The rise of genomic studies in Africa – not least due to projects funded under H3Africa – is associated with the development of a small number of biorepositories across Africa. For the ultimate success of these biorepositories, the creation of cell lines including those from selected H3Africa samples would be beneficial. In this paper, we map ethical challenges in the creation of cell lines.

BackgroundThe rise of genomic studies in Africa – not least due to projects funded under H3Africa – is associated with the development of a small number of biorepositories across Africa. For the ultimate success of these biorepositories, the creation of cell lines including those from selected H3Africa samples would be beneficial. In this paper, we map ethical challenges in the creation of cell lines.DiscussionThe first challenge we identified relates to the moral status of cells living in culture. There is no (...) doubt that cells in culture are alive, and the question is how this characteristic is relevant to ethical decision-making. The second challenge relates to the fact that cells in culture are a source of cell products and mitochondrial DNA. In combination with other technologies, cells in culture could also be used to grow human tissue. Whilst on the one hand, this feature increases the potential utility of the sample and promotes science, on the other it also enables further scientific work that may not have been specifically consented to or approved. The third challenge relates to ownership over samples, particularly in cases where cell lines are created by a biobank, and in a different country than where samples were collected. Relevant questions here concern the export of samples, approval of secondary use and the acceptability of commercialisation. A fourth challenge relates to perceptions of blood and bodily integrity, which may be particularly relevant for African research participants from certain cultures or backgrounds. Finally, we discuss challenges around informed consent and ethical review.SummaryIn this paper, we sought to map the myriad of ethical challenges that need to be considered prior to making cell line creation a reality in the H3Africa project. Considering the relative novelty of this practice in Africa, such challenges will need to be considered, discussed and potentially be resolved before cell line creation in Africa becomes financially feasible and sustainable. We suggest that discussions need to be undertaken between stakeholders internationally, considering the international character of the H3Africa project. We also map out avenues for empirical research. (shrink)

La autora presenta una critica a la concepcion clasica de los sentidos asumida por la mayoria de autores naturalistas que pretenden explicar el contenido mental. Esta crítica se basa en datos neurobiologicos sobre los sentidos que apuntan a que estos no parecen describir caracteristicas objetivas del mundo, sino que actuan de forma ʼnarcisita', es decir, representan informacion en funcion de los intereses concretos del organismo.El articulo se encuentra también en: Bechtel, et al., Philosophy and the Neuroscience.

The collateral effects of strike actions by academic staff in public universities in South West Nigeria were investigated through descriptive research design. An instrument tagged Perception of Undergraduates on the Influence of the Academic Staff Union of Universities Strike Actions Questionnaire was used for data collection. A study sample of 490 undergraduates was selected through purposive and simple random sampling techniques from seven universities in South West geopolitical zone of Nigeria. Four research questions were raised with two hypotheses generated. The (...) outcome of the study revealed both negative and positive impacts of ASUU strike on the undergraduates while gender of undergraduates and institutional ownership had no significant influence on undergraduates’ perception. It was recommended that causes of strike actions must be nipped in bud with granting of full autonomy to these universities while tax holidays should be given to private investors to finance universities. (shrink)

A common view in both philosophy and the vision sciences is that, in human vision, wavelength information is primarily ‘for’ colouring: for seeing surfaces and various media as having colours. In this article we examine this assumption of ‘colour-for-colouring’. To motivate the need for an alternative theory, we begin with three major puzzles from neurophysiology, puzzles that are not explained by the standard theory. We then ask about the role of wavelength information in vision writ large. How might wavelength information (...) be used by any monochromat or dichromat and, finally, by a trichromatic primate with object vision? We suggest that there is no single ‘advantage’ to trichromaticity but a multiplicity, only one of which is the ability to see surfaces and so on as having categorical colours. Instead, the human trichromatic retina exemplifies a scheme for a general encoding of wavelength information given the constraints imposed by high spatial resolution object vision. Chromatic vision, like its partner, luminance vision, is primarily for seeing. Viewed this way, the ‘puzzles’ presented at the outset make perfect sense. 1 Reframing the Problem1.1 Introduction1.2 Three puzzles1.2.1 Why is trichromatic vision an anomaly in diurnal mammals?1.2.2 Why does the colour system occupy such a large and central part in human vision?1.2.3 Why are the blue cones so rare?1.3 Recasting the question2 The Costs and Benefits of Spectral Vision2.1 Spectral information and object vision2.2 Encoding the spectral dimension of light2.2.1 ‘General’ versus ‘specific’ encoding2.2.2 Spectral encoding and the monochromat2.2.3 Spectral encoding and the dichromat2.2.4 Spectral encoding and the human trichromat2.3 Three puzzles revisited2.3.1 Why is trichromatic vision an anomaly in diurnal mammals?2.3.2 Why does the colour system occupy such a large and central part in human vision?2.3.3 Why are the blue cones so rare3 Conclusion. (shrink)

The paper examined the state of the academic staffing situation in Nigerian Public Universities with various factors constraining their professional development. Funding was identified as a major factor with attendant consequences such as brain drain, academic staff deficit, structural imbalance in the distribution of academic staff and inadequate capacity-building programmes for their staff. The paper observed that most Nigerian universities lack the framework for internal staff development programmes for their academic staff. Various internal capacity building programmes that could be organized (...) using senior academic staff within these universities were proposed. The paper identified professional development programmes in four world-class universities as models that could be adapted by Nigerian universities. The paper concluded that available potentials for academic staff development within Nigerian Public Universities remain largely untapped. (shrink)

: In Consciousness Explained, Daniel Dennett presents the Multiple Drafts Theory of consciousness, a very brief, largely empirical theory of brain function. From these premises, he draws a number of quite radical conclusions—for example, the conclusion that conscious events have no determinate time of occurrence. The problem, as many readers have pointed out, is that there is little discernible route from the empirical premises to the philosophical conclusions. In this article, I try to reconstruct Dennett's argument, providing both the philosophical (...) views behind the empirical premises, and the hidden empirical arguments behind the derivation of the philosophical conclusions. (shrink)

Over 35 years ago, Meltzoff and Moore (1977) published their famous article ‘Imitation of facial and manual gestures by human neonates’. Their central conclusion, that neonates can imitate, was and continues to be controversial. Here we focus on an often neglected aspect of this debate, namely on neonatal spontaneous behaviors themselves. We present a case study of a paradigmatic orofacial ‘gesture’, namely tongue protrusion and retraction (TP/R). Against the background of new research on mammalian aerodigestive development, we ask: How does (...) the human aerodigestive system develop and what role does TP/R play in the neonate’s emerging system of aerodigestion? We show that mammalian aerodigestion develops in two phases: (1) from the onset of isolated orofacial movements in utero to the post-natal mastery of suckling at 4 months after birth, and; (2) thereafter, from preparation to the mastery of mastication and deglutition of solid foods. Like other orofacial stereotypies, TP/R emerges in the first phase and vanishes prior to the second. Based upon recent advances in activity-driven early neural development, we suggest a sequence of three developmental events in which TP/R might participate: the acquisition of tongue control, the integration of the central pattern generator for TP/R with other aerodigestive CPGs, and the formation of connections within the cortical maps of S1 and M1. If correct, orofacial stereotypies are crucial to the maturation of aerodigestion in the neonatal period but also unlikely to co-occur with imitative behavior. (shrink)

Throughout the text, fundamental questions concerning the nature of visual perception are addressed.

This volume provides an up to date and comprehensive overview of the philosophy and neuroscience movement, which applies the methods of neuroscience to traditional philosophical problems and uses philosophical methods to illuminate issues in neuroscience. At the heart of the movement is the conviction that basic questions about human cognition, many of which have been studied for millennia, can be answered only by a philosophically sophisticated grasp of neuroscience's insights into the processing of information by the human brain. Essays in (...) this volume are clustered around five major themes: data and theory in neuroscience; neural representation and computation; visuomotor transformations; color vision; and consciousness. (shrink)

In this paper, I defend divine conceptualism against one prominent critique from William Lane Craig in his book God and Abstract Objects. Craig argues that the divine conceptualist’s only way out of the “bootstrapping objection” results in an unpalatable concession of defeat to the metaphysical anti-realist. Craig’s argument depends on an analysis whereby God is causally or logically prior to the divine concepts. As such, the conceptualist may resist it by adopting—following Ralph Cudworth—a version of divine conceptualism which does not (...) construe the relationship between God and His thoughts as one of either causal or logical priority. (shrink)

Studies on participation and spatial orientations of college students have examined aspects of university life, as projected through language, from a reportorial or narrative perspective, but hardly any one of these studies has been devoted exclusively to how students' participation structure, together with the activities participants orient to at the participation space, evokes shared socio-academic backgrounds and cultural constraints, a major way to gain access into the students' cognitive and pragmatic tendencies. This research, thus, addresses itself to Nigerian college students' (...) participation configuration, their participant roles, and the illocutionary goals of their encounters within the Goffmanian participation framework and discourse pragmatic parameters. For data, 100 interactions amongst students of the Faculty of Arts, University of Ibadan, Nigeria, were taped and scrutinised for participation forms and spatial descriptions. Two types of participation structure are manifest in the interactions, namely, unmarked and marked participations. The unmarked participation structure is the regular frame in which Goffman's ratification and non-ratification framework is strictly observed. The marked participation configuration, an unexpected interactional frame which bifurcates into accommodated and non-accommodated structures, takes interruptions by unaccredited participants as appropriate or inappropriate. The paper contends that participation configuration and contextual elements prescribe participant roles together with the pragmatic functions assigned to language and actions in the interactions. Thus, the illocutionary goals of participants, rooted in socio-academic matters and enabled by participation structures, spatial orientations and body language manipulations are contextually negotiated. (shrink)

Akin''s determinism paradox involves a physical system that predicts its own behavior, and then spitefully defies it. Here this paradox is reformulated in purely computational language, in terms of virtual machines. The paradox is related to the theory of self-reproducing automata; and a mathematical conjecture is given which, if verified, would resolve the paradox.

Nigerian Pidgin is a popular informal communicative code in Nigerian social, economic and political experience. It is sometimes spoken in formal situations in the hospital setting when participants find it pragmatically convenient. Despite its communicative significance, little research has been carried out on the use of Pidgin in conversational interactions in Nigerian hospitals, a gap this study fills by investigating how Pidgin is used in constructing emotions relating to social and medical conditions in hospitals. Seventy five interactions between doctors and (...) clients in Nigerian Pidgin were sampled; the data analysis was based centrally on relevance theory. Nigerian Pidgin evokes negative and positive emotions. Negative emotions manifest as pain and fear, while positive emotions appear as excitement and relief. Doctors and clients gain access to each other’s intentions through their shared knowledge of Pidgin, their co-construction of ailments, and their contextually based local interactional resources. They thus negotiate emotions as cue-dependent variables that are steered with the help of cognitive processes. (shrink)

Rönesans ve ardında Aydınlanma dönemiyle beraber gerçekleşen bilimsel ilerlemeler fazlaca dikkat çekmeyi başarmıştır. Bunun sonucunda modern bilim, bilginin en güvenilir kaynağı olarak kabul edilerek onun her meseleyi çözebileceği bir zemine oturtturulmuştur. Öyle ki bilim, Tanrı’nın var olup olmadığına dair de bilgi üretebileceği dillendirilmiştir. Bu aşamada ideolojik yaklaşımların ve din adına sergilenen bazı temelsiz akıl dışı argümanların katkısıyla da bilim artık kutsal bir müesseseye dönüştürülmüştür. Kutsala dönüştürülen bilim, bir diğer kutsal olan dinle artık ortak bir zeminde buluşamayacak hale dönüşmüş ve yanlış (...) bir dikotomiye alet edilmiştir. Dolayısıyla artık ilerleyen bilim, yavaş yavaş “Tanrı’yı yok etmeye” başlamıştır. Artık bu hale dönüşen bilim anlayışı ateistlerin de en büyük destek noktaları olmuştur. Kutsala dönüşen bu bilim anlayışı her ne kadar temelde Hıristiyanlık inancına karşıt olarak ortaya çıkmış olsa da yer yer tüm inançlara yansıtılmaya çalışılmıştır. Oysaki bilimden, “bilimin ilerlemesiyle Tanrı’nın yok olacağına” dair veri sunmasını beklemek aslında bilimin sınırlarından bihaber olmayı gerekli kılmaktadır. Bilimin ilerlemesiyle inancın yok olacağı söylemi, İslam dini açısından kabul edilebilir bir argüman olarak görülmemektedir. Çünkü İslam, aklı dinamik olarak tasvir etmekte ve tabiatı Tanrı’nın varlığının delili olarak sunmaktadır. Diğer taraftan bilimin ilerlemesiyle Tanrı’ya yer kalmayacağını iddia edenlerin unutmaması gereken önemli husus, dinin/imanın bir bilgi eksikliği olmadığı aksine bilginin insanı tasdiğe yönelttiği gerçeğidir. Ayrıca Müslümanların bilimde geri kalmalarının sebebini onların inançlarına bağlayanlar, bunu siyasi, sosyal ve ekonomik bazı sebeplerde araması gerekmektedir. (shrink)