Molecular genetic testing has increasingly been incorporated into clinical medicine, and this trend is likely to accelerate in the future. The introduction of genetic testing into medical practice is beginning to collide head on with patents that claim ownership of correlations between human genetic variants and predisposition to disease, response to therapeutic drugs, and susceptibility to pharmacologic side effects. Patent holders or licensees of genes, genetic variants, and their genotype-phenotype correlations are already using the threat of litigation to monopolize genetic (...) tests for important well-known syndromes like Duchenne Muscular Dystrophy and inherited breast and ovarian cancer, in addition to a host of less commonly discussed conditions. (shrink)

The calculus of relations was created and developed in the second half of the nineteenth century by Augustus De Morgan, Charles Sanders Peirce, and Ernst Schröder. In 1940 Alfred Tarski proposed an axiomatization for a large part of the calculus of relations. In the next decade Tarski's axiomatization led to the creation of the theory of relation algebras, and was shown to be incomplete by Roger Lyndon's discovery of nonrepresentable relation algebras. This paper introduces the calculus of relations and (...) the theory of relation algebras through a review of these historical developments. (shrink)

This book is intended as an equivalent to or substitute for that "more reflective reading" which Rousseau considered essential to an understanding of his ideas. It is designed to complement perusal of the texts themselves, and the arrangement is such that chapters on each of Rousseau's major writings can be consulted separately or the commentary may be read through in sequence. The author's purpose is not to present a "key" to Rousseau's political philosophy, but rather to explore the works themselves (...) in an effort to reveal Rousseau's "system," from which the reader may then draw his own conclusions. Originally published in 1976. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

The set of equations which use only one variable and hold in all representable relation algebras cannot be derived from any finite set of equations true in all representable relation algebras. Similar results hold for cylindric algebras and for logic with finitely many variables. The main tools are a construction of nonrepresentable one-generated relation algebras, a method for obtaining cylindric algebras from relation algebras, and the use of relation algebras in defining algebraic semantics for first-order logic.

Les chercheurs disputent depuis longtemps pour savoir si Machiavel est le "premier moderne", le chef de file du "républicanisme classique" ou un penseur laïc dans une perspective médiévale ou pré-moderne. Les rapports personnels entre Léonard de Vinci et Machiavel, dont les théoriciens politiques sont généralement inconscients, permettent de mieux comprendre le rôle de Machiavel dans la transition vers la modernité. La conception vincinienne d'une science de la nature et les possibilités qu'elle ouvrait aux innovations technologiques ont représenté un grand pas (...) dans le passage de la philosophie antique ou médiévale à la science naturelle moderne. Après avoir été l'ingénieur militaire de Ludovic Sforza puis de César Borgia, Vinci est rentré à Florence en 1503. Machiavel, qui l'avait apparemment rencontré en 1502, s'est assuré son aide technique pour diriger le cours de l'Arno afin de vaincre Pise, l'auteur du Prince semble aussi être lié à la commande du tableau de la Bataille d'Anghiari et il s'est arrangé pour que Vinci dirige une mission technique à Piombino en 1504. Les textes prouvent que Machiavel a été nettement influencé par ces expériences, ce qui suggère une réponse plausible aux controverses sur la "modernité" de Machiavel. La différence entre les approches des mathématiques et de la physique par Vinci puis par Galilée ou Newton illustre particulièrement bien les étapes ultérieurement nécessaires pour le développement complet d'une approche moderne de la politique comme celle de Hobbes ou Locke dans la tradition anglo-saxonne, ou de Descartes et des "philosophes" sur le continent. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 373 in the analysis of the "artificial" virtue of justice. Though he uses the term "faculties" as synonymous with energies or powers, he warns against the "faculty psychology" that uses faculties as explanations or causes. Hume writes: "By will I mean nothing but the internal impression we feel.., when we knowingly give rise to any new motion of our body or new perception of our mind." A (...) voluntary action, being "knowingly" aroused, is not a mere "direct " passion arising immediately from sensation; nevertheless, it belongs to the realm of passions rather than of judgments. It is included in the "bundle of impressions" psychology. Hume attempts to explain how the passion of sympathy serves to communicate impressions. Emotional expressions require the operation of the "imagination" to generate the social controls of conscience and to explain the origin of responsibility in terms of approvals and disapprovals. In this connection, /~rdal points out the differences between Hume's and Adam Smith's psychology of sympathy, ttume is content to rely largely on "imagination" to explain social sensitivities, whereas Adam Smith develops the theory that by sympathy men are led to put themselves in the place of others and thus to get a "disinterested spectator" view of passions. This seems to me a minor difference, and Hume, though he knew of Adam Smith's theory, and though he criticized him on other points, does not directly obiect to this particular doctrine of Adam Smith. It is, in fact, related to Hume's own analysis of justice as an "artificial" virtue, not directly related to the self-regarding passions. What separates Smith from Hume is his discussion of sympathy in the context of pity and benevolence which the Scottish moralists had made basic, whereas ttume keeps sympathy as a passion distinct from the virtues. In general, I have the "impression" that Hume, after he made this elaborate effort to apply experimental method to the passions and to valuational expressions, left the further development of this psychology to his close friend, Adam Smith, while he turned to "political essays" and to the more practical problems of the Enquiry. In his political essays, which brought him into public recognition in England and on the Continent while the Treatise continued to be basic for the Scottish social psychologists, Hume became especially concerned to call attention to the social operation of "opinions" and faiths. Therefore, it seems to me to be a mistake to regard the Enquiry as merely a "popular" edition of the Treatise. Hume shifted his interest from the critique of Locke's psychology to the practical problems of politics and morals. His History deals less with the psychological "origins" of customs, beliefs, and habits, more with their power in shaping the course of events. In other words, for Hume's ideas about judgments of value and the motivation of policies and principles, one must turn to Hume's later writings. The reader of ~rdal's excellent analysis of the Treatise cannot refrain from hoping that the author will make a similar examination of Hume's later "moral science." For, in addition to clarifying Hume, it will give.Ardal an opportunity to continue his own critical insights on present-day discussion of emotivist and intuitional ethics, which are not the least valuable feature of this volume. HERBERT W. SCHNEIDER Claremont, California Jean-Jacques Rousseau. By Jean Gu~henno. Translated from the French by John and Doreen Weightman. (2 vols. New York: Columbia University Press, 1967. Vol. I, pp. xvi + 460. Vol. II, pp. xi + 316. set $17.50.) Rousseau and Jean-Jacques It has been Rousseau's peculiar fate to exercise a double fascination. A major philosopher, especially in the fields of education, politics, and morality, Jean-Jacques has also been read, loved, and hated as a man. In reading again Jean Gu~henno's impressive biography, recently published in an excellent English translation, one wonders why so much attention has been paid to Rousseau's private life. Surely it is not because he lacks the credentials of a serious thinker; the Second Discourse alone, not to mention the Emile and Social Contract, would presumably ensure Rousseau's place in any historical survey of Western... (shrink)

Most people are familiar with the traditional view of the role of ethics in the auditing profession - the need for auditors with integrity and objectivity. This essay addresses a second dimension of ethics in the auditing profession - the demand for auditors to assess the integrity and ethical values of clients. This second dimension is a difficult task for auditors in practice and demands a deep and robust understanding of ethics, ethical infrastructures, and the products of those infrastructures. The (...) essay proposes how educators and researchers might facilitate that understanding. (shrink)

Conjecture (1) of [Ma83] is confirmed here by the following result: if $3 \leq \alpha < \omega$, then there is a finite relation algebra of dimension α, which is not a relation algebra of dimension α + 1. A logical consequence of this theorem is that for every finite α ≥ 3 there is a formula of the form $S \subseteq T$ (asserting that one binary relation is included in another), which is provable with α + 1 variables, but not (...) provable with only α variables (using a special sequent calculus designed for deducing properties of binary relations). (shrink)

The usage, derivation, and psychological, ethical, and legal aspects of slang terminology in medicine are discussed. The colloquial vocabulary is further described and a comprehensive glossary of common UK terms provided in the appendix. This forms the first list of slang terms currently in use throughout the British medical establishment.

Sound and complete semantics for classical propositional logic can be obtained by interpreting sentences as sets. Replacing sets with commuting dense binary relations produces an interpretation that turns out to be sound but not complete for R. Adding transitivity yields sound and complete semantics for RM, because all normal Sugihara matrices are representable as algebras of binary relations.

This monograph introduces the functional characteristics and conceptual significance of a simulation software system called CyberRat (Ray, 1996a, 2003a, 2012a, 2012b). CyberRat expands upon prior illustrations (Ray & Delprato, 1989; Ray, 1992) of how such computer-based simulations can serve to formatively enhance, and eventually validate, the descriptive research methodology upon which their development relies. To illustrate this process I also review highlights of previous publications (cf. Ray & Brown, 1975, 1976; Ray & Delprato, 1989), detailing the unique research methodology used (...) to collect data that guided CyberRat’s development. This methodology integrates interbehavioral psychology (Kantor, 1959) and general systems analysis (von Bertalanffy, 1968), and thus is referred to as interbehavioral systems analysis (IBSA). CyberRat’s validation of IBSA methods involves a process analogous to Turing’s (1950) famous test for simulation authenticity, in that it relies upon “phenomenological equivalence” criteria for observers to compare experiences of real vs. simulated events. And because IBSA stresses three convergent strategies for research, including structural analysis, functional analysis, and operations analysis, my organizing theme addresses how closely CyberRat comes to passing a trilogy of hypothetical Turing tests—one for each of these three analytic strategies. (shrink)

This essay discusses the attempt by seventeenth- and eighteenth-century British writers to achieve a clear definition of "wit." I provide a number of quotations from Hobbes, Locke, Pope, Addison, Dryden, and others to make the point that there was an unresolved tension between wit and judgment, imagination and reason, and rhetoric and philosophy, throughout the period.

Literary-communicational theory offers a foundation for two types of literary criticism whose workings are basically ameliorative: mediating criticism, which seeks to bridge the gaps between writers and readers who are differently positioned; and communicational criticism, which offers an ethical assessment of literary writing as communication. The present article illustrates the processes of mediating criticism, by trying to help its own readers understand the religio-historical sitedness of the early-seventeenth-century English Catholic poet, Sir John Beaumont. More extensively, the article pays attention to (...) Beaumont’s use of cultural memory, as an illustration of communicational criticism. In some of his poems, Beaumont was communicationally exclusive, appealing to past history in a defensive spirit, as part of an effort to purify and strengthen a Catholic identity under threat. Elsewhere, he resorted to cultural memory in communicational gestures that were more inclusive, and of three different kinds. Sometimes his Catholicism went on to the offensive, and he arrogated a common memorial ground in a coercive, missionary spirit. Sometimes his inclusivity may strike a present-day reader as disingenuous, in that it involved a self-disguising, self-betraying acquiescence in the royal court’s dominant, non-Catholic discourse. Sometimes the play of cultural memory was altogether more dialogical in spirit: an inclusiveness which was neither aggressive not self-demeaning, but which invited readers to compare notes in the hope of viable co-existence. (shrink)

Although it has become increasingly evident that an adequate theory of obligation must rest on evolutionary biology and human ethology, attempts toward this end need to explore the full range of personal, cultural, and political obligations observed in our species. The new naturalism reveals the complexity of social behavior and the defects of reductionist models that oversimplify the foundations of human duties and rights. Ultimately, this approach suggest a return to the Aristotelian concept of natural justice.

In lieu of an abstract, here is a brief excerpt of the content:Hume Studies Volume XXIII, Number 2, November 1997, pp. 315-335 Reid: Conception, Representation and Innate Ideas ROGER D. GALLIE Section I of this paper begins with a presentation of Thomas Reid's doctrine of the signification of words, of what words signify or represent. That presentation serves to introduce a problem of interpretation, namely, what Reid thinks the connection is between conceiving something and grasping what a term for (...) it signifies. It is pointed out that even if Reid maintains that what a word signifies is conceived by both speaker and hearer when that word is understood, this is a far cry from the position that he takes the stronger view, whether for all or only for some things, that their being conceived involves the understanding of a term or terms. The position that he does indeed take this stronger, although moderate, view is defended in sections II, III and IV. In sections II and III it is argued that, in Reid's view, for an adequate conception of an individual, real or imaginary, a conception of its attributes is needed. In section IV it is argued that the possession of general conceptions (in distinction from their formation), without which conception of attributes is impossible, requires appropriate understanding of general terms. So since for the conception of an individual a conception of its attributes is needed, and since for the conception of attributes appropriate understanding of general terms is required, we arrive at a textually well-founded position: for the conception of most things, in Reid's view, understanding of terms is indispensable. Roger D. Gallie is at the Department of Philosophy, Nottingham University, University Park, Nottingham NG7 2RD UK. email: Roger[email protected] 316 Roger D. Gallie The remainder of the paper considers the following question: to what extent, if any, Reid is committed to acceptance of nativist views on concept possession? To answer, in section V we consider to what extent Reid's moderate position on the possession of conceptions commits him to accepting Jerry Fodor's representational theory of mind (RTM) for propositional attitudes. It is clear that the view that a propositional attitude state such as belief involves some relation between a person and a representation such as a significant word, phrase or sentence of a natural language such as English can fairly be attributed to Reid. But it is also clear that Reid cannot be an adherent of the view that persons have a functional cum computational relation to Fodorean mental representations, so he cannot be an adherent of any nativism ex- plicitly contained in such a view. But it is to be noted that in his Inquiry, Chapter IV, Reid argues by a different route that in order to acquire a language such as English prior mastery of a system of significant signs is required. In section VI Keith Lehrer's argument in criticism of a reductionist interpretation of a position such as Fodor's is presented: that for a sign to signify something to someone presupposes that that person has a conception of what is signified. It is however pointed out that since there is a case for not viewing Fodor's position as reductionist overall Fodor can accept Lehrer's argument. Lehrer's innatist position, which he both claims to follow easily from this critical argument and to be a correct interpretation of Reid, is then presented: that we must presuppose an innate understanding of some signs to account for our learning the meaning of any signs. The objection that Reid too must accept the alleged innatist implications of Lehrer's critical argument in view of the implications of his moderate position on the possession of conceptions is considered and rebutted. In section VIII argue that while Lehrer makes a respectable case for innate principles of formation of conceptions such as that of hardness, something that Reid clearly endorses in his Inquiry, Chapter V, he does not succeed in making a case for there being any innate possession of conceptions. Finally, in section VIII, Reid's mature views in the Intellectual Powers, Essay VI, on how conceptions come to be possessed are expounded, and are fleshed out with some... (shrink)

It is undeniable that health care costs have been increasing at an alarming rate. During the ten-year period between 1983 and 1993, the medical care component of the Consumer Price Index rose at an average annual rate of 10 percent while the overall CPI increased by only 4.5 percent per year. These dramatic increases have obvious societal implications. For those without health insurance, a serious illness may mean personal bankruptcy. For those with health insurance coverage, premiums are rising while coverage (...) is shrinking. Employers are struggling to continue providing health insurance to their employees. Irrespective of whose fault it really is, much of the blame has been directed at health care providers.Faced with mounting criticism regarding the costs of delivering health care, the industry struck back. It claimed that collaboration—not competition—was necessary to reduce health care costs and improve efficiency, but that antitrust uncertainty deterred such collaborative efforts. (shrink)