems remain. For, third, Bickle and Hooker's function-to-structure token reduction is actually a guised form of eliminative materialism. But that should be unacceptable since the position extends well beyond any modest revisionism for suspect items from a folk theory, say, in folk psychology or folk biology. Instead, it applies to functional terms and concepts employed throughout well-developed and explanatorily successful sciences. (shrink)

UNDERSTANDING SCIENTIFIC REASONING develops critical reasoning skills and guides students in the improvement of their scientific and technological literacy. The authors teach students how to understand and critically evaluate the scientific information they encounter in both textbooks and the popular media. With its focus on scientific pedagogy, UNDERSTANDING SCIENTIFIC REASONING helps students learn how to examine scientific reports with a reasonable degree of sophistication. The book also explains how to reason through case studies using the same informal logic skills employed (...) by scientists and to analyze a complex series of propositions and hypotheses using sound scientific reasoning. (shrink)

John Bickle's new book on philosophy and neuroscience is aptly subtitled 'a ruthlessly reductive account'. His 'new wave metascience' is a massive attack on the relative autonomy that psychology enjoyed until recently, and goes even beyond his previous (Bickle, J. (1998). Psychoneural reduction: The new wave. Cambridge, MA: MIT Press.) new wave reductionsism. Reduction of functional psychology to (cognitive) neuroscience is no longer ruthless enough; we should now look rather to cellular or molecular neuroscience at the lowest possible (...) level for explanations of memory, consciousness and attention. Bickle presents a fascinating set of experimental cases of such molecule-to-mind explanations. This book qualifies as a showcase of naturalism in the philosophy of mind. Naturally, many of the traditional conceptual approaches in the philosophy of mind are given short shrift, but - in Bickle's metascientific scheme - the role of philosophy of science also seems reduced to explicating laboratory findings. The present reviewers think that this reductionism suffers from overstretching; in particular, the idea of 'explanation in a single bound' from molecule to mind is a bit too ruthless. Still, Bickle's arguments are worth serious attention. (shrink)

One of the central problems in the philosophy of psychology is an updated version of the old mind-body problem: how levels of theories in the behavioral and brain sciences relate to one another. Many contemporary philosophers of mind believe that cognitive-psychological theories are not reducible to neurological theories. However, this antireductionism has not spawned a revival of dualism. Instead, most nonreductive physicalists prefer the idea of a one-way dependence of the mental on the physical.In Psychoneural Reduction, John Bickle presents (...) a new type of reductionism, one that is stronger than one-way dependency yet sidesteps the arguments that sank classical reductionism. Although he makes some concessions to classical antireductionism, he argues for a relationship between psychology and neurobiology that shares some of the key aims, features, and consequences of classical reductionism. Parts of Bickle's "new wave" reductionism have emerged piecemeal over the past two decades; this is his first comprehensive statement and defense of it to appear. (shrink)

Social cognition, cognitive neuroscience, and neuroethics have reached a synthesis of late, but some troubling features are present. The neuroscience that currently dominates the study of social cognition is exclusively cognitive neuroscience, as contrasted with the cellular and increasingly molecular emphasis that has gripped mainstream neuroscience over the past three decades. Furthermore, the recent field of molecular and cellular cognition has begun to unravel some molecular mechanisms involved in social cognition, especially pertaining to the consolidation of memories of particular conspecific (...) organisms. Some new experimental techniques for positive interventions into these hypothesized mechanisms offer opportunities for establishing direct causal linkages between intra-neuronal molecular events and the behaviors used to measure social cognitive phenomena. Predicted results from an experiment described below also cast doubt on the application of the “extended mind” approach from recent cognitive science to ground the neuroscience of social cognition. Since neuroethics relies heavily on our best neuroscience of social cognition, that field may soon need to extend its attention beyond cognitive neuroscience, and into neuroscience’s cellular and molecular mainstream. (shrink)

We introduce a new model of reduction inspired by Kemeny and Oppenheim’s model [Kemeny & Oppenheim 1956] and argue that this model is operative in a “ruthlessly reductive” part of current neuroscience. Kemeny and Oppenheim’s model was quickly rejected in mid-20th-century philosophy of science and replaced by models developed by Ernest Nagel and Kenneth Schaffner [Nagel 1961], [Schaffner 1967]. We think that Kemeny and Oppenheim’s model was correctly rejected, given what a “theory of reduction” was supposed to account for at (...) that time. But their guiding insights about what constitutes scientific reduction—increases in explanatory scope and systematization—reflect actual practices of current reductionistic neuroscience. The key rehabilitative step to make their insights fit current scientific details is to restate them using resources from recent work on causal-mechanistic explanation. We begin with a scientific case study, drawn from the relatively new field of “molecular and cellular cognition”. It provides an explanation of the well-known Ebbinghaus spacing effect on learning and memory in terms of interactions between a transcriptional enhancer protein and its inhibiting phosphatase in neurons recruited into the memory trace. Next we briefly describe some popular models of reduction from mid-20th-century philosophy of science. We point out how these models fail to illuminate key features of our scientific case study. Finally we present our causal-mechanistically updated Kemeny and Oppenheim-inspired model and argue that it nicely accounts for the details of our scientific case study. We close with a remark that will hopefully undercut the surprise many may feel to learn that a long-rejected philosophical account of reduction actually is at work in one of the most prominent reductionistic endeavors in current science. (shrink)

David Marr's three-level method for completely understanding a cognitive system and the importance he attaches to the computational level are so familiar as to scarcely need repeating. Fewer seem to recognize that Marr defends his famous method by criticizing the “reductionistic approach.” This sets up a more interesting relationship between Marr and reductionism than is usually acknowledged. I argue that Marr was correct in his criticism of the reductionists of his time—they were only describing, not explaining. But a careful metascientific (...) account of reductionistic neuroscience over the past two decades reveals that Marr's criticisms no longer have force. Contemporary neuroscience now explains cognition directly, although in a fashion—causal-mechanistically—quite different than Marr recommended. So while Marr was correct to reject the reductionism of his day and offer an alternative method for genuinely explaining cognition, contemporary cognitive scientists now owe us a new defense of Marr's famous method and the advantages of its explanations over the type now pursued successfully in current reductionist neuroscience. There are familiar reasons for thinking that this debt will not be paid easily. (shrink)

Accounts of causal explanation are standard in philosophy of science. Less common are accounts of experimentation to investigate causal relations: detailed discussions of the specific kinds of experiments scientists design and run. Silva, Landreth, and Bickle’s account of “connection experiments” derives directly from landmark experiments in “molecular and cellular cognition.” We start with its key components, and then using a detailed case study from recent social neuroscience we emphasize and extend three features of SLB’s account: a division of distinct (...) types of connection experiments, each providing a different type of evidence for a hypothesized causal relationship; the typically downward-looking nature of the experimental search for mediating causes in mainstream neurobiology; and most importantly, the centrality of multiple-experiment research programs, with each experiment designed such that if successful its results can be integrated with the others, toward the goal of confirming multiple-phenomena causal pathways. Our extension of SLB’s account complements existing philosophical work on experimentation in neurobiology. (shrink)

Neurobiologists talk of linking mind to molecular dynamics in and between neurons. Such talk is dismissed by cognitive scientists, including many cognitive neuroscientists, due to the number of “levels” that separate behaviors from these molecular events. In this paper I explain what neurobiologists mean by such claims by describing the kinds of experiment tools that have forged these linkages, directly on lab benches. I here focus on one of these tools, gene targeting techniques, brought into behavioral neuroscience from developmental biology (...) more than a quarter-century ago. Discussion of this tool does more than illuminate these claims by neurobiologists, however. An account of its development shows the doubly dependent role that theory plays in neurobiology. Our best current theories about “how the brain works” depend entirely on the experiment tools neuroscientists have available. And these tools get developed via the solution of engineering problems, not the application of theory. Theory is thus of tertiary importance in neuroscience, not of the primary importance that many cognitive scientists assume it to occupy. (shrink)

Optogenetics and DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) are important research tools in recent neurobiology. These tools allow unprecedented control over activity in specifically targeted neurons in behaving animals. Two approaches in philosophy of neuroscience, mechanism and ruthless reductionism, provide explicit accounts of experiments and results using tools like these, but each offers a different picture about how levels of mechanisms relate. I argue here that the ruthless reductionist’s direct mind‐to‐cellular/molecular activities linkages “in a single bound” better fits (...) with both the experimental designs using these tools and some of the scientists’ own judgments about their results than does the mechanist’s “nested hierarchies of mechanisms‐within‐mechanisms.” So at least some important work in current neuroscience appears to be ruthlessly reductive. Mechanism may not correctly characterize all current work in neuroscience, despite its recent popularity. (shrink)

Davidson's principle of the anomalousness of the mental was instrumental in discrediting once-popular versions of mind-brain reductionism. In this essay I argue that a novel account of intertheoretic reduction, which does not require the sort of cross-theoretic bridge laws that Davidson's principle rules out, allows a version of mind-brain reductionism which is immune from Davidson's challenge. In the final section, I address a second worry about reductionism, also based on Davidson's principle, that survives this response. I argue that new reductionists (...) should revise some significant details of the program, particularly the conception of theories, to circumvent this more potent Davidson-inspired worry. (shrink)

The previous decade has seen renewed critical interest in the multiple realization argument. These criticisms constitute a "second wave" of challenges to this central argument in late-20th century philosophy of mind. Unlike the first wave, which challenged the premise that multiple realization is inconsistent with reduction or type identity, this second wave challenges the truth of the multiple realization premise itself. Since psychoneural reductionism was prominent among the explicit targets of the multiple realization argument, one might think that this second (...) wave of challenges provides important aid and comfort to reductionists. In this paper, however, I provide reasons for thinking it does not. This is not to the detriment of psychoneural reductionism because, as I also argue here, and unrecognized by the current non-reductive orthodoxy in philosophy of mind, one key argument among the first wave of criticisms of the multiple realization argument has never been adequately rejoined. (shrink)

I introduce two new tools in experimental neurobiology, optogenetics and DREADDs. These tools permit unprecedented control over activity in specific neurons in behaving animals. In addition to their inherent scientific interest, these tools make an important contribution to philosophy of science. They illustrate the very premises of Ian Hacking’s “microscope” argument for the relative independence of experiment from theory. This new example is important for generalizing Hacking’s argument because the background sciences and the fields of engineering producing these tools differ (...) significantly. (shrink)

The Oxford Handbook of Philosophy and Neuroscience is a state-of-the-art collection of interdisciplinary research spanning philosophy (of science, mind, and ethics) and current neuroscience. Containing chapters written by some of the most prominent philosophers working in this area, and in some cases co-authored with neuroscientists, this volume reflects both the breadth and depth of current work in this exciting field. Topics include the nature of explanation in neuroscience; whether and how current neuroscience is reductionistic; consequences of current research on the (...) neurobiology of learning and memory, perception and sensation, neurocomputational modeling, and neuroanatomy; the burgeoning field of neuroethics and the neurobiology of motivation that increasingly informs it; implications from neurology and clinical neuropsychology, especially in light of some bizarre symptoms involving misrepresentations of self; the extent and consequences of multiple realization in actual neuroscience; the new field of neuroeudamonia; and the neurophilosophy of subjectivity. This volume will interest philosophers working in numerous fields who wish to see how current neuroscience is being brought to bear directly on philosophical issues. It will also be of interest to neuroscientists who wish to learn how the research programs of some of their colleagues are being enriched by interaction with philosophers, and finally to those working in any interdisciplinary field who wish to see how two seemingly disparate disciplines--one traditional and humanistic, the other new and scientific--are being brought together to both disciplines' mutual benefit. (shrink)

Over the past three decades, philosophy of science has grown increasingly “local.” Concerns have switched from general features of scientific practice to concepts, issues, and puzzles specific to particular disciplines. Philosophy of neuroscience is a natural result. This emerging area was also spurred by remarkable recent growth in the neurosciences. Cognitive and computational neuroscience continues to encroach upon issues traditionally addressed within the humanities, including the nature of consciousness, action, knowledge, and normativity. Empirical discoveries about brain structure and function suggest (...) ways that “naturalistic” programs might develop in detail, beyond the abstract philosophical considerations in their favor. -/- The literature distinguishes “philosophy of neuroscience” and “neurophilosophy.” The former concerns foundational issues within the neurosciences. The latter concerns application of neuroscientific concepts to traditional philosophical questions. Exploring various concepts of representation employed in neuroscientific theories is an example of the former. Examining implications of neurological syndromes for the concept of a unified self is an example of the latter. In this entry, we will assume this distinction and discuss examples of both. (shrink)

Recently some philosophers have urged that connectionist artificial intelligence is (potentially) eliminative for the propositional attitudes of folk psychology. At the same time, however, these philosophers have also insisted that since philosophy of science has failed to provide criteria distinguishing ontologically retentive from eliminative theory changes, the resulting eliminativism is not principled. Application of some resources developed within the semantic view of scientific theories, particularly recent formal work on the theory reduction relation, reveals these philosophers to be wrong in this (...) second contention, yet by and large correct in the first. (shrink)

A number of influences have combined to make reductionism an unpopular position in recent philosophy of mind and psychology. Davidson’s Principle of the Anomalousness of the Mental, the multiple realizability arguments of Putnam, Fodor, and others, and attempts to characterize supervenience or dependency as the appropriate nonreductive relation to seek between psychological and physical kinds are the most well-known objections. And these have found their mark. Being a psychophysical reductionist nowadays, as Jaegwon Kim aptly puts it, “is a bit like (...) being a logical positivist or a member of the Old Left—an aura of doctrinaire naiveté hangs over such a person”. (shrink)

The focus of much recent debate between realists and eliminativists about the propositional attitudes obscures the fact that a spectrum of positions lies between these celebrated extremes. Appealing to an influential theoretical development in cognitive neurobiology, I argue that there is reason to expect such an “intermediate” outcome. The ontology that emerges is a revisionary physicalism. The argument draws lessons about revisionistic reductions from an important historical example, the reduction of equilibrium thermodynamics to statistical mechanics, and applies them to the (...) relationship developing between propositional attitude psychology and this potential neuroscientific successor. It predicts enough conceptual change to rule out a straightforward realism about the attitudes; but at the same time it also resists the eliminativist's comparison of the fate awaiting the propositional attitudes to that befalling caloric fluid, phlogiston, and the like. (shrink)

We briefly describe ways in which neuroeconomics has made contributions to its contributing disciplines, especially neuroscience, and a specific way in which it could make future contributions to both. The contributions of a scientific research programme can be categorized in terms of (1) description and classification of phenomena, (2) the discovery of causal relationships among those phenomena, and (3) the development of tools to facilitate (1) and (2). We consider ways in which neuroeconomics has advanced neuroscience and economics along each (...) line. Then, focusing on electrophysiological methods, we consider a puzzle within neuroeconomics whose solution we believe could facilitate contributions to both neuroscience and economics, in line with category (2). This puzzle concerns how the brain assigns reward values to otherwise incomparable stimuli. According to the common currency hypothesis, dopamine release is a component of a neural mechanism that solves comparability problems. We review two versions of the common currency hypothesis, one proposed by Read Montague and colleagues, the other by William Newsome and colleagues, and fit these hypotheses into considerations of rational choice. (shrink)

This chapter argues that much discussion between philosophers and neuroscientists is infected by philosophical assumptions about the nature of reduction. Instead we should pursue an unbiased examination of the methods used throughout relevant areas of neuroscience. The chapter focuses on reductionist work in the neurobiological discipline of molecular and cellular cognition. It is argued that reduction is a matter of causal intervention into low level mechanisms, and tracking of the effects of these interventions through levels. When interventions provide evidence that (...) activity in the proposed reductive mechanism co-varies reliably with activity in the target property, such that appealing to higher-level mechanisms will not add any extra explanatory power, reduction can succeed. This is explicitly contrasted with functionalisation and a posteriori approaches to reduction. (shrink)

The need for representations and computations over their contents in psychological explanations is often cited as both the mark of the genuinely cognitive and a source of skepticism about the reducibility of cognitive theories to neuroscience. A generic version of this anti-reductionist argument is rejected in this paper as unsound, since (i) current thinking about associative learning emphasizes the need for cognitivist resources in theories adequate to explain even the simplest form of this phenomena (Pavlovian conditioning), and yet (ii) the (...) most widely accepted recent theory of associative learning, which utilizes cognitivist resources, has already been reduced to a purely neurophysiological account. Psychoneural reduction of genuinely cognitivist theories is thus already an accomplished scientific fact, despite pronouncements by anti-reductionists about its conceptual impossibility or empirical implausibility. In addition, the specific form of reduction involved in this case (“combinatorial” reduction) provides a promising model for further cognitivist-to-neuroscience theory reductions. (shrink)

Scientists often respond to failures to replicate by citing differences between the experimental components of an original study and those of its attempted replication. In this paper, we investigate these purported mismatch explanations. We assess a body of failures to replicate in neuroscience studies on spinal cord injury. We argue that a defensible mismatch explanation is one where a mismatch of components is a difference maker for a mismatch of outcomes, and the components are relevantly different in the follow-up study, (...) given the scope of the original study. With this account, we argue that not all differences between studies are meaningful, even if they are difference makers. As our examples show, focusing only on these differences results in disregarding the representativeness of the original experiment’s components and the scope of its outcomes, undercutting other epistemic aims, such as translation, in the process. (shrink)

The argument from multiple realizability is that, because quite diverse physical systems are capable of giving rise to identical psychological phenomena, mental states cannot be reduced to physical states. This influential argument depends upon a theory of reduction that has been defunct in the philosophy of science for at least fifteen years. Better theories are now available.

The structuralist program has developed a useful metascientific resource: ontological reductive links (ORLs) between the constituents of the potential models of reduced and reducing theories. This resource was developed initially to overcome an objection to structuralist ``global'' accounts of the intertheoretic reduction relation. But it also illuminates the way that concepts at a higher level of scientific investigation (e.g., cognitive psychology) become ``structured through reduction'' to lower-level investigations (e.g., cellular/molecular neuroscience). After (briefly) explaining this structuralist background, I demonstrate how this (...) resource illuminates an actual, emerging scientific example: the link between the psychological concept of a ``consolidation switch'' from short-term to long-term memory and the cellular/molecular mechanisms of the transition from early- to late-phases of long-term potentiation (LTP) (an important type of synaptic plasticity in mammalian hippocampus and cortex). (shrink)

I reply to challenges raised by contributors to this book symposium. Key challenges include (but are not limited to): distancing my new account of reductionism-in-practice from my previous “new wave” account; clarifying my claimed “heuristic” status for higher-level investigations (including cognitive-neuroscientific ones); defending the “reorientation of philosophical desires” I claim to be required by my project; and addressing consideration about normativity.

Recent studies indicate that mammalian chromosomes contain discretecis‐acting loci that control replication timing, mitotic condensation, and stability of entire chromosomes. Disruption of the large non‐coding RNA gene ASAR6 results in late replication, an under‐condensed appearance during mitosis, and structural instability of human chromosome 6. Similarly, disruption of the mouse Xist gene in adult somatic cells results in a late replication and instability phenotype on the X chromosome. ASAR6 shares many characteristics with Xist, including random mono‐allelic expression and asynchronous replication timing. (...) Additional “chromosome engineering” studies indicate that certain chromosome rearrangements affecting many different chromosomes display this abnormal replication and instability phenotype. These observations suggest that all mammalian chromosomes contain “inactivation/stability centers” that control proper replication, condensation, and stability of individual chromosomes. Therefore, mammalian chromosomes contain four types ofcis‐acting elements, origins, telomeres, centromeres, and “inactivation/stability centers”, all functioning to ensure proper replication, condensation, segregation, and stability of individual chromosomes. (shrink)

A number of influences have combined to make reductionism an unpopular position in recent philosophy of mind and psychology. Davidson’s Principle of the Anomalousness of the Mental, the multiple realizability arguments of Putnam, Fodor, and others, and attempts to characterize supervenience or dependency as the appropriate nonreductive relation to seek between psychological and physical kinds are the most well-known objections. And these have found their mark. Being a psychophysical reductionist nowadays, as Jaegwon Kim aptly puts it, “is a bit like (...) being a logical positivist or a member of the Old Left—an aura of doctrinaire naiveté hangs over such a person”. (shrink)

Epigenetics investigates the dynamics of gene expression in various cells, and the signals from the internal and external environment affecting these dynamics. Neuroepigenetics extends this research into neurons and glia cells. Environmental-induced changes in gene expression are not only associated with the emerging structure and function of the nervous system during ontogeny, but are also fundamental to the wiring of neural circuitries responsible for learning and memory. Yet philosophers of science and neuroscience have so far paid little attention to these (...) findings. In this article, we describe some recent experimental work on the neuroepigenetics of fear and stress responses in rodents, its ingenious experimental translation into humans, and how this work seems not to be accurately described by popular “mechanist” accounts. Our final goal is to motivate broader philosophical attention to neuroepigenetics practices and findings, especially for how it considers environmentally driven and developmental plasticity in psychological explanations. (shrink)