The etiology of Tauopathies, a diverse class of neurodegenerative diseases associated with the Microtubule Associated Protein (MAP) Tau, is usually described by a common mechanism in which Tau dysfunction results in the loss of axonal microtubule stability. Here, we reexamine and build upon the canonical disease model to encompass other Tau functions. In addition to regulating microtubule dynamics, Tau acts as a modulator of motor proteins, a signaling hub, and a scaffolding protein. This diverse array of functions is related to (...) the dynamic nature of Tau isoform expression, post‐translational modification (PTM), and conformational flexibility. Thus, there is no single mechanism that can describe Tau dysfunction. The effects of specific pathogenic mutations or aberrant PTMs need to be examined on all of the various functions of Tau in order to understand the unique etiology of each disease state. (shrink)

The aim of this paper is to examine in detail the similarities and dissimilarities between Werner Heisenberg’s account of closed theories and Thomas Kuhn’s model of scientific revolutions. My analysis draws on a little‐known discussion that took place between Heisenberg and Kuhn in 1963, in which Heisenberg, having just read Kuhn’s Structure of Scientific Revolutions, compares Kuhn’s views to his own account of closed theories. I conclude that while Heisenberg and Kuhn share a holist conception of theories, a revolutionary model (...) of theory change, and even a notion of incommensurability, their views diverge fundamentally when it comes to the issue of scientific realism. I show that, contrary to popular opinion, Heisenberg is not an instrumentalist, but rather a pluralistic realist. (shrink)

From the Federal Theater Projects of the Great Depression to the disruptive performances of the 1960s and 1970s, theater has played an important role in American radicalism. This special issue of_ _Theater_ reports on socially conscious, politically active theaters in the United States. Despite the evaporation of Cold War passions and the rise of conservatism in the 1980s and 1990s, such theater work remains a persistent and evolving presence on the political landscape. Since the first inauguration of George W. Bush, (...) new opportunities have arisen for political performance and for significant new challenges to these artists. T_heater and Social Change_ not only tracks the historical evolution of political theater but also explores the current state and future prospects of different modes, including agit-prop, demonstrations, solo performance, Augusto Boal’s Theater of the Oppressed, and community-based production. With such notable contributors as Anna Deavere Smith, Jonathan Kalb, Holly Hughes, and Tony Kushner, the issue offers a diverse assemblage of personal statements, conversations, photographs, interviews, and performance text. _Contributors include:_ Reverend Billy, Jan Cohen-Cruz, Arlene Goldbard, Sharon Green, Lani Guinier, Holly Hughes, Jonathan Kalb, Tony Kushner, Judith Malina, Robbie McCauley, John O'Neal, Claudia Orenstein, Bill Rauch, Julie Salverson, Anna Deavere Smith, Alisa Solomon, Roberta Uno. (shrink)

We can think about ourselves in a variety of ways, but only some of the thoughts that we entertain about ourselves will be thoughts which we know concern ourselves. I call these first-person thoughts, and the component of such thoughts that picks out the object about which one is thinking—oneself—the self-concept. In this thesis I am concerned with providing an account of the content of the self-concept. The challenge is to provide an account that meets two conditions on first-person thought. (...) The account must show how we are aware of ourselves when we entertain first-person thoughts, so that we have an account that establishes the cognitive significance of first-person thoughts. But, in addition, this awareness must be as robust as the thinker’s ability to entertain first-person thoughts if our account is to respect the guaranteed referential success of the self-concept. I introduce both the subject matter of the thesis, and the constraints on a satisfactory account of that subject matter in the first chapter. In the second chapter I then set up a further problem: much of our self-knowledge is knowledge of our current mental states and it is often argued that we know about and can ascribe those mental states on the basis of introspection alone. The first constraint on an account of first-person thought described in the preceding paragraph requires that we be aware of ourselves in some way if our thoughts are to have the special cognitive significance of first-person thoughts. Yet, I argue, we neither do nor can introspectively observe a subject of thought and experience when we come to know about our mental states and experiences. The failure of introspection to supply us with perceptual information about a subject of thought presents us with the further potential problem. According to Fregean semantics sense determines reference: we count on the content of the elements of thought to determine the reference of terms that are used to express those elements. If we do not introspectively observe a subject of thought then we seem to be at a loss to account for the concept and we are at risk of having to accept that neither the self-concept nor the first-person pronoun are referential. In the remainder of my thesis I consider various responses that we can offer to this problem. First, I examine whether we can avoid the problem with an alternative account of first-person reference according to which reference is fixed by a reflexive rule, and whether we can also base an account of first-person thought on this account of first-person reference. Secondly, I look at the descriptivist view of first-person thought which could potentially provide both an account of first-person thought and first-person reference. These two suggestions must be rejected on the grounds that they fail to accommodate the special cognitive significance of first-person thought. A third approach to first-person thought argues that we employ an objective self-concept when we think about ourselves, a concept that is informed by bodily experience, rather than by introspective observation of a subject. Yet such an account cannot make sense of first-person thoughts in which we question our own embodiment. Lastly I consider whether it is possible to explain the cognitive significance of first-person thought in terms of non-conceptual first-person contents. (shrink)

This paper describes a long-standing, though little-known, debate between Paul Dirac and Werner Heisenberg over the nature of scientific methodology, theory change, and intertheoretic relations. Following Heisenberg’s terminology, their disagreements can be summarized as a debate over whether the classical and quantum theories are “open” or “closed.” A close examination of this debate sheds new light on the philosophical views of two of the great founders of quantum theory.

In this discussion, I engage the politics of intention to explore how structural racism structures the production of meaning and the practice of reason. Building on María Lugones's analysis of intention formation as a form of practical reasoning, I explore the reasoning at work during the 2011 Stand Your Ground (SYG) hearing of black survivor of domestic violence, Marissa Alexander, to contend that structural racism—in this case, both intimate personal violence and intimate state violence against black women—enacts race/gender domination through (...) projecting constructed intentions onto black women as a strategy to rationalize punishing black women. I also discuss two key black feminist critiques of reason—Patricia Hill Collins’ discussion of “controlling images” (2000) and Michelle Cliff's concept of the “mythic mind” (1982)—to propose controlling intentions as a framework to theorize how structural racism produces fictive intentions used to rationalize the criminal punishment of survival and justify that outcome as common sense. (shrink)

This article intervenes in a critical debate about the use of consent to distinguish sex from rape. Drawing from critical contract theories, it argues that sexual consent is a cruel optimism that often operates to facilitate, rather than alleviate, sexual violence. Sexual consent as a cruel optimism promises to simplify rape allegations in the popular cultural imagination, confounds the distinction between victims and agents of sexual violence, and establishes certainty for potential victimizers who rely on it to convince themselves and (...) others that their partners implicitly or explicitly agreed to sex. In each of these cases, the power of consent rests in its tendency to obscure sexual violence in a set of questions around victimhood and agency, rather than to clarify whether or when it has occurred. Following in the critical contract tradition, this article argues that the optimistic attachment to the clarifying power of consent helps to explain the persistent commitment to better sexual consent as a ‘solution’ to the problems of rape and sexual violence, and that this ‘solution’ is insufficient to the task. (shrink)

There is a growing recognition that fictions have a number of legitimate functions in science, even when it comes to scientific explanation. However, the question then arises, what distinguishes an explanatory fiction from a nonexplanatory one? Here I examine two cases—one in which there is a consensus in the scientific community that the fiction is explanatory and another in which the fiction is not explanatory. I shall show how my account of “model explanations” is able to explain this asymmetry, and (...) argue that realism—of a more subtle form—does have a role in distinguishing explanatory from non- explanatory fictions. (shrink)

At the center of quantum chaos research is a particular family of models known as quantum maps. These maps illustrate an important “horizontal” dimension to model construction that has been overlooked in the literature on models. Three ways in which quantum maps are being used to clarify the relationship between classical and quantum mechanics are examined. This study suggests that horizontal models may provide a new and fruitful framework for exploring intertheoretic relations.

The article engages with feminist care theories and practices of community building in the context of armed conflict. Based on an ethnographic study of the security concerns of Israeli citizens living in the Gaza Envelope and their positions regarding the siege on Gaza, we find that in this region, vernacular security is closely linked with care, social reproduction and communitarianism. Communitarian ethics is intertwined with separatist, state-centred discourses on national ‘trauma and resilience’. In this context, Jewish-Israeli women care for their (...) own communities as a way to ensure survival and civilian resilience. They generally disengage from moral dilemmas concerning the suffering of Palestinians. On a deeper level, the practice of security as care combines the hegemonic Israeli security paradigm of women’s soldierhood with an institutional and cultural obsession with trauma-oriented activities. Showing strong ethno-nationalist identifications, these women tend to overlook and even support the state’s violent siege on Gaza, which is seen as a zero-sum game. We conclude that the gendered dimensions of communitarian ethics in Israel are relevant for understanding the limitations and challenges of contemporary cosmopolitan feminism and a global politics of care. (shrink)

According to the psychological account of personal identity for someone to be one and the same person over time Y today must have some of the beliefs, desires, intentions and memories that X had yesterday, as well as some memories of the events that happened to X yesterday. But, on this account, we have the undesirable result that persons can be reduplicated unless we add an additional requirement: Y is uniquely psychologically continuous with X. In an attempt to avoid the (...) problem of reduplication in a different way I invoke arguments for active externalism and the embodied mind. The motivation for exploring embedded and embodied approaches to cognition is that they cast doubt on the easy separation of brain and body which is often taken for granted in the identity literature. With these approaches in mind, the simple assumptions by which brains are imagined to be transplanted into new bodies, and agents are said to be teletransported to new environments should be reviewed. Whilst embodiment provides us with some reasons to re-evaluate our understanding of brain transplant thought experiments, we ultimately see that the nature of teletransportation is consistent with the mind as both extended and embodied. (shrink)

One of the main goals of multicultural education is to prepare young people to participate in meaningful pedagogical and social issues. To achieve this goal, educators need to cultivate the basic rudiments of compassion and goodwill in the younger generation, rooted in a sense of empathy for others. Without a sense of compassion, the younger generation is unlikely to be motivated to reflect and act on the needs of the people around them. Therefore, it is necessary to start by involving (...) students in getting to know different ethnic cultures, where they can show compassion not only to people, but also to certain situations. Such knowledge forms the basis for interaction with different points of view and worldviews, as well as with the causes of pedagogical, psychological and social problems and the ways taken to solve them. (shrink)

Resident-to-resident aggression is quite prevalent in long-term care settings. Within popular and empirical accounts, this form of aggression is most commonly attributed to the actions of an aberrant individual living with dementia characterized as the “violent resident.” It is often a medical diagnosis of dementia that is highlighted as the ultimate cause of aggression. This neglects the fact that acts of aggression are influenced by broader structural conditions. This has ethical implications in that the emphasis on individual aberration informs public (...) policy strategies for prevention with a focus on restricting the freedom of individuals using behavioural modification, drugs, or other restraints with the intent to protect others from harm. A more ethical approach requires attention to the structural conditions of long-term care that both foster aggression and constrain prevention efforts. To this end, we turn to a model of relational citizenship that offers a theory of embodied selfhood and relationality as essential to human dignity, thus entailing human rights protections. The application of an ethic based on this model offers a more holistic prevention strategy for resident-to-resident aggression by drawing attention to the critical need and obligation to promote human flourishing through system level efforts. (shrink)

It has frequently been suggested that quantum mechanics may provide a genuine case of ontic vagueness or metaphysical indeterminacy. However, discussions of quantum theory in the vagueness literature are often cursory and, as I shall argue, have in some respects been misguided. Hitherto much of the debate over ontic vagueness and quantum theory has centered on the “indeterminate identity” construal of ontic vagueness, and whether the quantum phenomenon of entanglement produces particles whose identity is indeterminate. I argue that this way (...) of framing the debate is mistaken. A more thorough examination of quantum theory and the phenomenon of entanglement reveals that quantum mechanics is best interpreted as supporting what I call the “vague property” construal of ontic vagueness, where vague properties are understood in terms of determinable properties without the corresponding determinates. (shrink)

Pornographic speech harms women by playing a key role in sustaining the social conditions through which women's liberty and equality are undercut. Though there is a principled moral and constitutional basis for pursuing a legal strategy in fighting pornography, we should not overestimate the effectiveness of the law or underestimate its potential dangers. The struggle against pornography must be waged through education, expressive exploration, and protest, not through the law.

Morally contoured empathy is a form of reasonable partiality essential to the healthy care of dependents. It is critical as an epistemic aid in determining proper moral responsiveness; it is also, within certain richly normative roles and relationships, itself a crucial constitutive mode of moral connection. Yet the achievement of empathy is no easy feat. Patterns of incuriosity imperil connection, impeding empathic engagement; inappropriate empathic engagement, on the other hand, can result in self-effacement. Impartial moral principles and constraints offer at (...) best meager protection against these perils, and hence serve poorly in securing morally contoured empathy. More nuanced and practical guidance should be sought in normatively substantive conceptions of our roles and relationships and their defining moral stakes. These, joined with more abstract moral tools, can facilitate rich, narratively textured interpretations of moralitys demands. While the content of our normative conceptions must be continually debated, engaging in this debate is vital to the achievement of proper empathy, and thus to effective, respectful, morally healthy care of dependents. (shrink)

The Bayesian model of multisensory cue integration proposed by Ernst and Banks provides an attractive model for understanding a way that our sensory systems may interact. Moreover, it has been suggested that the process of multisensory integration that it models underpins conscious experiences with multisensory representational contents merged across modalities. Should we therefore take empirical support for the Bayesian model as evidence of the multimodality of perception? Focusing on evidence of integration across vision and touch, I argue that apparent support (...) for the model does not warrant the rejection of the view that each of our conscious perceptual experiences is associated with one and only one sense modality. (shrink)

Scientific models invariably involve some degree of idealization, abstraction, or nationalization of their target system. Nonetheless, I argue that there are circumstances under which such false models can offer genuine scientific explanations. After reviewing three different proposals in the literature for how models can explain, I shall introduce a more general account of what I call model explanations, which specify the conditions under which models can be counted as explanatory. I shall illustrate this new framework by applying it to the (...) case of Bohr's model of the atom, and conclude by drawing some distinctions between phenomenological models, explanatory models, and fictional models. (shrink)

Moral distress can consist in anxiety or concern about one’s capacity to meet challenges to one’s integrity; it can also consist in the sense that one has failed to meet these challenges, betraying fundamental moral values or commitments. When the sense of moral failure is compounded by feelings of frustration or impotence, of being constrained or impeded in one’s ability to act as one believes one ought, one experiences moral disempowerment. Drawing on narratives of moral distress emerging from work in (...) the clinical context, this essay explores a distinction between cases in which moral distress does, and does not, center around the experience of moral disempowerment. When moral distress is tied to moral disempowerment, the acute personal toll is joined with broader moral costs, for effective moral agency is stymied. If we are to support individuals’ resilience and effectiveness in working constructively with moral distress, we need to understand and redress the social, systemic, and institutional factors contributing to moral disempowerment. (shrink)

In her groundbreaking volume Anaesthetics of Existence: Essays on Experience at the Edge, Cressida Heyes provokes readers with the question, “How might experience not only motivate politics but also itself act as a medium of political change?” This essay builds on Heyes’s provocation by exploring self-making and self-advocacy within carceral political economies. Engaging Heyes’s discussion of “normative temporality,” I consider unstable subjectivities and a black feminist formation of “revelatory agency” to contend that the carceral consumption of human life-time expands, complicates, (...) or radically shifts the scope of the political. (shrink)

Terri Traudt, Joan Liaschenko, and Cynthia Peden-McAlpine’s study contributes to a much-needed reorientation in thinking about and working with the challenges of moral distress. In providing a vital example of nurses able to navigate morally distressing situations in positive and constructive ways, and offering an analysis of the component elements of these nurses’ success, the study helps identify promising directions we might take in addressing the epidemic of moral distress. It also invites important questions, concerning the challenges faced by clinicians (...) who do not who work in healthy “moral communities,” who lack the ethical competencies, and who don’t have the presumptive authority and recognition enjoyed by the seasoned clinicians studied here. We explore some of these questions, and suggest ways we might build on the insights of Traudt and colleagues’ study. (shrink)

Classical mechanics and quantum mechanics are two of the most successful scientific theories ever discovered, and yet how they can describe the same world is far from clear: one theory is deterministic, the other indeterministic; one theory describes a world in which chaos is pervasive, the other a world in which chaos is absent. Focusing on the exciting field of 'quantum chaos', this book reveals that there is a subtle and complex relation between classical and quantum mechanics. It challenges the (...) received view that classical and quantum mechanics are incommensurable, and revives another, largely forgotten tradition due to Niels Bohr and Paul Dirac. By artfully weaving together considerations from the history of science, philosophy of science, and contemporary physics, this book offers a new way of thinking about intertheory relations and scientific explanation. It will be of particular interest to historians and philosophers of science, philosophically-inclined physicists, and interested non-specialists. (shrink)

Despite widespread evidence that fictional models play an explanatory role in science, resistance remains to the idea that fictions can explain. A central source of this resistance is a particular view about what explanations are, namely, the ontic conception of explanation. According to the ontic conception, explanations just are the concrete entities in the world. I argue this conception is ultimately incoherent and that even a weaker version of the ontic conception fails. Fictional models can succeed in offering genuine explanations (...) by correctly capturing relevant patterns of counterfactual dependence and licensing correct inferences. Using the example of Newtonian force explanations of the tides, I show how, even in science, fiction can be a vehicle for truth. (shrink)

The problem of identity and identity of the individual, which exists throughout human history, is particularly acute at the intersection of epochs, when existing knowledge and skills are not enough to understand the processes taking place in society, history, and nature, and new theories and tools have not yet been developed. When a civilization was faced with a paradox, when it was decided whether to live as before or accept a new one, it was individuals who were able to go (...) beyond identity that showed a new path. It went against the existing dogmas, against identity. Moreover, over time, man had to accept many more rules and restrictions than at the beginning of his existence. At the intersection of epochs, there was an infusion of new ideas into society. This was done by people who did not just see the future in dreams or nightmares, but were able to imagine what the implementation of a particular postulate in the life of society entails. There was a crisis that literally buried all the old ideas about the world around us and other communities. It was then that the metaphysical perception of the world took on a real form, which, nevertheless, had to be worked out for the sake of the existence of society as a whole. (shrink)

We critically engage two traditional views of scientific data and outline a novel philosophical view that we call the pragmatic-representational view of data. On the PR view, data are representations that are the product of a process of inquiry, and they should be evaluated in terms of their adequacy or fitness for particular purposes. Some important implications of the PR view for data assessment, related to misrepresentation, context-sensitivity, and complementary use, are highlighted. The PR view provides insight into the common (...) but little-discussed practices of iteratively reusing and repurposing data, which result in many datasets’ having a phylogeny—an origin and complex evolutionary history—that is relevant to their evaluation and future use. We relate these insights to the open-data and data-rescue movements, and highlight several future avenues of research that build on the PR view of data. (shrink)

This volume presents an historical and philosophical revisiting of the foundational character of Turing's conceptual contributions and assesses the impact of the work of Alan Turing on the history and philosophy of science. Written by experts from a variety of disciplines, the book draws out the continuing significance of Turing's work. The centennial of Turing's birth in 2012 led to the highly celebrated "Alan Turing Year", which stimulated a world-wide cooperative, interdisciplinary revisiting of his life and work. Turing is widely (...) regarded as one of the most important scientists of the twentieth century: He is the father of artificial intelligence, resolver of Hilbert's famous Entscheidungsproblem, and a code breaker who helped solve the Enigma code. His work revolutionized the very architecture of science by way of the results he obtained in logic, probability and recursion theory, morphogenesis, the foundations of cognitive psychology, mathematics, and cryptography. Many of Turing's breakthroughs were stimulated by his deep reflections on fundamental philosophical issues. Hence it is fitting that there be a volume dedicated to the philosophical impact of his work. One important strand of Turing's work is his analysis of the concept of computability, which has unquestionably come to play a central conceptual role in nearly every branch of knowledge and engineering. (shrink)

We reconstruct Kuhn’s philosophy of measurement and data paying special attention to what he calls the “fifth law of thermodynamics”. According to this "law," there will always be discrepancies between experimental results and scientists’ prior expectations. The history of experiments to determine the values of the fundamental constants offers a striking illustration of Kuhn’s fifth law of thermodynamics, with no experiment giving quite the expected result. We highlight the synergy between Kuhn’s view and the systematic project of iteratively determining the (...) value of physical constants, initiated by spectroscopist Raymond Birge, that was ongoing when Kuhn joined Berkeley in 1956. Our analysis sheds light on various underappreciated aspects of Kuhn’s thought, especially his notion of progress as improvement in measurement accuracy. (shrink)

The ontic conception of explanation, according to which explanations are "full-bodied things in the world," is fundamentally misguided. I argue instead for what I call the eikonic conception, according to which explanations are the product of an epistemic activity involving representations of the phenomena to be explained. What is explained in the first instance is a particular conceptualization of the explanandum phenomenon, contextualized within a given research program or explanatory project. I conclude that this eikonic conception has a number of (...) benefits, including making better sense of scientific practice and allowing for the full range of normative constraints on explanation. (shrink)

This book will be of particular interest to those philosophers, scientists, and mathematicians who are interested in the foundations of science.

In 2012, the Geological Time Scale, which sets the temporal framework for studying the timing and tempo of all major geological, biological, and climatic events in Earth’s history, had one-quarter of its boundaries moved in a widespread revision of radiometric dates. The philosophy of metrology helps us understand this episode, and it, in turn, elucidates the notions of calibration, coherence, and consilience. I argue that coherence testing is a distinct activity preceding calibration and consilience, and I highlight the value of (...) discordant evidence and trade-offs scientists face in calibration. The iterative nature of calibration, moreover, raises the problem of legacy data. (shrink)

Despite an enormous philosophical literature on models in science, surprisingly little has been written about data models and how they are constructed. In this paper, I examine the case of how paleodiversity data models are constructed from the fossil data. In particular, I show how paleontologists are using various model-based techniques to correct the data. Drawing on this research, I argue for the following related theses: first, the ‘purity’ of a data model is not a measure of its epistemic reliability. (...) Instead it is the fidelity of the data that matters. Second, the fidelity of a data model in capturing the signal of interest is a matter of degree. Third, the fidelity of a data model can be improved ‘vicariously’, such as through the use of post hoc model-based correction techniques. And, fourth, data models, like theoretical models, should be assessed as adequate for particular purposes. (shrink)

Trust is more than mere reliance on another person. To trust someone is to rely on her goodwill for the care of something valuable. It is to have a confident expectation that the other person will take care of the valuable thing because she recognizes its value to you. It is to expect her to take care of it because she recognizes that she should take care of it. Therefore trust is a robustly moral attitude.