Background The European Union aims to optimize patient protection and efficiency of health-care research by harmonizing procedures across Member States. Nonetheless, further improvements are required to increase multicenter research efficiency. We investigated IRB procedures in a large prospective European multicenter study on traumatic brain injury, aiming to inform and stimulate initiatives to improve efficiency. Methods We reviewed relevant documents regarding IRB submission and IRB approval from European neurotrauma centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury. (...) Documents included detailed information on IRB procedures and the duration from IRB submission until approval. They were translated and analyzed to determine the level of harmonization of IRB procedures within Europe. Results From 18 countries, 66 centers provided the requested documents. The primary IRB review was conducted centrally or locally and primary IRB approval was obtained after one, two or three review rounds with a median duration of respectively 50 and 98 days until primary IRB approval. Additional IRB approval was required in 55% of countries and could increase duration to 535 days. Total duration from submission until required IRB approval was obtained was 114 days and appeared to be shorter after submission to local IRBs compared to central IRBs. Conclusion We found variation in IRB procedures between and within European countries. There were differences in submission and approval requirements, number of review rounds and total duration. Research collaborations could benefit from the implementation of more uniform legislation and regulation while acknowledging local cultural habits and moral values between countries. (shrink)

Reduced Environmental Stimulation Therapy (REST) alters the balance of sensory input to the nervous system by systematically attenuating sensory signals from visual, auditory, thermal, tactile, vestibular, and proprioceptive channels. Previous research from our group has shown that REST via floatation acutely reduces anxiety and blood pressure while simultaneously heightening interoceptive awareness in clinically anxious populations. Anorexia nervosa (AN) is an eating disorder characterized by elevated anxiety, distorted body representation, and abnormal interoception, raising the question of whether REST might positively impact (...) these symptoms. However, this approach has never been studied in eating disorders and it is unknown whether exposure to REST might worsen AN symptoms. To examine these possibilities we conducted an open-label study to investigate the safety and tolerability of REST in AN. We also explored the impact of REST on affective symptoms, body image disturbance, and interoception. Twenty-one partially weight-restored AN outpatients completed a protocol involving four sequential sessions of REST: reclining in a zero-gravity chair, floating in an open pool, and two sessions of floating in an enclosed pool. All sessions were 90 minutes, approximately one week apart. We measured orthostatic blood pressure before and immediately after each session (primary outcome), in addition to collecting blood pressure readings every 10 minutes during the session using a wireless waterproof system as a secondary outcome measure. Each participant's affective state, awareness of interoceptive sensations, and body image was assessed before and after every session (exploratory outcomes). There was no evidence of orthostatic hypotension following floating, and no adverse events (primary outcome). Secondary analyses revealed that REST induced statistically significant reductions in blood pressure, anxiety and negative affect, heightened awareness of cardiorespiratory but not gastrointestinal sensations, and reduced body image dissatisfaction. The findings from this initial trial suggest that individuals with AN can safely tolerate the physical effects of REST via floatation. Future randomized controlled trials will need to investigate whether these initial observations of improved anxiety, interoception, and body image disturbance can be effectively extended to acutely ill AN populations. (shrink)

Cet ouvrage vise à montrer l’importance « philosophique et scientifique » de traités biologiques d’Aristote qui, formant plus du tiers du corpus, pourraient faire de leur auteur le père de la sociobiologie et suggérer des réponses aux interrogations actuelles sur la distinction entre l’homme et l’animal (p. 13-14). Que la démarcation entre les deux soit moins tranchée qu’on ne l’a parfois admis, telle semble être la thèse rectrice de cette étude, une idée que l’A. cherche à établir par le bia...

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

China’s extensive media presence in Africa aims to distinguish itself through the use of constructive journalism in contrast with the perceived dominance of conflict journalism by Western media outlets. However, many scholars have raised questions of consistency surrounding Chinese media’s use of constructive journalism in representing Africa (e.g. Marsh, Citation2016). With perspectives from Galtung’s (Citation1987, p. 1998) conflict and peace journalism, this research applies Critical Discourse Analysis to examine Chinese media’s representation of Africa to an international audience. Using linguistic data (...) from China Radio International’s Today, it challenges the distinctions among peace journalism, solutions journalism and constructive journalism. The findings show that China’s claim of constructive journalism strongly favors the coverage of China, yet is largely absent in the coverage of the African continent. It suggests that while Chinese state-sponsored media utilizes the so-called constructive journalism when presenting information about a specific region to that region, these representations are not consistent across their international coverage. Hence, Africa remains a victim of conflict journalism. (shrink)

In trying to characterize the relationship between psychology and neuroscience, the trend has been to argue that reductionism does not work without suggesting a suitable substitute. I offer explanatory extension as a good model for elucidating the complex relationship among disciplines which are obviously connected but which do not share pragmatic explanatory features. Explanatory extension rests on the idea that one field can "illuminate" issues that were incompletely treated in another. In this paper, I explain how this "illumination" would work (...) between psychology and neuroscience. (shrink)

Introduction. Taking the Workers’ and Peasants’ Red Army of 1941—1945 as an example the authors identify features of the personnel selection in the army during military operations, conditions, requirements, criteria, qualities necessary for promotion to higher command positions. The aim of the study is to identify the mechanism of personnel selection in the armed forces during military operations. Methods. The authors use the following general scientific methods: modeling, structural and functional, systemic and comparative analysis; movement from the abstract to the (...) concrete and from the concrete to the abstract. The authors make use of P.A. Sorokin’s theory of vertical mobility. For further research of the problem, the methodology of synergetics and counterfactual modeling of the past can be involved. Scientific novelty of the research. The following existing concepts of the Red Army officers’ dynamics in 1941—1945 are generalized: positive, negative, moral and psychological selection. Their basic concepts and shortcomings are revealed. An initiativeintellectual concept of the officers’ selection in war is formulated on the basis of P. Sorokin’s theory of vertical mobility. The author identify specific conditions, requirements, and criteria influencing the selection of commanders during the war. Results. A clear opposition to the conditions, requirements and selection criteria in peacetime and wartime is given. The following specific criteria for selecting officers of the Red Army during the war are highlighted: the presence of combat experience; non-conformism; the ability to take personal responsibility; analyze and correct errors; nonstandard thinking. Military action creates specific conditions that give rise to the selection criteria for commanders. Conclusions. The selection criteria for personnel in peacetime and wartime armies differ sharply. At the beginning of battle actions, stereotyped commanders prevailed. Such people are replaced by commanders who are able to go beyond the established canons, orders of the chiefs. The work presents a diagram showing the stages of selecting officers in a war: military actions — conditions — selection criteria - requirements — new qualities of a person adapted to combat operations. This leads to the success of military operations, and, consequently, to the promotion of officers in rank and position. (shrink)

Recent research (e.g., Evans & Over, 2004) has provided support for the hypothesis that people evaluate the probability of conditional statements of the form if p then q as the conditional probability of q given p , P( q / p ). The present paper extends this approach to pragmatic conditionals in the form of inducements (i.e., promises and threats) and advice (i.e., tips and warnings). In so doing, we demonstrate a distinction between the truth status of these conditionals and (...) their effectiveness as speech acts. Specifically, while probability judgements of the truth of conditional inducements and advice are highly correlated with estimates of P( q / p ), their perceived effectiveness in changing behaviour instead varies as a function of the conditional probability of q given not-p , P( q / ∼p ). Finally, we show that the conditional probability approach can be extended to predicting inference rates on a conditional reasoning task. (shrink)

European Journal of Philosophy, Volume 29, Issue 1, Page 266-269, March 2021.

Cet ouvrage, publication d'une thèse d'Ecole des Chartes remaniée et soutenue comme thèse de doctorat en 1998, nous fait découvrir la figure remarquable d'une femme de pouvoir au XIVe siècle, Yolande de Flandre, dame de Cassel (1326-1395). Yolande, héritière du seigneur de Cassel, se marie jeune avec le comte de Bar. Veuve dès 1344, elle se trouve pour la première fois en position de gouverner comme régente du Barrois, position qu'elle revendique et défend jusqu'en 1360. En 1353, elle...

Hisashi Nasu, Lester Embree, George Psathas, and Ilja Srubar (eds.), Alfred Schutz and His Intellectual Partners; Sandra P. Thomas and Howard R. Pollio, Listening to Patients, A Phenomenological Approach to Nursing Research and Practice; Matthew Ratcliffe, Rethinking Commonsense Psychology: A Critique of Folk Psychology, Theory of Mind and Simulation.

Hisashi Nasu, Lester Embree, George Psathas, and Ilja Srubar (eds.), Alfred Schutz and His Intellectual Partners; Sandra P. Thomas and Howard R. Pollio, Listening to Patients, A Phenomenological Approach to Nursing Research and Practice; Matthew Ratcliffe, Rethinking Commonsense Psychology: A Critique of Folk Psychology, Theory of Mind and Simulation.

(No abstract is available for this citation).

The theory of mind (ToM) deficit associated with autism spectrum disorder has been a central topic in the debate about the modularity of the mind. In a series of papers, Philip Gerrans and Valerie Stone argue that positing a ToM module does not best explain the deficits exhibited by individuals with autism (Gerrans 2002; Stone & Gerrans 2006a, 2006b; Gerrans & Stone 2008). In this paper, I first criticize Gerrans and Stone’s (2008) account. Second, I discuss various studies of individuals (...) with autism and argue that they are best explained by positing a higher-level, domain-specific ToM module. (shrink)

The theory of mind (ToM) deficit associated with autism has been a central topic in the debate about the modularity of the mind. Most involved in the debate about the explanation of the ToM deficit have failed to notice that autism’s status as a spectrum disorder has implications about which explanation is more plausible. In this paper, I argue that the shift from viewing autism as a unified syndrome to a spectrum disorder increases the plausibility of the explanation of the (...) ToM deficit that appeals to a domain-specific, higher-level ToM module. First, I discuss what it means to consider autism as a spectrum rather than as a unified disorder. Second, I argue for the plausibility of the modular explanation on the basis that autism is better considered as a spectrum disorder. Third, I respond to a potential challenge to my account from Philip Gerrans and Valerie Stone’s recent work (Gerrans, Biol Philos 17:305–321, 2002; Stone and Gerrans, Trends Cogn Sci 10:3–4, 2006a; Soc Neurosci 1:309–319, 2006b; Gerrans and Stone, Br J Philos Sci 59:121–141, 2008). (shrink)

This pamphlet contains essays by Will Herberg, C. Herman Pritchett, David Fellman, Valerie Earle and Sidney Hook on the principle of academic freedom, its implications, and its recognition by the courts. Will Herberg in the opening essay argues that the greatest threat to academic freedom is the politicization of the university, the pressure to convert the university into an agency of social and political action. Unless the university is thoroughly depoliticized and rededicated exclusively to the cause of learning and scholarship, (...) warns Herberg, it will be destroyed. C. H. Pritchett provides a useful summary of nearly all the Supreme Court's decisions bearing in some way on the academic freedom of teachers. Sidney Hook maintains that the Supreme Court has failed to make certain basic distinctions in its opinions, i.e., between the obligations of public employees and employees in private institutions; between those in professions of public trust and those who are not; and between membership in highly disciplined organizations with purposes antithetical to democratic values and membership in others which are broad in purpose and loosely bound together. From an analysis of the opinions of the Supreme Court and the nature and defense of academic freedom, Hook concludes that the court is a very uncertain protector and guide. In matters of professional ethics, it is the faculties themselves which must uphold and enforce standards of professional integrity. Their failure to do so has led to unnecessary and unwise legislative intervention. Recent events on many college and university campuses, and in particular the increasing resort to civil courts to adjudicate what are basically professional disputes, have emphasized the need for the type of discussion contained in this brief volume.--J. P. D. (shrink)

The following is a revised version of a paper presented last May at a conference at L'Universite Paul Valery, Montpellier, France. The topic of the conference was "The Libertarian Problematic," that is, how the libertarian movement is to define itself, its premises, its composition,and its project for the future.

About seventy-five years ago, philosophers and literary intellectuals as diverse as Edmund Husserl, George Santayana, and Paul Valéry, aware of the declining influence of Christianity on Western culture, spoke of “the crisis of Western civilization.” Santayana observed: “The present age is a critical one and interesting to live in. The civilization characteristic of Christendom has not disappeared, yet another civilization has begun to take its place. We still understand the value of religious faith.... On the other hand, the shell (...) of Christendom is broken.” All three pinned their hopes for the future of the West, not so much on a revived influence of a divided Christendom, but on the revival of the classical sources of Western culture, and Valéry insisted on an acknowledgment of the West’s debt to Roman law and Roman Catholicism. (shrink)

Valerie Steele, conservatrice du musée du Fashion Institute of Technology de New York et rédactrice en chef d'une revue de grande qualité, Fashion Theory : the journal of Dress, Body and Culture, est une référence très importante dans le domaine de l'histoire de la mode. Ce livre (traduit de l'américain) ne répond que très imparfaitement à son titre ambitieux ­ « se vêtir » ­, qui est aussi celui d'une collection (deux ouvrages déjà parus, l'un sur le Moyen Âge et (...) l'autre sur le XVIIIe... (shrink)

L’ouvrage que publie Valérie Beaudouin, tiré de sa thèse soutenue en 2000, se signale par de nombreuses qualités, parmi lesquelles on distinguera l’ampleur de la matière étudiée, l’originalité de la démarche et des méthodes, l’intérêt neuf et majeur de maints résultats, le renouvellement méthodologique qu’il apporte dans le domaine de la métrique française. L’auteur s’est proposé de décrire le vers du théâtre classique, en s’appuyant sur un corpus constitué de la totalité des pièces de Cornei..

Depuis les travaux pionniers des années 1970, les domestiques étaient restés en marge des problématiques de l'histoire du travail et de l'histoire des femmes. Et pourtant, l'évolution de la condition ancillaire décline un ensemble de questions essentielles à la compréhension du tissu social et de la place des femmes sur le marché du travail. La recherche de Valérie Piette sur la Belgique du XIXe siècle en est une brillante démonstration. Elle repose sur une exploration méthodique des...

Ce livre est issu d’un mémoire de maîtrise, soutenue en 2006 et couronnée par le prix Mnémosyne. Il présente et discute le cas d’une femme de la haute noblesse normande, Marie de La Roche, qui, à la fin du XVe siècle, résista énergiquement aux spoliations dont la menaçait le lignage de son premier mari, Michel d’Estouteville, après la mort de ce dernier en 1469. Par une minutieuse enquête dans les archives dont témoigne une grosse pièce justificative publiée en Annexe (p. (...) 169-251) et utilemen... (shrink)

Sugar, pork, beer, corn, cider, scrapple, and hoppin' John all became staples in the diet of colonial America. The ways Americans cultivated and prepared food and the values they attributed to it played an important role in shaping the identity of the newborn nation. In A Revolution in Eating, James E. McWilliams presents a colorful and spirited tour of culinary attitudes, tastes, and techniques throughout colonial America. Confronted by strange new animals, plants, and landscapes, settlers in the colonies and West (...) Indies found new ways to produce food. Integrating their British and European tastes with the demands and bounty of the rugged American environment, early Americans developed a range of regional cuisines. From the kitchen tables of typical Puritan families to Iroquois longhouses in the backcountry and slave kitchens on southern plantations, McWilliams portrays the grand variety and inventiveness that characterized colonial cuisine. As colonial America grew, so did its palate, as interactions among European settlers, Native Americans, and African slaves created new dishes and attitudes about food. McWilliams considers how Indian corn, once thought by the colonists as "fit for swine," became a fixture in the colonial diet. He also examines the ways in which African slaves influenced West Indian and American southern cuisine. While a mania for all things British was a unifying feature of eighteenth-century cuisine, the colonies discovered a national beverage in domestically brewed beer, which came to symbolize solidarity and loyalty to the patriotic cause in the Revolutionary era. The beer and alcohol industry also instigated unprecedented trade among the colonies and further integrated colonial habits and tastes. Victory in the American Revolution initiated a "culinary declaration of independence," prompting the antimonarchical habits of simplicity, frugality, and frontier ruggedness to define American cuisine. McWilliams demonstrates that this was a shift not so much in new ingredients or cooking methods, as in the way Americans imbued food and cuisine with values that continue to shape American attitudes to this day. (shrink)