Histone acetylation is an important regulatory mechanism that controls transcription and diverse nuclear processes. While great progress has been made in understanding how localized acetylation and deacetylation control promoter activity, virtually nothing is known about the consequences of acetylation throughout entire chromosomal regions. An increasing number of genes have been found to reside in large chromatin domains that are controlled by regulatory elements many kilobases away. Recent studies have shown that broad histone acetylation patterns are hallmarks of chromatin domains. The (...) purpose of this review is to discuss how such patterns are established and their implications for regulating gene expression. BioEssays 23:820–830, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

This is a review of H. Duméry’s volume Imagination et religion. Éléments de judaïsme, éléments de christianisme. The author studies biblical religion and the origins of the Christian religion, classifying and recording the imaginative element that feeds the narratives of piety: hence the rehabilitation of the myths that frame the functioning of religious representations. The author suggests that the imagination, in its deepest resources, forges the human social, has the power to invent all social roles, and causes the emergence of (...) attitudes of devotion or renunciation which are a human prerogative. (shrink)

This is a review of H. Duméry’s volume Imagination et religion. Éléments de judaïsme, éléments de christianisme. The author studies biblical religion and the origins of the Christian religion, classifying and recording the imaginative element that feeds the narratives of piety: hence the rehabilitation of the myths that frame the functioning of religious representations. The author suggests that the imagination, in its deepest resources, forges the human social, has the power to invent all social roles, and causes the emergence of (...) attitudes of devotion or renunciation which are a human prerogative. (shrink)

Emery, Lucilius A. Concerning Justice. New Haven: Yale University Press, 1914. vii, 170 pp. Reprinted 2002 by The Lawbook Exchange, Ltd. ISBN 1-58477-234-4. Cloth. $60. * This volume reprints the Storrs lectures delivered by Emery [1840-1920] at Yale University in 1914. Emery's profound knowledge of constitutional law and keen interest in philosophy and history are clearly evident here. Beginning with conceptions of justice in Antiquity and in the Judeo-Christian tradition, Emery develops a general theory of rights, (...) and uses it as a basis for his definition of justice. His other lectures deal with the securing of justice. Influenced perhaps by the outbreak of hostilities in Europe, Emery asserts that the United States has created the finest system yet for its preservation. "It is most emphatically a book which, once read, is kept on hand for a re-reading." H.W.C. Yale L.J. 24: 263 as cited in Marke, A Catalogue of the Law Collection at New York University (1953) 191. Dictionary of American Biography 144-145. (shrink)

ipamati kistamati pari tumatimis: Luwian and Hittite Studies Presented to J. David Hawkins on the Occasion of His 70th Birthday. Edited by Itamar Singer. Emery and Claire Yass Publications in Archaeology, Monograph Series, vol. 28. Tel Aviv: Tel Aviv University Institute of Archaeology, 2010. Pp. xx + 262, illus. $65.

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 525 "an awareness of its perfection in perfect sell-identity" stems from his own theological bias: if God is to be connected with the world, His thinking cannot be merely a thinking about itself; His mind must also contain the Ideas of the sensible world. The inconsistency is quite apparent in the concluding paragraph of the introductory chapter three on "SellKnowledge ": If we study chapters seven and (...) nine of Book Lambda against the background of these texts on the meaning of friendship, it becomes apparent that a fortiori God's thinking must concern his own being and that "the thinking of thinking" is the supreme form of self-knowledge. Far from being an objectless returning to oneself, this knowledge concerns the very being of the First Principle. It would also seem to fot|ow that iust as knowing a friend is a certain degree of self-knowledge because of the ontological kinship between the self and a friend, God, in knowing himself, also knows, to a certain degree, the essential principles of things in so far as he is the first being encompassing within himself the perfections which other beings possess. This would, however, not imply that the first being would know the world as distinct from himself or as dependent on himself (pp. 33-34). How can God (the Unmoved Mover) think only of Himself, and at the same time, to a certain degree (whatever this means) know also the essential principles of things, the perfections which other beings possess? And what textual justification is there for attributing this position to Aristotle? There are a number of errors in the text. Some of them are as follows: (1) On p. 21 Elders quotes from Laws 987b, in spite of the fact that the Laws ends on 969c. The passage referred to would have to be in Epinomis, but at 987b there is nothing of the text he quotes, to wit, vo~g ~v n0ooXQf3o0oa~E~0~tv 6006g 0~tv. (2) On p. 24, note 41, he correctly gives the text at 432a4 as ~ ~oggdSEo~xotg do0n~o~g x6 vo~x6 ~oxt but makes it mean: '~ere are phantasmata in which the intelligible things are contained." Evidently he confuses this with the passage at 431b1--4. (3) On p. 279, p~.~oxr should read p~i~.t~r (4) On p. 5, ~oo~v should read 6.~ao6v. K. W. Hsaa~oroN Emery University In Our Image and Likeness: Humanity and Divinity in Italian Humanist Thought. Two Volumes. By Charles Trinkaus. (Chicago: The University of Chicago Press, 1970. Pp. 985. $22.50) I. Since the appearance of Burckhardt's classic essay more than a century ago, three schools of thought have grown up around the problem of the nature and extent of humanism 's relationship to Christianity. The classic position, represented by Burckhardt, Symends, Dilthey, Gentile, Cassirer, Saitta, and others, has interpreted humanism as an essentiaUy anti-Christian, anti-scholastic, rationatistic, and individualistic phenomenon caught up in an overwhelming concern for attaining to historical greatness in this world. If religion has been considered at all (and it is usually left to take care of itself), it has been so reinterpreted as to become consistent with the interests of emerging secularism, liberalism, and modern science. Opposing the Burckhardtian position, however, is one originally associated with the work of Giuseppe Toffanin and, more recently, Hiram Haydn. Here, Renaissance humanism is seen to be fundamentaUy Catholic, orthodox, and traditional---the two movements joined in perfect harmony by a common concern for antiquity and universaiism, for Latinity, faith, and corporate elitism, and by a common opposition to democratic particularism, heresy, individualism, modernity, and the vernaculars. What makes these two positions extreme, however, is the existence of the largest, most 526 HISTORY OF PHILOSOPHY moderate, and most diversified camp. Originating with Thode, Pastor, Olgiati, and Joachimsen, among a host of others, it has encompassed the general view that humanism and Christianity are separate yet interrelated. For some, medieval Catholicism is not the antithesis but the fountainhead of Renaissance humanism--the religious cause of a secular effect. For others, humanism is a novel intellectual movement, but one yet operating within a still... (shrink)

Process engraver and printer Emery Walker was a pivotal figure in the English, American, and continental European Private Press Movement from the 1880s until his death in 1933. This article looks at his theories for the typography, design, and production of books, and how those theories were developed by key designers and close associates of Walker such as William Morris, T. J. Cobden Sanderson, and Bruce Rogers and through the practical teaching of figures such as J. H. Mason and (...) Edward Johnston. It examines how the theories were then taken up by the exponents of fine printing from the early 20th century through to the 1930s, focusing on the presses of Bernard Newdigate, Harry Kessler, Harold Curwen, and Francis Meynell. From these presses, and also via Stanley Morison and the Monotype Corporation, Walker’s theories are shown to have spread into mainstream book publishing in the first half of the 20th century. The article considers questions of whether the improvement in the readability of books in the early 20th century has had a continuing impact in book publishing, and makes suggestions how to access the incunabula referenced by the designers discussed, as well as collections of private press books and other early 20th-century fine printing. (shrink)

I argue that there are such things as nomological probabilities—probabilities that play a certain explanatory role with respect to stable, long-run relative frequencies. Indeed, I argue, we should be willing to accept nomological probabilities even if they turn out to be metaphysically weird or even wholly sui generis entities. I then give an example of one way in which this argument should shape future work on the metaphysics of chance by describing a challenge to a common group of analyses of (...) objective probability—Humean analyses— understood as analyses of nomological probability. (shrink)

Ayahuasca, a hallucinogen with profound consciousness- altering properties, has been increasingly utilized in recent studies (e.g., Strassman, 2001; Shanon, 2002a,b). However, other than Shanon's recent work, there has been little attempt to examine the effects of ayahuasca on perceptual, affective and cognitive experience, its relation to fringe consciousness or to pertinent personality variables. Twenty-one volunteers attending a seminar on ayahuasca were administered personality measures and a semi-structured interview about phenomenal qualities of their experience. Ayahuasca ingestion was associated with profound alterations (...) of temporal- spatial experiences including expansive space and slowed time. Ayahuasca use was also associated with positive emotional states, higher levels of fantasy proneness and psychological absorption and a greater openness to mystical experiences. Conversely, quickened time was associated with negative emotionality. The results are discussed within a multi-faceted model of fringe consciousness with a particular emphasis on Hunt's (1995) models of cross-modal translation as the basis for higher-order symbolic cognition and support James' (1890/1950) contention that fringe consciousness is essential to human cognition. (shrink)

Social scientists have long examined the changing role of the individual, and the influence of individualism in social and economic arrangements as well as behavioral decisions. With respect to co-operative behavior among farmers, however, the ideology of individualism has been little theorized in terms of its relationship to the longstanding virtue of independence. This paper explores this relationship by combining analysis of historical literature on the agricultural cooperative movement with the accounts of contemporary English farmers. I show that the virtue (...) of independence is deployed to justify a variety of cooperative (formal and informal) and non-cooperative practices and that, despite apparently alternative interpretations, independence is most often conflated with individualistic premises. That conflation, I argue, leads farmers to see their neighbors as natural competitors: as those from whom which independence must be sought. This has the effect of masking the structural dependencies which farmers face (such as lenders and large purchasers) and limits the alternatives available to them to realize a view of independence that is maintained, rather than opposed, by interdependent collective action. Thus perceived, individualism is an ideological doctrine that succeeds by appealing to the virtue of independence, while simultaneously denying its actual realization. (shrink)