The Search for the Legacy of the USPHS Syphilis Study at Tuskegee is a collection of essays from experts in a variety of fields seeking to redefine the legacy of the infamous Tuskegee Syphilis Study. The essayists place the legacy of the study within the evolution of racial and ethnic relations in the United States. Contributors include two leading historians on the study, two former United States Surgeons General, and other prominent scholars from a wide range of fields.

The paper is written in response to those who fail to recognize the relation between a patient's mental competency and her state of pain. Some clinicians claim that a proper diagnosis can only be made in the absent of analgesia. Rather, the patient's state of pain directly affects her mental competency and thus her ability to give valid consent. Clinicians should rethink their approach to diagnosis when the patient is in pain.

Three studies were conducted to explore the psychological determinants of COVID-deterrent behaviors. In Study 1, using data collected and analyzed both before and after the release of COVID-19 vaccines, mask-wearing, other preventative behaviors like social distancing, and vaccination intentions were positively related to assessments of the Coronavirus Behavioral Health Mindset ; belief in the credibility of science; progressive political orientation; less use of repressive and more use of sensitization coping; and the attribution of COVID-19 safety to effort rather than ability, (...) powerful forces, fate, or luck. In Study 2, favorable COVID-19 vaccination intentions were related to greater willingness to work, lower emotional distress, and greater customer experience mindset. Study 3 examined the personality and motives of individuals who volunteered to help deliver COVID-19 inoculations to the local community. The vaccine-giving volunteers, especially those with prosocial motives, had high CVBHM scores, belief in the credibility of science, low use of repressive coping, greater attribution of COVID-19 protection to effort, low likelihood of voting conservative, were older, and had more education than others. The majority of public health volunteers expressed prosocial motives to help people or join a cause, but many expressed the personal motives of getting the COVID-19 vaccination for themselves, conveying a public image of compassion, or structuring time. Based on the three research studies, a COVID-19 Mindset Hierarchy model is proposed to integrate the results. (shrink)

Early versions of satellite and radiosonde datasets suggested that the tropical surface had warmed more than the troposphere, while climate models consistently showed tropospheric amplification of surface warming in response to human-caused increases in greenhouse gases. We revisit such comparisons here using new observational estimates of surface and tropospheric temperature changes. We find that there is no longer a serious discrepancy between modeled and observed trends in the tropics. Our results contradict a recent claim that all simulated temperature trends in (...) the tropical troposphere are inconsistent with observations. This claim was based on the use of older radiosonde and satellite datasets and on two methodological errors: the neglect of observational trend uncertainties introduced by interannual climate variability and application of an inappropriate statistical “consistency test”.This emerging reconciliation of models and observations has two primary explanations. First, because of changes in the treatment of buoy and satellite information, new surface temperature datasets yield slightly reduced tropical warming relative to earlier versions. Second, recently developed satellite and radiosonde datasets now show larger warming of the tropical lower troposphere. In the case of a new satellite dataset from remote sensing systems, enhancedRSS warming is due to an improved procedure of adjusting for inter-satellite biases. When the RSS-derived tropospheric temperature trend is compared with four different observed estimates of surface temperature change, the surface warming is invariably amplified in the tropical troposphere, consistent with model results. Even if we use data from a second satellite dataset with smaller tropospheric warming than in remote sensing systems RSS, observed tropical lapse rates are not significantly different from those in all model simulations.Our results contradict a recent claim that all simulated temperature trends in the tropical troposphere and in tropical lapse rates are inconsistent with observations. This claim was based on the use of older radiosonde and satellite datasets and on two methodological errors: the neglect of observational trend uncertainties introduced by interannual climate variability and application of an inappropriate statistical “consistency test”. (shrink)

BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.MethodsIn a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication (...) in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-group differences in the proportion of manuscripts meeting all ARRIVE guideline checklist subitems.ResultsWe randomised 1689 manuscripts (control: n = 844, intervention: n = 845), of which 1269 were sent for peer review and 762 (control: n = 340; intervention: n = 332) accepted for publication. No manuscript in either group achieved full compliance with the ARRIVE checklist. Details of animal husbandry (ARRIVE subitem 9b) was the only subitem to show improvements in reporting, with the proportion of compliant manuscripts rising from 52.1 to 74.1% (X2 = 34.0, df = 1, p = 2.1 × 10−7) in the control and intervention groups, respectively.ConclusionsThese results suggest that altering the editorial process to include requests for a completed ARRIVE checklist is not enough to improve compliance with the ARRIVE guidelines. Other approaches, such as more stringent editorial policies or a targeted approach on key quality items, may promote improvements in reporting. (shrink)

Wisdom, J. L. Susan Stebbing, 1885-1943, an appreciation.--Acton, H. B. Moral ends and means.--Laird, J. Reflections occasioned by ideals and illusions.--Edgell, B. The way of behaviour.--Oakeley, H. D. Is there reason in history?--Mace, C. A. The logic of elucidation.--Ewing, A. C. Philosophical analysis.--Duncan-Jones, A. The concert ticket.--Black, M. Logic and semantics.--Saw, R. L. The grounds of induction in Professor Whitehead's philosophy of nature.--Russell, L. J. Epistemology and the ego-centric predicament.--Susan Stebbing: publications (p. 155-156).

This critical editorial introduction summarizes and explicates Frederick Will’s pragmatic realism and his account of the nature, assessment, and revision of cognitive and practical norms in connection with: the development of Will’s pragmatic realism, Hume’s problem of induction, the oscillations between foundationalism and coherentism, the nature of philosophical reflection, Kant’s ‘Refutation of Idealism’, the open texture of empirical concepts, the correspondence conception of truth, Putnam’s ‘internal realism’, the redundancy theory of truth, sociology of knowledge, the governance of practice by norms (...) and the assessment and revision of norms in practice, scientific realism, the alleged independence of reason and tradition, rule-following, legal realism, ethical intuitionism and moral relativism, the regress problem (both in epistemology and in moral theory), the paradox of analysis, and culminating in Will’s account of the philosophical governance of norms. These issues are discussed in close consideration of the views of: William Alston, John Dewey, Descartes, Leibniz, Waismann, Austin, Russell, Schlick, Ayer, Richard Rorty, Michael Williams, Hempel, Carnap, Simon Blackburn, Ramsey, Strawson, Kuhn, Wilfrid Sellars, Wittgenstein, Nozick, Dretske, Quine, Barbara Herman, Hardy Jones, Marcus Singer, and Gerd Buchdahl. (shrink)

This volume is fifth in a series, Monuments of Western Thought. Most of the book consists of excerpts from the works of Bacon and Descartes The selections from Bacon are the preface and plan of The Great Instauration, parts of the New Organon, a bit of Advancement of Learning, and all of The New Atlantis. The selections from Descartes are a short passage from the Discourse on Method and all of the Meditations. The text is introduced by a historical sketch (...) of the intellectual, social, and political context in which Bacon and Descartes lived, and by brief intellectual biographies. The volume closes with short critical selections, pointing up and commenting on important issues in the source material. On Bacon: A. N. Whitehead deals with Bacon's concept of matter, the justification of induction, and Bacon's emphasis on quality; C. D. Broad discusses Bacon's concept of "Form" and its relation to the principle of limited variety; R. F. Jones discusses the Idols, especially the Idol of the Market-place, and Bacon's stress on experimentation; B. Farrington interprets Bacon's rejection of scholasticism as part of the contemporary effort to return to the Hebrew origins of Christianity. On Descartes: A. Koyré deals with consequences of the Cartesian identification of matter with extension; S. V. Keeling discusses the importance of the cogito and interprets it as giving knowledge of the existence of a substantival self; A. B. Gibson interprets Cartesian personalism as the foundation of a realism; M. Versfeld interprets Cartesian personalism as an error making knowledge impossible. Each section is followed by a few questions designed to force the student to think about what he has read and to return to the text.--L. G. (shrink)

This volume is fifth in a series, Monuments of Western Thought. Most of the book consists of excerpts from the works of Bacon and Descartes The selections from Bacon are the preface and plan of The Great Instauration, parts of the New Organon, a bit of Advancement of Learning, and all of The New Atlantis. The selections from Descartes are a short passage from the Discourse on Method and all of the Meditations. The text is introduced by a historical sketch (...) of the intellectual, social, and political context in which Bacon and Descartes lived, and by brief intellectual biographies. The volume closes with short critical selections, pointing up and commenting on important issues in the source material. On Bacon: A. N. Whitehead deals with Bacon's concept of matter, the justification of induction, and Bacon's emphasis on quality; C. D. Broad discusses Bacon's concept of "Form" and its relation to the principle of limited variety; R. F. Jones discusses the Idols, especially the Idol of the Market-place, and Bacon's stress on experimentation; B. Farrington interprets Bacon's rejection of scholasticism as part of the contemporary effort to return to the Hebrew origins of Christianity. On Descartes: A. Koyré deals with consequences of the Cartesian identification of matter with extension; S. V. Keeling discusses the importance of the cogito and interprets it as giving knowledge of the existence of a substantival self; A. B. Gibson interprets Cartesian personalism as the foundation of a realism; M. Versfeld interprets Cartesian personalism as an error making knowledge impossible. Each section is followed by a few questions designed to force the student to think about what he has read and to return to the text.--L. G. (shrink)

A central claim of Jones & Love's (J&L's) article is that Bayesian Fundamentalism is empirically unconstrained. Unless constraints are placed on prior beliefs, likelihood, and utility functions, all behaviour is consistent with Bayesian rationality. Although such claims are commonplace, their basis is rarely justified. We fill this gap by sketching a proof, and we discuss possible solutions that would make Bayesian approaches empirically interesting.

This paper attempts to explore a number of conceptual issues surrounding genetic testing. It looks at the meaning of the terms, genetic information and genetic testing in relation to the definition set out by the Advisory Committee on Genetic Testing in the UK, and by the Task Force on Genetic Testing in the USA. It argues that the special arrangements that may be required for the regulation of genetic tests should not be determined by reference to the nature or technology (...) of the test, but by considering those morally relevant features that justify regulation. Failure to do so will lead to the regulation of genetic tests that need not be regulated, and would fail to cover other tests which should be regulated. The paper also argues that there is little in the nature of the properties of gene tests, using DNA or chromosomes, that in itself justifies a special approach. (shrink)

This paper challenges historically preconceived notions surrounding a minor’s ability to make medical decisions, arguing that federal health law should be reformed to allow minors with capacity as young as age 12 to consent to their own Centers for Diseases Control and Prevention (CDC)-approved COVID-19 vaccinations. This proposal aligns with and expands upon current exceptions to limitations on adolescent decision-making. This analysis reviews the historic and current anti-vaccination sentiment, examines legal precedence and rationale, outlines supporting ethical arguments regarding adolescent decision-making, (...) and offers rebuttals to anticipated ethical counterarguments. (shrink)

Mr D. H. Mellor, in his article of this title in Religious Studies , Vol. 5 , distinguishes three senses of words such as ‘probable’ which might be used in a religious context, especially in that of attempted theistic proofs: statistical, subjective, and inductive probability. In each case he concludes that it is misleading to use these words in such contexts at all. With his discussion of the second I do not wish to quarrel; but there seem to me to (...) be serious defects in his discussions of the first and third. (shrink)