To determine the effects of early undernutrition on learning and long-term memory, Swiss mice were cross-fostered randomly at birth to produce litter sizes of 6 and 16, thereby providing “normally nourished” and “undernourished” conditions. At 28 days of age, the pups were housed in groups of 3 and 4, with ad-lib access to food and water until testing began at 60 days of age. Each mouse received 50 active-avoidance training trials daily for 14 consecutive days. Retention testing began 14 days (...) after the end of original training and consisted of 50 trials daily for 5 days. Overall, mice reared in large litters suffered deficits in learning but not in long-term memory. (shrink)

Recently, growing numbers of interns, apprentices, and volunteers are being recruited to work seasonally on ecologically oriented and organic farms across the global north. To date, there has been very little research examining these emergent forms of non-waged work. In this paper, we analyze the relationships between non-waged agricultural work and the economic circumstances of small- to medium-size farms and the non-economic ambitions of farm operators. We do so through a quantitative and qualitative analysis of farmers’ responses to two surveys (...) we conducted of farmers using non-waged workers in Ontario, Canada. We situate our analysis within debates on the agrarian question, which we contend requires an account for both the economic and non-economic dimensions of new forms of non-waged work on farms. We suggest that many ecologically oriented farm operators are struggling financially and report low gross on-farm revenues and personal incomes. We argue that in addition to relying on off-farm incomes and self-exploitation, many farms are managing to persist in a challenging economic climate through their use of intern, apprentice, and volunteer labor. However, we also suggest that the growth of non-waged work on farms is not simply being driven by economic processes but also a series of non-economic relationships focused on non-institutional farmer training, the pursuit of sustainability, and social movement building. We suggest, the “economic” and “non-economic” dimensions of internships, apprenticeships, and forms of volunteerism sit uneasily alongside of one another, generating questions about the politics, ethics, and sustainability of non-waged work and ecological farming. (shrink)

This volume has 41 chapters written to honor the 100th birthday of Mario Bunge. It celebrates the work of this influential Argentine/Canadian physicist and philosopher. Contributions show the value of Bunge’s science-informed philosophy and his systematic approach to philosophical problems. The chapters explore the exceptionally wide spectrum of Bunge’s contributions to: metaphysics, methodology and philosophy of science, philosophy of mathematics, philosophy of physics, philosophy of psychology, philosophy of social science, philosophy of biology, philosophy of technology, moral philosophy, social and political (...) philosophy, medical philosophy, and education. The contributors include scholars from 16 countries. Bunge combines ontological realism with epistemological fallibilism. He believes that science provides the best and most warranted knowledge of the natural and social world, and that such knowledge is the only sound basis for moral decision making and social and political reform. Bunge argues for the unity of knowledge. In his eyes, science and philosophy constitute a fruitful and necessary partnership. Readers will discover the wisdom of this approach and will gain insight into the utility of cross-disciplinary scholarship. This anthology will appeal to researchers, students, and teachers in philosophy of science, social science, and liberal education programmes. 1. Introduction Section I. An Academic Vocation Section II. Philosophy Section III. Physics and Philosophy of Physics Section IV. Cognitive Science and Philosophy of Mind Section V. Sociology and Social Theory Section VI. Ethics and Political Philosophy Section VII. Biology and Philosophy of Biology Section VIII. Mathematics Section IX. Education Section X. Varia Section XI. Bibliography. (shrink)

Large‐scale patterns of correlated growth in development are partially driven by competition for metabolic and informational resources. It is argued that competition between organs for limited resources is an important mesoscale morphogenetic mechanism that produces fitness‐enhancing correlated growth. At the genetic level, the growth of individual characters appears independent, or “modular,” because patterns of expression and transcription are often highly localized, mutations have trait‐specific effects, and gene complexes can be co‐opted as a unit to produce novel traits. However, body parts (...) are known to interact over the course of ontogeny, and these reciprocal exchanges can be an important determinant of developmental outcomes. Genetic mechanisms underlie cell and tissue behaviors that allow organs to communicate with one another, but they also create evolutionarily adaptive competitive dynamics that are driven by physiological and biophysical processes. Advances in the understanding of competitive and closely related coordinative interactions across scales will complement existing research programs that emphasize the role of cellular mechanisms in morphogenesis. Study of the large‐scale order produced by competitive dynamics promises to facilitate advances in basic evolutionary and developmental biology, as well as applied research in fields such as bioengineering and regenerative medicine that aim to regulate patterning outcomes. (shrink)

Wedin offers an interpretation of Metaphysics Zeta 13, a very important and difficult chapter, where Aristotle apparently denies that substance is a universal, having, on most accounts, already claimed that form is substance, and that form is a universal. This interpretation of the argument of Z.13, Wedin argues, threatens the possibility of attaining a definition of substance, and places in doubt what has gone before in the treatise. According to Wedin, what Aristotle is concerned with in Z.13 is not the (...) denial that substance is a universal but rather with the denial that anything predicated universally of a c‐substance is the substance‐of the c‐substance, which Wedin calls ‘Weak proscription’. In Wedin's account of Z.13, then, Aristotle is continuing to pursue issues first raised in Z.10–11 that have to do with the relations between form and definition, and form and the universal. Wedin also argues that the dilemma at the conclusion of Z.13, regarding the definability of substance, is resolved in Z.16, with the notion of ‘Dual Complexity’, according to which the parts of a form exist potentially in the form, just as the parts of the c‐substance exist potentially in the c‐substance. (shrink)

This essay introduces a special report from The Hastings Center entitled Democracy in Crisis: Civic Learning and the Reconstruction of Common Purpose, which grew out of a project supported by the John S. and James L. Knight Foundation. This multiauthored report offers wide‐ranging assessments of increasing polarization and partisanship in American government and politics, and it proposes constructive responses to this in the provision of objective information, institutional reforms in government and the electoral system, and a reexamination of cultural and (...) political values needed if democracy is to function well in a pluralistic and diverse society. The essays in the special report explore the norms of civic learning and institutions, social movements, and communal innovations that can revitalize civic learning in practice. This introductory essay defines and explains the notion of civic learning, which is a lynchpin connecting many of the essays in the report. Civic learning pertains to the ways in which citizens learn about collective social problems and make decisions about them that reflect the duties and responsibilities of citizenship. Such learning can occur in many social settings in everyday life, and it can also be facilitated through participation in the processes of democratic governance on many levels. Civic learning is not doctrinaire and is compatible with a range of public goals and policies. It is an activity that increases what might be called the democratic capability of a people. (shrink)

Growth factor receptor tyrosine kinases (RTKs), such as the fibroblast growth factor receptor (FGFR), play a major role in how cells communicate with their environment. FGFR signaling is crucial for normal development, and its misregulation in humans has been linked to developmental abnormalities and cancer. The precise molecular mechanisms by which FGFRs transduce extracellular signals to effect specific biologic responses is an area of intense research. Genetic analyses in model organisms have played a central role in our evolving understanding of (...) these signal transduction cascades. Genetic studies in the nematode C. elegans have contributed to our knowledge of FGFR signaling by identifying genes involved in FGFR signal transduction and linking their gene products together into signaling modules. This review will describe FGFR-mediated signal transduction in C. elegans and focus on how these studies have contributed to our understanding of how FGFRs orchestrate the assembly of intracellular signaling pathways. BioEssays 23:1120–1130, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

This book brings together contributions from academics and practitioners to explore the implications of legal pluralism for legal development.

Graphical AbstractThe exquisite morphology of a complex body results from the sum of competitive and cooperative interactions among its subsystems. More details can be found in article number 1900245 by Richard Gawne et al. The cover image shows immunohistochemical staining (in red) of the head of a tadpole of Xenopus laevis, showing the brain, nostrils, and peripheral innervation.

_Paradoxes from A to Z, Third edition_ is the essential guide to paradoxes, and takes the reader on a lively tour of puzzles that have taxed thinkers from Zeno to Galileo, and Lewis Carroll to Bertrand Russell. Michael Clark uncovers an array of conundrums, such as Achilles and the Tortoise, Theseus’ Ship, and the Prisoner’s Dilemma, taking in subjects as diverse as knowledge, science, art and politics. Clark discusses each paradox in non-technical terms, considering its significance and looking at (...) likely solutions. This third edition is revised throughout, and adds nine new paradoxes that have important bearings in areas such as law, logic, ethics and probability. Paradoxes from A to Z, Third edition is an ideal starting point for those interested not just in philosophical puzzles and conundrums, but anyone seeking to hone their thinking skills. (shrink)

Michael J. Loux here presents a fresh reading of two of the most important books of the Metaphysics, Books Z and H, in which Aristotle presents his mature theory of primary substances. Focusing on the interplay of Aristotle's early and late views, Loux maintans that the later concept of ousia should be understood in terms of a theory of predication that carries interesting implications for contemporary metaphysics. Loux argues that in his first attempt in identifying ousiai in the Categories, (...) Aristotle encountered a set of ontological problems which he wrestled with again in Metaphysics Z and H. In the Categories, where the primary realities are basic subjects of predication construed in essentialist terms as things falling under natural kinds, familiar particulars are the primary ousiai. In subsequent works, Aristotle holds that since familiar particulars come into being and pass away, they must be composites of matter and form; and in Metaphysics Z and H, he explores the implications of this insight for the search for ousia. Maintaining that the substantial forms of familiar particulars are the primary ousiai, the later Aristotle interprets forms as predicable universals rather than as particulars, each uniquely possessed by a single object. (shrink)

Michael J. Loux here presents a fresh reading of two of the most important books of the Metaphysics, Books Z and H, in which Aristotle presents his mature ...

Aristotle claims in Metaphysics Z.17 that form is both a cause and principle of c‐substances. In this chapter, Wedin argues that the explanatory, or causal, role of form is in the background of the entire discussion, and indeed directs much of the argumentation of Metaphysics Zeta. Form is the cause of some matter being a unity and not a heap, because form alone explains how the material parts of a thing are united in a single whole. Wedin draws together the (...) main results of the preceding investigation of Zeta—that form is essence, that form must not contain matter or actual parts, and that form must not be a certain kind of universal—and he argues that these constraints on form are designed to serve the explanatory role that Aristotle explicitly gives to form in Z.17. Wedin emphasizes that the notions isolated in the examination of the earlier chapters, such as the purity of form, weak proscription, and dual complexity, each contribute to the account of form as the explanatory principle of c‐substance. (shrink)

Wedin argues that Aristotle makes form the substance of c‐substances because it is the essence of the c‐substance. Much of this chapter consists of a careful examination of a passage in Metaphysics Zeta 4, which Wedin calls the ‘New Primacy Passage’, that is crucial to Wedin's overall thesis, because here Aristotle appeals to a notion of definitional primacy, as opposed to the ontological primacy of the Categories. Z.4 focuses on this claim that form must be essence: Wedin argues that essence (...) is a certain kind of form, a form of a genus ; this does not mean ‘species’, as some commentators have thought. This is because the species is a combination of form and matter, whereas the genous eidos, Wedin argues, is the formal part only of the definition that applies to the thing. On Wedin's account, Aristotle introduces the notion of explanatory primacy of form in Z.4. (shrink)

Chapters 10 and 11 are critical to the argument of Metaphysics Zeta: these chapters are concerned with the purification of form. Z.10 introduces the apparatus of part and whole and consists of an argument to the end that form and its parts have priority over the other internal structural components of c‐substances, i.e. matter and the compound of form and matter; while in Z.11 Aristotle argues that form and its parts cannot involve any admixture of matter. Wedin argues that the (...) causal role of form presupposes its purity: if form is to explain why a certain portion of matter constitutes a c‐substance of a given kind, then matter—whether this latter is understood as functional, or remnant matter—cannot already be contained in the form. This is the ‘purity thesis’, as Wedin calls it: matter cannot be included in the definitions of natural organisms, Wedin points out, because that would make the explanandum a part of the principle that explains it. Wedin also argues that form must be sufficiently complex to provide definitions of the natures of particular compounds, which are complex, even though form itself is a kind of universal. (shrink)

In the Metaphysics, Aristotle often says that ‘form is substance’: in this chapter, Wedin argues that ‘substance’ in this context means the ‘substance‐of’ c‐substances. Wedin begins by examining Aristotle's use, and retention, of the framework of the Categories in Metaphysics Zeta, before turning to discuss Z.3, which is crucial to understanding the relation between the Categories and Metaphysics theories of substance, because it is usually thought that here Aristotle departs from the substance of the Categories. Wedin denies that Z.3 involves (...) a rejection of the Categories subjecthood criterion for primary substance: Aristotle rejects only the claim that one thing is the substance of another simply if it is the primary underlying subject of the other. Wedin argues that in Z.3 Aristotle introduces the idea of the ‘substance‐of’ a thing, and identifies as candidates for the substance of c‐substances the internal structural components form, matter, and the compound of form and matter. (shrink)

Blair equates the constructs of working memory (WM), executive function, and general fluid intelligence (gF). We argue that there is good reason not to equate these constructs. We view WM and gF as separable but highly related, and suggest that the mechanism behind the relationship is controlled attention – an ability that is dependent on normal functioning of the prefrontal cortex. (Published Online April 5 2006).

This essential guide to paradoxes takes the reader on a lively tour of puzzles that have taxed thinkers from Zeno to Galileo and Lewis Carroll to Bertrand Russell. Michael Clark uncovers an array of conundrums, such as Achilles and the Tortoise, Theseus' Ship, Hempel's Raven, and the Prisoners' Dilemma, taking in subjects as diverse as knowledge, ethics, science, art and politics. Clark discusses each paradox in non-technical terms, considering its significance and looking at likely solutions.