Results for 'methioinine metabolism'

531 found
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  1.  4
    The role of lipoylation in mitochondrial adaptation to methionine restriction.Jingyuan Xue & Cunqi Ye - 2024 - Bioessays 46 (6):2300218.
    Dietary methionine restriction (MR) is associated with a spectrum of health‐promoting benefits. Being conducive to prevention of chronic diseases and extension of life span, MR can activate integrated responses at metabolic, transcriptional, and physiological levels. However, how the mitochondria of MR influence metabolic phenotypes remains elusive. Here, we provide a summary of cellular functions of methionine metabolism and an overview of the current understanding of effector mechanisms of MR, with a focus on the aspect of mitochondria‐mediated responses. We propose (...)
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  2. Metabolism Instead of Machine: Towards an Ontology of Hybrids.Julia Rijssenbeek, Vincent Blok & Zoë Robaey - 2022 - Philosophy and Technology 35 (3):1-23.
    The emerging field of synthetic biology aims to engineer novel biological entities. The envisioned future bio-based economy builds largely on “cell factories”: organisms that have been metabolically engineered to sustainably produce substances for human ends. In this paper, we argue that synthetic biology’s goal of creating efficient production vessels for industrial applications implies a set of ontological assumptions according to which living organisms are machines. Traditionally, a machine is understood as a technological, isolated and controllable production unit consisting of parts. (...)
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  3.  6
    Materiality Versus Metabolism in the Hybrid World: Towards a Dualist Concept of Materialism as Limit of Post-humanism in the Technical Era.Vincent Blok - 2024 - Philosophy and Technology 37 (60):1-22.
    The point of departure of this article is the trend towards hybridisation in new technology development, which makes classical dichotomies between machines, human life and the environment obsolete and leads to the post-human world we live in today. We critically reflect on the post-human concept of the hybrid world. Although we agree with post-humanists that human life can no longer be opposed to machines but appears as a decentralized human-technology relation, alliance or network that constitutes a hybrid world, we ask (...)
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  4.  95
    Is metabolism necessary?M. A. Boden - 1999 - British Journal for the Philosophy of Science 50 (2):231-248.
    Metabolism is a criterion of life. Three senses are distinguished. The weakest allows strong A-Life: virtual creatures having physical existence in computer electronics, but not bodies, are classes as 'alive'. The second excludes strong A-Life but allows that some non-biochemical A-Life robots could be classed as alive. The third, which stresses the body's self-production by energy budgeting and self-equilibrating energy exchanges of some (necessary) complexity, excludes both strong A-Life and living non-biochemical robots.
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  5.  21
    Metabolism and pulse rate as related to reading under high and low levels of illumination.R. A. McFarland, C. A. Knehr & C. Berens - 1939 - Journal of Experimental Psychology 25 (1):65.
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  6.  29
    Iron metabolism: microbes, mouse, and man.Gladys O. Latunde-Dada - 2009 - Bioessays 31 (12):1309-1317.
    Recent advances in research on iron metabolism have revealed the identity of a number of genes, signal transduction pathways, and proteins involved in iron regulation in mammals. The emerging paradigm is a coordination of homeostasis within a network of classical iron metabolic pathways and other cellular processes such as cell differentiation, growth, inflammation, immunity, and a host of physiologic and pathologic conditions. Iron, immunity, and infection are intricately linked and their regulation is fundamental to the survival of mammals. The (...)
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  7. Metabolism, energy, and entropy in Marx's critique of political economy: Beyond the Podolinsky myth.Paul Burkett & John Bellamy Foster - 2006 - Theory and Society 35 (1):109-156.
  8.  8
    Metabolism and chromatin: A dynamic duo that regulates development and ageing.Andromachi Pouikli & Peter Tessarz - 2021 - Bioessays 43 (5):2000273.
    Bone‐marrow mesenchymal stem cell (BM‐MSC) proliferation and lineage commitment are under the coordinated control of metabolism and epigenetics; the MSC niche contains low oxygen, which is an important determinant of the cellular metabolic state. In turn, metabolism drives stem cell fate decisions via alterations of the chromatin landscape. Due to the fundamental role of BM‐MSCs in the development of adipose tissue, bones and cartilage, age‐associated changes in metabolism and the epigenome perturb the balance between stem cell proliferation (...)
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  9.  12
    “Minimal metabolism”: A key concept to investigate the origins and nature of biological systems.Nino Lauber, Christoph Flamm & Kepa Ruiz-Mirazo - 2021 - Bioessays 43 (10):2100103.
    The systems view on life and its emergence from complex chemistry has remarkably increased the scientific attention on metabolism in the last two decades. However, during this time there has not been much theoretical discussion on what constitutes a metabolism and what role it actually played in biogenesis. A critical and updated review on the topic is here offered, including some references to classical models from last century, but focusing more on current and future research. Metabolism is (...)
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  10.  44
    Carbon metabolism of the terrestrial biosphere: A multitechnique approach for improved understanding.J. G. Canadell, H. A. Mooney, D. D. Baldocchi, J. A. Berry, J. R. Ehleringer, C. B. Field, S. T. Gower, D. Y. Hollinger, J. E. Hunt, R. B. Jackson, S. W. Running, G. R. Shaver, W. Steffen, S. E. Trumbore, R. Valentini & B. Y. Bond - unknown
    Understanding terrestrial carbon metabolism is critical because terrestrial ecosystems play a major role in the global carbon cycle. Furthermore, humans have severely disrupted the carbon cycle in ways that will alter the climate system and directly affect terrestrial metabolism. Changes in terrestrial metabolism may well be as important an indicator of global change as the changing temperature signal. Improving our understanding of the carbon cycle at various spatial and temporal scales will require the integration of multiple, complementary (...)
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  11.  27
    Energy metabolism and the evolution of reproductive suppression in the human female.Grazyna Jasienska - 2003 - Acta Biotheoretica 51 (1):1-18.
    Reproduction places severe demands on the energy metabolism in human females. When physical work entails higher energy expenditure, not enough energy will be left for the support of the reproductive processes and temporal suppression of the reproductive function is expected. While energy needed for reproduction may be obtained by increases in energy intake, utilization of fat reserves, or reallocation of energy from basal metabolism, several environmental or physiological constraints render such solutions unlikely. For human ancestors increases in energy (...)
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  12. Mind, Matter, and Metabolism.Peter Godfrey-Smith - 2016 - Journal of Philosophy 113 (10):481-506.
    I discuss the bearing on the mind-body problem of some general characteristics of living systems, including the physical basis of metabolism and the relation between living activity and cognitive capacities in simple organisms. I then attempt to describe stages in the history of animal life important to the evolution of subjective experience. Features of the biological basis of cognition are used to criticize arguments against materialism that draw on the conceivability of a separation between mental and physical. I also (...)
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  13. Materiality Versus Metabolism in the Hybrid World : Towards a Dualist Concept of Materialism as Limit of Post-humanism in the Technical Era.Vincent Blok - unknown
    The point of departure of this article is the trend towards hybridisation in new technology development, which makes classical dichotomies between machines, human life and the environment obsolete and leads to the post-human world we live in today. We critically reflect on the post-human concept of the hybrid world. Although we agree with post-humanists that human life can no longer be opposed to machines but appears as a decentralized human-technology relation, alliance or network that constitutes a hybrid world, we ask (...)
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  14.  47
    Metabolism: Utopian Urbanism and the Japanese Modern Architecture Movement.Tomoko Tamari - 2014 - Theory, Culture and Society 31 (7-8):201-225.
    The Fukushima catastrophe has led to important practical and conceptual shifts in contemporary Japanese architecture which in turn has led to a re-evaluation of the influential 1960s Japanese modern architecture movement, Metabolism. The Metabolists had the ambition to create a new Japanese society through techno-utopian city planning. The new generation of Japanese architects, after the Fukushima event, no longer seek evolutionally social change; rather, the disaster has made them re-consider what architecture is and what architects can do for people (...)
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  15. The logic of metabolism and its fuzzy consequences.A. Danchin - 2014 - Environmental Microbiology 16 (1):19-28.
    Intermediary metabolism molecules are orchestrated into logical pathways stemming from history (L-amino acids, D-sugars) and dynamic constraints (hydrolysis of pyrophosphate or amide groups is the driving force of anabolism). Beside essential metabolites, numerous variants derive from programmed or accidental changes. Broken down, variants enter standard pathways, producing further variants. Macromolecule modification alters enzyme reactions specificity. Metabolism conform thermodynamic laws, precluding strict accuracy. Hence, for each regular pathway, a wealth of variants inputs and produces metabolites that are similar to (...)
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  16.  12
    Managing enzyme promiscuity in plant specialized metabolism: A lesson from flavonoid biosynthesis.Toshiyuki Waki, Seiji Takahashi & Toru Nakayama - 2021 - Bioessays 43 (3):2000164.
    Specificities of enzymes involved in plant specialized metabolism, including flavonoid biosynthesis, are generally promiscuous. This enzyme promiscuity has served as an evolutionary basis for new enzyme functions and metabolic pathways in land plants adapting to environmental challenges. This phenomenon may lead, however, to inefficiency in specialized metabolism and adversely affect metabolite‐mediated plant survival. How plants manage enzyme promiscuity for efficient specialized metabolism is, thus, an open question. Recent studies of flavonoid biosynthesis addressing this issue have revealed a (...)
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  17. From Obesity to Energy Metabolism: Ontological Perspectives on the Metrics of Human Bodies.Davide Serpico & Andrea Borghini - 2020 - Topoi 40 (3):577-586.
    In this paper, we aim at rethinking the concept of obesity in a way that better captures the connection between underlying medical aspects, on the one hand, and an individual’s developmental history, on the other. Our proposal rests on the idea that obesity is not to be understood as a phenotypic trait or character; rather, obesity represents one of the many possible states of a more complex phenotypic trait that we call ‘energy metabolism.’ We argue that this apparently simple (...)
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  18.  53
    When metabolism meets topology: Reconciling metabolite and reaction networks.Raul Montañez, Miguel Angel Medina, Ricard V. Solé & Carlos Rodríguez-Caso - 2010 - Bioessays 32 (3):246-256.
    The search for a systems‐level picture of metabolism as a web of molecular interactions provides a paradigmatic example of how the methods used to characterize a system can bias the interpretation of its functional meaning. Metabolic maps have been analyzed using novel techniques from network theory, revealing some non‐trivial, functionally relevant properties. These include a small‐world structure and hierarchical modularity. However, as discussed here, some of these properties might actually result from an inappropriate way of defining network interactions. Starting (...)
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  19.  39
    The Metabolism of the State.Sean Erwin - 2015 - Epoché: A Journal for the History of Philosophy 20 (1):81-104.
    At Discorsi II.20, Machiavelli defines auxiliary arms as those, “whom a prince or a republic send captained and already paid for, for your aid.” My contention is that Machiavelli’s treatment of auxiliary arms is much more nuanced than it may seem at first glance. Throughout his works, Machiavelli articulates this type of force from the standpoint of the prince but also, surprisingly, from the standpoint of the people. In their princely employment, auxiliary arms act instrumentally as means for the projection (...)
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  20.  35
    Carbohydrate metabolism during vertebrate appendage regeneration: What is its role? How is it regulated?Nick R. Love, Mathias Ziegler, Yaoyao Chen & Enrique Amaya - 2014 - Bioessays 36 (1):27-33.
    We recently examined gene expression during Xenopus tadpole tail appendage regeneration and found that carbohydrate regulatory genes were dramatically altered during the regeneration process. In this essay, we speculate that these changes in gene expression play an essential role during regeneration by stimulating the anabolic pathways required for the reconstruction of a new appendage. We hypothesize that during regeneration, cells use leptin, slc2a3, proinsulin, g6pd, hif1α expression, receptor tyrosine kinase (RTK) signaling, and the production of reactive oxygen species (ROS) to (...)
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  21. Metabolism, autonomy, and individuality.Hannah Landecker - 2017 - In Scott Lidgard & Lynn K. Nyhart (eds.), Biological Individuality: Integrating Scientific, Philosophical, and Historical Perspectives. University of Chicago Press.
     
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  22. Marx’s Theory of Metabolism in the Age of Global Ecological Crisis.Kohei Saito - 2020 - Historical Materialism 28 (2):3-24.
    When the existing order cannot offer a solution, the solution to climate crisis must come from the radical left, and this is precisely why Karl Marx’s idea of ecosocialism is more important than ever. In this context, it is worth revisiting not only the legacy of István Mészáros’s theory of ‘social metabolism’ and that of his successors – who can be categorised as comprising the ‘metabolic rift school’, which includes John Bellamy Foster, Paul Burkett, and Brett Clark –, but (...)
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  23.  17
    Intermediary metabolism in the early twentieth century.Frederic L. Holmes - 1986 - In William Bechtel (ed.), Integrating Scientific Disciplines. University of Chicago Press. pp. 59--76.
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  24.  18
    Gut microbial metabolism and colon cancer: Can manipulations of the microbiota be useful in the management of gastrointestinal health?Antoaneta Belcheva, Thergiory Irrazabal & Alberto Martin - 2015 - Bioessays 37 (4):403-412.
    The gut microbiota is an important component of the human body and its immune‐modulating and metabolic activities are critical to maintain good health. Gut microbes, however, are sensitive to changes in diet, exposure to antibiotics, or infections, all of which cause transient disruptions in the microbial composition, a phenomenon known as dysbiosis. It is now recognized that microbial dysbiosis is at the root of many gastrointestinal disorders. However, the mechanisms through which bacterial dysbiosis initiates disease are not fully understood. Microbially‐derived (...)
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  25.  46
    Sortilin: An unusual suspect in cholesterol metabolism.Joseph B. Dubé, Christopher T. Johansen & Robert A. Hegele - 2011 - Bioessays 33 (6):430-437.
    The concentration of low‐density lipoprotein (LDL) cholesterol (C) in plasma is a key determinant of cardiovascular disease risk and human genetic studies have long endeavoured to elucidate the pathways that regulate LDL metabolism. Massive genome‐wide association studies (GWASs) of common genetic variation associated with LDL‐C in the population have implicated SORT1 in LDL metabolism. Using experimental paradigms and standards appropriate for understanding the mechanisms by which common variants alter phenotypic expression, three recent publications have presented divergent and even (...)
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  26.  34
    How can we understand metabolism.David A. Fell - 2007 - In Fred C. Boogerd, Frank J. Bruggeman, Jan-Hendrik S. Hofmeyr & Hans V. Westerhoff (eds.), Systems Biology: Philosophical Foundations. Elsevier. pp. 87--102.
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  27.  27
    Citrate transport and metabolism in mammalian cells.Maria E. Mycielska, Ameet Patel, Nahit Rizaner, Maciej P. Mazurek, Hector Keun, Anup Patel, Vadivel Ganapathy & Mustafa B. A. Djamgoz - 2009 - Bioessays 31 (1):10-20.
    Citrate, an organic trivalent anion, is a major substrate for generation of energy in most cells. It is produced in mitochondria and used either in the Krebs' cycle or released into cytoplasm through a specific mitochondrial carriers. Citrate can also be taken up from blood through different plasma membrane transporters. In the cytoplasm, citrate can be used ultimately for fatty acid synthesis, which is increased in cancer cells. Here, we review the ways in which citrate can be transported and discuss (...)
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  28.  14
    Information metabolism as a model of consciousness.Andrzej Kokoszka - 1993 - International Journal of Neuroscience 68:165-77.
  29.  11
    Metabolic Reprogramming is a Hallmark of Metabolism Itself.Miguel Ángel Medina - 2020 - Bioessays 42 (10):2000058.
    The reprogramming of metabolism has been identified as one of the hallmarks of cancer. It is becoming more and more frequent to connect other diseases with metabolic reprogramming. This article aims to argue that metabolic reprogramming is not driven by disease but instead is the main hallmark of metabolism, based on its dynamic behavior that allows it to continuously adapt to changes in the internal and external conditions.
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  30.  16
    Mitochondrial one‐carbon metabolism is adapted to the specific needs of yeast, plants and mammals.Karen E. Christensen & Robert E. MacKenzie - 2006 - Bioessays 28 (6):595-605.
    In eukaryotes, folate metabolism is compartmentalized between the cytoplasm and organelles. The folate pathways of mitochondria are adapted to serve the metabolism of the organism. In yeast, mitochondria support cytoplasmic purine synthesis through the generation of formate. This pathway is important but not essential for survival, consistent with the flexibility of yeast metabolism. In plants, the mitochondrial pathways support photorespiration by generating serine from glycine. This pathway is essential under photosynthetic conditions and the enzyme expression varies with (...)
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  31.  17
    Hypothalamic fatty acid metabolism: A housekeeping pathway that regulates food intake.Miguel López, Christopher J. Lelliott & Antonio Vidal-Puig - 2007 - Bioessays 29 (3):248-261.
    The hypothalamus is a specialized area in the brain that integrates the control of energy homeostasis. More than 70 years ago, it was proposed that the central nervous system sensed circulating levels of metabolites such as glucose, lipids and amino acids and modified feeding according to the levels of those molecules. This led to the formulation of the Glucostatic, Lipostatic and Aminostatic Hypotheses. It has taken almost that much time to demonstrate that circulating long‐chain fatty acids act as signals of (...)
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  32. Regional cerebral glucose metabolism in akinetic catatonia and after remission.S. Goldman - unknown
    K L Kahlbaum published in 1874 the first recorded description of catatonia. Akinetic catatonia is now defined as a neuropsychiatric syndrome principally characterised by akinesia, mutism, stupor, and catalepsy. 1 Even if some advances have been made in the recognition of catatonia, in particular by the development of different rating scales, 1 the pathophysiology of this syndrome is not clearly established. A right handed 14 year old girl presented with akinetic catatonia during an episode of depression in the context of (...)
     
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  33.  12
    Studies of vitamin A metabolism in mouse model systems.Max E. Gottesman, Loredana Quadro & William S. Blaner - 2001 - Bioessays 23 (5):409-419.
    Over the past several years, discoveries from mouse genetics have had direct impact on our understanding of vitamin A metabolism. Although the metabolism of vitamin A in the mouse does have some special features (for example very large stores of liver and pulmonary retinyl esters), the ability to construct knockout and transgenic mouse models has yielded an impressive amount of information directly relevant to understanding the general principles of vitamin A transport, storage and degradation. We discuss below the (...)
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  34.  37
    Selfish metabolism.Harold J. Morowitz, Eric Smith & Vijayasarathi Srinivasan - 2008 - Complexity 14 (2):7-9.
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  35.  73
    Metabolism in a-life: Reply to Boden.Mark Alliksaar - 2001 - British Journal for the Philosophy of Science 52 (1):131-135.
  36. Adaptivity: From metabolism to behavior.Xabier Barandiaran & Alvaro Moreno - 2008 - Adaptive Behavior 16 (5):325-344.
  37.  50
    Learned regulation of brain metabolism.Niels Birbaumer, Sergio Ruiz & Ranganatha Sitaram - 2013 - Trends in Cognitive Sciences 17 (6):295-302.
  38.  6
    Underground metabolism.Richard D'Ari & Josep Casadesús - 1998 - Bioessays 20 (2):181-186.
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  39.  14
    Brain Metabolism During A Lower Extremity Voluntary Movement Task in Children With Spastic Cerebral Palsy.Eileen G. Fowler, William L. Oppenheim, Marcia B. Greenberg, Loretta A. Staudt, Shantanu H. Joshi & Daniel H. S. Silverman - 2020 - Frontiers in Human Neuroscience 14.
  40.  4
    Time‐restricted feeding regulates lipid metabolism under metabolic challenges.Yiming Guo, Christopher Livelo & Girish C. Melkani - 2023 - Bioessays 45 (12):2300157.
    Dysregulation of lipid metabolism is a commonly observed feature associated with metabolic syndrome and leads to the development of negative health outcomes such as obesity, diabetes mellitus, non‐alcoholic fatty liver disease, or atherosclerosis. Time‐restricted feeding/eating (TRF/TRE), an emerging dietary intervention, has been shown to promote pleiotropic health benefits including the alteration of diurnal expression of genes associated with lipid metabolism, as well as levels of lipid species. Although TRF likely induces a response in multiple organs leading to the (...)
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  41.  65
    Carbon metabolism: Global capitalism, climate change, and the biospheric rift. [REVIEW]Brett Clark & Richard York - 2005 - Theory and Society 34 (4):391-428.
  42.  12
    Metabolism and the triggering of feeding behavior.C. Laria-Timo - 1983 - Behavioral and Brain Sciences 6 (4):745.
  43.  36
    The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity.Snehal N. Chaudhari & Edward T. Kipreos - 2018 - Bioessays 40 (8):1800005.
    Fused, elongated mitochondria are more efficient in generating ATP than fragmented mitochondria. In diverse C. elegans longevity pathways, increased levels of fused mitochondria are associated with lifespan extension. Blocking mitochondrial fusion in these animals abolishes their extended longevity. The long‐lived C. elegans vhl‐1 mutant is an exception that does not have increased fused mitochondria, and is not dependent on fusion for longevity. Loss of mammalian VHL upregulates alternate energy generating pathways. This suggests that mitochondrial fusion facilitates longevity in C. elegans (...)
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  44.  23
    Long non‐coding RNAs in cancer metabolism.Zhen-Dong Xiao, Li Zhuang & Boyi Gan - 2016 - Bioessays 38 (10):991-996.
    Altered cellular metabolism is an emerging hallmark of cancer. Accumulating recent evidence links long non‐coding RNAs (lncRNAs), a still poorly understood class of non‐coding RNAs, to cancer metabolism. Here we review the emerging findings on the functions of lncRNAs in cancer metabolism, with particular emphasis on how lncRNAs regulate glucose and glutamine metabolism in cancer cells, discuss how lncRNAs regulate various aspects of cancer metabolism through their cross‐talk with other macromolecules, explore the mechanistic conceptual framework (...)
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  45.  25
    Long non‐coding RNAs in cancer metabolism.Zhen-Dong Xiao, Li Zhuang & Boyi Gan - 2016 - Bioessays 38 (10):991-996.
    Altered cellular metabolism is an emerging hallmark of cancer. Accumulating recent evidence links long non‐coding RNAs (lncRNAs), a still poorly understood class of non‐coding RNAs, to cancer metabolism. Here we review the emerging findings on the functions of lncRNAs in cancer metabolism, with particular emphasis on how lncRNAs regulate glucose and glutamine metabolism in cancer cells, discuss how lncRNAs regulate various aspects of cancer metabolism through their cross‐talk with other macromolecules, explore the mechanistic conceptual framework (...)
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  46.  31
    From the selfish gene_ to _selfish metabolism: Revisiting the central dogma.Víctor de Lorenzo - 2014 - Bioessays 36 (3):226-235.
    The standard representation of the Central Dogma (CD) of Molecular Biology conspicuously ignores metabolism. However, both the metabolites and the biochemical fluxes behind any biological phenomenon are encrypted in the DNA sequence. Metabolism constrains and even changes the information flow when the DNA‐encoded instructions conflict with the homeostasis of the biochemical network. Inspection of adaptive virulence programs and emergence of xenobiotic‐biodegradation pathways in environmental bacteria suggest that their main evolutionary drive is the expansion of their metabolic networks towards (...)
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  47.  11
    Inborn errors of GABA metabolism.Kenneth M. Gibson, William L. Nyhan & Jaak Jaeken - 1986 - Bioessays 4 (1):24-27.
    Defects in man in four steps of 4‐aminobutyric acid (GABA) metabolism may interefere with the function of this major inhibitory neurotransmitter. Glutamic acid decarboxylase, 4‐aminobutyric acid aminotransferase, succinic semialdehyde dehydrogenase, and homocarnosinase are closely identified with the brain, but two of these enzymes are expressed in cultured peripheral cells, which may permit novel approaches to the study of the metabolism and regulation of GABA.
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  48.  33
    The capitalist metabolism: an unachieved subsumption of life under the value-form.Timothée Haug - 2018 - Journal for Cultural Research 22 (2):191-203.
    This article views capitalism not only as a mode of production, but also as a mediation of the reproduction of life, following the concept of ‘social metabolism’ that Marx employs to analyze the interaction between the individuals composing a society and their natural environment. Insofar as the ‘value-form’ is the distinctive social relation of capitalism, it appears necessary to ask whether the metabolic process of reproduction can be fully subsumed under this form. Marx takes for granted the idea that (...)
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  49.  34
    Mathematical Modeling of Metabolism and Hemodynamics.J. Francoise, C. Menuel, M. Lahutte & J. -N. Vallée - 2012 - Acta Biotheoretica 60 (1-2):99-107.
    We provide a mathematical study of a model of energy metabolism and hemodynamics of glioma allowing a better understanding of metabolic modifications leading to anaplastic transformation from low grade glioma.This mathematical analysis allows ultimately to unveil the solution to a viability problem which seems quite pertinent for applications to medecine.
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  50.  9
    Metabolomics meets lipidomics: Assessing the small molecule component of metabolism.Hector Gallart-Ayala, Tony Teav & Julijana Ivanisevic - 2020 - Bioessays 42 (12):2000052.
    Metabolomics, including lipidomics, is emerging as a quantitative biology approach for the assessment of energy flow through metabolism and information flow through metabolic signaling; thus, providing novel insights into metabolism and its regulation, in health, healthy ageing and disease. In this forward‐looking review we provide an overview on the origins of metabolomics, on its role in this postgenomic era of biochemistry and its application to investigate metabolite role and (bio)activity, from model systems to human population studies. We present (...)
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