The Global Workspace Theory and Information Integration Theory are two of the most currently accepted consciousness models; however, these models do not address many aspects of conscious experience. We compare these models to our previously proposed consciousness model in which the thalamus fills-in processed sensory information from corticothalamic feedback loops within a proposed 3D default space, resulting in the recreation of the internal and external worlds within the mind. This 3D default space is composed of all cells of the body, (...) which communicate via gap junctions and electrical potentials to create this unified space. We use 3D llustrations to explain how both visual and non-visual sensory information may be filled-in within this dynamic space, creating a unified seamless conscious experience. This neural sensory memory space is likely generated by baseline neural oscillatory activity from the default mode network, other salient networks, brainstem, and reticular activating system. (shrink)

Multilevel research strategies characterize contemporary molecular inquiry into biological systems. We outline conceptual, methodological, and explanatory dimensions of these multilevel strategies in microbial ecology, systems biology, protein research, and developmental biology. This review of emerging lines of inquiry in these fields suggests that multilevel research in molecular life sciences has significant implications for philosophical understandings of explanation, modeling, and representation.

Immanuel Kant was a German philosopher. He is a central figure of modern philosophy, and set the terms by which all subsequent thinkers have had to grapple. He argued that human perception structures natural laws, and that reason is the source of morality. His thought continues to hold a major influence in contemporary thought, especially in fields such as metaphysics, epistemology, ethics, political philosophy, and aesthetics.

The complex activity of the human brain makes it difficult to get a big picture of how the brain works and functions as the mind. We examine pertinent studies, as well as evolutionary and embryologic evidence to support our theoretical model consisting of separate but interactive layers of human neural activity. The most basic layer involves default mode network (DMN)activity and cardiorespiratory oscillations. We propose that these oscillations support other neural activity and cognitive processes. The second layer involves limbic system (...) activity accompanied by corresponding changes in cardiorespiratory oscillations. The third layer consists of corticothalamic processing and involves higher cortical functions including awareness, cognition,and consciousness. These layers interact to form the complex neural activity of the human brain. Examining the origins and relationships of various neural and physiologic oscillations may provide better understanding of human neurophysiology and consciousness. (shrink)

One of the most compelling questions still unanswered in neuroscience is how consciousness arises. In this article, we examine visual processing, the parietal lobe, and contralateral neglect syndrome as a window into consciousness and how the brain functions as the mind and we introduce a mechanism for the processing of visual information and its role in consciousness. We propose that consciousness arises from integration of information from throughout the body and brain by the thalamus and that the thalamus reimages visual (...) and other sensory information from throughout the cortex in a default three-dimensional space in the mind. We further suggest that the thalamus generates a dynamic default three-dimensional space by integrating processed information from corticothalamic feedback loops, creating an infrastructure that may form the basis of our consciousness. Further experimental evidence is needed to examine and support this hypothesis, the role of the thalamus, and to further elucidate the mechanism of consciousness. (shrink)

Intercellular signaling plays an important role in spatially regulated developmental processes. Myxococcus xanthus C signal transmission during fruiting body formation requires motile, densely packed, well aligned cells. tThe fruiting body consists of two domains: an outer domain which has densely packed, well aligned, motile cells: and an inner domain of more loosely packed, non‐motile, sporulating cells. The two domains are characterized by different patterns of C‐dependent gene expression, which begins in the outer domain where C‐signaling is most efficient, and reaches (...) its maximum in the inner domain. These domains may be maintained by a dynamic mechanism which relies on passive transport of the sporulating cells from the outer domain, where sporulation is initiated, to the inner domain by the motile cells in the outer domain. (shrink)

Defining and identifying causal intervention effects for transmissible infectious disease outcomes is challenging because a treatment – such as a vaccine – given to one individual may affect the infection outcomes of others. Epidemiologists have proposed causal estimands to quantify effects of interventions under contagion using a two-person partnership model. These simple conceptual models have helped researchers develop causal estimands relevant to clinical evaluation of vaccine effects. However, many of these partnership models are formulated under structural assumptions that preclude realistic (...) infectious disease transmission dynamics, limiting their conceptual usefulness in defining and identifying causal treatment effects in empirical intervention trials. In this paper, we propose causal intervention effects in two-person partnerships under arbitrary infectious disease transmission dynamics, and give nonparametric identification results showing how effects can be estimated in empirical trials using time-to-infection or binary outcome data. The key insight is that contagion is a causal phenomenon that induces conditional independencies on infection outcomes that can be exploited for the identification of clinically meaningful causal estimands. These new estimands are compared to existing quantities, and results are illustrated using a realistic simulation of an HIV vaccine trial. (shrink)

This is the third of a series of books by Aschenbrenner dealing with the nature of appraisive concepts, following The Concept of Value and The Concepts of Criticism. In the previous works he attempted to identify, classify and provide a general theoretical framework for all appraisive or value concepts. The first part of the present book expands that analysis by investigating the emergence of appraisive concepts and exploring in depth the nature of the classifications made in the previous books. Aschenbrenner (...) begins with elemental sense experience and works his way to complex human interactions, where he finds that expectations of others lead to demands, and that their fulfillment or nonfulfillment leads to the use of appraisive characterization, ranging from the expression of emotions to the articulation of rights and duties. He provides details of the verbal and conceptual means by which credit and discredit are expressed, modes of opposition between concepts, and various dimensions of meaning. On a more general level, his view is that assertions using appraisive terms are not true or false, nor in need of verification; rather they are evaluated as apt or unapt and as fair or unfair, just or unjust. But these evaluations are themselves appraisive discourse, only at another level. (shrink)

I interpret and defend Sellars’ intemalist view of perceptual justification which argues that perceivers have evidence for their perceptual beliefs that includes a higher-order belief about the circumstances in which those beliefs arise, and an epistemic belief about the reliability of beliefs that are formed in those circumstances. The pattem of inference that occurs in ordinary cases of perception is elicited.I then defend this account of perceptual evidence against 1) AIston’s objection that ordinary perceivers are not as critical and reflective (...) as this view requires them to be; and 2) the charge that intemalism leads to various forms of infinite regress and circular reasoning. It is granted that subjects must have further grounds for their justifying reasons, and an attempt is made to identify these second-order reasons. In particular, I argue that epistemic beliefs are grounded in the perceiver’s awareness that his present experience-cum-conditions fits into a larger pattem of similar past experiences that were reliably connected with their objects. (shrink)

In Making it Explicit Robert Brandom claims that perspectivally hybrid de re attitude ascriptions explain what an agent actually did, from the point of view of the ascriber, whether or not that was what the agent intended to do. There is a well-known problem, however, first brought to attention by Quine, but curiously ignored by Brandom, that threatens to undermine the role of de re ascriptions in the explanation of action, a problem that stems directly from the fact that, unlike (...) de dicto ascriptions, they permit the attribution of inconsistent attitudes to agents. I propose a solution to the problem which I believe is consistent with Brandom’s approach to the nature of intentionality and the explanation of action. (shrink)

The grammarian Caesellius Vindex, writing under Trajan, criticized Furius Antias for his newly coined verbs lutescere, noctescere, opulescere and vīrescere. Their meanings in classical Latin are classified by Nicolaie as follows: becoming, the intensification of a quality, the acquisition of a quality. Their number increases in post-classical Latin, in which we also find them used causatively as transitive verbs, e.g. innotescere ‘make known’; Gellius' causative use of inolesco is mentioned below. Incohative verbs descend to Romance languages, where forms in -o (...) and in -sco both contribute to some conjugations, e.g. Fr. finir, finissant; It. finire, finisco, and to English. (shrink)

The late Jacob Klein’s important book is, remarkably, a lucid presentation of esoteric argument. Dealing with the famed Platonic triad, Theaetetus, Sophist, and Statesman, Klein settles the dispute about the missing dialogue, "The Philosopher," by first denying that it is missing and second showing that it is unnecessary. He argues, in short, that the triad is a dyad. That argument is reinforced by the distinction Klein strongly implies between the Socratic Theaetetus and the Eleatic Sophist and Statesman. "We can now (...) understand why the conversations of the ‘trilogy’ occur in two, not three, days and why the Sophist, the Statesman, and the Philosopher are dealt with in two, not three, dialogues". (shrink)