The Hippo pathway, a cascade of protein kinases that inhibits the oncogenic transcriptional coactivators YAP and TAZ, was discovered in Drosophila as a major determinant of organ size in development. Known modes of regulation involve surface proteins that mediate cell‐cell contact or determine epithelial cell polarity which, in a tissue‐specific manner, use intracellular complexes containing FERM domain and actin‐binding proteins to modulate the kinase activities or directly sequester YAP. Unexpectedly, recent work demonstrates that GPCRs, especially those signaling through Galpha12/13 such (...) as the protease activated receptor PAR1, cause potent YAP dephosphorylation and activation. This response requires active RhoA GTPase and increased assembly of filamentous (F‐)actin. Morever, cell architectures that promote F‐actin assembly per se also activate YAP by kinase‐dependent and independent mechanisms. These findings unveil the ability of GPCRs to activate the YAP oncogene through a newly recognized signaling function of the actin cytoskeleton, likely to be especially important for normal and cancerous stem cells. (shrink)

This paper proposes an adaptive formation tracking control algorithm optimized by Q-learning scheme for multiple mobile robots. In order to handle the model uncertainties and external disturbances, a desired linear extended state observer is designed to develop an adaptive formation tracking control strategy. Then an adaptive method of sliding mode control parameters optimized by Q-learning scheme is employed, which can avoid the complex parameter tuning process. Furthermore, the stability of the closed-loop control system is rigorously proved by means of matrix (...) properties of graph theory and Lyapunov theory, and the formation tracking errors can be guaranteed to be uniformly ultimately bounded. Finally, simulations are presented to show the proposed algorithm has the advantages of faster convergence rate, higher tracking accuracy, and better steady-state performance. (shrink)

Introduction -- Approaching reality: Chinese ontology and the potentiality of time -- Cinema of thought: directed consciousness in Chinese Marxist film theory -- Soft film theory: life in all its presence and concreteness -- Fey Mou: the presence of an absence -- Cinema of ideation, cinema of play: the early Cantonese sound film -- Conclusion.

v. 1-32. Mou Zongsan xian sheng quan ji -- [33] Mou Zongsan xian sheng quan ji. Zong xu xiang mu.

本书收录了作者讲授宋明儒学、反映学者思想发展的讲辞文本形式,以及对于明代名儒刘蕺山的学术及刘氏区分“心宗”与“性宗”进行研究的文章等。.

In this paper, I give a metaphilosophical analysis of the core idea of deflationism by discussing some basic conceptual and methodological issues involved in the debate between deflationism and substantivism. In so doing, I argue for three positive points. First, the crux of the dispute between deflationism and substantivism is whether or not truth is substantive in its metaphysical nature and in its explanatory role in philosophical enterprises, rather than whether or not a minimal approach regarding conceptual resources is taken (...) to explain truth; a minimal approach itself is philosophically innocent. Second, there is no intrinsic connection between the core idea of deflationism and the Tarski-style equivalence thesis, which is often identified as implying or supporting the former. Third, there are some unbridged fundamental gaps between the core idea of deflationism and various redundancy theses; these redundancy theses cannot be identified as the former, nor can they be used to justify the former on their own. (shrink)

Any counterfactual with a true antecedent and a true consequent is invariably predicted to be true by the standard Stalnaker–Lewis semantics. But many such true–true counterfactuals appear false to ordinary speakers, which is considered by many authors as evidence that the standard semantics should be revised. However, Walters and Williams prove that allowing true–true counterfactuals to be false would unacceptably invalidate some very plausible logical principles. The objective of this paper is to provide a pragmatic account of seemingly false true–true (...) counterfactuals, which explains why such counterfactuals seem false to ordinary speakers while being true semantically. In particular, a pluralistic pragmatic account is pursued: I argue that some true–trues seem false because they conversationally implicate some falsehood, and some others seem false because the focus (intonation stress) involved in them invokes some pragmatic re‐interpretation that affects speakers' truth‐value judgments. (shrink)

A concise alphabetic guide to the main concepts, figures, topics and important movements of thought that have shaped Chinese philosophy over the last three thousand years. The entries are concisely written, terms are cross-referenced and transcriptions are typically given in the pinyin system while the Chinese originals for important concepts are also provided. Chinese Philosophy A-Z stresses philosophical relevance in choosing entries while paying due attention to historical links between relevant ideas and movements of thought. The volume also shows how (...) some of the central ideas under discussion contribute to the philosophical enterprise as a whole. The book is aimed at students, teachers of philosophy, and educated non-specialists who are interested in Chinese philosophy, particularly those readers new to Chinese philosophy. (shrink)

本书包括周敦颐的“太极图”,张载“气”的哲学,王安石的“新学”思想,二程的理学思想,朱熹的理本体论哲学,陆九渊的“心学”,陈亮“道在物中”的思想等内容。.

The History of Chinese Philosophy is a comprehensive and authoritative examination of the movements and thinkers that have shaped Chinese philosophy over the last three thousand years. An outstanding team of international contributors provide seventeen accessible entries organised into five clear parts: Identity of Chinese Philosophy Classical Chinese Philosophy : Pre-Han Period Classical Chinese Philosophy : From Han Through Tang Classical Chinese Philosophy : From Song Through Early Qing Modern Chinese Philosophy: From Late Qing Through 21st Century This outstanding collection (...) is essential reading for students of Chinese philosophy, and will be of interest to those seeking to explore the lasting significance this rich and complex philosophical tradition. (shrink)

Ruiping Fan responds to Ho Chuen Kwan by arguing that Kwan’s criticisms are grounded in liberal individualist presumptions and misrepresent traditional Confucian teachings. Confucian morality and its value of harmony do not imply self-determination; rather, authentically Confucian views support family determination: for important individual issues, both the individual and the family possess moral authority and hold a veto right in decisions. This is a middle-way position, as it rejects not only individual determination but also parental domination. Fan admits that his (...) notion of Confucian family determination is not found directly in the classical texts, but believes broader understanding of the importance of the family in Confucian teachings supports his notion, as do the ritual practices recorded in classical texts. Fan argues also that Kwan draws a false contrast between familial decision making and the subject’s own determination of what is good and right: in Confucian tradition, family determination is itself precisely how we find and follow the proper way. Moreover, a distinctively Confucian value of liberty is embedded within traditional notions of harmony; this Confucian conception of harmonious liberty contrasts with liberal tradition’s self-initiating conception of liberty, while also avoiding the opposite extreme of family authoritarianism imposed by compulsory laws. Confucian familial decision making is neither paternalistic nor democratic, but rather harmonious. (shrink)

Production and comprehension have long been viewed as inseparable components of language. The study of vision, by contrast, has centered almost exclusively on comprehension. Here we investigate drawing—the most basic form of visual production. How do we convey concepts in visual form, and how does refining this skill, in turn, affect recognition? We developed an online platform for collecting large amounts of drawing and recognition data, and applied a deep convolutional neural network model of visual cortex trained only on natural (...) images to explore the hypothesis that drawing recruits the same abstract feature representations that support natural visual object recognition. Consistent with this hypothesis, higher layers of this model captured the abstract features of both drawings and natural images most important for recognition, and people learning to produce more recognizable drawings of objects exhibited enhanced recognition of those objects. These findings could explain why drawing is so effective for communicating visual concepts, they suggest novel approaches for evaluating and refining conceptual knowledge, and they highlight the potential of deep networks for understanding human learning. (shrink)

本书介绍了证据法学的基本知识、基本理论,并以科学性、准确性为原则来解决实务问题。.

Ben shu hui ji le zhu zhe de wei rao 20 shi ji zi ran ke xue yan jiu zhong suo she ji"ke xue ben yuan"yi ji"ke xue fang fa lun"deng ji ben ming ti,Zhen dui jin xie nian fa sheng zai guo nei wai ke xue sheng huo zhong mou xie zhong da shi jian suo zuo de ruo gan fan si.

本书不仅从证据学意义上探讨了“视听资料的概念”、“视听资料的收集”、“视听资料的审查判断”、“视听资料的运用”等程序性内容,而且从实际性出行,对视听资料的几种主要表现形式,如录音资料、录像证据、计算机 证据、电子数据资料分别作了深入的论述。.

Notions of unknown truths and unknowable truths are important in formal epistemology, which are related to each other in e.g. Fitch’s paradox of knowability. Although there have been some logical research on the notion of unknown truths and some philosophical discussion on the two notions, there seems to be no logical research on unknowable truths. In this paper, we propose a logic of unknowable truths, investigate the logical properties of unknown truths and unknowable truths, which includes the similarities of the (...) two notions and the relationship between the two notions, and axiomatize this logic. (shrink)

The graph tong同and its associated concepts, such as da-tong (Great tong大同) and xuan-tong (mystic or dark tong玄同), have played important roles in the development of Chinese philosophy. Yet tong has received scant attention from either western or eastern scholarships. This paper is a first attempt to remedy such regret. Unlike usual understandings of tong as sameness or unity, this paper presents a nuanced account from early China, that is, ‘difference to one,’ a definition from the Mozi墨子. This definition can be (...) supported from etymological, textual, and lexical evidence. ‘Difference to one’ should not be solely attributed to a Mohist understanding; it in fact represents a common understanding of tong across philosophical streams in early China. This nuanced account provides new insights into the concept of tong in early philosophical texts, and furthermore breaks solid grounds for further studies of tong and its associated concepts. (shrink)

In recent years, knowledge management has been utilized as an essential strategy to foster the creation of organizational intellectual capital. Organizational intellectual capital can be derived both individually and collectively in the process to create, store, share, acquire, and apply personal and organizational knowledge. However, some organizations only focus on the development of public good, despite the concerns arising from individuals' self-interest or possible risks. The different concern of individual and collective perspectives toward knowledge management inevitably leads to ethical conflicts (...) and ethical culture in the organization (Jarvenpaa et al., J Manage Inf Syst 14(4): 29-64, 1998; Ruppel and Harrington, IEEE Trans Prof Commun 44(l): 37-52, 2000). The purpose of this study is to examine the ethical climate within the organization and its possible influence on members' evaluation, satisfaction, engagement, and job performance with respect to knowledge management practice. The research results reveal that several types of organizational ethical climate coexist in the organization and have different degrees of influence on employees' attitude as well as participation in knowledge management activities. In this article, we argue the importance of organizational ethical climate and highlight the implications of such a climate for facilitating knowledge management. (shrink)

Healthcare systems in Singapore, Hong Kong, and mainland China are strikingly distinct from those in the West. Economically speaking, each of the aforementioned Eastern systems relies in great measure on private expenditures supplemented by savings accounts. Western nations, on the other hand, typically exhibit government funding and wariness about healthcare savings accounts. This essay argues that these and other differences between Pacific Rim healthcare systems and Western systems should be assessed in light of background Confucian commitments operating in the former. (...) In the Confucian context, bioethics and healthcare policy have a unique content, texture, and set of implications that often affront Western assumptions about the appropriate individual autonomy of patients and the appropriate character of social safety nets for healthcare. (shrink)

Contrastivism is the view that knowledge is a ternary relation between an agent, a content proposition, and a contrast, and it explains that a binary knowledge ascription sentence appears to be context-sensitive because different contexts can implicitly fill the contrast with different values. This view is purportedly supported by certain linguistic evidence. An objective of this paper is to argue that contrastivism is not empirically adequate, as there are examples that favor its contextualist cousin. Thereafter, I shall develop a contextualist (...) account for the relevant linguistic data. The account consists of a contextualist semantics and some rules of pragmatics. The two parts combined show that contrastivism is neither sufficient nor necessary as a satisfactory theory of knowledge ascriptions. (shrink)

Xuantong 玄同 (tentatively translated as dark oneness) is a unique Daoist idea that represents an ideally mental and physical state as a result of cultivation. However, owing to limited context in the Laozi, there is no consensus on the interpretation of xuantong. Contemporary studies have also neglected xuantong’s evolution in early texts and assumed a homogeneous understanding, and hence, failed to provide a nuanced account. In this article, I investigate how xuantong evolves from the Guodian Laozi to the Huainanzi and (...) Wenzi. I argue that although xuantong may originate from the Laozi, it is in the Wenzi that a coherent theory of xuantong is accomplished. This theory advocates an orderly process of cultivation that covers internal mental states, external acts, and integration with the whole universe. The cultivation would eventually lead people to adopt an undifferentiated perspective on, and reach oneness with, all things in the universe. (shrink)

Parental participation has gained significant attention in environmental psychology, which has revealed a need for an instrument that can measure parental participation with children regarding environmental issues. The present study met this need by validating the parental participation in the environment scale. This process began with 45 Chinese parents participating in an individual interview and group discussions, which helped generate a list of eighteen parent-child environmental activities. The activities were then modified and validated in the current study with a diverse (...) group of 969 parents recruited from six major Chinese cities. Both score structure evidence and generalizability evidence were obtained within this sample, and psychometric tests suggested a single factor construct with nine items. Once the PPE scale was revised, it showed measurement invariance across the parent who responded to the items, across the child’s primary caregiver, across the family’s living region, as well as across the family’s income group. Finally, evidence based on relations to other variables showed a relationship among parents’ PPE, pro-environmental behavior, and connectedness with nature. As a result, the study provided a novel measure to assess pro-environmental socialization via parental participation. (shrink)

The ‘Wu xing’ belongs to Guodian bamboo slips texts, which were buried around 300 BCE and excavated in 1993. Its relation with Mengzi is widely investigated. Yet how it is philosophically related to Xunzi receives little attention. In this article, I illustrate a neglected relation between ‘Wu xing’ and Xunzi, by elucidating how shan 善 (goodness) is first raised in ‘Wu xing’ and developed by Xunzi into a concrete idea. Both ‘Wu xing’ and Xunzi propose that shan exists in action, (...) which boils down to the harmonious unity of the mind and body, and to secure the ideal relation between the mind and body requires constant learning and practicing, particularly, of rituals. Learning and practicing not only lead one to realize shan, but eventually to become a consummate practitioner of rituals, to use Xunzi’s words, to become a sage. (shrink)