Neuronal aggregates involved in conscious awareness are not evenly distributed throughout the CNS but comprise key components referred to as the neural network correlates of consciousness (NNCC). A critical node in this network is the posterior cingulate, precuneal, and retrosplenial cortices. The cytological and neurochemical composition of this region is reviewed in relation to the Brodmann map. This region has the highest level of cortical glucose metabolism and cytochrome c oxidase activity. Monkey studies suggest that the anterior thalamic projection likely (...) drives retrosplenial and posterior cingulate cortex metabolism and that the midbrain projection to the anteroventral thalamic nucleus is a key coupling site between the brainstem system for arousal and cortical systems for cognitive processing and awareness. The pivotal role of the posterior cingulate, precuneal, and retrosplenial cortices in consciousness is demonstrated with posterior cingulate epilepsy cases, midcingulate lesions that de-afferent this region and are associated with unilateral sensory neglect, observations from stroke and vegetative state patients, alterations in blood flow during sleep, and the actions of general anesthetics. Since this region is critically involved in self reflection, it is not surprising that it is similarly a site for the NNCC. Interestingly, information processing during complex cognitive tasks and during aversive sensations such as pain induces efforts to terminate self reflection and result in decreased processing in posterior cingulate and precuneal cortices. (shrink)

Given someone’s fully specified posterior probability distribution q and information about the revision method that they employed to produce q, what can you infer about their prior probabilistic commitments? This question provides an entrée into a thoroughgoing discussion of a class of parameterizations of Jeffrey conditioning in which the parameters furnish information above and beyond that incorporated in \. Our analysis highlights the ubiquity of Bayes factors in the study of probability revision.

The problem of Galileo's logical methodology has long interested scholars. In this volume William A. Wallace offers a solution that is completely unexpected, yet backed by convincing documentary evidence. His analysis starts with an early notebook Galileo wrote at Pisa, appropriating a Jesuit professor's exposition of the Posterior Analystics of Aristotle, and ends with one of the last letters Galileo wrote, stating that in logic he has been a Peripatetic all his life. Wallace's detective work unearths the complete logic course (...) from which the notebook was excerpted, then proceeds to show how its terminology and methodology continue to surface in Galileo's later writings in which he founds his new sciences of the heavens and of local motion. The result is a tour de force that commends itself not only to Galileo's scholars and to logicians, philosophers, and historians, but to anyone interested in the epistemic roots of modern science. (shrink)

Las "Investigaciones Lógicas" han marcado la filosofía contemporánea como quizá ningún otro libro lo haya hecho. Sin embargo, la edición original se ha interpretado casi siempre desde la segunda, es decir, desde un estadio posterior y esencialmente diferente del desarrollo de la escuela fenomenológica. Edmund Husserl, en efecto, no permitió que su gran obra se reeditara sin modificarla muy hondamente, de acuerdo con las tesis nuevas de la fenomenología transcendental. Tampoco consintió traducciones que no se hicieran sobre la edición corregida. (...) De este modo, el contenido real de las primitivas Investigaciones se olvidó. No se tuvo presente en su justa medida hasta qué punto la psicognosia y la metafísica de Franz Brentano habían influido en Husserl. Este libro permite leer los Prolegómenos a la Lógica Pura tal como aparecieron primitivamente. Además, ofrece ya una clave hermenéutica global sobre el conjunto de las Investigaciones, cuya traducción comentada queda reservada para un volumen futuro. (shrink)

ABSTRACT Wilfrid Sellars argued that Kant’s account of the conceptual structures involved in experience can be given a linguistic turn so as to provide an analytic account of the resources a language must have in order to be the bearer of empirical knowledge. In this paper I examine the methodological aspects of Kant’s transcendental philosophy that Sellars took to be fundamental to influential themes in his own philosophy. My first aim here is to clarify and argue for the plausibility of (...) what I claim is Sellars’ interpretation of Kant’s ‘analytic’ transcendental method in the first Critique, based ultimately on non-trivial analytic truths concerning the concept of an object of our possible experience. Kant’s ‘transcendental proofs’ thereby avoid a certain methodological trilemma confronting the candidate premises of any such proof, taken from Sellars’ 1970s undergraduate exam question on Kant. In part II of the essay I conclude by highlighting in general terms how Kant’s method, as interpreted in the analytic manner explained in part I, was adapted by Sellars to produce some of the more influential aspects of his own philosophy, expressed in terms of what he contends is their sustainable reformulation in light of the so-called linguistic turn in twentieth-century philosophy. (shrink)

This volume collects Late Ancient, Byzantine and Medieval appropriations of Aristotle's Posterior Analytics, addressing the logic of inquiry, concept formation, the question whether metaphysics is a science, and the theory of demonstration.

The Drosophila anterior‐posterior pattern genes of the terminal class, particularly the tailless gene, affect structures derived from the acron and the tail region of the embryo. These domains correspond in position and function to asegmental domains at the termini of annelids and more primitive insect embryos. This suggests that terminal genes in Drosophila may have originated in an ancestor common to both annelids and arthropods, and thus that the specification of termini in these metameric organisms is an ancient, evolutionarily conserved (...) process. (shrink)

"Al igual que otras manifestaciones de la cultura occidental, la filosofía del derecho aparece en las más antiguas reflexiones de los filósofos griegos. Ello se patentiza sobre todo en el estudio de los textos de los grandes clásicos. La justicia, que es uno de los temas que con más persistencia se presentan en el desarrollo histórico de la filosofía jurídica, es objeto de un tratamiento especial en los autores de esta época. Ahora bien, el conocimiento de lo que estos filósofos (...) pensaron, no tiene un mero valor histórico, sino que muchas veces encierra una actualidad sorprendente, por la forma como han condicionado, y condicionan todavía la meditación jusfilosófica. De ahí su actualidad e importancia. No obstante, el reconocimiento de este hecho, los filósofos del derecho no han prestado la debida atención a la reflexión que surge de esta época germinal, que abarca un período relativamente breve (siglo VI a IV a. C.). Y son pocos, muy pocos, los jusfilósofos que abordan sin intermediarios, el tratamiento y estudio de este período. Ello explica nuestro interés en analizarlo a través de las fuentes mismas. A fin de precisar el objeto de este trabajo, creemos conveniente hacer algunas delimitaciones. Así, en cuanto a su extensión, intenta cubrir las primeras manifestaciones (desde Tales de Mileto, y aún antes) hasta Aristóteles de Estagira, que cierra el período clásico. La evolución posterior, aun siendo rica en desarrollos, es dejada para otra oportunidad. En cuanto a su alcance, este trabajo no pretende ser una exégesis detallada de la filosofía griega en su conjunto, ni tampoco un análisis de carácter histórico, económico, sociológico o político. No es incluso la obra de un helenista o un filólogo, sino de un interesado en los problemas de la filosofía del derecho, aunque el autor ha cuidado de premunirse de los mejores elementos de trabajo que utiliza la crítica para dar un mayor respaldo a sus afirmaciones. Se trata, si se quiere, de un estudio de carácter teórico sobre la Justicia —de lo que ella es en sí misma— de lo cual, sin embargo, pueden desprenderse enormes consecuencias en el mundo de la práctica". (shrink)

It has been argued that complex subjective sense of self is linked to the brain default-mode network (DMN). Recent discovery of heterogeneity between distinct subnets (or operational modules - OMs) of the DMN leads to a reconceptualization of its role for the experiential sense of self. Considering the recent proposition that the frontal DMN OM is responsible for the first-person perspective and the sense of agency, while the posterior DMN OMs are linked to the continuity of ‘I’ experience (including autobiographical (...) memories) through embodiment and localization within bodily space, we have tested in this study the hypothesis that heterogeneity in the operational synchrony strength within the frontal DMN OM among patients who are in a vegetative state (VS) could inform about a stable self-consciousness recovery later in the course of disease (up to six years post-injury). Using EEG operational synchrony analysis we have demonstrated that among the three OMs of the DMN only the frontal OM showed important heterogeneity in VS patients as a function of later stable clinical outcome. We also found that the frontal DMN OM was characterized by the process of active uncoupling (stronger in persistent VS) of operations performed by the involved neuronal assemblies. (shrink)

Using theoretical analysis of self-consciousness concept and experimental evidence on the brain default mode network (DMN) that constitutes the neural signature of self-referential processes, we hypothesized that the anterior and posterior subnets comprising the DMN should show differences in their integrity as a function of meditation training. Functional connectivity within DMN and its subnets (measured by operational synchrony) has been measured in ten novice meditators using an electroencephalogram (EEG) recording in a pre-/post-meditation intervention design. We have found that while the (...) whole DMN was clearly suppressed, different subnets of DMN responded differently after 4 months of meditation training: The strength of EEG operational synchrony in the right and left posterior modules of the DMN decreased in resting post-meditation condition compared to a pre-meditation condition, whereas the frontal DMN module on the contrary exhibited an increase in the strength of EEG operational synchrony. These findings combined with published data on functional–anatomic heterogeneity within the DMN and on trait subjective experiences commonly found following meditation allow us to propose that the first-person perspective and the sense of agency (the witnessing observer) are presented by the frontal DMN module, while the posterior modules of the DMN are generally responsible for the experience of the continuity of ‘I’ as embodied and localized within bodily space. Significance of these findings is discussed. (shrink)

There is renewed interest in how the different body plans of extant phyla are related. This question has traditionally been addressed by comparisons between vertebrates and Drosophila. Fortunately, there is now increasing emphasis on animals representing other phyla. Pentamerally symmetric echinoderms are a bilaterian metazoan phylum whose members exhibit secondarily derived radial symmetry. Precisely how their radially symmetric body plan originated from a bilaterally symmetric ancestor is unkown, however, two recent papers address this subject. Peterson et al.(1) propose a hypothesis (...) on evolution of the anteroposterior axis in echinoderms, and Arenas-Mena et al.(2) examine expression of five posterior Hox genes during development of the adult sea urchin. BioEssays 23:211–214, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

The presence of asymmetry in the human cerebral hemispheres is detectable at both the macroscopic and microscopic scales. The horizontal expansion of cortical surface during development (within individual brains), and across evolutionary time (between species), is largely due to the proliferation and spacing of the microscopic vertical columns of cells that form the cortex. In the asymmetric planum temporale (PT), minicolumn width asymmetry is associated with surface area asymmetry. Although the human minicolumn asymmetry is not large, it is estimated to (...) account for a surface area asymmetry of approximately 9% of the region’s size. Critically, this asymmetry of minicolumns is absent in the equivalent areas of the brains of other apes. The left-hemisphere dominance for processing speech is thought to depend, partly, on a bias for higher resolution processing across widely spaced minicolumns with less overlapping dendritic fields, whereas dense minicolumn spacing in the right hemisphere is associated with more overlapping, lower resolution, holistic processing. This concept refines the simple notion that a larger brain area is associated with dominance for a function and offers an alternative explanation associated with “processing type.” This account is mechanistic in the sense that it offers a mechanism whereby asymmetrical components of structure are related to specific functional biases yielding testable predictions, rather than the generalization that “bigger is better” for any given function. Face processing provides a test case – it is the opposite of language, being dominant in the right hemisphere. Consistent with the bias for holistic, configural processing of faces, the minicolumns in the right-hemisphere fusiform gyrus are thinner than in the left hemisphere, which is associated with featural processing. Again, this asymmetry is not found in chimpanzees. The difference between hemispheres may also be seen in terms of processing speed, facilitated by asymmetric myelination of white matter tracts ( Anderson et al., 1999 found that axons of the left posterior superior temporal lobe were more thickly myelinated). By cross-referencing the differences between the active fields of the two hemispheres, via tracts such as the corpus callosum, the relationship of local features to global features may be encoded. The emergent hierarchy of features within features is a recursive structure that may functionally contribute to generativity – the ability to perceive and express layers of structure and their relations to each other. The inference is that recursive generativity, an essential component of language, reflects an interaction between processing biases that may be traceable in the microstructure of the cerebral cortex. Minicolumn organization in the PT and the prefrontal cortex has been found to correlate with cognitive scores in humans. Altered minicolumn organization is also observed in neuropsychiatric disorders including autism and schizophrenia. Indeed, altered interhemispheric connections correlated with minicolumn asymmetry in schizophrenia may relate to language-processing anomalies that occur in the disorder. Schizophrenia is associated with over-interpretation of word meaning at the semantic level and over-interpretation of relevance at the level of pragmatic competence, whereas autism is associated with overly literal interpretation of word meaning and under-interpretation of social relevance at the pragmatic level. Both appear to emerge from a disruption of the ability to interpret layers of meaning and their relations to each other. This may be a consequence of disequilibrium in the processing of local and global features related to disorganization of minicolumnar units of processing. (shrink)

More than 50 years ago, Bongard introduced 100 visual concept learning problems as a challenge for artificial vision systems. These problems are now known as Bongard problems. Although they are well known in cognitive science and artificial intelligence, only very little progress has been made toward building systems that can solve a substantial subset of them. In the system presented here, visual features are extracted through image processing and then translated into a symbolic visual vocabulary. We introduce a formal language (...) that allows representing compositional visual concepts based on this vocabulary. Using this language and Bayesian inference, concepts can be induced from the examples that are provided in each problem. We find a reasonable agreement between the concepts with high posterior probability and the solutions formulated by Bongard himself for a subset of 35 problems. While this approach is far from solving Bongard problems like humans, it does considerably better than previous approaches. We discuss the issues we encountered while developing this system and their continuing relevance for understanding visual cognition. For instance, contrary to other concept learning problems, the examples are not random in Bongard problems; instead they are carefully chosen to ensure that the concept can be induced, and we found it helpful to take the resulting pragmatic constraints into account. (shrink)

Current report assessed measurement reproducibility and reliability of magnetic resonance spectroscopy (1H-MRS) at 3 Tesla in left and right posterior insular, pregenual and anterior midcingulate subdivisions. 10 healthy male volunteers aged 20 to 30 years were tested on four different days, of which 9 were included in the data analysis. Intra- and inter-subject variability of myo-Inositol (mI), Creatine (Cre), Glutamate (glu), total-Choline (tCho), total-N-acetylaspartate (tNAA) and combined Glutamine-Glutamate (Glx) were calculated considering the influence of movement parameters, age, daytime of measurements (...) and tissue composition. Overall mean intra-subject variability revealed small mean coefficients of variation (CV) across the four regions: 5.3% in aMCC, 6.6% in pgACC, 7.3% in pIL and 8.2% in pIR. For all neurochemicals combined, mean inter-subject variability demonstrated mean CVs of 9.05% (aMCC), 8.84% (pgACC), 10.00% (pIL) and 10.55% (pIR). Head movement, tissue composition and day time revealed no significant explanatory variance contribution suggesting a negligible influence on data. A strong correlation between Cramer-Rao Lower Bounds (CRLB; a measure of fitting errors) and the mean intra-subject CV (r=0.799, p<0.001) outlined the importance of low CRLB in order to obtain robust and finally meaningful 1H-MRS measures. The present findings confirm 1H-MRS as a reliable tool to measure brain neurochemistry in small subregions of the human brain. (shrink)

Psycholinguistic theories of meaning have developed within a univocal, explanatory model of science which is concerned with the use of language rather than its creation. Such a model is insufficient to deal with the complex data of human discourse with its multiple domains in speech, writing, reading, and interpreting. While recognizing the necessity of univocal explanatory procedures in the analysis of meaning the hermeneutic circle of explanation and understanding demands that "interpretation" occupy both a preliminary and a posterior place within (...) a scientific procedure. Problems of the univocal procedure in the study of language development, thought processes, and content analyses are more adequately handled by a hermeneutic model, such as the one developed by Paul Ricoeur on the works of Freud. Freudian psychoanalysis while approximating this model tends to be univocal rather than plurivocal in its treatment of the role of symbols in the creation of meaning. A hermeneutic model would place the crucial emphasis on a dialectic of both suspicion and affirmation. (shrink)

Sortal concepts are at the center of certain logical discussions and have played a significant role in solutions to particular problems in philosophy. Apart from logic and philosophy, the study of sortal concepts has found its place in specific fields of psychology, such as the theory of infant cognitive development and the theory of human perception. In this monograph, different formal logics for sortal concepts and sortal-related logical notions are characterized. Most of these logics are intensional in nature and possess, (...) in addition, a bidimensional character. That is, they simultaneously represent two different logical dimensions. In most cases, the dimensions are those of time and natural necessity, and, in other cases, those of time and epistemic necessity. Another feature of the logics in question concerns second-order quantification over sortal concepts, a logical notion that is also represented in the logics. Some of the logics adopt a constant domain interpretation, others a varying domain interpretation of such quantification. Two of the above bidimensional logics are philosophically grounded on predication sortalism, that is, on the philosophical view that predication necessarily requires sortal concepts. Another bidimensional logic constitutes a logic for complex sortal predicates. These three sorts of logics are among the important novelties of this work since logics with similar features have not been developed up to now, and they might be instrumental for the solution of philosophically significant problems regarding sortal predicates. The book assumes a modern variant of conceptualism as a philosophical background. For this reason, the approach to sortal predicates is in terms of sortal concepts. Concepts, in general, are here understood as intersubjective realizable cognitive capacities. The proper features of sortal concepts are determined by an analysis of the main features of sortal predicates. Posterior to this analysis, the sortal-related logical notions represented in the above logics are discussed. There is also a discussion on the extent to which the set-theoretic formal semantic systems of the book capture different aspects of the conceptualist approach to sortals. These different semantic frameworks are also related to realist and nominalist approaches to sortal predicates, and possible modifications to them are considered that might represent those alternative approaches. (shrink)

This article compares the De ordine and the De libero arbitrio in order to show how in the works after the so-called “Dialogues of Cassiciacum” a greater philosophical and dialectical complexity is evident. In particular, the complexity of the method used is analysed, the development of the topic of moral evil is highlighted, as well as the issue of the necessity of evil.

Spatially and temporally restricted expression of Hox genes requires multiple mechanisms at both the transcriptional and the post-transcriptional levels. New insight into this precise expression mechanism comes from recent findings of a novel sense–antisense miRNA combination from the bithorax complex of Drosophila melanogaster.1-4 These two miRNAs encoded from the same locus target 3′ untranslated regions of anterior hox genes, Antp, Ubx and abd-A to establish the dominance of posterior hox gene Abd-B in its expression domain. Such double-edge tools, sense–antisense miRNA (...) combinations, also operate at multiple loci in the genome implicating their wider impact on the post-transcriptional gene regulation in eukaryotes. BioEssays 30:1058–1061, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Frank A. Lewis presents a close study of book Zeta of Aristotle's Metaphysics, one of his most dense and controversial texts, commonly understood to contain his deepest thoughts on the definition of substance and related metaphysical issues. Lewis argues that Aristotle returns to the causal view of primary substance from his Posterior Analytics.

Single-cell studies of monkey posterior parietal cortex (PPC) have revealed the extensive neuronal representations of three-dimensional subject motion and three-dimensional layout of the environment. I propose that navigational planning integrates this PPC information, including gravity signals, with horizontal-plane based information provided by the hippocampal formation, modified in primates by expansion of the ventral stream.

In Posterior Analytics II 19 Aristotle likens the way in which sense perception gives rise to knowledge of the universal to the way in which one soldier’s ceasing his flight from the enemy leads other soldiers to do the same ‘heôs epi archên êlthen.’ Although the remark seems intended to characterize knowledge as the end result of an accumulative process, the concluding reference to ‘a starting point’ or archê has no clear meaning. I argue that the phrase can be plausibly (...) understood in light of Aristotle’s explanation of how a single calm thought can spread calm to other thoughts (Problems 917a29-33) and a single cloud can serve as a starting point (archê) for a revival of stormy weather (Problems 941a9-13). In addition, Aristotle elsewhere (e.g. Generation of Animals 788a13-16) speaks of the archê as the person or thing which initiates a process. Thus, when one soldier’s stopping causes another soldier to stop, this process can continue ‘until they come to the one who initiated the process.’ . (shrink)

Aristotle, in the Posterior Analytics, connects his account of definition and explanation with the theory of division. The features that figure in the relevant explanation include those that distinguish the kind in its relevant genus. His account of differentiation into genera and species is strongly interconnected with his explanation‐involving account of definition.