The Fist-Edge-Palm task, a manual hand task, has been used to detect frontal dysfunctions in clinical situations: its performance failures are observed in various prefrontal cortex -related disorders, including schizophrenia. However, previous imaging studies reported that the performance of the FEP task activated motor-related areas, but not the PFC. Here, we aimed to investigate the relationships between the performance of the FEP task and PFC functions. Hemodynamic activity in the PFC, including the dorsolateral PFC and frontal pole, was recorded. Healthy (...) young subjects performed the FEP task as well as a palm tapping task three times. The subjects also completed a Wisconsin Card Sorting Test and Schizotypal Personality Scale questionnaire. We found that hemodynamic activity in the PFC increased in the first trial of the FEP task but decreased considerably in the second and third trials compared to the PT task. The number of performance errors in the FEP task also decreased in the second and third trials. Error reduction in the FEP task between the first and second trials was negatively correlated with schizotypal trait and the number of perseveration errors in the WCST. Furthermore, changes in the PFC hemodynamic activity between the first and second trials were positively correlated with error reduction in the FEP task between the first and second trials, and negatively correlated with the number of perseveration errors in the WCST. These results suggest that learning in the FEP task requires PFC activation, which is negatively associated with perseveration errors in the WCST. The results further suggest that the FEP task, in conjunction with near-infrared spectroscopy, may be useful as a diagnostic method for various disorders with PFC dysfunction. (shrink)

dai 1-kan. Ningen, kyōiku ga umarekawaru tame -- dai 2-kan. Ningen to no deai, kyōiku to no deai -- dai 3 kan. Ningenrashiku naru tedate -- dai 4-kan. Jinrui no kibō, osanago -- dai 5-kan. Shishū, ushinawareta kisetsu o motomete -- dai 6-kan. Aru mazushiki shōgai no kiroku -- [7] Kyōiku to kyōikugaku.

It has been reported as a robust effect that people are likely to select a matching case in the Wason selection task. For example, they usually select the 5 case, in the Wason selection task with the conditional "if an E, then a not-5". This was explained by the matching bias account that people are likely to regard a matching case as relevant to the truth of the conditional (Evans, 1998). However, because a positive concept usually constructs a smaller set (...) than its negative one does (a rarity assumption), it is more effective to get information on the truth of the conditional in a positive set than in a negative set. Thus the optimal data selection account can also explain the effect. The set size of Q and matching by introducing negation were manipulated independently in four experiments. From the results it was inferred that the so-called matching bias was an amalgam of two different cognitive components-relevance judgement by matching and optimal data selection. (shrink)

『日本唯物論史』などで知られるわが国の唯物論哲学の開拓者・永田廣志の生涯をまとめ、その理論活動の意義を解明。哲学研究者と在野の郷土史家との共同研究が生み出した成果。本邦初公開の貴重な資料や秘蔵写真も多 数紹介。.

Since the first half of the nineteenth century in which English was introduced as the language of higher education in India, the word and concept of “philosophy” has played an important role in Indian intellectual life. First the study of philosophy must have meant the study of Western philosophy in Indian universities, butlater various attempts were made to discover the Indian versions of philosophical traditions in Sanskrit literature. Today no one doubts that there has been a rich and very long (...) tradition of such intellectual activities as are fully compatible with what European philosophers have actually been doing. Nevertheless, it is sometimes very difficult to draw a strict line between philosophy and religion in Indian thought. The present study will focus on that passage of the Nyāyamañjarī by a Kashmirian Nyāya scholar Jayanta which deals with the justification of the authority of the Vedas and other religious scriptures. From the analysis of the passage we may detect that there are two different dimensions in his application of logic for this issue. On the one hand he appeals to logical thinking for the defence of the Vedic authority and tries to establish the proper proof. But on the other hand he seems to be conscious of the limitation of reasoning, for he refers to those thinkers without refuting them in the latter half of the passage, according to whom every religious scripture must be accepted as valid insofar as the path of reasoning and argumentation is taken. (shrink)

Minami–Sakai :883–898, 2016) investigated the cofinal types of the Katětov and the Katětov–Blass orders on the family of all \ ideals. In this paper we discuss these orders on analytic P-ideals and Borel ideals. We prove the following:The family of all analytic P-ideals has the largest element with respect to the Katětov and the Katětov–Blass orders.The family of all Borel ideals is countably upward directed with respect to the Katětov and the Katětov–Blass orders. In the course of the proof of (...) the latter result, we also prove that for any analytic ideal \ there is a Borel ideal \ with \. (shrink)

We investigate how weak square principles are denied by Chang’s Conjecture and its generalizations. Among other things we prove that Chang’s Conjecture does not imply the failure of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\square_{\omega_1, 2}}$$\end{document}, i.e. Chang’s Conjecture is consistent with \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\square_{\omega_1, 2}}$$\end{document}.

A proof is given for the theorem that at least one bound state exists in a one-dimensional attractive potential however weak it may be. The proof is constructive in that it provides a method to explicitly solve the eigenvalue problem for the eigenvalues as well as the eigenfunctions. The method is well suited to precise numerical calculations.

The genesis for this volume was in the bombing of Japan during World War II, where the author, as a young boy, watched the bombers overhead, speculating about the lives of the pilots and their relationship with those huddled on the ground._ From this disturbing diorama, Professor Hiroshi Kojima, the translator of Martin Buber into Japanese, unfolds a new approach to Buber's “I-Thou” relation, drawing upon insights from Husserl, Heidegger, and others in the tradition of continental philosophy to extend (...) and deepen Buber's thought. In chapters that reflect upon a wide range of phenomena—from religion, science, and technology, to imagination, embodiment, and power—Professor Kojima articulates a conception of what it means to be a human being that stands as an alternative to atomism and alienation of the modern world. Analyses of haiku and other aspects of Japanese culture demonstrate how Kojima's theory can illuminate the spiritual traditions of both East and West. Original in its thought and revealing in its insight into Japanese thought and culture, _Monad and Thou__ represents the life's work of one of Japan's great thinkers. (shrink)

Rheumatoid arthritis (RA) may not be a multifactorial disease; it can be hypothesized that RA is developed through a series of events following a triggering event, which is the emergence of a chemokine for neutrophils in the synovium. IL‐17A, secreted by infiltrated neutrophils, stimulates synoviocytes to produce CCL20, which attracts various CCR6‐expressing cells, including Th17 cells. Monocytes (macrophages) appear after neutrophil infiltration according to the natural course of inflammation and secrete IL‐1β and TNFα. Then, IL‐17A, IL‐1β, and TNFα stimulate synoviocytes (...) to produce CCL20, amplifying the inflammation. Varieties of chemokines secreted by infiltrating cells accumulate in the synovium and induce synoviocyte proliferation by binding to the corresponding G protein‐coupled receptors, thus expanding the synovial tissue. CCL20 in this tissue attracts circulating monocytes that express both CCR6 and receptor activator of NF‐κB (RANK), which differentiate into osteoclasts in the presence of RANKL. In this way, pannus is formed, and bone destruction begins. (shrink)

Yama (2001) argued that the matching bias effect was an amalgam of a genuine matching effect and a set size effect. However, Evans (2002) pointed out some problems with Yama's argument. One was on the matching index used in Yama (2001). The others concerned a gap between Yama's (2001) interpretation of matching bias and Evans' (1998) recent discussions that had placed emphasis on the problem of implicit negation. I reply to these claims taking Oaksford (2002) into consideration. Further, I propose (...) a framework connecting context, goal, utility, and relevance, and including a hierarchical structure of goals. I argue that theories of reasoning can be developed and extended with the framework. (shrink)

The lingering mystery of John Rawls’s reflective equilibrium is that its nature is unclear. Rawls at times suggests he is merely describing people’s conceptions of justice, whereas at other times he implies that his reflective equilibrium is a way to justify his conception of justice. Faced with seemingly conflictual passages, most scholars privilege the justificatory ones. However, I argue that this is not an effective strategy because understanding how the descriptive and justificatory aspects of reflective equilibrium fit together is the (...) key to unlocking its nature and actual force. This paper compares Rawls’s method to the philosophical method of later Wittgenstein in his so-called private language argument to argue how the descriptive and justificatory aspects of Rawls’s reflective equilibrium fit together. In my view, both philosophers’ methods are descriptive clarifications of our unclear conceptions. However, their clarification is not just descriptive; they also aim at their readers achieving enlightenment. Importantly, I argue, that enlightenment offers us justification of the conception resulting from their clarification. Hence, their methods are justificatory as well. Finally, I claim that this way of understanding reflective equilibrium makes us realise how Rawls could respond to a prominent objection to it. (shrink)

I examine the tension between biopolitics and necropolitics through three themes that I have perceived and that are related to my life in Japan. First, I examine the transformation of hospitals and medical care, particularly for the elderly, through my experience of sharing the end of my mother’s life. Modern medicine has made great achievements in treating diseases that used to be fatal, but it has become institutionalized in the context of Big Pharma interests, with no insight into the natural (...) ageing and death of human beings. Second, I discuss how the ecological worldview on parasitism and symbiosis has been distorted by industrial logic, drawing on the work of my esteemed friend and parasitologist Professor Koichiro Fujita, who passed away in 2021. Finally, with regard to the Covid-19 pandemic, I would argue that it is not a sudden phenomenon triggered by a new virus, but in a sense a disaster that has been prepared for decades and must be seen as a war using bioengineering and epidemiology as weapons, rather than tanks and bombs. (shrink)

It is important to manage individuals’ personal data after their death to maintain their dignity or follow their wishes as much as possible. From this perspective, this report describes the real-world commercialization of immortal digital personalities, which gives eternal life to the deceased in a digital form. We identify the problems with the commercialization of deceased users’ images and personal data, which becomes postmortem entertainment. Considering these problems, we seek out the ideal form of deceased users’ personal data for commercialization. (...) We conduct a social survey to understand how ordinary Japanese people feel about the various types of publicly available services that use personal data after death, such as social network service logs. By analyzing our survey results approximately 20% of respondents would allow the commercial use of their personal data, such as browsing their social network service logs, if they could receive compensation during their lifetime. (shrink)

The mitogenic action of cytokines such as epidermal growth factor (EGF)d̊ or platelet dericed growth factor (PDGF) involves the stimulation of a signal cascade controlled by a small G protein called Ras. Mutations of Ras can cause its constitutive activation and, as a consequence, bypass the regulation of cell growth by cytokines. Both growth factor‐induced and oncogenic activation of Ras involve the conversion of Ras from the GDP‐bound (D‐Ras) to the GTP‐bound (T‐Ras) forms. T‐Ras activates a network of protein kinases (...) including c‐Mos, c‐Raf‐1 and MAP kinase. Eventually the activation of MAP kinase leads to the activation of the elongation factor 4E and several transcription factors such as c‐Jun, c‐Myc and c‐Fos. There are several modulators of Ras activity, such as the GTPase activating proteins (GAP1 and NF1), which stimulate the coversion of T‐Ras to D‐Ras. A series of small NF1 fragments, which bind T‐Ras, as well as truncated forms or derivatives of c‐Raf‐1, c‐Jun and c‐Myc, are capable of blocking the T‐Ras‐activated mitogenesis in a competitive manner. These agents offer a unique opportunity to control the proliferation of T‐Ras‐associated tumors, which represent more than 30% of total human carcinomas. (shrink)

We give simple proofs of the Singular Cardinal Hypothesis from the Weak Reflection Principle and the Fodor-type Reflection Principle which do not use better scales.

Research interest in cuteness perception and its effects on subsequent behavior and physiological responses has recently been increasing. The purpose of the present study was to produce a dataset of Japanese infant faces that are free of portrait rights and can be used for cuteness research. A total of 80 original facial images of 6-month-old infants were collected from their parents. The cuteness level of each picture was rated on a 7-point scale by 200 Japanese people. Prototypical high- and low-cuteness (...) faces were created by averaging the top 10 and bottom 10 faces according to the mean cuteness ratings. Then, 50 composite faces were made by mixing two faces randomly chosen from the 60 unused middle-cuteness faces. The normative cuteness ratings of these composite faces were obtained from 229 Japanese men and women in their 20s–60s. The shape of each composite face was transformed to be cuter or less cute along a continuum between the high- and low-cuteness prototypical faces. A two-alternative forced-choice task confirmed that cuteness discrimination was better than the chance level for all 50 face pairs. Moreover, the results showed that young men had poorer sensitivity to cuteness differences in infant faces than older men and women of any age. This Japanese Cute Infant Face dataset, including composite face images and normative rating scores, is publicly available online. (shrink)

In the scholarship on Wittgenstein’s later philosophy of mathematics, the dominant interpretation is a theoretical one that ascribes to Wittgenstein some type of ‘ism’ such as radical verificationism or anti-realism. Essentially, he is supposed to provide a positive account of our mathematical practice based on some basic assertions. However, I claim that he should not be read in terms of any ‘ism’ but instead should be read as examining philosophical pictures in the sense of unclear conceptions. The contrast here is (...) that basic assertions that frame philosophical ‘isms’ are propositional such that they are subject to normal argumentative evaluation, while pictures in Wittgenstein’s sense are non-propositional—they lack a clear truth condition. They, therefore, need clarification rather than argumentation. In this paper, I provide a detailed analysis of Wittgenstein’s treatment of philosophical pictures with special focus on his argument on contradiction. I begin by explaining the problem with this trend of theoretical interpretation, taking Steve Gerrard’s otherwise excellent interpretation as a representative example and pointing out why it is problematic. Next, I will argue that those problems do not arise if we take Wittgenstein’s task as the clarification of philosophical pictures. I do this, first, by explaining Wittgenstein’s method using his argument concerning the Augustinian Picture in Philosophical Investigations and then pointing out that the same method can be identified in the crucial arguments in his philosophy of mathematics. Finally, in order to connect my interpretation with the current scholarship, I will explain the relation of my interpretation with those of New Wittgensteinian scholars. (shrink)

In this paper, I will investigate Wittgenstein’s idea about the context-sensitivity of utterance. It is the idea that there is a big gap between understanding a sentence in the sense of knowing the idioms and discerning the grammar in it, and what is said by using it in a particular context. Although context-sensitivity in this moderate sense is a familiar idea in Wittgensteinian scholarship, it has mainly been studied as an idea in “Wittgenstein’s philosophy of language.” However, Wittgenstein’s interest in (...) language is always connected with his interest in the treatment of philosophical problems. Therefore, what is lacking in those preceding studies is the study of the relation between Wittgenstein’s engagement with the idea of context-sensitivity and his philosophical therapy. Therefore, I shall investigate that relation and show that Wittgenstein’s philosophical method cannot be intelligible without taking context-sensitivity into consideration and Wittgenstein’s focus on context is deeply connected with his method for treating philosophers’ “pictures.” Below, I will examine recent debates on grammar, and argue that the standard interpretation is untenable once proper consideration is given to context-sensitivity. Next, I will argue that context-sensitivity is important because it gives us a good grasp of the process of a philosopher’s being caught in a picture by citing the discussion about mental process and about the Augustinian picture and rule-following in Philosophical Investigations. Finally, I will talk about the significance of my interpretation for contemporary arguments about philosophical methods. (shrink)

In this paper, I will investigate Wittgenstein’s idea about the context-sensitivity of utterance. It is the idea that there is a big gap between understanding a sentence in the sense of knowing the idioms and discerning the grammar in it, and what is said by using it in a particular context. Although context-sensitivity in this moderate sense is a familiar idea in Wittgensteinian scholarship, it has mainly been studied as an idea in “Wittgenstein’s philosophy of language.” However, Wittgenstein’s interest in (...) language is always connected with his interest in the treatment of philosophical problems. Therefore, what is lacking in those preceding studies is the study of the relation between Wittgenstein’s engagement with the idea of context-sensitivity and his philosophical therapy. Therefore, I shall investigate that relation and show that Wittgenstein’s philosophical method cannot be intelligible without taking context-sensitivity into consideration and Wittgenstein’s focus on context is deeply connected with his method for treating philosophers’ “pictures.” Below, I will examine recent debates on grammar, and argue that the standard interpretation is untenable once proper consideration is given to context-sensitivity. Next, I will argue that context-sensitivity is important because it gives us a good grasp of the process of a philosopher’s being caught in a picture by citing the discussion about mental process and about the Augustinian picture and rule-following in Philosophical Investigations. Finally, I will talk about the significance of my interpretation for contemporary arguments about philosophical methods. (shrink)

双子のようによく似たギリシャ懐疑哲学と仏教の〈空〉の思想。両者を丹念に読み解くとき、透徹した「縁起=言語ゲーム」の世界に揺らめくわれわれの生の真実が浮かびあがる。ウィトゲンシュタインを起点に世界史的規 模で展開する哲学の本当の意味を求める旅。.