Recent insights reveal the significant role of TRPV3 in warmth sensation. A novel finding elucidated how thermosensation is affected by TRPV3 membrane abundance that is modulated by the transmembrane protein TMEM79. TRPV3 is a warmth‐sensitive ion channel predominantly expressed in epithelial cells, particularly skin keratinocytes. Multiple studies investigated the roles of TRPV3 in cutaneous physiology and pathophysiology. TRPV3 activation by innocuous warm temperatures in keratinocytes highlights its significance in temperature sensation, but whether TRPV3 directly contributes to warmth sensations in vivo (...) remains controversial. This review explores the electrophysiological and structural properties of TRPV3 and how modulators affect its intricate regulatory mechanisms. Moreover, we discuss the multifaceted involvement of TRPV3 in skin physiology and pathology, including barrier formation, hair growth, inflammation, and itching. Finally, we examine the potential of TRPV3 as a therapeutic target for skin diseases and highlight its diverse role in maintaining skin homeostasis. (shrink)

We propose a new game to strategically justify the constrained equal awards rule in claims problems. Our game is “procedurally fair” and “multilateral”. In addition, even if claimants cannot reach an agreement in any period, they can renegotiate in the next period. We show that, for each claims problem, the awards vector chosen by the constrained equal awards rule achieved at period 1 is the unique subgame perfect equilibrium outcome of the game.

Estrogen receptor α (ERα) is a ligand‐dependent transcription factor that regulates the expression of estrogen‐responsive genes. Approximately 70% of patients with breast cancer are ERα positive. Estrogen stimulates cancer cell proliferation and contributes to tumor progression. Endocrine therapies, which suppress the ERα signaling pathway, significantly improve the prognosis of patients with breast cancer. However, the development of de novo or acquired endocrine therapy resistance remains a barrier to breast cancer treatment. Therefore, understanding the regulatory mechanisms of ERα is essential to (...) overcome the resistance to treatment. This review focuses on the regulation of ERα expression, including copy number variation, epigenetic regulation, transcriptional regulation, and stability, as well as functions from the point of view post‐translational modifications. (shrink)

Within a weak subsystem of second-order arithmetic , that is -conservative over , we reformulate Kreisel's proof of the Second Incompleteness Theorem and Boolos' proof of the First Incompleteness Theorem.

Akama et al. [1] systematically studied an arithmetical hierarchy of the law of excluded middle and related principles in the context of first-order arithmetic. In that paper, they first provide a prenex normal form theorem as a justification of their semi-classical principles restricted to prenex formulas. However, there are some errors in their proof. In this paper, we provide a simple counterexample of their prenex normal form theorem [1, Theorem 2.7], then modify it in an appropriate way which still serves (...) to largely justify the arithmetical hierarchy. In addition, we characterize a variety of prenex normal form theorems by logical principles in the arithmetical hierarchy. The characterization results reveal that our prenex normal form theorems are optimal. For the characterization results, we establish a new conservation theorem on semi-classical arithmetic. The theorem generalizes a well-known fact that classical arithmetic is $\Pi _2$ -conservative over intuitionistic arithmetic. (shrink)

In this paper, I show that the availability of what some authors have called the weak reading and the strong reading of donkey sentences with relative clauses is systematically related to monotonicity properties of the determiner. The correlation is different from what has been observed in the literature in that it concerns not only right monotonicity, but also left monotonicity (persistence/antipersistence). I claim that the reading selected by a donkey sentence with a double monotone determiner is in fact the one (...) that validates inference based on the left monotonicity of the determiner. This accounts for the lack of strong reading in donkey sentences with MON determiners, which have been neglected in the literature. I consider the relevance of other natural forms of inference as well, but also suggest how monotonicity inference might play a central role in the actual process of interpretation. The formal theory is couched in dynamic predicate logic with generalized quantifiers. (shrink)

We give a proof of Gödel's first incompleteness theorem based on Berry's paradox, and from it we also derive the second incompleteness theorem model-theoretically.

By formalizing Berry's paradox, Vopěnka, Chaitin, Boolos and others proved the incompleteness theorems without using the diagonal argument. In this paper, we shall examine these proofs closely and show their relationships. Firstly, we shall show that we can use the diagonal argument for proofs of the incompleteness theorems based on Berry's paradox. Then, we shall show that an extension of Boolos' proof can be considered as a special case of Chaitin's proof by defining a suitable Kolmogorov complexity. We shall show (...) also that Vopěnka's proof can be reformulated in arithmetic by using the arithmetized completeness theorem. (shrink)

It is well known that Gödel’s incompleteness theorems hold for ∑1-definable theories containing Peano arithmetic. We generalize Gödel’s incompleteness theorems for arithmetically definable theories. First, we prove that every ∑n+1-definable ∑n-sound theory is incomplete. Secondly, we generalize and improve Jeroslow and Hájek’s results. That is, we prove that every consistent theory having ∏n+1set of theorems has a true but unprovable ∏nsentence. Lastly, we prove that no ∑n+1-definable ∑n-sound theory can prove its own ∑n-soundness. These three results are generalizations of Rosser’s (...) improvement of the first incompleteness theorem, Gödel’s first incompleteness theorem, and the second incompleteness theorem, respectively. (shrink)

Some formal properties of enriched systems of Lambek calculus with analogues of conjunction and disjunction are investigated. In particular, it is proved that the class of languages recognizable by the Lambek calculus with added intersective conjunction properly includes the class of finite intersections of context-free languages.

We provide a fine‐grained analysis on the relation between König's lemma, weak König's lemma, and the decidable fan theorem in the context of constructive reverse mathematics. In particular, we show that double negated variants of König's lemma and weak König's lemma are equivalent to double negated variants of the general decidable fan theorem and the binary decidable fan theorem, respectively, over a nearly intuitionistic system containing a weak countable choice only. This implies that the general decidable fan theorem is not (...) equivalent to the binary decidable fan theorem in the absence of a strong countable choice. In addition, we introduce a principle which fills the gap between König's lemma and weak König's lemma, and show that König's lemma is equivalent to weak König's lemma plus this principle. We also solve several problems arising from the investigation. (shrink)

By using a provability predicate of PA, we define ThmPA(M) as the set of theorems of PA in a modelMof PA. We say a modelMof PA is (1) illusory if ThmPA(M) ⊈ ThmPA(ℕ), (2) heterodox if ThmPA(M) ⊈ TA, (3) sane ifM⊨ ConPA, and insane if it is not sane, (4) maximally sane if it is sane and ThmPA(M) ⊆ ThmPA(N) implies ThmPA(M) = ThmPA(N) for every sane modelNof PA. We firstly show thatMis heterodox if and only if it is (...) illusory, and that ThmPA(M) ∩ TA ≠ ThmPA(ℕ) for any illusory modelM. Then we show that there exists a maximally sane model, every maximally sane model satisfies ¬ConPA+ConPA, and there exists a sane model of ¬ConPA+ConPAwhich is not maximally sane. We define that an insane model is (5) illusory by nature if its every initial segment being a nonstandard model of PA is illusory, and (6) going insane suddenly if its every initial segment being a sane model of PA is not illusory. We show that there exists a model of PA which is illusory by nature, and we prove the existence of a model of PA which is going insane suddenly. (shrink)

We systematically study several principles and give a principle which is weaker than disjunctive Markov’s principle. We also show that the principle is underivable and strictly weaker than MP∨ in certain extensions of the system EL of elementary analysis.

On sait que Platon fait grand cas des êtres intelligibles en instaurant la théorie des Idées. Mais il n’est pas approprié de le considérer comme penseur qui néglige le rôle de l’apparence sensible. Ce philosophe demeure très sensible à la modalité par laquelle les phénomènes apparaissent dans le champ de notreperception. En distinguant deux types d’apparence : image et simulacre, il donne à l’image le rôle d’intermédiaire actif entre le sensible et l’intelligible. L’examen des modalités des actions humaines qui reçoivent (...) et créent des images, nous aide à voir comment Platon intègre la fonction des images dans la structure de sa philosophie. La réception et la création des images sont étroitement reliées et synthétisées pour former le système original de Platon, système dans lequel le fondement de la théorie des Idées relève d’un certain dynamisme de l’action humaine. Dans la recherche relative à la modalité de réception et de création des images, je porte mon attention sur l’usage platonicien du terme tupos qui exprime le principe de la conformité de l’image et de son modèle.Notamment dans la théorie de la formation des futurs gardiens de la cité idéale, le tupos fonctionne, comme un principe qui réglemente et oriente à plusieurs niveaux les activités de la mimèsis et de la poièsis qui portent sur les images. La réflexion sur cette fonction conductrice. (shrink)

Translated text is chapt. 7, pt. 2 of Kirisutokyō no benshō.

As Hegel suggests, there is no philosophy apart from the history of philosophy. Each philosophy represents the spirit peculiar to its own period. Heidegger, too, holds that every philosophy is the sound of Being, and the history of philosophy is the history of Being. This is true for the Kyoto School philosophy of modern Japan represented by Kitaro Nishida, Hajime Tanabe, and Tetsuro Watsuji, who made to endeavor to construct a new synthesis of Western and Eastern philosophy in the critical, (...) confrontational, and creative ways in the given historical contexts. In particular, Tanabe attempts at the dialectical unification of Christianity and Buddhism in the last resort from the standpoint of Absolute Nothingness. As, in Whitehead’s conception of process, actuality is composed of the past objective being as the given data and the present subjective act of becoming, so it might be highly significant to analyze the constitutive elements of Tanabe’s system of thought from the historical and comparative contexts. (shrink)

We refine the arithmetical hierarchy of various classical principles by finely investigating the derivability relations between these principles over Heyting arithmetic. We mainly investigate some restricted versions of the law of excluded middle, De Morgan's law, the double negation elimination, the collection principle and the constant domain axiom.

We systematically study conservation theorems on theories of semi-classical arithmetic, which lie in-between classical arithmetic $\mathsf {PA}$ and intuitionistic arithmetic $\mathsf {HA}$. Using a generalized negative translation, we first provide a structured proof of the fact that $\mathsf {PA}$ is $\Pi _{k+2}$ -conservative over $\mathsf {HA} + {\Sigma _k}\text {-}\mathrm {LEM}$ where ${\Sigma _k}\text {-}\mathrm {LEM}$ is the axiom scheme of the law-of-excluded-middle restricted to formulas in $\Sigma _k$. In addition, we show that this conservation theorem is optimal in the (...) sense that for any semi-classical arithmetic T, if $\mathsf {PA}$ is $\Pi _{k+2}$ -conservative over T, then ${T}$ proves ${\Sigma _k}\text {-}\mathrm {LEM}$. In the same manner, we also characterize conservation theorems for other well-studied classes of formulas by fragments of classical axioms or rules. This reveals the entire structure of conservation theorems with respect to the arithmetical hierarchy of classical principles. (shrink)

We shall prove the second incompleteness theorem via Kolmogorov complexity.

In this collection on the Kyoto School of Philosophy, the author offers the reader Tanabe's religious philosophy, but also, and for the first time, his ...