The return of individual research results and incidental findings from biobanking research is a much debated ethical issue globally but has extensive relevance in India where the burden of out of pocket health care expenses is high for the majority. The views of 21 ethics committee (EC) members and 22 researchers from Bengaluru, India, concerning the ethics of biobanking research were sought through in‐depth interviews using an unfolding case vignette with probes. A shared view among most was that individual research (...) results which are ‘actionable’ or have ‘clinical significance’ should be returned to the sample contributors through their treating physicians. This was seen as an ethical obligation and a moral duty on the side of the researcher to “give back” to the person who contributed to the research. The challenges foreseen were that of resources, both financial and personnel, for the time and counseling needed to accompany the disclosure of results. Perceptions of ‘ownership’ appear to influence the concept of benefit sharing. While benefit sharing in financial terms was considered ethically challenging, certain researchers and ethics committee members made a case for “two way altruism” where the researcher in return for the altruistic ‘valuable contribution’, shares with the contributor/ community, benefits of the research which could include research findings, improved patient care, and more affordable access to the new diagnostic tests or products arising from the research. This defines the emerging ethic of “giving back” which goes beyond individual rights and ensures reciprocity and distributive justice. (shrink)

On Advaita philosophy; Sanskrit text with commentary and translation.

RAID-II is a high-bandwidth, network-attached storage server designed and implemented at the University of California at Berkeley. In this paper, we measure the performance of RAID-II and evaluate various architectural decisions made during the design process. We first measure the end-to-end performance of the system to be approximately 20 MB/s for both disk array reads and writes. We then perform a bottleneck analysis by examining the performance of each individual subsystem and conclude that the disk subsystem limits performance. By adding (...) a custom interconnect board with a high-speed memory and bus system and parity engine, we are able to achieve a performance speedup of 8 to 15 over a comparative system using only off-the-shelf hardware. (shrink)

Ni-44 at.% Al and Ni-50 at.% Al single crystals were tested in compression in the hard d 001 ¢ orientation. The dislocation processes and deformation behaviour were studied as a function of temperature, strain and strain rate. A slip transition in NiAl occurs from a d 111 ¢ slip to non- a d 111 ¢ slip at intermediate temperatures. In Ni-50 at.% Al single crystals, only a d 010 ¢ dislocations are observed above the slip transition temperature. In contrast, a (...) d 101 ¢ {101} glide has been observed to control deformation beyond the slip transition temperature in Ni-44 at.% Al. a d 101 ¢ dislocations are observed primarily along both d 111 ¢ directions in the glide plane. High-resolution transmission electron microscopy observations show that the core of the a d 101 ¢ dislocations along these directions is decomposed into two a d 010 ¢ dislocations, separated by a distance of approximately 2 nm. The temperature window of stability for these a d 101 ¢ dislocations depends upon the strain rate. At a strain rate of 1.4 2 10 m 4 s m 1 , a d 101 ¢ dislocations are observed between 800 and 1000 K. Complete decomposition of a d 101 ¢ dislocations into a d 010 ¢ dislocations occurs beyond 1000 K, leading to a d 010 ¢ climb as the deformation mode at higher temperatures. At lower strain rates, decomposition of a d 101 ¢ dislocations has been observed to occur along the edge orientation at temperatures below 1000 K. Embedded-atom method calculations and experimental results indicate that a d 101 ¢ dislocations have a large Peierls stress at low temperatures. Based on the present microstructural observations and a survey of the literature with respect to vacancy content and diffusion in NiAl, a model is proposed for a d 101 ¢ {101} glide in Ni-44 at.% Al, and for the observed yield strength versus temperature behaviour of Ni-Al alloys at intermediate and high temperatures. (shrink)

What ought one to do, epistemically speaking, when faced with a disagreement? Faced with this question, one naturally hopes for an answer that is principled, general, and intuitively satisfying. We want to argue that this is a vain hope. Our claim is that a satisfying answer will prove elusive because of non-transparency: that there is no condition such that we are always in a position to know whether it obtains. When we take seriously that there is nothing, including our own (...) minds, to which we have assured access, the familiar project of formulating epistemic norms is destabilized. In this paper, we will show how this plays out in the special case of disagreement. But we believe that a larger lesson can ultimately be extracted from our discussion: namely, that non-transparency threatens our hope for fully satisfying epistemic norms in general. (shrink)

This paper explains how the practice of ‘no platforming’ can be reconciled with a liberal politics. While opponents say that no platforming flouts ideals of open public discourse, and defenders see it as a justifiable harm-prevention measure, both sides mistakenly treat the debate like a run-of-the-mill free speech conflict, rather than an issue of academic freedom specifically. Content-based restrictions on speech in universities are ubiquitous. And this is no affront to a liberal conception of academic freedom, whose purpose isn’t just (...) to protect the speech of academics, but also to give them the prerogative to determine which views and speakers have sufficient disciplinary credentials to receive a hearing in academic contexts. No platforming should therefore be acceptable to liberals, in principle, in cases where it is used to support a university culture that maintains rigorous disciplinary standards, by denying attention and credibility to speakers without appropriate disciplinary credentials. (shrink)

This article presents a novel challenge to epistemic internalism. The challenge rests on a set of cases which feature subjects forming beliefs under conditions of “bad ideology”—that is, conditions in which pervasively false beliefs have the function of sustaining, and are sustained by, systems of social oppression. In such cases, the article suggests, the externalistic view that justification is in part a matter of worldly relations, rather than the internalistic view that justification is solely a matter of how things stand (...) from the agent’s individual perspective, becomes the more intuitively attractive theory. But these “bad ideology” cases do not merely yield intuitive verdicts that favor externalism over internalism. These cases are, moreover, analogous to precisely those canonical cases widely taken to be counterexamples to externalism: cases featuring brains-in-vats, clairvoyants, and dogmatists. That is, such “bad ideology” cases are, in all relevant respects, just like cases that are thought to count against externalism—except that they intuitively favor externalism. This, the author argues, is a serious worry for internalism. What is more, it bears on the debate over whether externalism is a genuinely “normative” epistemology. (shrink)

We suffer from genealogical anxiety when we worry that the contingent origins of our representations, once revealed, will somehow undermine or cast doubt on those representations. Is such anxiety ever rational? Many have apparently thought so, from pre-Socratic critics of Greek theology to contemporary evolutionary debunkers of morality. One strategy for vindicating critical genealogies is to see them as undermining the epistemic standing of our representations—the justification of our beliefs, the aptness of our concepts, and so on. I argue that (...) this strategy is not as promising as it might first seem. Instead, I suggest that critical genealogies can wield a sort of meta-epistemic power; in so far as we wish to resist the genealogical critic, we are under pressure to see ourselves as the beneficiaries of a certain kind of good luck: what I call genealogical luck. But there is also a resolutely non-epistemic way of understanding the power of critical genealogies, one that is essential, I argue, for understanding the genealogical projects of various theorists, including Nietzsche and Catharine MacKinnon. For critical genealogies can reveal what it is that our representations do—and what we, in turn, might do with them. (shrink)

Computability theory is the mathematical theory of algorithms, which explores the power and limitations of computation. Classical computability theory formalized the intuitive notion of an algorithm and provided a theoretical basis for digital computers. It also demonstrated the limitations of algorithms and showed that most sets of natural numbers and the problems they encode are not decidable (Turing computable). Important results of modern computability theory include the classification of the computational difficulty of sets and problems. Arithmetical and hyperarithmetical hierarchies and (...) the Turing degrees provide important measures of the level of such difficulty. There are uncountably many Turing degrees and they are partially ordered. These classifications are used in contemporary research to investigate the complexity of problems in modern computable mathematics, for example, regarding structures and their properties. (shrink)

Mindfulness can be understood as the mental ability to focus on the direct and immediate perception or monitoring of the present moment with a state of open and nonjudgmental awareness. Descriptions of mindfulness and methods for cultivating it originated in eastern spiritual traditions. These suggest that mindfulness can be developed through meditation practice to increase positive qualities such as awareness, insight, wisdom, and compassion. In this article we focus on the relationships between mindfulness, with associated meditation practices, and the cognitive (...) neuroscience of attention and awareness. Mindful awareness is related to distributed attention, phenomenal consciousness, and momentary self-awareness, as characterized by recent findings in cognitive psychology and neuroscience as well as in influential consciousness models. Finally, we outline an integrated neurocognitive model of mindfulness, attention, and awareness, with a key role of prefrontal cortex. (shrink)

Since its appearance over a decade ago, Timothy Williamson's anti-luminosity argument has come under sustained attack. Defenders of the luminous overwhelmingly object to the argument's use of a certain margin-for-error premise. Williamson himself claims that the premise follows easily from a safety condition on knowledge together with his description of the thought experiment. But luminists argue that this is not so: the margin-for-error premise either requires an implausible interpretation of the safety requirement on knowledge, or it requires other equally implausible (...) assumptions. In this paper I bolster the margin-for-error premise against these attacks by recasting Williamson's own two-part defence, the first part intended to work on the assumption that there is no constitutive connection between the phenomenal and the doxastic, and the second intended to work without this assumption. Pace various luminists, I argue that the appeals to safety needed for Williamson's two-part defence are plausible. I also argue that all that is needed to generate the margin-for-error premise from these safety conditions is an empirical assumption about the kinds of creatures we are: that is, creatures whose beliefs are structured by certain dispositions. By recasting the anti-luminosity argument in this way, we can understand what is really at stake in the debate about luminosity: that is, whether we are luminous. (shrink)

Metaphors and other tropes are commonly thought to reflect asymmetries in concreteness, with concrete sources being used to talk about relatively more abstract targets. Similarly, originating sense...

Current EEG research emphasizes gamma band coherence as a signature of functional integration, that is, the solution to the binding problem. We note that spatial patterns of coherent neural activity are also observed at other EEG frequencies. If these oscillations reflect Nunez's resonant modes, they offer a solution to the binding problem that emerges naturally from the architecture of cortical connections.

We examined proactive and reactive control effects in the context of task-relevant happy, sad, and angry facial expressions on a face-word Stroop task. Participants identified the emotion expressed by a face that contained a congruent or incongruent emotional word. Proactive control effects were measured in terms of the reduction in Stroop interference as a function of previous trial emotion and previous trial congruence. Reactive control effects were measured in terms of the reduction in Stroop interference as a function of current (...) trial emotion and previous trial congruence. Previous trial negative emotions exert greater influence on proactive control than the positive emotion. Sad faces in the previous trial resulted in greater reduction in the Stroop interference for happy faces in the current trial. However, current trial angry faces showed stronger adaptation effects compared to happy faces. Thus, both proactive and reactive control mechanisms are dependent on emotional valence of task-relevant stimuli. (shrink)

Text document classification and clustering is an important learning task which fits to both data mining and machine learning areas. The learning task throws several challenges when it is required to process high dimensional text documents. Word distribution in text documents plays a very key role in learning process. Research related to high dimensional text document classification and clustering is usually limited to application of traditional distance functions and most of the research contributions in the existing literature did not consider (...) the word distribution in documents. In this research, we propose a novel similarity function for feature pattern clustering and high dimensional text classification. The similarity function proposed is used to carry supervised learning based dimensionality reduction. The important feature of this work is that the word distribution before and after dimensionality reduction is the same. Experiment results prove the proposed approach achieves dimensionality reduction, retains the word distribution and obtained better classification accuracies compared to other measures. (shrink)

Integrated information theory of consciousness proposes an identity between its causal structure and phenomenology. Through this assertion, IIT aims to explain consciousness by prioritizing first-person experience. However, despite its phenomenology-first stance, developments in IIT have overlooked temporality. As such, we argue that at present IIT’s phenomenological analysis is incomplete. In this critique, we show how IIT takes a non-identical illusionist stance towards the experiences of continuity, flow, and extent of our experiences. Moreover, in isolating temporal grains of experience to a (...) single timescale, IIT misses out on capturing the multi-scale nested nature of temporal phenomena. Hence, we contend that IIT needs an axiom for time, through which its causal structure can be refined to account for temporal experiences. Here, we propose an axiom to address these concerns. We conclude by discussing how IIT may need to be revised if our concerns hold true. (shrink)

ABSTRACT:We extend the Base of the Pyramid (BoP) poverty-alleviation approach by recognizing the poor as valuable suppliers—specifically of intellectual property. Although the poor possess huge reserves of intellectual property, they are unable to participate in global knowledge networks owing to their illiteracy and poverty. This is a crippling form of social exclusion in today’s growing knowledge economy because it adversely affects their capabilities for advancement at several levels. Providing the poor access to global knowledge networks as rightful participants—as suppliers of (...) intellectual property—leads to poverty alleviation as a result of their increased social inclusion, not only through economic benefits, but also through the poor’s improved well-being as a result of their increased self-esteem and dignity. Using concepts from social network theory, we develop a poverty-alleviation approach to harness and integrate the intellectual property of the poor into global knowledge networks through trust-based partnerships among the poor, non-governmental organizations, and multinational corporations. (shrink)