Cross-border reproductive care (CBRC) can be defined as the movement from one jurisdiction to another for medically assisted reproduction (MAR). CBRC raises many ethical concerns that have been addressed extensively. However, the conclusions are still based on scarce evidence even considering the global scale of CBRC. Empirical ethics appears as a way to foster this ethical reflection on CBRC while attuning it with the experiences of its main actors. To better understand the ‘in and out’ situation of CBRC in Canada, (...) we conducted an ethnographic study taking a ‘critically applied ethics’ approach. This article presents a part of the findings of this research, obtained by data triangulation from qualitative analysis of pertinent literature, participant observation in two Canadian fertility clinics and 40 semidirected interviews. Based on participants’ perceptions, four themes emerged: (1) inconsistencies of the Canadian legal framework; (2) autonomy and the necessity to resort to CBRC; (3) safety and the management of CBRC individual risks; and (4) justice and solidarity. The interaction between these four themes highlights the problematic of ‘reproductive outsourcing’ that characterised the Canadian situation, a system where the controversial aspects of MAR are knowingly pushed outside the borders. (shrink)

Abstractp53 has a determinant role in cancer prevention and is among the most studied proteins in the world. The majority of studies devoted to this protein are carried out in cell lines because they are easy to use and have naturally emerged as the main research tool in laboratories. However, the p53 pathway is commonly deregulated in cancer cells, from which the experimental cell lines are generally derived. The fact that the pathway is deregulated challenges the relevance of using cancer‐derived (...) cell lines to study wild‐type p53 activities, or, in a broader sense, to study any normal cellular process. In the present article, we identify and discuss a number of limitations of cell lines using examples related to p53. Finally, we point out the general limitations of cell lines and propose solutions as alternatives to these cells. (shrink)

Pour soutenir les élèves du primaire dans leur apprentissage de la langue et des disciplines scolaires, tant en contexte de français langue d’enseignement que de français langue seconde, l’élaboration d’une liste de vocabulaire dit « transdisciplinaire » (Hiebert et Lubliner 2008) s’avère nécessaire. Il n’existe en effet pas de liste de référence pour l’enseignement ciblé des mots qui apparaissent fréquemment dans les matières scolaires au primaire en français et qui ont comme caractéristiques : soit d’être utilisés dans un même sens (...) quelle que soit la matière (souligner, examiner, répondre, expliquer, premièrement, enfin, etc.), soit de posséder des sens différents dans les différentes disciplines et dans la langue (nombre, base, somme, résultat, valeur, représenter, etc.). Dans cet article, nous rendons compte d’un projet de recherche ayant mené 1) à la constitution d’un corpus de plus de 4 millions de mots, à partir de manuels scolaires en usage au Québec pour tous les cycles du primaire, dans cinq disciplines (français, mathématiques, sciences, univers social, éthique et culture religieuse) et 2) à la sélection d’une liste de vocabulaire transdisciplinaire de plus de 2 000 vocables à des fins d’enseignement de la langue et des disciplines scolaires. (shrink)

The world of insects is at once beneath our feet and unfathomably alien. Small and innumerable, insects surround and disrupt us even as we scarcely pay them any mind. Insects confront us with the limits of what is imaginable, while at the same time being essential to the everyday functioning of all terrestrial ecosystems. In this book, the philosopher and historian of science Jean-Marc Drouin contends that insects pose a fundamental challenge to philosophy. Exploring the questions of what insects (...) are and what scientific, aesthetic, ethical, and historical relationships they have with humanity, he argues that they force us to reconsider our ideas of the animal and the social. He traces the role that insects have played in language, mythology, literature, entomology, sociobiology, and taxonomy over the centuries. Drouin emphasizes the links between humanistic and scientific approaches—how we have projected human roles onto insects and seen ourselves in insect form. Caught between the animal and plant kingdoms, insects force us to confront and reevaluate our notions of gender, family, society, struggle, the division of labor, social organization, and individual and collective intelligence. A remarkably original and thought-provoking work, A Philosophy of the Insect is an important book for animal studies, environmental ethics, and the history and philosophy of science. (shrink)

Dans la Théorie élémentaire de la botanique, dont la première édition date de 1813, Augustin-Pyramus de Candolle se propose d’expliquer et de fonder rationnellement la méthode naturelle de classification des plantes. Pour cela, il est amené à comparer les différentes méthodes existantes. Par ailleurs, dans l’introduction, il propose une classification générale des sciences. Dans les deux cas, on retrouve un même souci de justifier le statut scientifique de la botanique.

Tout au long de sa longue carrière, Henri Lecoq a eu une réputation contrastée dans la communauté scientifique. Son oeuvre est citée par Mendel et par Darwin; cependant certains de ses compatriotes, tels qu'Adolphe Brongniart lui ont dénié originalité et profondeur. Dans une certaine mesure, Lecoq a subi le destin de beaucoup de naturalistes provinciaux dont les efforts n'étaient pas vraiment reconnus par les maîtres de la discipline. Mais une explication plus spécifique se trouve peut-être dans l'habitude qu'avait Lecoq d'utiliser (...) dans le même texte différents styles considérés comme incompatibles. Son travail sur l'hybridation végétale est à cet égard significatif: des bribes de vulgarisation hautes en couleurs y côtoient des conseils pratiques pour les horticulteurs, et les descriptions pittoresques s'y mêlent aux réflexions théoriques. Au terme de cette étude, Lecoq apparaît comme un homme de science qui combine un sens aigu de l'observation avec les caractéristiques d'un auteur romantique. (shrink)

t. 1. Rêver l'égalité, penser la culture -- t. 2. Pensées philosophiques et pédagogiques.

The phrase “regenerative medicine” is used so often and for so many different things, with such enthusiasm or worry, and often with a sense that this is something radically new. This paper places studies of regeneration and applications in regenerative medicine into historical perspective. In fact, the first stem cell experiment was carried out in 1907, and many important lines of research have contributed since. This paper explores both what we can learn about the history and what we can learn (...) from the history of regenerative medicine research. (shrink)

A growing body of literature argues that achieving radical change in the agri-food system requires a radical renegotiation of our relationship with the environment alongside a change in our thinking and approach to transformational food politics. This paper argues that relational approaches such as a more-than-human ethic of care (MTH EoC) can offer a different and constructive perspective to analyse agri-food system transformation because it emphasises social structures and relationships as the basis of environmental change. A MTH EoC has not (...) yet been applied to regenerative agriculture, yet other literature on regenerative agriculture suggests that care may be present in these spaces and calls for the need for social science analysis of the regenerative movement. This paper uses a MTH EoC lens to reveal a diverse array of ways in which power is and can be deployed for change in the regenerative agriculture movement in Aotearoa, New Zealand. Globally, regenerative agriculture tends to be analysed through positivist, scientific approaches that focus on biophysical markers of ecological improvement. Yet, a relational approach reveals how engagement in regenerative agriculture is creating significant shifts in mindset towards more holistic and relational understandings of biological and social ecosystems. A regenerative mindset framework is suggested as a method of understanding the connection between a regenerative form of thinking, being and doing for farmers. Interviews suggested that this shift in farmers’ socio-ecological relations is crucial to the transformational potential of regenerative agriculture. This paper argues that relational analyses such as the MTH EoC approach used to analyse regenerative agriculture in this research, refresh the way we analyse agri-food system change. They also are critical to guiding and supporting on-the-ground socio-ecological shifts that are necessary to see agricultural transformation. (shrink)

Regenerative Medicine promises to develop treatments to regrow healthy tissues and cure the physical body. One of the emerging developments within this field is regenerative implants, such as jawbone or heart valve implants, that can be broken down by the body and are gradually replaced with living tissue. Yet challenges for embodiment are to be expected, given that the implants are designed to integrate deeply into the tissue of the living body, so that implant and body become one. In this (...) paper, we explore how regenerative implants may affect the embodied experience of implant recipients. To this end, we take a phenomenological approach. First, we explore what insights the existing phenomenological and empirical literature on embodiment offers regarding the experience of illness and of living with regular (non-regenerative) implants and organ transplants. Second, we apply these insights to better understand how future implant recipients might experience living with regenerative implants. Third, we conclude that concepts and considerations from the existing phenomenological literature do not sufficiently address what it might be like to live with an implantable technology that, over time, becomes one with the living body. We argue that the interwovenness and intimate relationship of people living with regenerative implants should be understood in terms of ‘entanglement’. Entanglement allows us to explore the complexities of human-technology relations, acknowledging the inseparability of humans and implantable technologies. Our theoretical foundations regarding the role of embodiment may be tested empirically once more people will be living with regenerative implants. (shrink)

In recent years, interest has increased in regenerative practices as a strategy for transforming food systems and solving major environmental problems such as biodiversity loss and climate change. However, debates persist regarding these practices and how they ought to be defined. This paper presents a framework for exploring the regenerative potential of food systems, focusing on how food systems activities and technologies are organized rather than the specific technologies or practices being employed. The paper begins with a brief review of (...) debates over sustainable food systems and the varying ways that regenerative food systems have been defined and theorized. Then, it provides the theoretical backing of the framework—the conservation of change principle—which is an interpretation of the laws of thermodynamics and theories of adaptive change as relevant to the regenerative capacity of living systems. Next, the paper introduces the framework itself, which comprises two independent but intersecting dimensions of food systems organization: resource diversity and livelihood flexibility. These two dimensions result in four archetypical regimes for food systems: degenerative, regenerative, impoverished, and coerced. The paper defines each and offers real-world examples. Finally, the paper concludes with a discussion of pathways for transforming food systems and opportunities for additional research. (shrink)

Regulation of Regenerative Medicines: A Global Perspective covers regenerative medicine regulations globally where frameworks have been or are being established. Chapters by discipline include manufacturing, supply chain, pharmacology, pharmacokinetics, toxicology, and combination product.

From organ transplants to genetic therapies by way of the manufacture of replacement tissue, regenerative medicine incarnates a biomedical reasoning that is unique to contemporary society. As a re-engineering of the body, regenerative medicine is the most accomplished manifestation of contemporary biopolitics: it concretely announces the emergence of what sociologist Karin Knorr Cetina calls the ‘culture of life’, in which individual existence is symbolically assimilated to biological conditions. This article will examine the symbolic and ethical issues of regenerative medicine, notably (...) regarding representations of the ageing body. In doing so, it will place this new branch of biomedical research back into the context from which it emerged, with the goal of grasping the social and cultural suppositions on which regenerative medicine is based. The growing number of elderly people in Western societies is one such central element. This article therefore intends to demonstrate how regenerative medicine is rooted in the modern biomedical deconstruction of death, which underlies the contemporary technoscientific fantasy of indefinitely extending longevity. (shrink)