Understanding the neural basis of schizophrenia (SZ) is important for shedding light on the neurobiological mechanisms underlying this mental disorder. Structural and functional alterations in the anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), hippocampus, and medial prefrontal cortex (MPFC) have been implicated in the neurobiology of SZ. However, the effective connectivity among them in SZ remains unclear. The current study investigated how neuronal pathways involving these regions were affected in first-episode SZ using functional magnetic resonance imaging (fMRI). Forty-nine patients (...) with a first-episode of psychosis and diagnosis of SZ—according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision—were studied. Fifty healthy controls (HCs) were included for comparison. All subjects underwent resting state fMRI. We used spectral dynamic causal modeling (DCM) to estimate directed connections among the bilateral ACC, DLPFC, hippocampus, and MPFC. We characterized the differences using Bayesian parameter averaging (BPA) in addition to classical inference (t-test). In addition to common effective connectivity in these two groups, HCs displayed widespread significant connections predominantly involved in ACC not detected in SZ patients, but SZ showed few connections. Based on BPA results, SZ patients exhibited anterior cingulate cortico-prefrontal-hippocampal hyperconnectivity, as well as ACC-related and hippocampal-dorsolateral prefrontal-medial prefrontal hypoconnectivity. In summary, spectral DCM revealed the pattern of effective connectivity involving ACC in patients with first-episode SZ. This study provides a potential link between SZ and dysfunction of ACC, creating an ideal situation to associate mechanisms behind SZ with aberrant connectivity among these cognition and emotion-related regions. (shrink)

本书内容包括:和谐文化思想的历史探析、建设中国特色社会主义与和谐文化、现代化进程中的和谐文化建设、云南和谐文化建设的探索与实践。.

本书针对当前文化现状中存在的问题,系统探讨了建设和谐文化五个方面的内容,并提出可操作的具体措施,以期对我国社会主义和谐文化建设的深入开展有所裨益。.

Ben shu xi tong chan shu liao Zhongguo zhe xue de yuan qi, fa zhan he wei lai.quan shu gong fen cheng si ge da bu fen:yuan qi yu chu xing; er, ge ming hua de ding xing; san, xin shi dai de zhuan xiang;si, zou xiang quan qiu hua shi dai de Zhongguo zhe xue.

Diseases of complex origin have a component of quantitative genetics that contributes to their susceptibility and phenotypic variability. However, after several studies, a major part of the genetic component of complex phenotypes has still not been found, a situation known as “missing heritability.” Although there have been many hypotheses put forward to explain the reasons for the missing heritability, its definitive causes remain unknown. Complex diseases are caused by multiple intermediate phenotypes involved in their pathogenesis and, very often, each one (...) of these intermediate phenotypes also has a component of quantitative inheritance. Here we propose that at least part of the missing heritability can be explained by the genetic component of intermediate phenotypes that is not detectable at the level of the main complex trait. At the same time, the identification of the genetic component of intermediate phenotypes provides an opportunity to identify part of the missing heritability of complex diseases. (shrink)

Ben shu yi jian ming e yao de bi chu xiang du zhe ti gong le yi fu quan jing shi de xi fang mei xue li shi hua juan.Qi nei rong han gai cong gu xi la,Luo ma zhi dao 20 shi ji de xi fang mei xue si xiang he li lun cheng guo,Qi zhong yi li lun xing tai de mei xue si xiang wei zhu gan,Tong shi she ji wen xue yi shu yi ji she (...) hui feng shang suo ti xian de shen mei yi shi. (shrink)

Because they are key components of aircraft, improving the safety, reliability and economy of engines is crucial. To ensure flight safety and reduce the cost of maintenance during aircraft engine operation, a prognostics and health management system that focuses on fault diagnosis, health assessment, and life prediction is introduced to solve the problems. Predicting the remaining useful life is the most important information for making decisions about aircraft engine operation and maintenance, and it relies largely on the selection of performance (...) degradation features. The choice of such features is highly significant, but there are some weaknesses in the current algorithm for RUL prediction, notably, the inability to obtain tendencies from the data. Especially with aircraft engines, extracting useful degradation features from multisensor data with complex correlations is a key technical problem that has hindered the implementation of degradation assessment. To solve these problems, deep learning has been proposed in recent years to exploit multiple layers of nonlinear information processing for unsupervised self-learning of features. This paper presents a deep learning approach to predict the RUL of an aircraft engine based on a stacked sparse autoencoder and logistic regression. The stacked sparse autoencoder is used to automatically extract performance degradation features from multiple sensors on the aircraft engine and to fuse multiple features through multilayer self-learning. Logistic regression is used to predict the remaining useful life. However, the hyperparameters of the deep learning, which significantly impact the feature extraction and prediction performance, are determined based on expert experience in most cases. The grid search method is introduced in this paper to optimize the hyperparameters of the proposed aircraft engine RUL prediction model. An application of this method of predicting the RUL of an aircraft engine with a benchmark dataset is employed to demonstrate the effectiveness of the proposed approach. (shrink)

Ben shu yi Ming ru Li Cai de jiang xue huo dong yu xue pai jian gou wei zhong xin, tan tao cong shi liu shi ji chu dao shi qi shi ji mo li xue qun ti zhong xin xing xue shuo he xue pai de chan sheng, chuan bo, kuo zhan yu chuan cheng de mo shi, bing zhuo zhong cong si xiang shi de jiao du jie shi zhe zhong mo shi chan sheng he yun xing (...) de si xiang gen yuan yu nei zai dong li. Quan shu zheng wen gong qi zhang, zhu yao nei rong fen wei shang xia liang bian, shang bian yi hong guan zong lun de fang shi, cong li xue jing dian "Da xue" de wen ben bian dong he quan shi jing zheng qie ru, tan tao zhong wan Ming li xue xue shuo he xue pai jian gou de li lun gen ju; xia bian yi Li Cai de "zhi xiu" xue shuo ji qi jiang xue huo dong zuo wei ge an yan jiu, tan tao li xue xue shuo he xue pai de chuan bo ji chuan cheng de she hui hua tu jing. (shrink)

Du Weiming xian sheng shi dang dai yan jiu he chuan bo ru jia wen hua de zhong yao si xiang jia. Ta 1940 nian chu sheng yu Kunming, xian hou qiu xue yu Taiwan dong hai da xue he Meiguo Hafo da xue, ren jiao yu Pulinsidun da xue, Bokeli Jiazhou da xue. Zi 1981 nian, Du Weiming xian sheng yi zhi zai Hafo da xue Dong Ya xi dan ren li shi ji zhe xue jiao shou,qi jian (...) huo xuan Meiguo ren wen she hui ke xue yuan yuan shi, hai ceng dan ren Hafo Yanjing xue she she zhang. Chang qi yi lai, Du Weiming xian sheng zhi li yu ru xue di 3 qi fa zhan, quan shi Zhongguo wen hua, fan si xian dai jing shen, chang dao wen ming dui hua, zai hai nei wai xiang you hen gao de xue shu sheng yu. Du xian sheng fei chang re xin Zhongguo you xiu chuan tong wen hua zai ben tu de chuan bo, duo ci hui guo can jia jiao yu he xue shu jiao liu huo dong. Ta yu Beijing da xue you zhe te shu de yuan fen,zao zai 1985 nian jiu lai Beijing da xue jiang shou ru jia zhe xue. Zui jin Du Weiming xian sheng yi zheng shi shou pin wei Beijing da xue gao deng ren wen yan jiu yuan yuan zhang. (shrink)

Ben shu gong you ba jiang zu cheng, fen bie shi sheng ren bi ke xue er zhi, Wang Yangming de xin xue ti xi, shi gong yu bing xue, wen xue si xiang yu shi wen chuang zuo, jiao yu si xiang yu shi jian, Yangming hou xue, Yangming xue zai jin xian dai de ying xiang, Yangming wen hua yu Guizhou lü you. Mei ge lun ti lun shu ji zhong, shen du shi zhong, xu shu xing (...) yu yan tong su liu chang, gu shi xing qiang, hen shi he da zhong du zhe yue du. wei qi fa du zhe si kao, zeng qiang yue du xiao guo, zai mei yi jiang zhi hou shi liang she zhi le yi xie ming ci jie shi, jian da tao lun ti. ling pei he xiang guan wen zi, she zhi le yi xie tu pian, bei ke he Yangming shu fa zuo pin deng, ju you ji jia de guan shang xing. (shrink)

主要内容为:文艺新学科的立科学研究,文艺新学科方法论、发生论、发展论、文艺新学科属性论等。.

主要内容为:文艺新学科的立科学研究,文艺新学科方法论、发生论、发展论、文艺新学科属性论等。.

The sizes of individual data files have steadily increased along with rising demand for customized services, leading to issues such as low efficiency of web-based geographical information system -based data compression, transmission, and rendering for rich Internet applications in complicated visualization systems. In this article, a WebGIS-based technical solution for the efficient transmission and visualization of meteorological big data is proposed. Based on open-source technology such as HTML5 and Mapbox GL, the proposed scheme considers distributed data compression and transmission on (...) the server side as well as distributed requests and page rendering on the browser side. A high-low 8-bit compression method is developed for compressing a 100 megabyte file into a megabyte-scale file, with a compression ratio of approximately 90%, and the recovered data are accurate to two decimal places. Another part of the scheme combines pyramid tile cutting, concurrent domain name request processing, and texture rendering. Experimental results indicate that with this scheme, grid files of up to 100 MB can be transferred and displayed in milliseconds, and multiterminal service applications can be supported by building a grid data visualization mode for big data and technology centers, which may serve as a reference for other industries. (shrink)

The N-Queens problem plays an important role in academic research and practical application. Heuristic algorithm is often used to solve variant 2 of the N-Queens problem. In the process of solving, evaluation of the candidate solution, namely, fitness function, often occupies the vast majority of running time and becomes the key to improve speed. In this paper, three parallel schemes based on CPU and four parallel schemes based on GPU are proposed, and a serial scheme is implemented at the baseline. (...) The experimental results show that, for a large-scale N-Queens problem, the coarse-grained GPU scheme achieved a maximum 307-fold speedup over a single-threaded CPU counterpart in evaluating a candidate solution. When the coarse-grained GPU scheme is applied to simulated annealing in solving N-Queens problem variant 2 with a problem size no more than 3000, the speedup is up to 9.3. (shrink)

The construct of learned helplessness, as one of the noticeable emotional issues in education, has been investigated and approved its prominent place in education for its stimulus on students' accomplishment, enthusiasm, and commitment in learning. Moreover, the role of teachers as the most crucial issues in the learning viewpoint is at the center of attention since they help learners to be more motivated and provide a supportive context by caring. So, the current review of literature tries to emphasize teachers' care (...) and its effects on decreasing learned helplessness in EFL classrooms. The review of this study underscores the important role of the teachers' care and support in learners' improvement of learned helplessness that can be alleviated in this way. Afterward, some suggestions are offered to illuminate the exercise of teachers, learners, teacher trainers, and syllabus designers. (shrink)

In this study, we examined the effects of parental phubbing on learning burnout in elementary and secondary school students and its mechanism of action. A questionnaire method was applied to investigate parental phubbing, parent–child attachment, ego depletion, and learning burnout among 2090 elementary and secondary school students in Anhui Province, China. The results are as follows: Parental phubbing was significantly correlated with parent–child attachment, ego depletion, and learning burnout; Parental phubbing has an indirect impact on learning burnout in elementary and (...) secondary school students through three pathways: a separate mediating effect on parent–child attachment, a separate mediating effect on ego depletion, and a chain mediating effect on both. Parental phubbing is a risk factor for Learning Burnout, which can positively affect Learning Burnout in elementary and secondary school students. The findings of the study contribute to revealing the influence mechanism of parental phubbing on learning burnout in elementary and secondary school students. (shrink)

Despite considerable disruption of social order caused by the COVID-19 pandemic, it has also been said to contribute to positive psychological changes and influence on the perception of public life satisfaction. The present study aimed to explore the association between the COVID-19 related posttraumatic growth and life satisfaction and the mediating role of personal values. A two-wave longitudinal design was used. 226 self-quarantined Chinese college students completed post traumatic growth inventory, satisfaction with life scale, personal values questionnaire between February 2020 (...) and May 2021. Results showed that more than half of self-quarantined Chinese college students reported moderate to high levels of the COVID-19 related posttraumatic growth. A structural equation model revealed that COVID-19 related posttraumatic growth was positively associated to life satisfaction, and self-transcendence and self-enhancement values partially mediated this association. These findings shed light on whether and how pandemic-related posttraumatic growth influenced personal life satisfaction, supporting the outcome and process perspectives of posttraumatic growth as well as Schwartz’s value theory. Based on the findings, some positive psychology interventions, such as online rumination activities and mindfulness practice, were proposed to enhance self-quarantined college students’ posttraumatic growth and life satisfaction. (shrink)

Post-stroke depression is a serious complication of stroke that significantly restricts rehabilitation. The use of immersive virtual reality for stroke survivors is promising. Herein, we investigated the effects of a novel immersive virtual reality training system on PSD and explored induced effective connectivity alterations in emotional networks using multivariate Granger causality analysis. Forty-four patients with PSD were equally allocated into an immersive-virtual reality group and a control group. In addition to their usual rehabilitation treatments, the participants in the immersive-virtual reality (...) group participated in an immersive-virtual reality rehabilitation program, while the patients in the control group received 2D virtual reality rehabilitation training. The Hamilton Depression Rating Scale, modified Barthel Index, and resting-state functional magnetic resonance imaging data were collected before and after a 4-week intervention. rsfMRI data were analyzed using multivariate GCA. We found that the immersive virtual reality training was more effective in improving depression in patients with PSD but had no statistically significant improvement in MBI scores compared to the control group. The GCA showed that the following causal connectivities were strengthened after immersive virtual reality training: from the amygdala, insula, middle temporal gyrus, and caudate nucleus to the dorsolateral prefrontal cortex; from the insula to the medial prefrontal cortex; and from the thalamus to the posterior superior temporal sulcus. These causal connectivities were weakened after treatment in the control group. Our results indicated the neurotherapeutic use of immersive virtual reality rehabilitation as an effective non-pharmacological intervention for PSD; the alteration of causal connectivity in emotional networks might constitute the neural mechanisms underlying immersive-virtual reality rehabilitation in PSD. (shrink)

Improving the innovation ability of organizations is the focal point of management study. This paper puts forward that innovative self-efficacy and employees’ innovative behaviour are continuous mediating variables, and discusses the influence mechanism of employees’ involvement and open service innovation from the individual factor level. In this study, a sample of 103 employees from travel companies was used to examine the hypothesis. The results show that employee engagement is positively related to open service innovation. Innovative self-efficacy plays a completely intermediary (...) role between employee engagement and employee innovative behaviour; Creative self-efficacy and employees’ innovative behaviour play a continuous intermediary role between employees’ engagement and open service innovation. The results of this study will eventually help enterprises to carry out service innovation behaviour. (shrink)

ObjectiveTo investigate the attitudes of Chinese parents regarding the storage of dried blood spots collected for newborn screening (NBS) and their use in research.MethodsWe conducted a hospital-based survey of parents and examined parental attitudes regarding (a) allowing NBS sample storage, (b) permitting use of children’s NBS samples for research with parental permission, and (c) permitting use of children’s NBS samples for research without parental permission.ResultsThe response rate was 52 percent. Of parents surveyed, 68 percent would permit their infant’s NBS sample (...) to be stored for at least some length of time. If permission is obtained, 69 percent of parents “strongly agreed” or “agreed” to permit use of the NBS sample for research. If permission is not obtained, only 14 percent of parents “strongly agreed” or “agreed.” There was no significant association between permitting use of NBS samples for research and parental gender, education, household income, number of children, or site of residence.ConclusionsThis is the first survey of Chinese parents regarding the use of NBS samples for different types of research, with results indicating that most parents would permit their infant’s sample to be stored and would support the use of NBS dried blood spots for research purposes. (shrink)

Hua-Ching Ni encourages each person to go beyond religion and theology in order to rediscover his or her own spiritual nature. He provides the tools with which one can unlock the spiritual treasures of the universe, lighting the way to internal and external harmony and fulfilment.

Institutional review boards distinguish health care quality improvement and health care quality improvement research based primarily on the rigor of the methods used and the purported generalizability of the knowledge gained. Neither of these criteria holds up upon scrutiny. Rather, this apparently false dichotomy may foster under-protection of participants in QI projects and over-protection of participants within QIR.

BackgroundThe Basal ganglia (BG) played a crucial role in the brain-level mechanisms of chronic pain disorders. However, the functional changes of BG in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are still poorly understood. This study investigated the BG subregions’ resting-state functional connectivity (rs-FC) in CP/CPPS patients compared with healthy controls.MethodsTwenty eight patients with CP/CPPS and 28 age- and education-matched healthy males underwent clinical measurements and 3T brain MR imaging, including T1-weighted structural images and resting-state functional imaging. The data were analyzed (...) by the seeded-based rs-FC analysis. Then, a machine learning method was applied to assess the feasibility of detecting CP/CPPS patients through the changed rs-FC.ResultsCompared with healthy males, patients presented decreased rs-FC between the BG subregions and right middle cingulate cortex, and correlated with pain (r = 0.51, p-uncorrected = 0.005) and urinary symptoms (r = –0.4, p-uncorrected = 0.034). The left superior temporal gyrus and right supramarginal gyrus showed decreased rs-FC with the BG subregions as well. The area under the receiver operating characteristic curve of 0.943 (accuracy = 80%, F1-score = 80.6%) was achieved for the classification of CP/CPPS patients and healthy males with support vector machine (SVM) based on the changed rs-FC.ConclusionThese findings provide evidence of altered BG subregions’ rs-FC in CP/CPPS, which may contribute to our understanding of the BG’s role in CP/CPPS. (shrink)

法律文化,是各民族、各国家和各地区法律善的整体表现,涉及法制建设和法律发展的整体水平,如立法、执法、司法和守法,以及法律教育、法律职业,民众的法律意识和法律观念等的发展状态。.

ObjectiveTwo subregions of the dorsolateral prefrontal cortex have been identified as effective repetitive transcranial magnetic stimulation targets for the “anxiosomatic” and “dysphoric” symptoms, respectively. We aimed to develop a convenient approach to locate these targets on the scalp.Materials and methodsIn a discovery experiment, the two personalized targets were precisely identified on 24 subjects using a neuronavigation system. Then, a localized approach was developed based on individual scalp landmarks. This “landmark-based approach” was replicated and validated in an independent cohort. Reliability of (...) the approach was tested by calculating the correlation of both the inter-rater and intra-rater results. Validity was tested by comparing the mean distance between the personalized and landmark-based targets to the TMS spatial resolution. We further conducted a total of 24 sham rTMS sessions to estimate the misplacement between the coil center and target during a 10-min stimulation without neuronavigation.ResultsThe parameters of the “landmark-based approach” in the discovery experiment were replicated well in an independent cohort. Using discovery parameters, we successfully identified the symptom-specific targets in the independent cohort. Specifically, the mean distance between the personalized and landmark-based targets on the cortex was not significantly larger than 5 mm. However, the personalized and landmark-based targets distance exceeded 5 mm in more than 50% of subjects. During the 10-min sham rTMS session, the average coil misplacement was significantly larger than 5 mm.ConclusionThe “landmark-based approach” can conveniently and reliably locate the two symptom-specific targets at group level. However, the accuracy was highly varied at individual level and further improvement is needed. (shrink)

Publications by Chinese researchers in scientific journals have dramatically increased over the past decade; however, academic misconduct also becomes more prevalent in the country. The aim of this prospective study was to understand the perceptions of Chinese biomedical researchers towards academic misconduct and the trend from 2010 to 2015. A questionnaire comprising 10 questions was designed and then validated by ten biomedical researchers in China. In the years 2010 and 2015, respectively, the questionnaire was sent as a survey to biomedical (...) researchers at teaching hospitals, universities, and medical institutes in mainland China. Data were analyzed by the Chi squared test, one-way analysis of variance with the Tukey post hoc test, or Spearman’s rank correlation method, where appropriate. The overall response rates in 2010 and 2015 were 4.5% and 5.5%, respectively. Data from 15 participants in 2010 were invalid, and analysis was thus performed for 1263 participants. Among the participants, 54.7% thought that academic misconduct was serious-to-extremely serious, and 71.2% believed that the Chinese authorities paid no or little attention to the academic misconduct. Moreover, 70.2 and 65.2% of participants considered that the punishment for academic misconduct at the authority and institution levels, respectively, was not appropriate or severe enough. Inappropriate authorship and plagiarism were the most common forms of academic misconduct. The most important factor underlying academic misconduct was the academic assessment system, as judged by 50.7% of the participants. Participants estimated that 40.1% of published scientific articles were associated with some form of academic misconduct. Their perceptions towards academic misconduct had not significantly changed over the 5 years. Reform of the academic assessment system should be the fundamental approach to tackling this problem in China. (shrink)

Sun Yat-sen’s superior position in modern Chinese history is represented in the movement of the modernization of China with him as a representative went from the stage of ‘imitation’ to the stage of ‘creativity’. He put forward, China, as a country engaging in modernization late, could draw on Western experience and lessons, run (“突驾”) from capitalism directly into socialism, and realize ‘accomplishing both the political revolution and the social revolution at one stroke’. He designed the modernization program of ‘accomplishing both (...) at one stroke’ as the Three People's Principles (Nationalism, Democracy and the People's Livelihood); each separately connects with Human rights, civil rights and national sovereignty pursued by modern Chinese and the essence of them develops around the value of equality approved by socialist thoughts of the day. According to Sun’s thinking: 1. People’s livelihood is the root of the Three People'sPrinciples, which involves most primary human rights --- right of survival because the value of human’s seeking survival necessarily directs to ‘equality and helping each other’, which is the law of the evolution of humanity. So the justice of socialism lies in ‘Leveling out the differences between the rich and the poor’, which can be realized with many ‘artificial’ elements such as nation and morality, etc. What must be done by People’s livelihood in contemporary China are ‘equalizing landownership’, ‘regulating capital’ and ‘developing industry’. 2. Democracy is the request of ‘civil rights’ in the sense of modern democracy. In the special national situation of China, it presents itself as the specific political framework ‘balancing people’s civil rights with elite administration’. 3. The essence of nationalism lies in constructing modern Chinese national country to save the nation from crises. Sun Yat-sen pointed out: First, the foundation on which Chinese nations build up their country is totally different from that of the West. So the country must take ‘collectivism’ as its value direction. Secondly, the ethos of the Chinese nation is different from that of the West. Chinese national country must take ‘morality first’ as the direction of value. Sun’s point of view is unique and single-eyed but contains unavoidable historical limits. (shrink)