Gluten ataxia is a rare immune-mediated neurological disorder caused by the ingestion of gluten. The diagnosis is not straightforward as antibodies are present in only up to 38% of patients, but often at lower titers. The symptoms of ataxia may be mild at the onset but lead to permanent damage if remain untreated. It is characterized by damage to the cerebellum however, the pathophysiology of the disease is not clearly understood. The present study investigated the neurochemical profile of vermis and (...) right cerebellum and structural changes in various brain regions of patients with gluten ataxia and compared it with healthy controls. Volumetric 3-D T1 and T1-weighted magnetic resonance imaging in the three planes of the whole brain and single-voxel 1H- magnetic resonance spectroscopy of the vermis and right cerebellum were acquired on 3 T human MR scanner. The metabolite concentrations were estimated using LC Model while brain volumes were estimated using the online tool volBrain pipeline and CERES and corrected for partial volumes. The levels of neuro-metabolites were found to be significantly lower in vermis, while N-acetyl aspartate + N-acetyl aspartate glutamate and glycerophosphocholine + phosphocholine was lower in cerebellum regions in the patients with gluten ataxia compared to healthy controls. A significant reduction in the white matter of ; reduction in the volumes of cerebellum lobe and thalamus while lateral ventricles were increased in the patients with gluten ataxia compared to healthy controls. The reduced neuronal metabolites along with structural changes in the brain suggested neuronal degeneration in the patients with gluten ataxia. Our preliminary findings may be useful in understanding the gluten-induced cerebral damage and indicated that MRI and MRS may serve as a non-invasive useful tool in the early diagnosis, thereby enabling better management of these patients. (shrink)

Metaethical constitutivists seek to ground normativity in facts about what is constitutive of agency. One strand of constitutivism locates the foundations of normativity in constitutive aims, which are standardly conceived of in teleological terms. I present three challenges that show that the teleological conception of constitutive aims is inadequate for the constitutivist project. I then sketch an alternative conception of constitutive aims in the form of a commitment-based conception. On the commitment-based conception, actions and attitudes constitutively represent their objects as (...) having certain properties, and their constitutive aims are fixed by the accuracy-conditions of these representations. Because such representations constitutively involve a commitment on the part of the agent to the object’s having the relevant property, they generate authoritative norms for the agent. I conclude that, unlike the teleological conception, the commitment-based conception promises to yield a unified constitutivism that delivers authoritative normative standards for both actions and attitudes. (shrink)

La literatura nacida en ámbito monástico o asociada al mismo, ofrece aspectos ponderables sobre la antropología teológica. Señalaremos algunos conceptos al respecto, sobre todo a partir de la memoria y la construcción de la propia identidad. El Himno de la Perla se caracteriza por haber sido objeto de disímiles interpretaciones, siendo considerado desde un texto iranio a una composición gnóstica. Presentaremos una lectura narrativa, tomando como categorías de aproximación el recuerdo y el olvido, a partir de las cuales plantearemos un (...) posible vínculo entre el Himno de la Perla y el Pseudo-Macario. Quispel, ya en 1967, estableció un parentesco de Teología (Verwandschaft der Teologie), destacando que también se encuentran paralelismos de forma. Tomando en cuenta este notable aporte, procuraremos indagar en la literatura pseudo-macariana acerca de tales parentescos con el Himno de la Perla y la literatura sobre el apóstol Tomás. (shrink)

Year after year, our exposure to the Gita remains limited to these fleeting visual engagements as they become part of our muscle memory as we go about our chores.

Women's exclusion from political enfranchisement in Kant's political writings has frequently been noted in the literature, and yet has not been closely scrutinized. More often than not, commentators suggest that this reflects little more than Kant's sharing in the prejudices of his era. This paper argues that, for Kant, women's civil incapacities stem from defects relating to their capacities as moral agents, and more specifically, to his teleological account of the conditions within which we, as imperfect beings, develop our moral (...) capacities. Women are not incidentally or tangentially excluded from the boundaries of political and moral agency, but rather must adopt an explicitly nonmoral character if we are to understand humanity as moving toward its naturally given, moral ends. I argue (1) that Kant's teleological view of human development requires women to develop an explicitly nonmoral character; (2) that this teleology is inextricable from his view of the moral agency that human—and not merely rational—beings are capable of; and (3) that taken together, these suggest that women's subordinate status is internally connected to Kant's view of moral personhood. (shrink)

This study addresses the complex and often fractious relationship between liberal political theory and difference by examining how distinctive liberalisms respond to human diversity. Drawing on published and unpublished writings, private correspondence and lecture notes, the study offers comprehensive reconstructions of Immanuel Kant's and John Stuart Mill's treatment of racial, cultural, gender-based and class-based difference to understand how two leading figures reacted to pluralism, and what contemporary readers might draw from them. The book mounts a qualified defence of Millian liberalism (...) against Kantianism's predominance in contemporary liberal political philosophy, and resists liberalism's implicit association with imperialist domination by showing different divergent responses to diversity. Here are two distinctive liberal visions of moral and political life. (shrink)

Essays on Sikh philosophy, ethos and politics ; previously published in Panjabi newspapers and magazines.

This article examines how Kant’s conceptualizations of natural history and teleological judgement shape his understanding of human difference and race. I argue that the teleological framework encasing Kant’s racial theory implies constraints on the capacity of non-whites to make moral progress. While commentators tend to approach Kant’s racial theory in relation to his political theory, his late-life cosmopolitanism, and his treatments (or non-treatments) of colonialism, empire and slavery, the problem I focus on here is that race is itself only intelligible (...) in relation to a teleological natural history limiting certain races’ capacities to engage in humanity’s moral vocation. (shrink)

In this commentary, I raise a few questions about Schmidt’s argument against (R-E): whether facts about incoherence are directly reasons for suspension on particular propositions, as opposed to reasons against sets of attitudes; whether (R-E) should really be formulated in terms of a broad category of “doxastic attitudes” that includes transitional attitudes like suspension; and whether incoherence-based reasons really must fit into the category of “epistemic reasons,” as opposed to be a more general category of right-kind reasons. Though my questions (...) reflect some skepticism about the specifics of Schmidt’s argument, I conclude that it succeeds in what I take to be its broader aim. (shrink)

Our concern in this paper lies with a common argument from racial discrimination to realism about races: some people are discriminated against for being members of a particular race (i.e., racial discrimination exists), so some people must be members of that race (i.e., races exist). Error theorists have long responded that we can explain racial discrimination in terms of racial attitudes alone, so we need not explain it in terms of race itself. But to date there has been little detailed (...) discussion of whether it is better to explain racial discrimination in terms of race or in terms of racial attitudes alone. Our goal is to offer a novel and detailed argument in defense of explaining racial discrimination in terms of racial attitudes alone, by attending to the neglected phenomenon of misperception discrimination, which involves differential treatment due to misperceived race. We argue that the discriminatory action in misperception cases must be explained in the same way as cases where (according to the realist) the victim’s race is accurately perceived. Thus, the victim’s actual race cannot provide the best explanation. The main upshot of our argument is that explanatory arguments from racial discrimination to realism about race fail. (shrink)

ABSTRACT In his ‘Rationality versus Normativity’, John Broome argues against the view that rationality is reducible to normativity. Broome’s argument rests on the claim that while rationality supervenes on the mind, normativity does not. In this commentary, I argue that Broome's arguments succeed only against views on which reasons and normativity are univocal. Once we admit of multiple kinds of normative reasons, some fact-given and others non-factive, a version of the reasons-responsiveness view emerges that is untouched by Broome's arguments. On (...) such a view, rationality supervenes on non-factive reasons, not on fact-given ones, so rationality supervenes on a kind of normativity that supervenes on the mind. This shows that Broome has not refuted reasons-responsiveness views wholesale. Moreover, because Broome’s arguments do refute univocal versions of reasons-responsiveness views, they provide a justification for preferring non-univocal versions of reasons-responsiveness views to univocal ones. (shrink)

Lord Rabinder Singh has been one of the leading lights in the recent development of the common law, most notably in the field of human rights and the law of privacy. Here, for the first time, he reflects on the defining themes of his career as advocate and judge. Combining his trademark originality of thought and impeccable scholarship, he selects previously published and unpublished writings to track the evolution of his approach to the common law. A substantial introduction gives (...) context to the book, while opening introductions to each piece reflect on their relevance to contemporary legal thought. The essays explore themes as diverse as judicial review, equality, and privacy and personal autonomy. Insightful, erudite, and thought-provoking, this collection is a must read for all those interested in the law and its role in society. (shrink)

This article examines the idioms of ‘modernity’ with specific focus on indigenous peoples and their engagement with larger society in respect of culture, development and jurisprudence. This engagement in the past 50 years has largely been within the terms of the nation-state system, and related international fora. It is argued that these indigeneous communities, in all their great diversity across the world, have nevertheless been largely successful in carving out adequate political spaces to stake their claims as distinct ‘peoples’ rather (...) than simply being recognized as one among the several ethnic groups or minorities of a nation-state polity. This distinction is crucial and this paper shows why and how. This is not to say that the indigenous communities the world over have similar terms of engagement as their own heterogeneity defies any neat typological schema. At the same time, the multiple idioms of the current indigenous discourse, however, should not be treated as cacophonic but as embodying consciously crafted tools for boundary negotiations and voicing indigenous identities. This article reflects on this achievement by providing a survey of these developments even as it critically explores the terms of the discourses themselves. (shrink)

The Present Book Contains The Philosophy Of Organism Associated With The Teachings Of Prof. An Whitehead With Comparative Reference To Indian Philosophical Doctrines And Chinese Philosophy Of Change. In Part I The Author Deals With Sage Philosopher'S Conc.

The Present Book Contains The Philosophy Of Organism Associated With The Teachings Of Prof. An Whitehead With Comparative Reference To Indian Philosophical Doctrines And Chinese Philosophy Of Change. In Part I The Author Deals With Sage Philosopher'S Conc.

Evaluative Conditioning (EC) refers to changes in our liking or disliking of a stimulus due to its pairing with other positive or negative stimuli. In addition to stimulus-based mechanisms, recent research has shown that action-based mechanisms can also lead to EC effects. Research, based on action control theories, has shown that pairing a positive or negative action with a neutral stimulus results in EC effects (Stimulus-Response binding). Similarly, research studies using Operant Conditioning (OC) approaches have also observed EC effects. The (...) aim of the present study is to directly compare EC effects elicited by two different response-based approaches – S-R bindings and OC. To this end, participants were randomly assigned to an S-R binding procedure and an OC procedure. EC effects were measured in conditions and compared. Implications for EC theory are discussed. (shrink)

In recent years, Kant’s lesser-known works on anthropology, education, and history have received increasing scholarly attention, illuminating his views on human nature, moral psychology, and historical development. This paper contributes to this literature by exploring Kant's conceptualization of culture. While recent commentary has drawn on Kant's “impure ethics” to suggest that his anti-imperialism and cosmopolitanism reflect a concern for the preservation of different cultures, I argue that this misinterprets the nature and function of culture in Kant’s thought. Rather than regarding (...) culture as a constitutive good, I argue that Kant understands culture as a transitory good, as a sphere of individual and collective cultivation drawing humanity towards its teleologically given end: the perfection of our rational capacities. This suggests that only certain kinds of culture--those that “prepare [humanity] for a sovereignty in which reason alone is to dominate”--are valuable for Kant. Given this, I argue that Kant’s view of culture in fact presents far greater problems than prospects for theorizing an anti-imperial and cosmopolitan politics. (shrink)

Recent critics have declaimed against John Stuart Mill's liberalism, arguing that his conception of civilization is inexorably bound to a hierarchal conception of social progress justifying Europeans' moral right to 'civilize' barbarian peoples. Without exonerating him from his undoubtedly problematic views regarding non-European cultures, I would like to argue that Mill in fact has a much subtler view of historical development and of civilization than such critics attribute to him. Central to these critics' charges is an 'aggregative' view of Mill's (...) conceptualization of historical development--suggesting that Mill understood societies to move through discrete stages of social development, characterized by internally-correlated stages of economic, political, cultural and moral development--which fails to be borne out under close examination. I argue that Mill's view of historical development and his liberalism more generally are in fact significantly more capacious than is often recognized and are not inextricably bound to the project of imperialism. (shrink)

The West has a stereotypical image of businesses, officials, and politicians, etc., in the East (Third World) countries being pervasively corrupt while it views itself as being almost completely uncorrupt. One closer look, however, realities turn out to be quite different. Business corruption is much more universal that Westerners are generally willing to accept. The major differences are that corruption in the East is practiced so blatantly that it makes major news. Western businesses, on the other hand, have, over time, (...) developed sophisticated techniques whereby corruption becomes almost invisible. This paper discusses the myths and realities of Eastern versus Western corruption and discusses several means which have allowed Western companies to exploit others through subtle and, almost invisible means. The overall advantage, however, still goes to the West where petty corruption has been pretty much eliminated. (shrink)

... Introduction to Buddhist Tantra Tantra forms the esoteric basis of all major religions. It stands for the awakening of dormant divinity. It is a mystic technique to invoke the spirituality of man and woman.

This Reader provides a comprehensive introduction to the study of contemporary Indian political theory. Tracing the development of the discipline and offering a clear presentation of the most influential literature in the field, it brings together contributions by outstanding and well-known academics on contemporary Indian political thought. The Reader weaves together relevant works from the social sciences — sociology, anthropology, law, history, philosophy, feminist and postcolonial theory — which shape the nature of political thought in India today. Themes both unique (...) to the Indian political milieu as well as of universal significance are reflected upon, including tradition, secularism, communalism, modernity, feminism, justice and human rights. Presenting a canon of names and offering a framework for further research within the broad thematic categories, this is a timely and invaluable reference tool, indispensable to both students and scholars. (shrink)

Intensely loyal, practical, straightforward, almost fearless, with a wry sense of humor, Amos is also analytical, a quick thinker, and exceedingly aware of his surroundings. Amos wasn't always fond of Holden. After spending tough and adventurous times together, Amos changes his attitude toward Holden and regards him as a good person. Amos embodies Friedrich Nietzsche's famous slogan, “live dangerously!” Nietzsche traced the beginning of slave morality to a creative reversal of values fueled by ressentiment. According to Nietzsche, our fundamental drive (...) is the desire to gain and express power. Looking at Amos through a Nietzschean lens makes us reluctant to judge the character as good or evil. Amos has not channeled or sublimated his will to power. He has not overcome himself and humanity. Ultimately, he is far from becoming Nietzsche's ideal figure, the Ubermensch. (shrink)

This book critically analyses the "mutual illuminations" between literature, religion, architecture, films, performative arts, paintings, woodworks, memes and masks cutting across time and space. In architecture for example, the eventual success of a project depends on the harmony between physical sciences and aesthetics, design and planning, knowledge of building material, the local climate, and awareness of cultural sensibilities. This volume affirms that aesthetics and arts are deeply linked through existential issues of who I am. The essays in this volume present (...) diverse discursive structures showcasing the in-between spaces between various art forms and mediums, such as, architecture, literature and memory, Kafka in SoHo; Kafka and Bernhard, Kirchner's woodcuts; pictorial and stage representations of E.T.A Hoffmann, Hesse's fairy tales; translations of Pañcatantra; Nietzsche, ritual arts and face masks; martyrdom in La chanson de Roland, Goethe and Hafiz, Indian thought in Martin Buber; Rhythms of the 'Third' across cultures; Dadaism and contemporary memes This book examines these sublime linkages in a comparative and interdisciplinary way. Engaging and intersectional, this volume will appeal to students and scholars of arts and aesthetics, literature, philosophy, architecture, sociology, translation studies and readers who are interested in cultural, intertextual, intermedial, and comparative studies. (shrink)

As an epistemological perspective, 'nomadism' is an emerging field of scholarship, offering intersectionality with eco-criticism, feminism, post-colonialism, migration studies, and translation. Much of the scholarship that uses the precepts of nomadism to read cultural texts and phenomena is scattered as separate articles in academic journals or as single chapters in books wherein the primary focus is the intersectional fields. Few book-length publications solely focus on the ramifications of nomadism; Posthumanist Nomadisms across non-Oedipal Spatiality fills that void. The fifteen chapters in (...) this volume explore the possibilities offered by the nomadic perspective to explore a wide range of literary and cultural texts; organized into three sections, "Nomadic Assemblages," "Non-Oedipal Cartographies", and "Space-Time Montages", that work as one to negate absorption into the interiority of sovereign territory. These sections are not an attempt at corralling the nomadic spirit into separate enclosures; instead, they are bands of warriors that operate the violence of the hunted animal, dehumanized human others, and earth others. The chapters are in constant multi-vocal conversations with narratives that camp on the turbulent weathers of global transitory spaces. They charter real or intellectual turfs of interstitial/rhizomatic nomadic epistemologies as political resistance to the exclusionary practices of a violently wired world. This book will appeal to post-graduate students, researchers, and faculty in the departments of literature, comparative literary and cultural studies. Researchers in sociology, cultural anthropology, gender studies, and migration studies will also find the material applicable to the expanding approaches available in their fields. (shrink)